Table of Contents Table of Contents
Previous Page  506 / 812 Next Page
Information
Show Menu
Previous Page 506 / 812 Next Page
Page Background

S502

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1463

EV479

Depressive episode among young

Moroccan students

I. Jaouahir

1 ,

, F. Z

. Azzaoui

2 , A.

Ahami

1 , M.

Faid

3

1

Faculty of Science, Department of Biology, Kenitra, Morocco

2

Faculty of Science Ben M’sik, Department of Biology, Casablanca,

Morocco

3

Agronomic and Veterinary Hassan II Institute, IAV, Rabat, Morocco

Corresponding author.

Introduction

In Morocco, 48.9% of the population surveyed in

2003, had at least one mental health disorder

[1,2] . M

ood disorder

was the most prevalent psychopathology found among children of

15 years (26.5%)

[2] .

Objective

To study the prevalence of depressive episode (DE) of

young Moroccan students.

Subjects and methods

The present study is a cross-sectional study

conducted among 942 students, aged 18 to 25 and studying in

a vocational training institute in Mohammedia (North West of

Morocco). DE is evaluated by the Mini International Neuropsychi-

atric Interview.

Results

The results showed that 86% of trainees present a DE,

The distribution of DE percentages varies according to its differ-

ent degrees; 50% of studied students suffer from a severe DE, 62%

suffer from a moderate DE, 24% had a mild DE and 14% had no DE.

Conclusion

The rate of depression is very high among these stu-

dents. Deeper investigations are needed to determine all factors

involved in this psychopathology.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

References

[1] Ministère de la Santé. Stratégie nationale, Santé mentale

et toxicomanie. Enquête nationale sur la santé, direction

d’épidémiologie; 2003.

[2] Asouab F, Agoub M, Kadri N, Moussaoui D, Rachidi S, Tazi

MA, et al. Prévalences des troubles mentaux dans la popula-

tion générale marocaine (enquête nationale). D.E.L.M. bulletin

épidémiologique; 2005.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1464

EV480

Associations among immune

activation, the clinical characteristics,

and the current severity of the “with

anxious distress” specifier in patients

with depressive disorders

W.M. Bahk

1 ,

, I.H. Shim

2

, Y.S. Woo

1

, S.Y. Lee

3

, Y.J. Kwon

4

,

D.I. Jon

5 , H.J

. Seo

1 , B.W

. Nam

6 , J.S.

Seo

6

1

Yeouido St. Mary’s Hospital, psychiatry, Seoul, Republic of Korea

2

Dongnam Institute of Radiological & Medical Sciences, psychiatry,

Busan, Republic of Korea

3

Wonkwang University School of Medicine, psychiatry, Iksan,

Republic of Korea

4

Soonchunhyang Cheonan Hospital, psychiatry, Cheonan, Republic of

Korea

5

Sacred Heart Hospital, Hallym University, psychiatry, Anyang,

Republic of Korea

6

Konkuk University, Chungju Hospital, psychiatry, Chungju, Republic

of Korea

Corresponding author.

Introduction

This study assessed the levels of immune factors,

demographic and clinical characteristics, and pharmacological

treatments of patients with depressive disorders and com-

pared them between patients with mild-to-moderate and

moderate/severe-to-severe anxiety.

Methods

This study included 177 patients diagnosed with a

depressive disorder who were hospitalized between March 2012

and April 2015. The patients were categorized into mild-to-

moderate anxious distress andmoderate/severe-to-severe anxious

distress groups, based on the criteria of the Diagnostic and Statis-

tical Manual of Mental Disorders, Fifth Edition (DSM-5) based on

the “with anxious distress” specifier. The current severity of symp-

toms was determined using the Hamilton Depression Rating Scale

(HAM-D) scores on the Agitation and Anxiety-Psychic subscales.

The charts of the patients were reviewed to evaluate immune fac-

tors, including C-reactive protein (CRP) and white blood cell (WBC)

levels, confounding factors, such as smoking, other general med-

ical disorders, and body mass index (BMI), and demographic and

clinical characteristics.

Results

The moderate–severe to severe anxious distress group

tended to have higher CRP and monocyte levels compared with the

mild to moderate anxious distress group. However, after adjust-

ing for the total HAM-D scores, there was a significant difference

only in monocyte levels. After this adjustment, patients with

moderate–severe to severe anxious distress had a significantly

greater trend toward significance for suicidality and a higher rate

of antipsychotic use.

Conclusions

High levels of anxiety symptoms may influence

various underlying pathophysiological factors and modulate the

inflammatory response and course of illness, affecting treatment

planning.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1465

EV481

The effectiveness of various potential

predictors of response to treatment

with SSRIs in patients with depressive

disorder

M. Bares

1 ,

, T. Novak

1

, M. Brunovsky

2

1

National Institute of Mental Health Czech Republic, 2nd

Department, Klecany, Czech Republic

2

National Institute of Mental Health Czech Republic, Department of

Applied Electrophysiology of Brain, Klecany, Czech Republic

Corresponding author.

Introduction

The substantial non-response rate in depressive

patients indicates a need to identify predictors of treatment out-

come.

Objective and aims

The aim of the open-label, 6-week study was:

– to compare efficacy of a priori definedpredictors:

20% reduction

inMADRS score at week 1,

20% reduction inMADRS score at week

2 (RM

20% W2), decrease of prefrontal theta cordance value (RC)

and increase of serum/plasma brain-derived neurotrophic factor

(BDNF) at week 1;

– to assess whether the combination of these factors yield more

robust predictive power than when used singly.

Methods

All patients (

n

= 38) were hospitalized and treated with

various SSRIs. Areas under curve (AUC) as well as predictive values

were calculated to compare predictive effect of single and com-

bined predictor model.

Results

Twenty-one patients (55%) achieved response. The

RM

20% W2 (AUC-0.83) showed better predictive efficacy com-

pared to all other predictors with exception of RC. Other

significant differences were not detected. The identified (logis-

tic regression) combined predictive model (RM

20% W2 + RC)

predicted response with accuracy of 82% (AUC-0.92) and was

significantly better than other predictors but not RM

20% W2

and RC.