Table of Contents Table of Contents
Previous Page  509 / 812 Next Page
Information
Show Menu
Previous Page 509 / 812 Next Page
Page Background

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S505

a cluster of other vegetative and cognitive symptoms causing sig-

nificant distress of functioning. It has a relapsing and recurring

course and frequently becomes chronic. Thus, there is a need to fur-

ther develop therapeutic techniques to improve the course and the

prognosis of depressive disorders. Recent clinical trials suggest that

botulinum toxin (BTX) treatment may also have an antidepressant

effect.

Objective

The authors aim to conduct a non-systematic review

in order to understand the relationship between MDD and BTX

treatment.

Aims

To assess whether current evidence supports the BTX to

treat major depressive patients.

Methods

A non-systematic review of English scientific literature

was conducted through research in the PubMed search engine,

using the keywords “botulinum toxin” and “depression”.

Results

There is a small but growing body of evidence suggesting

that botulinum toxin may be useful for the treatment of depres-

sion. The main hypothesis for the proposed beneficial effects of

botulinum toxin is through the facial feedback. Low mood and

depression are often associated with a sad facial expression. Inject-

ing botulinum toxin and improving facial expression would lead to

the improvement of depression symptoms.

Conclusions

Positive effects on mood have been observed in

subjects who underwent treatment of glabellar frown lines with

botulinumtoxin. It supports the concept that the facial musculature

not only expresses, but also regulates mood states.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1473

EV489

Impact and importance of anhedonia

as a mediating variable in

amelioration of social functioning in

depressed patients

D. Gourion

1 ,

, F . V

inckier

2 , S. M

ouchabac

3

1

Private practice, Paris, France

2

Centre hospitalier Saint-Anne, Psychiatry, Paris, France

3

Centre hospitalier Saint-Antoine, Psychiatry, Paris, France

Corresponding author.

Background

Anhedonia is a core dimension of major depressive

disorder (MDD). Paradoxically, the association between anhedonia

and social impairment is poorly known.

Objective

To determine the longitudinal relationships between

depressive symptoms, anhedonia, and social functioning in

depressed patients treated with agomelatine.

Material and method

One thousand five hundred and seventy

patients withMDD starting treatment with agomelatine prescribed

by their GPs were included in a prospective study (follow-up: 10 to

14 weeks). Patients were assessed at baseline and at the end point

of the study, using the MADRS to assess antidepressant efficacy,

the SHAPS scale and an original visual analog scale exploring the

subjective pleasure felt by patients in their main leisure activity to

measure anhedonia, and the QFS to measure social functioning in

its qualitative and quantitative dimensions. In addition to the uni-

variate analyses, a mediation path analysis was performed using

the Sobel test.

Results

The results showed a robust and significant improvement

in symptoms of depression, anhedonia, and social functioning. The

correlations between the SHAPS and QFS scores were high and

significant. Subsequent analyses showed that amelioration of anhe-

donia is a significant mediating variable between the progression

of depressive symptoms and social functioning ( QFS G = –14.3,

P

< 0.0001) and explains around one third of the variance of the

model (35.37%).

Conclusion

Anhedonia, a major dimension of depression, pro-

vides specific insights into the understanding of the complex links

between residual symptoms of MDD and social functioning. In con-

clusion, improving the evaluation of anhedonia is a fundamental

issue in primary care.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1474

EV490

Acceptance and commitment therapy

(ACT) predictive factors of return to

work after depression

S. Darbeda

, J.C.

Seznec

Institut national de la santé et de la recherche médicale Inserm,

UMR-1178 Mental Health and Public Health, Paris, France

Corresponding author.

Introduction

Prolonged sick leaves are a major risk to quit the

world of work and depression is the leading cause of disability in

France. New therapies from the third wave of CBT as the Commit-

ment and Acceptance Therapy (ACT) may be interesting to promote

the return to work (RTW).

Objectives

To assess predictive factors of return to work after

depression.

Methods

This is a descriptive, prospective andmulticentric study.

The recruitment of investigating doctors was conducted by the

publication of an advertisement in a French journal of occu-

pational medicine. Each investigator recruited patients during

reinstatement medical examination after a prolonged sick leave

for depressive syndrome. Sociodemographic, occupational, medi-

cal and psychological factors (particularly in connection with the

ACT) was assessed at baseline and 3 months later.

Results

Thirty-one patients were initially included in the study,

but 2 were lost to follow up at 3 months and 29 were analyzed.

Twenty three patients RTW at 3 months. Those who RTW were

less anxious (

P

= 0.023), less depressed (

P

= 0.021), had a better

impression of improvement (

P

= 0.0066) and had a lower score of

experiential avoidance (

P

= 0.0025).

Conclusions

The ACT, through its action on the reduction of expe-

riential avoidance, and the definitions of new life values could allow

a faster RTW after a sick leave for depressive syndrome.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1475

EV491

Childhood abuse in adult women with

unipolar depression seeking

treatment at a tertiary care centre in

India, compared to healthy women

G. Devasthali

1 ,

, K. Jangam

2

, T. Ka

2

, A. Raj

2

, M. Kesavan

1

1

National Institute of Mental Health and Neurosciences, Dept of

Psychiatry, Bangalore, India

2

National Institute of Mental Health and Neurosciences, Deptt of

Psychiatry Social Work, Bangalore, India

Corresponding author.

Introduction

Childhood abuse has been reported as a precursor

and maintaining factors for adult psychiatric disorders. Childhood

physical abuse, neglect and sexual abuse have been independently

reported in women with depression. There is a serious dearth of

literature on the incidence of childhood abuse among women with

depression from India.

Objectives & aims

We investigated and compared the incidence

of childhood abuse (overall) – physical, emotional and sexual (indi-

vidual components)- amongwomen seeking treatment for unipolar

depression (UD) compared to healthy women (HW).