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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S343

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.764

EW647

Kynurenine pathway metabolites and

suicide attempters among psychiatric

inpatients: Preliminary results

M. Pompili

1 ,

, D .

Erbuto

2 , A. F

orte

2 , F. M

ontebov

i 2 , L. L

ionetto

2 ,

P. Girardi

2

1

Rome, Italy

2

Sapienza University of Rome, Department of Neurosciences-Mental

Health and Sensory Organs, Rome, Italy

Corresponding author.

Introduction

Increased concentrations of kynurenine (KYN)

pathwaymetabolites have been associated to several groups of psy-

chiatric disorders. As for suicide risk literature is still inconclusive

due to the limited evidence.

Objectives

to test the hypothesis of Increased concentrations of

kynurenine as related to suicide attempter.

Aims

We aim to investigate the association between kynurenine

pathway metabolites blood levels and suicidal behaviour, in affec-

tive disorder patients, in order to explore if kynurenine pathway

metabolites could be potential diagnostic biomarkers.

Sample

We enrolled a sample of affective disorder patients and

perform detailed diagnoses, as well as detailed assessment of sui-

cidal behaviour using validated questionnaires. We also aim to

follow-up individuals included in the current study.

Methods

Plasma KYN was assayed by high performance liq-

uid chromatography in three groups: healthy volunteers (

n

= 90),

patients withmood disorders with a recent suicide attempt (

n

= 44)

and without (

n

= 44) history of suicide attempt. Analysis of vari-

ance tested for group differences in KYN levels. Each was evaluated

with psychometric scales. Patients were sampled for 10 cc of

venous blood for assay. The preparation of blood samples and

assay was processed by a specialist using high performance liquid

chromatography-tandem mass spectrometry (HPLC-MS/MS).

Results

Preliminary results will be presented as to shed light if

KYN levels differed across groups. According to preliminary calcula-

tions we expect that KYN is higher in suicide attempters compared

with non-attempters, who did not differ from healthy volunteers.

Conclusions

Our work-in-progress study suggests that KYN and

related molecular pathways may be implicated in the precipitation

of suicidal behavior.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.765

EW648

The psychiatry recruitment crisis

across Europe: Evaluation by the

European Federation of psychiatric

trainees

H. Ryland

1 ,

, F . B

aessler

2 , M.

Casanova Dias

3 , L. D

e Picker

4 ,

M. Pinto Da Costa

5 , A.

Kanellopoulos

6 , E. S

onmez

7 , P. A

lfimov

8 ,

D. Sebbane

9

, S.M. Birkle

10

1

West London Mental Health Trust, Broadmoor Hospital, London,

United Kingdom

2

University of Heidelberg, Department of Psychiatry, Heidelberg,

Germany

3

Camden and Islington NHS Foundation Trust, General Adult

Psychiatry, London, United Kingdom

4

University of Antwerp, Collaborative Antwerp Psychiatric Research

Institute, Antwerp, Belgium

5

University of Porto, Hospital de Magalhães Lemos, Porto, Portugal

6

National & Kapodistrian University of Athens, Evgenidion

Therapeftirion, Athens, Greece

7

Marmara University, Department of Psychiatry, Istanbul, Turkey

8

Moscow Research Institute of Psychiatry, Department of Psychiatry,

Moscow, Russia

9

University of Lille, Lille, France

10

Ruhr-University Bochum, LWL-University Hospital for Child and

Adolescent Psychiatry, Hamm, Germany

Corresponding author.

Introduction

Recruitment of medical students and junior doc-

tors in to psychiatry is a long-standing concern in many countries,

with low proportions of medical graduates choosing it as a spe-

cialty and ongoing stigma from within the medical profession. In

some countries the reverse problem is the case, with toomany doc-

tors wishing to enter psychiatry, and insufficient training places

available.

Objectives

To understand the current situation within Europe

with regards to recruitment in to psychiatry and to identify existing

recruitment initiatives.

Methods

The European Federation of Psychiatric Trainees con-

ducts an annual survey of all member organisations. A delegate of

each national association of psychiatric trainees is asked to identify

if their country has a problem with recruitment and if so, whether

there were too many or too few applicants for training places. Del-

egates from countries with recruitment initiatives were contacted

to provide further details.

Results

In 2014, a total of 31 countries completed the survey,

with 17 stating that too few medical practitioners choose psychi-

atry. In total 8 countries with recruitment problems reported that

initiatives exist to encourage doctors to enter psychiatric training.

Of these, 7 responded to describe the initiatives, which included

national recruitment strategies, financial incentives, careers fairs,

mentoring schemes and a whole host of other projects.

Conclusions

Recruitment in to psychiatry remains a serious prob-

lem in a significant proportion of European countries, but a wide

range of initiatives exist which aim to combat this shortfall. It will

be important over the coming years to establish which initiatives

are most effective at increasing recruitment.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.766

EW649

Study of the sexual dysfunction

secondary to antidepressants in

animal models

Y. Santana Hernández

1 ,

, M .V

. Redondo Vega

1 ,

E. Zamora Gracia

1 , A.L

. Montejo Gonzalez

1 , J.L.

Blázquez Arroyo

2 ,

G. Llorca Ramón

1

1

Universidad de Salamanca, Psiquiatría, Salamanca, Spain

2

Universidad de Salamanca, Anatomía e histología humanas,

Salamanca, Spain

Corresponding author.

Introduction

Sexual dysfunction is a very important problem

in western countries. One of the causes is the treatment with

antidepressants; most of the currently available produce sexual

dysfunction in men and women (lower libido, anorgasmia, etc.).

Objective

Comparing the nervous system of the animals we

expect tofinddifferences to explain the biological substratumof the

sexual dysfunction that produce the selective serotonin reuptake

inhibitors.

Method

Twenty Wistar rats; approximate weight 150 g. It is

divided into 4 groups: 2 experimental (paroxetine and agome-

latina mouth) and 2 controls. There is a daily conduct. Weighing

at the beginning of the study, 14 and 28 days. Is performed

sacrifice by decapitation, is extracted from the brain and after

fixing paraffin cuts are carried out for their subsequent staining