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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S363

Objectives

To identify predictors of QoL in clients undergoing

MMT, taking into account psychological variables.

Aims

To see if EA is related to QoL in clients undergoing MMT.

Methods

Using a cross-sectional design, information was gath-

ered from 48 opiate-dependent individuals undergoing MMT.

Variables included were QoL (IDUQOL), severity of drug use, social

adjustment and physical and mental health (ASI-6), emotional dis-

tress (HAD) and EA (AAQ and its version for substance-abusing

individuals, AAQ-SA). Mean-comparison tests and correlation tests

were carried out, and several variableswere entered into a stepwise

multiple regression analysis.

Results

Anxiety and EA were the only variables which made it

into the regression model, accounting for 41.9% of variance of QoL.

Conclusions

Contrary to previous research, the predictors of QoL

were psychological. It is the first time that EA is related to QoL in

this population. Interventions should explicitly target EA and anx-

iety. Additional research should make use of longitudinal designs

and take into account further psychological variables (emotion reg-

ulation, coping).

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1026

EV42

The relationship between previous

trauma and alcohol and substance

misuse in women

M. Husain

1 ,

, K. Moosa

2

, K. Khan

3

1

Manchester, United Kingdom

2

Leicester Medical School, Medical School, Leicester, United Kingdom

3

University of Liverpool, School of Psychology, Liverpool, United

Kingdom

Corresponding author.

Introduction

The association between previous trauma and the

development of alcohol and substance misuse is well established,

however, much of the research is focused on the association of PTSD

with alcohol and substance misuse. This research will be focussing

on trauma in general and its influence on the development of alco-

hol and substance misuse in women.

Objectives

The main objective of this study was to investigate the

relationship between previous traumatic events and the develop-

ment of alcohol and substance misuse in women.

Methods

This was a retrospective case note study of 146 female

patients from a UK based detoxification and rehabilitation centre.

Trauma history from patient files were audited, with the trauma

experienced being assigned a category.

Results

Out of 146 women with alcohol and/or substance mis-

use, 132 (90%) had experienced a previous trauma. The types of

trauma experienced include; domestic (53%), traumatic grief (36%),

sexual abuse (35%), physical (15%), bullying (4%) and neglect (4%).

These results show that women who suffer from alcohol/substance

misuse are highly likely to have suffered a previous trauma.

Conclusions

The results from this study suggest that women who

have suffered previous trauma are high risk for alcohol and sub-

stance misuse problems, therefore early intervention and a robust

psychological support system should be provided to women who

have a history of trauma. Furthermore in addition to addiction

treatment and behaviour focused therapy already in place trauma

focussed therapy may prove beneficial.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1027

EV43

Dynamics of psychopathological

symptomatology at patients with

opiate addiction in the process of

complex rehabilitation

S. Igumnov

1 ,

, E. Stanko

2

1

Institute of Management and Social Technologies of Belarusian

State University, Social Work and Rehabilitology, Minsk, Belarus

2

Grodno State Medical University, Psychiatry, Grodno, Belarus

Corresponding author.

The aimof theworkwas to study the structure and dynamics of psy-

chopathological symptoms among HIV-positive and HIV-negative

patients with opiate addiction.

Material and methods

The survey was attended by 820 patients.

We studied the parameters of the main psychopathological symp-

toms using a questionnaire SCL-90-R in the dynamics. The structure

of psychopathology in patients with opiate addiction is presented.

The changes psychopathological indicators of the state of the exam-

ined patients before and after complex rehabilitation, after 1, 3, 6

and 12 months from the start of observation are given.

Results

The findings suggest the presence of more severe psy-

chopathology HIV-positive patients than HIV-negative patients

with opiate addiction. It was found that the quantity indicators

SCL-90-R in the examined patients, despite the positive trend at

discharge significantly higher than in healthy individuals.

Conclusion

The results of the study indicate a lack of short-stage

therapy to normalize the mental state of opiate addiction and the

need to develop an algorithm of a long, corrected with the needs of

patients, comprehensive rehabilitation programs.

Keywords

Psychopathology; Dynamic assessment; Opiate

addiction; HIV

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1028

EV44

Torsades-de-Pointes Predisposing

Risk Factors (TdPPRFs) in a cohort of

patients maintained on high dose

methadone – a clinical safety

caseload analysis

R. Iosub

1 ,

, S. Hawkins

2

, C. McCarville

2

, H. Kennedy

2

,

K. Williams

1

, B. Watson

1

1

Avon and Wiltshire Mental Health Partnership NHS Trust, Bristol

Specialist Drug & Alcohol Service, Bristol, United Kingdom

2

University of Bristol, School of Physiology & Pharmacology, Bristol,

United Kingdom

Corresponding author.

Introduction

Methadone, a long-acting opioid agonist commonly

used in the treatment of opiate dependence, has been reported to

cause QTc interval prolongation, increasing the risk of a fatal car-

diac arrhythmia – Torsades-de-Pointes (TdP). This effect seems

to be attributable to methadone’s inhibitory effect on the car-

diac “hERG”-K

+

ion channel and is dose-dependent. There is a lack

of consensus regarding when to perform an ECG for patients on

methadone.

Objectives

Identifying other TdPPRFs in a cohort of patients

receiving

85mg (high dose) methadone daily to inform local clin-

ical safety guidelines.

Methods

Our outpatient caseload was filtered to select opiate-

dependent patients receiving more than 85mg methadone daily.

Primary care summaries and laboratory results databases were

analysed for the presence of other TdPPRFs: female sex a docu-

mented history of ECG abnormalities, electrolyte imbalance, liver