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S348

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

Conclusion

We validated the 3-factor OtLQ scale, which produced

valid and reliable data for a cross-national samplewith older adults.

Hence, it is an adequate instrument for assessing sense of coherence

among older people in health care practice and program develop-

ment contexts.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.779

EW662

The effect of Qing Huan Ling

combined risperidone on the open

field behavior of schizophrenic mice

model

Y. Zhang

, F. Liu , Z. Dai , B. Wu , Q. Wu

Xi’an Mental Health Center, Pharmacy Lab, China

Corresponding author.

Objective

To observe the effect of Qing Huan Ling and (or)

risperidone on locomotor activity and explorative behavior of

schizophrenia mice model by open field test.

Methods

Seventy kunming mice were randomly divided into 5

groups, one group as blank group. The rest groups ip MK-801

continuously 14 day, then randomly numbered: model group,

risperidone group, QingHuan Ling group and risperidone combined

Qing Huan Ling group. Ig give corresponding drugs for each group

4 weeks, observe the change of locomotor activity and explorative

behavior by open field test.

Results

After Ig 4 weeks, compared with the blank group, there

were no obvious difference in locomotor activity and explorative

behavior between risperidone group, Qing Huan Ling group and

the combined group. Compared with the model group, risperi-

done had statistics meaning in the repression of explorative

behavior (

P

< 0.05),the combined group has statistics meaning in

the repression of locomotor activity and explorative behavior

(78.92

±

36.18m vs. 186.92

±

41.08m,

P

< 0.01).

Conclusion

Qing Huan Ling regulate the central nervous system

of schizophrenia mice model; when combined with risperidone, it

restrain the central nervous system of schizophrenia mice model

and the effect is stronger than risperidone alone.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.780