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S364

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

or renal failure, and concomitant use of other QT prolonging med-

ication or stimulants.

Results

Fourteen opiate-dependent patients (10.29% of patients

on methadone) were maintained on

85mg methadone daily.

Gender distributionwas F:M= 1:1.8; 64%misused illicit stimulants;

57% were prescribed other QTc prolonging medication and 29% had

a documented history of liver/renal failure or electrolyte imbalance.

Only 14% had previous ECGs documented in primary care sum-

maries. Of patients on high dose methadone, 85.7% had at least

one TdPPRFs present and 64.3% had at least two.

Conclusions

These results demonstrate an increased rate of TdP-

PRFs in this patient group and highlight the importance of ECG

monitoring which ideally should be offered to patients receiving

even lower doses of methadone.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1029

EV45

Place of methadone in practice of

tunisian psychiatrists

G. Jmii

1 ,

, M. El Karoui

2

, M. Zghal

2

, L. Robbana

2

, I. Ben Ghzaeil

2

,

O. Moula

2

, R. Ghachem

2

1

Tunis, Tunisia

2

Hopital Razi, Mannouba, Tunis, Tunisia

Corresponding author.

Introduction

Substance abuse is a widespread phenomenon in

Tunisia. However, although the principles of prevention and addic-

tion treatment are accepted in Tunisia, the laws of our country

remains sketchy and marked by the traditional punitive approach

to drug users.

Aims

Assess knowledge of methadone, opioid substitution ther-

apy, among Tunisian psychiatrists.

Methods

This is a descriptive cross-sectional study that included

psychiatrists in the public sector, liberal sector or in training

courses. These doctors completed a self-administered question-

naire posted on the website of the Tunisian Society of Psychiatry

and the Association of Tunisian residents and young psychiatrists.

The survey includes 18 items. The questions were grouped under

three main headings:

– sociodemographic data;

– general knowledge of methadone;

– methadone and its place in their daily practice.

Results

The participation rate was 15% (

n

= 35).

The average participant age was 32.13 years.

Psychiatry residents were the most represented grade 94%.

Twenty-eight percent of participants had training in addiction

(

n

= 10)

Eighty-five percent have heard about methadone.

Conclusion

Given the importance of the scourge of drug abuse

including opioids, political circles have expressed the desire to

improve the Tunisian legislation on substitution treatment. Never-

theless, others projects more directly related to “Arab Spring” are

government priorities.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1030

EV46

Alcohol addiction in patients with

comorbidity of borderline personality

disorder and Bipolar disorder

S. Jonovska

1 ,

, V. ˇSendula Jengi´c

2

, V. Oreˇskovi´c

3

,

S. Soldo Bagari´c

4

1

Psychiatric hospital Rab, Department of Addictions, Rab, Croatia

2

Psychiatric hospital Rab, Department of Forensic Psychiatry, Rab,

Croatia

3

Psychiatric hospital Rab, Department of Acute Psuchiatry, Rab,

Croatia

4

Prison’s Hospital Sveto ˇSimunska, Department of Acute Psychiatry,

10000 Zagreb, Croatia

Corresponding author.

Comorbidity of borderline personality disorder (BPD) and Bipolar

disorder (BD) has frequently been seen in psychiatry. Some authors

consider them separate psychiatric diagnoses appears in the same

patient as comorbidity; some others consider affective oscillations

a part of BPD diagnosis. Often in mentioned patients secondary

appears different kind of addictions, mostly drug addiction, but also

alcohol addiction (AA).

In this study we going to present 2 case reports of patients with

all 3 diagnoses: AA, BPD and BD. First, female patient, 40 years of

age, about 10 years in psychiatric treatment, with primarily diag-

nosed AA, and secondary diagnosed BPD and BD in development.

She had marital problems for many years, now in phase of divorc-

ing, and several suicide attempts. Second, male patient, 30 years of

age, working as nurse, not married, living with parents, more than

5 years in psychiatric treatment. Primarily diagnosed as AA than BD

and BPD and suspect, but undiagnosed gambling. Bothwere treated

several times in Department of Addictions at Psychiatric Hospital

Rab in Croatia. Both were also only in partialy, not continued psy-

chotherapeutic treatment during years of psychiatric treatment.

Still now, both were alcohol addicted.

In conclusion, we realized that both of themwere primarily comor-

bidity of BPD and BD with secondary developed alcohol addiction.

Without continued, long-term, systematic psychotherapeutic and

family treatment completed with psychopharmacological treat-

ment of BD, we could not expect successful treatment of alcohol

addiction.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1031

EV47

Gamma-hydroxybutyrate (GHB)

withdrawal syndrome: First case

report in Lithuania (Kaunas addiction

treatment center)

K. Jucys

1 ,

, A. Leleikiene

2

, D. Jokuboonis

2

1

Birstonas, Lithuania

2

LSMUL, Psychiatric, Kaunas, Lithuania

Corresponding author.

Gamma-hydroxybutyrate (GHB) is a -aminobutyric acid (GABA)

precursor and metabolite that naturally occurs in the human body.

Initially, GHB was used as an anaesthetic agent but was later also

found to have anabolic, hypnotic, antidepressant, anxiolytic as well

as cholesterol lowering effects. Recently though, research into GHB

has been carried out primarily in assessing its effectiveness in

treating alcohol and opioid withdrawal syndrome. There are no

epidemiological data about GHB consumption in Lithuania, how-

ever during last decade there were observed many fatal cases of

GHB users due to GHB intoxication or withdrawal abroad. In this

article we will present the clinical case and problems which face

the patient of 2-year daily GHB consumption. There were observed

mild tomoderate abstinence state presentedwith its clinical course

and peculiarities. Whereas using GHB is becoming more popular in

Lithuania, it is very important to pay attention to this substance

and problems related to its usage.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1032