European Psychiatry - Volume 33 - March 2016

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S348 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
Conclusion We validated the 3-factor OtLQ scale, which produced
valid and reliable data for a cross-national samplewith older adults.
Hence, it is an adequate instrument for assessing sense of coherence
among older people in health care practice and program develop-
ment contexts.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW662
The effect of Qing Huan Ling
combined risperidone on the open
field behavior of schizophrenic mice
model
Y. Zhang ∗, F. Liu , Z. Dai , B. Wu , Q. Wu
Xi’an Mental Health Center, Pharmacy Lab, China
∗ Corresponding author.
Objective To observe the effect of Qing Huan Ling and (or)
risperidone on locomotor activity and explorative behavior of
schizophrenia mice model by open field test.
Methods Seventy kunming mice were randomly divided into 5
groups, one group as blank group. The rest groups ip MK-801
continuously 14 day, then randomly numbered: model group,
risperidone group, QingHuan Ling group and risperidone combined
Qing Huan Ling group. Ig give corresponding drugs for each group
4 weeks, observe the change of locomotor activity and explorative
behavior by open field test.
Results After Ig 4 weeks, compared with the blank group, there
were no obvious difference in locomotor activity and explorative
behavior between risperidone group, Qing Huan Ling group and
the combined group. Compared with the model group, risperi-
done had statistics meaning in the repression of explorative
behavior (P < 0.05),the combined group has statistics meaning in
the repression of locomotor activity and explorative behavior
(78.92± 36.18m vs. 186.92 ±41.08m, P < 0.01).
Conclusion Qing Huan Ling regulate the central nervous system
of schizophrenia mice model; when combined with risperidone, it
restrain the central nervous system of schizophrenia mice model
and the effect is stronger than risperidone alone.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.