European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S343
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW647
Kynurenine pathway metabolites and
suicide attempters among psychiatric
inpatients: Preliminary results
M. Pompili ∗ Erbuto orte ontebov ionetto
P. Girardi
1 Rome, Italy
2 Sapienza University of Rome, Department of Neurosciences-Mental
Health and Sensory Organs, Rome, Italy
∗ Corresponding author.
Introduction Increased concentrations of kynurenine (KYN)
pathwaymetabolites have been associated to several groups of psy-
chiatric disorders. As for suicide risk literature is still inconclusive
due to the limited evidence.
Objectives to test the hypothesis of Increased concentrations of
kynurenine as related to suicide attempter.
Aims We aim to investigate the association between kynurenine
pathway metabolites blood levels and suicidal behaviour, in affec-
tive disorder patients, in order to explore if kynurenine pathway
metabolites could be potential diagnostic biomarkers.
Sample We enrolled a sample of affective disorder patients and
perform detailed diagnoses, as well as detailed assessment of sui-
cidal behaviour using validated questionnaires. We also aim to
follow-up individuals included in the current study.
Methods Plasma KYN was assayed by high performance liq-
uid chromatography in three groups: healthy volunteers (n = 90),
patients withmood disorders with a recent suicide attempt (n = 44)
and without (n = 44) history of suicide attempt. Analysis of vari-
ance tested for group differences in KYN levels. Each was evaluated
with psychometric scales. Patients were sampled for 10 cc of
venous blood for assay. The preparation of blood samples and
assay was processed by a specialist using high performance liquid
chromatography-tandem mass spectrometry (HPLC-MS/MS).
Results Preliminary results will be presented as to shed light if
KYN levels differed across groups. According to preliminary calcula-
tions we expect that KYN is higher in suicide attempters compared
with non-attempters, who did not differ from healthy volunteers.
Conclusions Our work-in-progress study suggests that KYN and
related molecular pathways may be implicated in the precipitation
of suicidal behavior.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW648
The psychiatry recruitment crisis
across Europe: Evaluation by the
European Federation of psychiatric
trainees
H. Ryland ∗ aessler Casanova Dias e Picker
M. Pinto Da Costa Kanellopoulos onmez lfimov
D. Sebbane , S.M. Birkle
1 West London Mental Health Trust, Broadmoor Hospital, London,
United Kingdom
2 University of Heidelberg, Department of Psychiatry, Heidelberg,
Germany
3 Camden and Islington NHS Foundation Trust, General Adult
Psychiatry, London, United Kingdom
4 University of Antwerp, Collaborative Antwerp Psychiatric Research
Institute, Antwerp, Belgium
5 University of Porto, Hospital de Magalhães Lemos, Porto, Portugal
6 National & Kapodistrian University of Athens, Evgenidion
Therapeftirion, Athens, Greece
7 Marmara University, Department of Psychiatry, Istanbul, Turkey
8 Moscow Research Institute of Psychiatry, Department of Psychiatry,
Moscow, Russia
9 University of Lille, Lille, France
10 Ruhr-University Bochum, LWL-University Hospital for Child and
Adolescent Psychiatry, Hamm, Germany
∗ Corresponding author.
Introduction Recruitment of medical students and junior doc-
tors in to psychiatry is a long-standing concern in many countries,
with low proportions of medical graduates choosing it as a spe-
cialty and ongoing stigma from within the medical profession. In
some countries the reverse problem is the case, with toomany doc-
tors wishing to enter psychiatry, and insufficient training places
available.
Objectives To understand the current situation within Europe
with regards to recruitment in to psychiatry and to identify existing
recruitment initiatives.
Methods The European Federation of Psychiatric Trainees con-
ducts an annual survey of all member organisations. A delegate of
each national association of psychiatric trainees is asked to identify
if their country has a problem with recruitment and if so, whether
there were too many or too few applicants for training places. Del-
egates from countries with recruitment initiatives were contacted
to provide further details.
Results In 2014, a total of 31 countries completed the survey,
with 17 stating that too few medical practitioners choose psychi-
atry. In total 8 countries with recruitment problems reported that
initiatives exist to encourage doctors to enter psychiatric training.
Of these, 7 responded to describe the initiatives, which included
national recruitment strategies, financial incentives, careers fairs,
mentoring schemes and a whole host of other projects.
Conclusions Recruitment in to psychiatry remains a serious prob-
lem in a significant proportion of European countries, but a wide
range of initiatives exist which aim to combat this shortfall. It will
be important over the coming years to establish which initiatives
are most effective at increasing recruitment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW649
Study of the sexual dysfunction
secondary to antidepressants in
animal models
Y. Santana Hernández ∗ . Redondo Vega
E. Zamora Gracia . Montejo Gonzalez Blázquez Arroyo
G. Llorca Ramón
1 Universidad de Salamanca, Psiquiatría, Salamanca, Spain
2 Universidad de Salamanca, Anatomía e histología humanas,
Salamanca, Spain
∗ Corresponding author.
Introduction Sexual dysfunction is a very important problem
in western countries. One of the causes is the treatment with
antidepressants; most of the currently available produce sexual
dysfunction in men and women (lower libido, anorgasmia, etc.).
Objective Comparing the nervous system of the animals we
expect tofinddifferences to explain the biological substratumof the
sexual dysfunction that produce the selective serotonin reuptake
inhibitors.
Method Twenty Wistar rats; approximate weight 150 g. It is
divided into 4 groups: 2 experimental (paroxetine and agome-
latina mouth) and 2 controls. There is a daily conduct. Weighing
at the beginning of the study, 14 and 28 days. Is performed
sacrifice by decapitation, is extracted from the brain and after
fixing paraffin cuts are carried out for their subsequent staining