European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S363
Objectives To identify predictors of QoL in clients undergoing
MMT, taking into account psychological variables.
Aims To see if EA is related to QoL in clients undergoing MMT.
Methods Using a cross-sectional design, information was gath-
ered from 48 opiate-dependent individuals undergoing MMT.
Variables included were QoL (IDUQOL), severity of drug use, social
adjustment and physical and mental health (ASI-6), emotional dis-
tress (HAD) and EA (AAQ and its version for substance-abusing
individuals, AAQ-SA). Mean-comparison tests and correlation tests
were carried out, and several variableswere entered into a stepwise
multiple regression analysis.
Results Anxiety and EA were the only variables which made it
into the regression model, accounting for 41.9% of variance of QoL.
Conclusions Contrary to previous research, the predictors of QoL
were psychological. It is the first time that EA is related to QoL in
this population. Interventions should explicitly target EA and anx-
iety. Additional research should make use of longitudinal designs
and take into account further psychological variables (emotion reg-
ulation, coping).
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV42
The relationship between previous
trauma and alcohol and substance
misuse in women
M. Husain ∗, K. Moosa , K. Khan
1 Manchester, United Kingdom
2 Leicester Medical School, Medical School, Leicester, United Kingdom
3 University of Liverpool, School of Psychology, Liverpool, United
Kingdom
∗ Corresponding author.
Introduction The association between previous trauma and the
development of alcohol and substance misuse is well established,
however, much of the research is focused on the association of PTSD
with alcohol and substance misuse. This research will be focussing
on trauma in general and its influence on the development of alco-
hol and substance misuse in women.
Objectives The main objective of this study was to investigate the
relationship between previous traumatic events and the develop-
ment of alcohol and substance misuse in women.
Methods This was a retrospective case note study of 146 female
patients from a UK based detoxification and rehabilitation centre.
Trauma history from patient files were audited, with the trauma
experienced being assigned a category.
Results Out of 146 women with alcohol and/or substance mis-
use, 132 (90%) had experienced a previous trauma. The types of
trauma experienced include; domestic (53%), traumatic grief (36%),
sexual abuse (35%), physical (15%), bullying (4%) and neglect (4%).
These results show that women who suffer from alcohol/substance
misuse are highly likely to have suffered a previous trauma.
Conclusions The results from this study suggest that women who
have suffered previous trauma are high risk for alcohol and sub-
stance misuse problems, therefore early intervention and a robust
psychological support system should be provided to women who
have a history of trauma. Furthermore in addition to addiction
treatment and behaviour focused therapy already in place trauma
focussed therapy may prove beneficial.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV43
Dynamics of psychopathological
symptomatology at patients with
opiate addiction in the process of
complex rehabilitation
S. Igumnov ∗, E. Stanko
1 Institute of Management and Social Technologies of Belarusian
State University, Social Work and Rehabilitology, Minsk, Belarus
2 Grodno State Medical University, Psychiatry, Grodno, Belarus
∗ Corresponding author.
The aimof theworkwas to study the structure and dynamics of psy-
chopathological symptoms among HIV-positive and HIV-negative
patients with opiate addiction.
Material and methods The survey was attended by 820 patients.
We studied the parameters of the main psychopathological symp-
toms using a questionnaire SCL-90-R in the dynamics. The structure
of psychopathology in patients with opiate addiction is presented.
The changes psychopathological indicators of the state of the exam-
ined patients before and after complex rehabilitation, after 1, 3, 6
and 12 months from the start of observation are given.
Results The findings suggest the presence of more severe psy-
chopathology HIV-positive patients than HIV-negative patients
with opiate addiction. It was found that the quantity indicators
SCL-90-R in the examined patients, despite the positive trend at
discharge significantly higher than in healthy individuals.
Conclusion The results of the study indicate a lack of short-stage
therapy to normalize the mental state of opiate addiction and the
need to develop an algorithm of a long, corrected with the needs of
patients, comprehensive rehabilitation programs.
Keywords Psychopathology; Dynamic assessment; Opiate
addiction; HIV
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV44
Torsades-de-Pointes Predisposing
Risk Factors (TdPPRFs) in a cohort of
patients maintained on high dose
methadone – a clinical safety
caseload analysis
R. Iosub ∗, S. Hawkins , C. McCarville , H. Kennedy ,
K. Williams , B. Watson
1 Avon and Wiltshire Mental Health Partnership NHS Trust, Bristol
Specialist Drug & Alcohol Service, Bristol, United Kingdom
2 University of Bristol, School of Physiology & Pharmacology, Bristol,
United Kingdom
∗ Corresponding author.
Introduction Methadone, a long-acting opioid agonist commonly
used in the treatment of opiate dependence, has been reported to
cause QTc interval prolongation, increasing the risk of a fatal car-
diac arrhythmia – Torsades-de-Pointes (TdP). This effect seems
to be attributable to methadone’s inhibitory effect on the car-
diac “hERG”-K+ ion channel and is dose-dependent. There is a lack
of consensus regarding when to perform an ECG for patients on
methadone.
Objectives Identifying other TdPPRFs in a cohort of patients
receiving≥ 85mg (high dose) methadone daily to inform local clin-
ical safety guidelines.
Methods Our outpatient caseload was filtered to select opiate-
dependent patients receiving more than 85mg methadone daily.
Primary care summaries and laboratory results databases were
analysed for the presence of other TdPPRFs: female sex a docu-
mented history of ECG abnormalities, electrolyte imbalance, liver