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S344

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

(immunohistochemistry) with their corresponding murine anti-

body and viewing through optical microscope.

Results

Lower immunoreactivitywith the antibody anti-TH in the

animals treated with paroxetine, at all levels of the dopaminergic

activity (tracks mesolimbica, cortical circuit, nigrostriatal pathway

and tubero-infundibular). This decrease is reaffirmed after the sta-

tistical treatment of data.

Conclusions

Treatment with paroxetine in animal models causes

a depletion of the dopaminergic system that can be one of the

biological bases of sexual dysfunction, altering the reward mecha-

nisms as well as producing hyperprolactinemia.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.767

EW650

Protective effect of curcumin on

diazepam-induced behavioral

changes and oxidative stress in rats

A. Sevastre-Berghian

1 ,

, V. F˘ag˘ar˘as¸ ˘an

1

, N. Decea

1

, R. Moldovan

1

,

B. Sevastre

2

, M. T˘aulescu

3

, A.G. Filip

1

1

University of Medicine and Pharmacy “Iuliu Hatieganu”, Physiology,

Cluj-Napoca, Romania

2

University of Agricultural Science and Veterinary Medicine, Faculty

of Veterinary Medicine, Pathophysiology, Cluj-Napoca, Romania

3

University of Agricultural Science and Veterinary Medicine, Faculty

of Veterinary Medicine, Morphopathology, Cluj-Napoca, Romania

Corresponding author.

Introduction

Curcumin (CUR), a polyphenolic compound,

extracted from Curcuma longa, is known for its neuroprotective,

antioxidant and anti-inflammatory effects.

Objectives

To evaluate the effect of CUR on ambulatory activity,

spatial working memory and on oxidative stress in rats induced by

Diazepam (DZP) administration.

Aims

To analyze whether CUR may improve the cognitive per-

formance and offer systemic protection from oxidative stress.

Methods

The effect of CUR on DZP-induced memory impairment

and oxidative stress was studied on Wistar rats. Group I received

a vehicle, group II – vehicle and CUR, group III – vehicle and DZP,

group IV – vehicle, CUR and DZP. CUR (150mg/kg bw) and vehicle

were orally administered for fiveweeks long. DZP (2mg/kg bw) was

administered i.p. 20minutes before the behavioral tests. Behavioral

tests, i.e. Open Field and Y Maze Test, were performed. Malondi-

aldehyde and reduced glutathione/oxidized glutathione ratio were

determined in the serum and brain tissue homogenate. Hippocam-

pal sectionswere histologically assessed. The datawere statistically

analyzed by one-way ANOVA, followed by Dunns post-test.

Results

DZP decreased (

P

< 0.01) the number of spontaneous

alternations, as compared to control group, thus suggesting an

impairment of spatial working memory. Behavioral tests revealed

no enhancing effect of CUR on spontaneous alternation behaviors

in Y Maze. CUR reversed (

P

< 0.01) the inhibitory effect of diazepam

(

P

< 0.05) on the ambulatory activity in OFT and decreased the lipid

peroxidation in the serum (

P

< 0.05).

Conclusions

The results show that CUR may offer systemic

protection from oxidative stress, thus improving the cognitive per-

formance.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.768

EW651

Right prefrontal deep TMS effects on

attention symptoms: Behavioral

outcomes and electrophysiological

correlates

H. Shahar

1 ,

, U. Alyagon

2

, A. Lazarovits

2

, A. Hadar

2

, D. Cohen

2

,

H. Shalev

2

, A. Zangen

2

1

Ben-Gurion University of the Negev, Sede Boqer, Israel

2

Ben-Gurion University of the Negev, Life sciences, Sede Boqer, Israel

Corresponding author.

Introduction

The validated treatment for ADHD is chronic admin-

istration of psychostimulants, which is associated with side effects

and occasionally not tolerated. Deep TMS using special coil designs

for targeting neural networks linked with ADHD, may become a

potential alternative.

Objectives

Comparison of rTMS treatment using deep, figure-8

and sham coils on ADHD symptoms.

Methods

In the current randomized, sham-controlled study,

adult ADHD patients (

n

= 30) received 15 daily sessions of high-

frequency rTMS directed to the right PFC, using either deep,

figure-8, or a sham coil. ADHD symptoms and cognitive alterations

were assessed using the CAARS-INV, self–report questionnaires and

performance tests. Additionally, the stop signal task (SST) com-

binedwith EEGmeasures was used to assess behavioural inhibition

and ERPs. EEG responses to an inhibitory protocol of paired TMS

pulses over the rPFC were measured before and after treatments.

A healthy control group was evaluated at baseline for comparison

(

n

= 39).

Results

dTMS treated patients (but not standard figure-8 or

sham) showed improvement of ADHD symptoms. Differences

between ADHD patients and healthy controls were demonstrated

in N200 and P300 components of ERP during the SST, and in

response to single and paired TMS pulses. The amplitudes of ERPs

in patients correlated with ADHD symptoms and behavioural inhi-

bitionmeasures. Neurophysiological measures were found to serve

as predictors for effectiveness of dTMS treatment.

Conclusions

Repeated stimulation of deep areas in the rPFC has

therapeutic potential in ADHD patients. Ongoing analysis attempts

to evaluate the extent of these findings and establish biomarkers

for treatment efficacy.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.769

EW652

The F-Multidimensional

Perfectionism Scale-18 (FMSP-18):

Internal consistency, construct,

concurrent and divergent validity

M.J. Soares

1 ,

, A.T. Pereira

1

, A. Araújo

1

, D. Silva

1

, A.P. Amaral

2

,

J. Valente

1

, N. Madeira

1

, M. Bajouco

1

, A. Macedo

1

1

Faculty of Medicine, University of Coimbra, Department of

Psychological Medicine, Coimbra, Portugal

2

Institute Polytechnic of Coimbra, College of Health Technologies,

Coimbra, Portugal

Corresponding author.

Introduction

The FMPS is a 35-item self-report questionnaire to

measure perfectionism. It evaluates: concern over mistakes/CM,

doubts about actions/DA, parental criticism/PC and expecta-

tions/PE, personal standards/PS and organization/O.

Objectives

To develop a shortened version of FMPS and study

its internal consistency, the construct, concurrent and divergent

validity.

Methods

One hundred and ninety-two university students

(78.1% females), aged 19.74 years (sd = 2.10) completed the