European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S153
associated with the subtypes of those seizures have not been char-
acterized.
Objective/aim To compare the occurrence of seizure disorders
(partial and generalized) between patients with and without a
dementia diagnosis from the OPTUM database.
Methods All ages, and patients with full eligibility between Jan-
uary of 2005 to December of 2014, were included. Data from
OPTUM, a de-identified, HIPAA compliant database, made up of 40.7
million private insured patient individual electronic health records
from the US, were utilized. Using ICD-9 diagnoses, the occurrence
of generalized or partial seizure disorderswas identified. A compar-
ison between patients with and without dementia was performed.
Results A total of 150,516 patient records had a dementia diag-
nosis, and, 56.38% of them were females. Patients with dementia
when compared to those without dementia had higher risk for
seizure disorders [odds ratio (OR) = 6.5 95% CI = 4.4–9.5]; grand
mal status (OR = 6.5, 95% CI = 5.7–7.3); partial seizures (OR = 6.0,
95% CI = 5.5–6.6); motor simple partial status (OR = 5.6, 95%
CI = 3.5–9.0); epilepsy (OR = 5.0, 95% CI = 4.8–5.2); complex partial
epileptic seizures (OR = 4.9, 95% CI = 4.6–5.2); generalized con-
vulsive epilepsy (OR = 4.8, 95% CI = 4.5–5.0); localization-related
epilepsy (OR = 4.5, 95% CI = 4.1–4.9); petit mal status (OR = 4.2, 95%
CI = 2.9–6.1); fits convulsions (OR = 3.5, 95% CI = 3.4–3.6); and com-
plex febrile seizure (OR = 2.5, 95% CI = 1.6–3.9).
Conclusions The present study confirms that patients with
dementia have higher risks for either generalized or partial seizures
disorders when compared with patients without dementia.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW109
Effects of BET inhibitor JQ1 on
neurotoxicity in rat primary cortical
neurons: A potential therapeutic
approach in Alzheimer’s disease
S.H. Han ∗ . Kwon . Shin . Chung
1 Konkuk University Medical Center, Neurology, Seoul, Korea
2 Konkuk University School of Medicine, Pharmacology, Seoul, Korea
3 The Catholic University of Korea Incheon St-Mary Hospital,
Pediatrics, Incheon, Korea
∗ Corresponding author.
Introduction The neuropathological features of Alzheimer’s dis-
ease (AD) are deposition of amyloid plaques, neurofibrillary tangles
and neuro-inflammation. Among these, neuro-inflammation is a
common pathological substrate of neurodegenerative disease, such
as AD, and Parkinson disease.
Aims Herein, we tested whether the inhibition of bromodomain
and extra-terminal domain (BET) protein, a critical regulators of
transcription in neurons, could attenuate the neuronal cell death
and amyloid beta aggregation using rat primary cortical neurons.
We also investigated whether a BET inhibitor could prevent the
inflammatory processes and cognitive decline in an animal model
of AD.
Methods The effects of BET inhibition on neuronal cell deathwere
assessed in the followings:
– cell viability and reactive oxygen species generation;
– enzyme activity of tPA/PAI-1 measured by casein zymography;
– the signal pathways including BDNF/CREB and MAPKs using
western blotting;
– the effects on inflammatory responses in an animal model of AD
using immunohistochemistry.
Results JQ1, an inhibitor of Brd2/4 protein, significantly
decreased the neuronal cell death in mixed cortical neurons
in concentration-dependent manner but not in pure neurons.
JQ1 increased the enzyme activity of tPA, which decreased the
expression of Brd2 protein. JQ1 also decreased the ROS generation
and decreased cleaved caspase-3 expression. Moreover, Brd2
inhibition by transfection of Brd2 siRNA reduced amyloid beta
aggregation.
Conclusion Our results suggested that BET inhibition might have
therapeutic potential for AD. That is, Brd2 inhibition by JQ1 can
prevent the neuronal cell death and neuroinflammation as well as
amyloid beta aggregation through regulation of tPA/PAI-1 system.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW110
Cognitive engagement profile of the
fluency tasks performance by patients
with schizophrenia
H. Karakula-Juchnowicz ∗, P. Krukow ,
J. Morylowska-Topolska , M. Flis
1 Medical University of Lublin, Department of Clinical Psychiatry, I
Department of Psychiatry, Psychotherapy and Early Intervention,
Lublin, Poland
2 Medical University of Lublin, Department of Clinical Psychiatry,
Lublin, Poland
3 Medical University of Lublin, I Department of Psychiatry,
Psychotherapy and Early Intervention, Lublin, Poland
∗ Corresponding author.
Introduction Fluency tasks, e.g. verbal, designfluency test, etc. are
often used in the evaluation of cognitive function in patients with
schizophrenia. In the standard approach, the test result is the sum
of stimuli generated in a given time period. However, this approach
does not allow to determinate of what strategies are used by sub-
jects to regulate the cognitive engagement during task execution.
Aim To investigate the specific dynamic profile of fluency tests
performance comparing with healthy controls.
Methods Thirty patients diagnosed with schizophrenia and 30
demographically matched healthy controls took part in the study.
Participants performed two tests: COWAT (3 trials) and Ruff Figural
Fluency Test in accordance with the original instructions. During
the generation of these stimuli, the investigator wrote down their
quantity in 15-second intervals, which enables the assessment of
cognitive engagement variability in different parts of the whole
time (1minute).
Results Comparison of cognitive engagement variation in both
fluency tests showed statistically significant differences. The differ-
ences in repeated measures ANOVA with group as an independent
variables reached P < 0.0001. Factor differentiating the profiles in
verbal and figural fluency was first 15 seconds after the tasks
started.
Conclusions The beginning of task was the most difficult part for
patients with schizophrenia, which may indicate that the overall
worse performance of fluency tests is associated with significant
difficulties in mobilizing the cognitive activity.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW111
Temporal correlates of intuition and
cognitive control in moral decision,
making in different social contexts
F. Keshvari ∗, Z. Rezvani , F. Ghassemi , H. Pouretemad
1 Shahid Beheshti University, Institute for cognitive and brain science,
Tehran, Iran
2 Amirkabir University if Tehran, Faculty of Bioelectric Engineering,
Tehran, Iran
∗ Corresponding author.