European Psychiatry - Volume 33 - March 2016

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S346 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
scoring system for use in phase 2/3 clinical trials with DS popula-
tions.
Methods Impairment in functional and adaptive behaviors in
DS – “speech”, “activities of daily living”, “social function-
ing” and “non-compliance” – were proposed as anchors for
assessment in determining a global score of severity and improve-
ment/deterioration. In a non-intervention study among individuals
with DS (n = 90, M age = 18.23, SD = 23.27), the CGI was conducted
with the ADAMS, CELF-2, CELF-4, BRIEF-P and VABS-II. Descriptive
and comparative analyses were performed.
Results At screening, the CGI-S speech, social functioning, and
non-compliant domains correlated positively with ADAMS Social
avoidance (r = 0.400, 0.272 and 0.294, respectively) supporting con-
struct validity. The CELF negatively correlated with CGI-S Speech
(r = –0.469, P = 0.037). The CGI-I correlated negatively with the
VABS-II at Day 1, W4 and W24.
Conclusions The CGI developed for Down syndrome (DS) is a valid
clinical outcome measure. It offers a number of advantages includ-
ing established utility in clinical research, sensitivity to change, and
consistency with neurocognitive measures in DS.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EW656
Are there clinical and care differences
in real care intensity among patients
in general hospitals suffering from
psychiatric comorbidity?
J. Valdes-Stauber ∗, S. Bachthaler
1 Zentrum für Psychiatrie Südwürttemberg, Psychosomatic Medicine,
Ravensburg, Germany
2 Zentrum für Psychiatrie Südwürttemberg Germany, Head Physician,
Psychosomatics, Ravensburg, Germany
∗ Corresponding author.
Background According to literature, about 30–40% of individuals
admitted in general hospitals suffer from psychiatric comorbidity.
Consultation-liaison services (CLS) cover internationally 1–10% of
admissions and are able to improve care quality, treatment adher-
ence and to reduce length of stay.
Objectives To assess possible clinical and care differences
between individuals with and without psychiatric comorbidity as
well as differences among principal diagnostic groups.
Aims To find out, whether individuals suffering fromspecific psy-
chiatric diagnoses show a higher degree of care needs held by a
CLS.
Method Retrospective, ethical approved full-survey assessment
(n = 2940) over three years (2012–2014). ICD-10 diagnoses, clinical
factors and care variables were considered. Group differences were
calculated by means of chi-square and ANOVA as well as Scheffé
post-hoc estimation. Associations were conducted by means of
multivariate regression as well as logistic regression models.
Results Individuals suffering from psychiatric comorbidity (48%
of sample) were seldom primarily oncologic patients (30%),
they showed more distress (DT = 6.5), more performance lim-
itations (ECOG = 1.38), and less functionality (GAF = 59.6). They
received more contacts by CLS (1.95), more cumulative treatment
time (89.7min), and more psychopharmacological interventions
(30.6%). People suffering from recurrent depressive and somato-
form disorders received much more contacts and treatment time
than other diagnostic groups. Age was negatively associated with
care intensity.
Conclusions CLS services are able to offer differentiated psy-
chiatric care depending on diagnoses. Individuals suffering from
classical psychiatric disorders received rather treatment as
usual, oncologic patients more psychotherapeutic interventions.
Depressive as well as somatoformpatients seem to needmore time
and personal resources.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW657
Psychopathology, temperament and
suicide risk in adolescence: The role of
early traumatic experience
P. Venturini ∗ agioli apienza oldrini
E. Bonaccorsi Erbuto ontebovi irardi
M. Pompili
1 Department of Neurosciences, Mental Health and Sensory
Functions, Suicide Prevention Center, Sant’Andrea Hospital, Sapienza
University of Rome, Rome, Italy
2 Department of Mental Health, Rome E Health Trust. Adolescents
Department Via Plinio 31, Rome, Italy
3 Department of Dynamic and Clinical Psychology. Sapienza
University of Rome, Rome, Italy
∗ Corresponding author.
Introduction Previous researches showed that adolescents are at
high risk of suicide. Suicide is a trans-nosographic phenomenon
regardless of psychiatric diagnosis. Trauma is an important risk
factor for suicide and young help-seeking patients usually refer
traumatic experiences, especially during childhood.
Objectives The objective of this study is to assess the relationship
between traumatic experience and suicide risk comparing adoles-
cents with suicide risk with adolescents without suicide risk.
Aims To investigate correlations between trauma, psychopathol-
ogy and suicide risk in a sample of young help-seeking outpatients.
Methods We recruited 99 outpatients aged between 14 and 21
years admitted to department for prevention and early intervention
in adolescence of Rome. We administered psychometric instru-
ments exploring suicide risk (SHSS, BHS), prodromal (SIPS/SOPS),
affective and anxious symptoms (HAM-A, HAM-D,MRS), child
abuse (CTQ) and experiences of depersonalization (CDS).
Results Sample is composed of 31 men and 68 women. A total
of 34.3% had mood disorder. A total of 28.3% reported history of
emotional neglect, 20.2% emotional abuse, 9.15 sexual abuse, 5.1%
physical neglect, 9,1% sexual abuse, 4% physical abuse. More than
30% of patients were at increased suicide risk. Depressive, irritable,
anxious and cyclothymic temperament was associated with sui-
cide risk. Patients with suicide risk had higher score at HAM-D
(t 63 = 2.65; P = 0.01), CDS (t63 = 2.77; P= 0.007), in CTQ (t63 = 3.20;
P = 0.002) and BHS (t63 = 3.23; P = 0.002).
Conclusions Adolescents with suicide risk, compared with those
without, reportedmore frequently early traumatic experiences and
psychiatric symptoms. Early traumatic experiences constitute a risk
factor for both suicide risk and psychiatric symptoms during ado-
lescence.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW658
Sexual well-being among a
cross-national sample of older adults
S. von Humboldt∗, I. Leal , A. Monteiro
ISPA-Instituo Universitário, William James Research Center, Lisbon,
Portugal
∗ Corresponding author.
Introduction Sexual well-being (SWB) has been an ignored
dimension that may contribute to successful aging.