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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S365

EV48

Treatment of patients with opioid

addiction with different disease

duration

N. Khodjaeva

, S. Sultanov

Tashkent medical academy, Psychiatry and Narcology, Tashkent,

Uzbekistan

Corresponding author.

To study the characteristics of medical and rehabilitation care for

patients with opioid dependence we have investigated 50 patients.

All patients on long-termuse of opioids were divided into 2 groups.

The duration of drug abuse in group 1 ranged from 4 months

up to 5 years. In the second group, the duration of dependence

was more than 5 years. Patients in the second group of somatic-

neurological symptoms were having somatic disorders and organic

brain damage. Systematic observation in drug treatment clinics at

the place of and maintenance treatment of at least one year was

achieved in 8.48% of patients of group 1 and 3.85% of the second

group. Consequently, the role of the therapeutic factor in trying to

achieve regression syndrome pathological attraction in early stages

of the disease, we recognizemore productive. Patients of the second

group with a large weighting of disease duration was noted clinical

abstinence syndrome both by somatic and neurological disorders,

as well as by more severe anxiety, dysphoric disorders. These dis-

orders require the inclusion in the scheme of treatment techniques

aimed at more effective detoxification and immune reactivity of

the organism. Patients of the second group was added to the treat-

ment nootropics and immunomodulators. Analysis of the results

of treatment in patients with drug addiction with different disease

duration showed significant differences in the effectiveness. In the

second group with a duration of more than 5 years of addiction, it

is advisable to the treatment nootropics, immunomodulators.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1033

EV49

Neurobiological basis of mutual

influence of stress burden and alcohol

addiction: Review of data

V. Korostiy

1 ,

, M. Markova

2

, H. Kozhyna

1

, K. Gaponov

2

,

V. Lytvynenko

2

1

Kharkiv National Medical University, Psychyatry- Narcology and

Medical Psychology, Kharkov, Ukraine

2

Kharkiv Medical Academy of Postgraduate Education, Medical

Psychology and Sexology, Kharkiv, Ukraine

Corresponding author.

Introduction

The current situation in Ukraine is characterized by

multitude social-stress factors, resulting in an increase in alcohol

consumption and alcohol addiction, which arises as a mechanism

to compensate the adverse mental stress and different variant of

chronic stress disorder.

Objective

Substantiate the neurobiological basis of mutual influ-

ence of stress burden and alcohol addiction.

Aim

To study the biochemical mechanisms that underlie the

vicious circle of stress and alcohol addiction.

Methods

Studies the features of hypothalamic-pituitary-adrenal

(HPA) axis under stress and alcohol available in Medline, Insti-

tute for Scientific Information Databases (Science citation index

expanded and Social sciences citation index), EMBASE, and

Cochrane Library were identified and reviewed.

Results

Alcohol, just like stress, affects the HPA axis, chang-

ing the reaction of its parts and, by reducing the production of

cortisol, which produces in response to stress and prolongs sub-

jective experiences of nervous tension caused by stress. Stress,

through the output of cortisol, reduces the effect of alcohol leads

to a desire to further alcohol abuse. The system includes elements

of the extended amygdala, which have as reinforcement and stress

reactivity. Central nucleus amygdala plays a leading role in the rein-

forcing effects of pharmacological agents with narcogene potential

and performs persuasive role in the activation of hypothalamic

reinforcement mechanisms. This allows us to consider neurohor-

monal system, including the amygdala, hypothalamus, pituitary

and adrenal glands as structural and functional basis of formation

depending on various narcogene, primarily alcohol.

Conclusions

Dysregulation of the HPA axis is a neurobiological

basis of mutual influence of stress burden and alcohol addiction.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1034

EV50

Clinical implications of codependency

as a model of health disorders

associated with stress, in wives of men

with alcohol dependence

V. Korostiy

1 ,

, H. Kozhyna

1

, M. Markova

2

, V. Yaruj

2

1

Kharkiv National Medical University, Psychyatry – narcology and

medical psychology, Kharkov, Ukraine

2

Kharkiv Medical Academy of Postgraduate Education, Medical

psychology and sexology, Kharkiv, Ukraine

Corresponding author.

Introduction

The potential adverse consequences, personal dis-

tress, shame and guilt presented by patients who suffer from

codependency require a more in-depth understanding of the phe-

nomenology of this disorder.

Objective

To determine targets of psychotherapy work with the

codependency wives of men with alcohol dependence (AD).

Aim

To determine the features of clinical manifestations of code-

pendency as a model of health disorders associated with stress.

Methods

Integrated clinical-psychopathological and psychodi-

agnostic research, using anxiety and depression scalesM. Hamilton,

scale of psychosocial stress L. Reeder and methods for determining

stress and social adaptation of Holmes and Rahe.

Results

One hundred and sixty wives of men with AD, depending

on the type of AD (TF Babor’s classification), were divided into two

groups: group A, 80 patients with AD type A and 80 their wives, and

group B, 80 men with AD by type B TF Babor, and 80 wives. Com-

parison group consisted of 50 married women whose husbands are

not suffering from AD.

All the wives of men with AD distortions emotional state of the

prevalence of pathological manifestations of depression and anxi-

ety clinically delineated levels and high levels of psychosocial stress

and low stress, unlike women men without alcohol problems. It

was found that the more severe psychopathological manifestations

occurring in the wives of men with a family history, burdened alco-

hol and drug abuse (group B).

Conclusions

Available data suggest that a single mechanism of

family experiences a stressful situation, we were put in the basis for

developing a comprehensive treatment measures and psychother-

apeutic support codependent wives patients with AD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1035