European Psychiatry - Volume 33 - March 2016

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S150 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
in reduced and full models of ANOVA in regression anal-
ysis. (Reduced model Y = ˇ0 + ˇ 1X1 + . . . and the full model
Y = ˇ0 + ˇ1X1 + ˇ2 X2 + ˇ3 X3 + ˇ4X4 + ˇ5X5 + ˇ6X6 + . . .)
Results Polymorphic eruption of pregnancy with perinatal
depression was statistically significant in maternal weight gain in
gestation [odds ratio (OR) 1.20; 95% (CI): 1.15–1.30], hormonal
changes [(OR) 2.78; 95% (CI): 2.52–2.82], deficit in iron and zinc
[(OR) 2.18; 95% (CI): 2.04–2.38], dysregulation of hypothalamic
pituitary axis [(OR) 1.37; 95% (CI): 1.18–1.49] and was not sta-
tistically significant in pre-maturity, pre-eclampsia and pre-term
labour in cases and controls.
Conclusion Pruritic urticarial papules and plaques of gestation
are commonly associated in patients with perinatal derpession.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW100
Biomarkers of response to
transcranial magnetic stimulation in
youth with treatment resistant major
depression
T. Wilkes ∗, Y. Jasaui , A. Kirton , L.M. Langevin , M. Sembo ,
F. MacMaster
1 Foothills Medical Centre, Psychiatry, Calgary, Canada
2 Alberta Children’s Hospital Research Institute, Behavioral Research
Unit, Calgary, Canada
3 Alberta Children’s Hospital Research Institute, Paediatric Stroke
Program, Calgary, Canada
4 Alberta Children’s Hospital Research Institute, Psychiatry and
Paediatrics, Calgary, Canada
∗ Corresponding author.
Background Major depressive disorder (MDD) affects approxi-
mately 15% of youth, half of who do not respond to standard
treatment. One promising intervention is repetitive transcranial
magnetic stimulation (rTMS). However, response is limited, high-
lighting the need to focus on biomarkers to predict treatment
response.
Objectives To explore baseline biomarkers of response associated
with rTMS treatment in adolescent MDD.
Aims To determine the association between dorsolateral pre-
frontal cortex (DLPFC) glutamate levels, cortical thickness, and
cerebral blood flow (CBF) with MDD symptomatology decrease
after rTMS intervention.
Methods Twenty-four MDD youth underwent 3weeks of rTMS,
baseline and post-intervention magnetic resonance imaging scans,
and short echo proton magnetic resonance spectroscopy. Response
was determined by a 50% reduction of depression scores.
Results Depressive symptoms decreased with rTMS (t = 8.304,
P = 0.00). Glutamate levels differed significantly between respon-
ders and non-responders (t = 2.24, P = 0.0039), where higher
glutamate changes were associated with a better response
(r= 0.416, P = 0.038). Responders also exhibited thinner DLPFC
(r= –0.797, P = 0.000) and lower CBF levels.
Conclusions The development of biomarkers for rTMS represents
a novel and encouraging technique for a personalized and effective
treatment while reducing ineffective treatment costs and personal
burden in adolescent MDD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW101
Adults with persistent ADHD: Gender
and psychiatric comorbidities –
a population-based longitudinal study
K. Yoshimasu ∗, W.J. Barbaresi , R.C. Colligan , R.G. Voigt ,
J.M. Killian , A.L. Weaver , S.K. Katusic
1 Wakayama Medical University, Hygiene, Wakayama city, Japan
2 Boston Children’s Hospital, Medicine, Boston, USA
3 Mayo Clinic, Psychiatry and Psychology, Rochester, USA
4 Baylor College of Medicine, Pediatrics, Houston, USA
5 Mayo Clinic, Health Sciences Research, Rochester, USA
∗ Corresponding author.
Objective To evaluate in adults the associations between per-
sistent ADHD and comorbid psychiatric disorders and gender
differences, among subjects from a population-based birth cohort.
Method Subjects were recruited from a birth cohort of all chil-
dren born during 1976–1982 who remained in Rochester, MN
after five years of age. Participating subjects with research-
identified childhood ADHD (n = 232; mean age 27.0 years; 72%
men) and non-ADHD controls (n = 335; mean age 28.6 years; 63%
men) were administered a structured psychiatric interview (MINI-
International Neuropsychiatric Interview) to assess current ADHD
status and comorbid psychiatric disorders.
Results Among the 232 with research-identified childhood
ADHD, 68 (49 men and 19 women) had persistent adult ADHD.
Compared to subjects without childhood ADHD, adults with per-
sistent ADHD were significantly more likely to have any (81% vs.
35%, P< 0.001) as well as each of the specific psychiatric comor-
bidities. The associations retained significance when stratified by
gender and there were no significant gender by ADHD interac-
tions on psychiatric disorders except for dysthymia with which
ADHD was more strongly associated in women than men. Among
subjects with persistent ADHD, externalizing psychiatric disorders
were more common in men (73%) and internalizing disorders were
more common in women (53%).
Conclusion Persistent ADHD is associated with an increased risk
of comorbid psychiatric disorders in both adult men and women.
Clinicians treating adults with persistent ADHD need to be aware of
comorbid psychiatric disorders, especially externalizing disorders
for men and internalizing disorders for women.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW102
Clinical correlates of comorbid
chronic tics and Tourette syndrome in
a National Inpatient Children’s Unit
S. Zinna ∗, M. Kyriakopoulos
1 South London and Maudsley NHS Foundation Trust, National and
Specialist Acorn Lodge Children’s Inpatient Unit, London, United
Kingdom
2 Tourette Syndrome Clinic, Great Ormond Street Hospital for
Children, London, United Kingdom
3 Institute of Psychiatry Psychology and Neuroscience, Kings College
London, Child and Adolescent Psychiatry, London, United Kingdom
∗ Corresponding author.
Introduction Chronic tics and Tourette syndrome (TS) can be
comorbid with several neuropsychiatric conditions and may add
to the complexity of children’s clinical presentation and need for
inpatient input.
Objectives To review the clinical notes of all children admitted
to a National Children’s Inpatient Unit (aged up to 12 years) over a
5-year period and analyse their demographic and clinical charac-
teristics including the presence of chronic tics/TS.