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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S155

Methods

Fifty-eight outpatients with stable SCZ completed the

intention-inferencing task (IIT), in which the ability to infer a char-

acter’s intentions from28 short comic strip stories is assessed. They

also completed a neuro-cognitive battery comprising the following

tests: the Hopkins Verbal Learning Test–Revised (HVLT-R), the Let-

ter Digit Substitution Test (LDST), the Stroop Test (ST), the “Double

Barrage” of Zazzo (DBZ), the Modified Card Sorting Test (MCST),

Verbal Fluency (VF), the Trail Making Test-Part A (TMT-A) and the

Digit Span (DS).

Results

The performance in the IIT significantly correlated with

performance in some neuro-cognitive tests including efficiency in

DBZ, number of uncorrected mistakes in ST, number of correct cat-

egories in MCST and the time needed to succeed the TMT-A. No

correlations were found between performance in the ITT and in

memory tasks (HVLT-R and DS).

Conclusions

ToM may rely on some neuro-cognitive functions

(mainly attention and executive functioning). Elucidating the exact

relationship between ToM and NF may be useful as both are tar-

geted in specific psychotherapeutic interventions.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.232

EW115

Cognitive, anxiety and depressive

disorders in middelage subjects with

metabolic syndrome are associated

with elevated endocannabinoid

plasma level

V. Piotrovskaya

, N. Neznanov

First State Pavlov Medical University, Psychiatry, St. Petersburg,

Russia

Corresponding author.

Obesity and metabolic syndrome (MS) are associated with an

increased risk of developing psychiatric disorders, such as mood

disorders and cognitive disorders. Endocannabinoids (EC) are

neuromodulators which are involved in a plenty of physio-

logical processes: regulation of motor activity, neuroprotection,

modulation of immune function and inflammatory responses,

antiproliferative actions in tumoral cells, control appetite. Endoge-

nous cannabinoids playmodulatory role in cognitive and emotional

processes (1).

Aim of this study was to evaluate a possible association

between EC plasma levels, such as anandamide (AEA) and

2-arachidonoylglycerol (2-AG), and mental processes such as, cog-

nitive impairment and anxiety in obesity. And thus determine the

participation of the EC system in the development of cognitive and

emotional disorders with obesity.

Methods and results

Data analyzed from 271 patients with MS

according IDF criteria (aged 30–60 years). Current mild cognitive

impairment (MCI), depressive (D) and anxiety disorders (A) were

confirmed by psychodiagnostic interview according to the criteria

of ICD-10. All patients passed through: MMSE test, scales HADS,

HARS, HAM-A. Determining the ES level (anandamide, 2-AG) by

liquid chromatography. Subjects were divided into 2 groups, group

A – withDand/or A (139) and groupB – without affective disorders

(132). Using Mann-Whitney test significant connection between

high levels of 2-AG level and affective disorders in group A were

obtained. Subjects with D and A and MCI had higher level of 2-AG

and AEA in comparison with only MCI.

Conclusion

Increased levels of 2-AG and AEA provoke comorbid-

ity of MCI depression and anxiety.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.233

EW116

Neurocognitive and functional

performance in psychotic and

non-psychotic bipolar patients and

schizophrenia patients

A. Aparicio

1 ,

, E.M. Sánchez-Morla

2

, J.L. Santos

3

1

University of Castilla La Mancha, School of Nursery, Cuenca, Spain

2

University of Alcalá, School of Medicine, Psychiatry, Alcalá de

Henares, Spain

3

Hospital Virgen de La Luz, Psychiatry, Cuenca, Spain

Corresponding author.

Introduction

It has been suggested that psychotic bipolar patients

havemore severe cognitive deficits and lower functioning that non-

psychotic bipolar patients.

Objectives

To evaluate neurocognitive and functional perfor-

mance in stabilized psychotic bipolar patients (BP+), non-psychotic

bipolar patients (BP

) and schizophrenia patients (SZ).

Aims

To examine whether BP+ might be defined as a more

homogenous subtype of bipolar disorder with more severe cog-

nitive deficit and more severe functional impairment.

Methods

Fifty TB+, 50 TB

, 50 SZ and 51 controls were eval-

uated with a comprehensive neurocognitive battery (WCST, FAS,

TMT-A and B, Stroop Test, Digits span, letters and numbers –

WMS-III

, CVLT, ROCFT, CPT-DS). Moreover, patients were eval-

uated with clinical scales (PANSS, MADRS, YMRS) and functionality

scales (WHOs Disability Assessment Scales, QLS and GAF). IBMSPSS

Statistics (version 19.0) was used to the data analysis.

Results

No significant differences were found between three

patients’ samples (

P

< 0.0001). No significant differences in neu-

rocognitivemeasureswere found between BP+ and BP

. Significant

differenceswere found betweenboth groups of bipolar patients and

schizophrenia in working memory measures (

P

< 0.0001). BP+ and

BP

showed significant higher functionality than SZ (

P

< 0.0001),

without significant differences in functionality between BP+ and

BP

.

Conclusions

The pattern of neurocognitive and functional deficit

is similar in BP+ and BP

. The neurocognitive deficit is very simi-

lar in both groups of bipolar patients groups in comparison to SZ;

functionality is better in both bipolar groups than in schizophrenia

patients.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.234

EW117

Neurocognitive training in the

complex therapy of patients with

schizophrenia

A. Sofronov

1 ,

, A. Spikina

2

1

Saint Petersburg, Russia

2

North West Medical University named by I.I. Mechnikov,

psychiatry, Saint Petersburg, Russia

Corresponding author.

Neurocognitive deficits in schizophrenia patients is a major health

and social problem of modern psychiatry nowadays. Many patients

with schizophrenia are of working age and there is a high enough

percentage of their disability.

Objective

To study the influence of neurocognitive training on

higher cortical functions in schizophrenia patients and to evaluate

their effectiveness in the treatment of schizophrenia.

Material and methods

We formed groups of patients diagnosed

with paranoid schizophrenia undergoing treatment in the depart-

ments of rehabilitation and day hospital. Patients of themain group

(102 patients) additionally participated in the training of cognitive

deficits. Patients included in the comparison group (48 patients)

received only pharmacotherapy.