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S360

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

21.75). Mean distribution of anxiety and depression symptoms

among COPD subjects was corresponding to a 10.65

±

3.54 SD anx-

iety score, respectively to 9.93

±

3.80 SD depression score. Panic

attacks were found in 43.3% of the patients.

Conclusions

Anxiety, depression and panic attacks were frequent

findings among severe, unstable COPD patients. More carefully

screening for anxiety, depression and panic attacks in this category

of patients, thus adding a specific psychotherapeutic component to

the COPD general treatment plan, would improve patients’ health

benefits.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1017

EV33

Substance use disorders: Baclofen as a

promising drug

S. Gomes da Costa

1 ,

, O. Yanina Pasini

2

, B. Maside Oliete

3

,

M.M. Balcells Olivero

1

1

Hospital Clinic i Provincial de Barcelona, Psychiatry, Barcelona,

Spain

2

HIEAyC Dr. Alejandro Korn, Psychiatry, Melchor Romero – La Plata,

Argentina

3

Hospital Clinic i Provincial de Barcelona, Mental Health Nursing,

Barcelona, Spain

Corresponding author.

Introduction

Baclofen, a drug currently used in the treatment of

spasticity, has been reported to be useful in reducing the intensity

of withdrawal symptoms of substance use disorders of alcohol or

other psychotropic drugs.

Objectives

With our clinical case we aim to demonstrate that

baclofen reduces severe withdrawal symptoms and also helps to

achieve andmaintain abstinence in severe cases, in agreement with

the current literature.

Aims/methods

We present a clinical case of a 68 year-old patient

with alcohol use disorder since his childhood, with familiar

antecedents, multiples relapses and associated organic pathology

such as alcoholic polyneuropathy and Wernicke syndrome. We

used to high doses of baclofen to reduce the craving andwithdrawal

symptoms. Additionally, we searched in PubMed for more case

reports and for a systematic review of the efficacy and tolerability

of baclofen.

Results

We were able to demonstrate that high doses of baclofen

can be useful in resistant cases of substance use disorders like alco-

holism. For our case study, we obtained positive results with a large

remission, in comparison with the previous detoxications, with

doses up to 150mg/day.

Conclusions

We conclude that baclofen is an interesting alterna-

tive for resistant cases, with a good outcome and tolerability, in

complicated patients, with important organic repercussions.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1018

EV34

Prevalence of substance use disorder

among bipolar affective disorder

C. Gómez Sánchez-Lafuente

1 ,

,

R. Reina Gonzalez (General Practitioner)

2

, A. De Severac Cano

1

,

E. Mateos Carrasco

1

, F. Moreno De Lara

1

, I. Tilves Santiago

1

1

Hospital Universitario Virgen de la Victoria, Psychiatry, Málaga,

Spain

2

Hospital Regional Universitario, Málaga, Spain

Corresponding author.

Introduction

High rates of substance abuse have been reported

in the general population and users of mental health services. In

our environment, relationship between substance abuse andmanic

phase has not been well characterized.

Aims

Determining the prevalence of active substance abuse

among patients admitted to acute mental health unit at Virgen de

la Victoria Hospital at Malaga, diagnosed with mania or hipomanía.

Methods

We analysed urine and blood seeking for ethanol,

cannabis and other 11 substances in 140 patients previously diag-

nosed with bipolar disorder prior to their admission at the Hospital

for mania or hipomanía phase.

Results

Thirty-seven percent of the patients were positive for

drugs. Eighteen percent were positive for two or more drugs. Males

had higher rates of abuse than females, except in MDMA and

amphetamines. By subtypes, cannabis (37.2%) and ethanol (29.62%)

were the most consumed drugs. In young age cohorts had higher

rates of active substance abuse. Dual patients had longer average

stays at hospital (2.6 days more)

( Fig. 1 ).

Conclusions

Substance abuse is a major comorbidity in bipolar

patients withmanic phase. The active consumption of cannabis and

ethanol especially emphasizes in men younger than 35 years.

We believe priority should be given to recognition andmultidisclip-

inary approach to substance use disorders in bipolar patients.

Bipolar patients with comorbid substance abuse may have a more

severe course, and may be a preventable factor of new relapses.

This rate could increase healthcare costs and worse quality of life

of these patients.

Fig. 1

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1019

EV35

Alcohol consumption in 2049 patients

with paranoia

M. Guerrero Jiménez

1 ,

, C.M. Carrillo de Albornoz Calahorro

2

,

A. Porras Segovia

1

, J.A. Cervilla Ballesteros

3

1

University Hospital San Cecilio, Psychiatry, Granada, Spain

2

Santa Ana Hospital, Mental Health Unit, Motril, Granada, Spain

3

University Hospital San Cecilio, University of Granada, CIBERSAM

Granada, Psychiatry, Granada, Spain

Corresponding author.

Introduction

Epidemiological studies have reported associa-

tions between alcohol consumption or abuse and occurrence of