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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S153

associated with the subtypes of those seizures have not been char-

acterized.

Objective/aim

To compare the occurrence of seizure disorders

(partial and generalized) between patients with and without a

dementia diagnosis from the OPTUM database.

Methods

All ages, and patients with full eligibility between Jan-

uary of 2005 to December of 2014, were included. Data from

OPTUM, a de-identified, HIPAA compliant database, made up of 40.7

million private insured patient individual electronic health records

from the US, were utilized. Using ICD-9 diagnoses, the occurrence

of generalized or partial seizure disorderswas identified. A compar-

ison between patients with and without dementia was performed.

Results

A total of 150,516 patient records had a dementia diag-

nosis, and, 56.38% of them were females. Patients with dementia

when compared to those without dementia had higher risk for

seizure disorders [odds ratio (OR) = 6.5 95% CI = 4.4–9.5]; grand

mal status (OR = 6.5, 95% CI = 5.7–7.3); partial seizures (OR = 6.0,

95% CI = 5.5–6.6); motor simple partial status (OR = 5.6, 95%

CI = 3.5–9.0); epilepsy (OR = 5.0, 95% CI = 4.8–5.2); complex partial

epileptic seizures (OR = 4.9, 95% CI = 4.6–5.2); generalized con-

vulsive epilepsy (OR = 4.8, 95% CI = 4.5–5.0); localization-related

epilepsy (OR = 4.5, 95% CI = 4.1–4.9); petit mal status (OR = 4.2, 95%

CI = 2.9–6.1); fits convulsions (OR = 3.5, 95% CI = 3.4–3.6); and com-

plex febrile seizure (OR = 2.5, 95% CI = 1.6–3.9).

Conclusions

The present study confirms that patients with

dementia have higher risks for either generalized or partial seizures

disorders when compared with patients without dementia.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.226

EW109

Effects of BET inhibitor JQ1 on

neurotoxicity in rat primary cortical

neurons: A potential therapeutic

approach in Alzheimer’s disease

S.H. Han

1 ,

, K .J

. Kwon

1 , C.Y

. Shin

2 , S.Y

. Chung

3

1

Konkuk University Medical Center, Neurology, Seoul, Korea

2

Konkuk University School of Medicine, Pharmacology, Seoul, Korea

3

The Catholic University of Korea Incheon St-Mary Hospital,

Pediatrics, Incheon, Korea

Corresponding author.

Introduction

The neuropathological features of Alzheimer’s dis-

ease (AD) are deposition of amyloid plaques, neurofibrillary tangles

and neuro-inflammation. Among these, neuro-inflammation is a

common pathological substrate of neurodegenerative disease, such

as AD, and Parkinson disease.

Aims

Herein, we tested whether the inhibition of bromodomain

and extra-terminal domain (BET) protein, a critical regulators of

transcription in neurons, could attenuate the neuronal cell death

and amyloid beta aggregation using rat primary cortical neurons.

We also investigated whether a BET inhibitor could prevent the

inflammatory processes and cognitive decline in an animal model

of AD.

Methods

The effects of BET inhibition on neuronal cell deathwere

assessed in the followings:

– cell viability and reactive oxygen species generation;

– enzyme activity of tPA/PAI-1 measured by casein zymography;

– the signal pathways including BDNF/CREB and MAPKs using

western blotting;

– the effects on inflammatory responses in an animal model of AD

using immunohistochemistry.

Results

JQ1, an inhibitor of Brd2/4 protein, significantly

decreased the neuronal cell death in mixed cortical neurons

in concentration-dependent manner but not in pure neurons.

JQ1 increased the enzyme activity of tPA, which decreased the

expression of Brd2 protein. JQ1 also decreased the ROS generation

and decreased cleaved caspase-3 expression. Moreover, Brd2

inhibition by transfection of Brd2 siRNA reduced amyloid beta

aggregation.

Conclusion

Our results suggested that BET inhibition might have

therapeutic potential for AD. That is, Brd2 inhibition by JQ1 can

prevent the neuronal cell death and neuroinflammation as well as

amyloid beta aggregation through regulation of tPA/PAI-1 system.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.227

EW110

Cognitive engagement profile of the

fluency tasks performance by patients

with schizophrenia

H. Karakula-Juchnowicz

1 ,

, P. Krukow

2

,

J. Morylowska-Topolska

2

, M. Flis

3

1

Medical University of Lublin, Department of Clinical Psychiatry, I

Department of Psychiatry, Psychotherapy and Early Intervention,

Lublin, Poland

2

Medical University of Lublin, Department of Clinical Psychiatry,

Lublin, Poland

3

Medical University of Lublin, I Department of Psychiatry,

Psychotherapy and Early Intervention, Lublin, Poland

Corresponding author.

Introduction

Fluency tasks, e.g. verbal, designfluency test, etc. are

often used in the evaluation of cognitive function in patients with

schizophrenia. In the standard approach, the test result is the sum

of stimuli generated in a given time period. However, this approach

does not allow to determinate of what strategies are used by sub-

jects to regulate the cognitive engagement during task execution.

Aim

To investigate the specific dynamic profile of fluency tests

performance comparing with healthy controls.

Methods

Thirty patients diagnosed with schizophrenia and 30

demographically matched healthy controls took part in the study.

Participants performed two tests: COWAT (3 trials) and Ruff Figural

Fluency Test in accordance with the original instructions. During

the generation of these stimuli, the investigator wrote down their

quantity in 15-second intervals, which enables the assessment of

cognitive engagement variability in different parts of the whole

time (1minute).

Results

Comparison of cognitive engagement variation in both

fluency tests showed statistically significant differences. The differ-

ences in repeated measures ANOVA with group as an independent

variables reached

P

< 0.0001. Factor differentiating the profiles in

verbal and figural fluency was first 15 seconds after the tasks

started.

Conclusions

The beginning of task was the most difficult part for

patients with schizophrenia, which may indicate that the overall

worse performance of fluency tests is associated with significant

difficulties in mobilizing the cognitive activity.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.228

EW111

Temporal correlates of intuition and

cognitive control in moral decision,

making in different social contexts

F. Keshvari

1 ,

, Z. Rezvani

1

, F. Ghassemi

2

, H. Pouretemad

1

1

Shahid Beheshti University, Institute for cognitive and brain science,

Tehran, Iran

2

Amirkabir University if Tehran, Faculty of Bioelectric Engineering,

Tehran, Iran

Corresponding author.