European Psychiatry - Volume 33 - March 2016

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S154 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
In the streamof flurry of publications grappling different paradigms
to tackle underlyingmechanisms of moral decision-making, EVENT
RELATED POTENtial (ERP) studies is beginning to explore psy-
chophysiological components in the moral domain, focused on
observing various moral behaviors in the experimental situations.
This research was aimed at providing a newmethod of study inves-
tigating neural correlates of subjective moral decision-making in
which we hypothesize that the social congruent or in-congruent
context, could emerge a salience brain response in intuitive or
cognitive control related responses toward moral dilemmas. Elec-
trophysiological data were recorded from the scalp a 32-channel
recording system complying with the international 10–20 system.
The average N2 (175–300ms) and LPP (300–600ms) amplitude
and latency were measured after the onset of putative counter-
part response. Repeated measure ANOVA revealed that there was a
difference between congruent versus in-congruent social response
to high conflict scenarios in LPP amplitude in right lateral and
frontal electrodes F(4, 174) = 5.812, P < 0.001 (Fig. 1). The findings
also, suggest that N2 latency in less conflict moral scenarios may
appear earlier compared with high conflict moral scenarios dur-
ing in congruent social response in frontal electrodes especially
left area F(3, 174) = 3.013, P < 0.05 (Fig. 2, figures are not available for
this abstract). In conclusion, these results were either extend pre-
vious neurophysiological findings on classic moral scenarios and
consistent with the notion that right hemisphere would be much
more representative of cognitive control process during high con-
flict moral decision-making, while left frontal electrodes engaged
in early intuitive process.
Keywords Moral decision-making; Cognitive control; Intuition;
Social context; Late positive potential; N2
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW112
Depressive pseudodementia in Greek
patients: How differential diagnosis
can lead to early diagnosis
G. Lyrakos ∗, N. Tsioumas , V. Spinaris , E. Margioti , P. Sakka ,
I. Spyropoulos
1 General Hospital Nikaia “Ag. Panteleimon”, Psychiatric, Nikaia,
Greece
2 City Unity College-Cardiff MET, MSc Health Psychology, Athens,
Greece
3 Day Center of Alzheimer’s Disease, Day center, Athens, Greece
∗ Corresponding author.
Background The term Pseudodementia, as presented by Kiloh, is
being used to describe the clinical image characterized by depres-
sion combinedwith impairment in cognitive functionswhich reacts
positively in treatment with antidepressants.
Aim To explore the aspects that make this condition unique, so
that mental health professional will be able to use the proper psy-
chometric tools when they face patients with confusing symptoms.
Method Hundred and thirty-one participants were recruited
from the B’ Psychiatric Clinic of G.H.N.P “Agios Panteleimon” and
Day Center of Alzheimer’s Disease in Amarousion, with 56 (42.7%)
males and 75 (57.3%) females. All participants were administered
the MoCA and the DASS21 questionnaires. Statistical analysis was
performed with SPSS21.
Results The findings reported a significant difference in the scores
of MoCA done by patients with dementia (M= 13.9, SD = 5.4) and
patients with depression (M= 20.5, SD = 4.9) while both groups
scored below the accepted scores indicating cognitive impair-
ment [CI]. However, analysis showed that in the following sectors
of MoCA, depressive patients scored significantly higher than
demented ones: visuospatial (MD = 0.651), clock (MD = 1.288), ori-
entation (MD = 1.212) and delayed recall (MD = 1.329).
Conclusion Findings shows a significant pattern in the difference
between depressed and patients with cognitive impairment. These
findings suggest that mental health professionals should use neu-
ropsychological measurements like MoCA when evaluating such
cases in order to be able to diagnose effectively cases of pseudode-
mentia.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW113
Hemispheric processing of idioms in
schizophrenia and autism spectrum
disorder
N. Mashal ∗, R. Saban-Bezalel , S. Hess , D. Dolfin ,
H. Hermesh
1 Bar Ilan university, Education, Ramat gan, Israel
2 Geha Mental Health, Geha Mental Health, Petah Tikva, Israel
∗ Corresponding author.
Introduction Schizophrenia (SZ) and autism (ASD) have been his-
torically considered as a related diagnostic category. Studies point
to difficulties in comprehension of figurative language and a ten-
dency to interpret it in a literal manner in both populations.
Aims To examine idiom comprehension and pattern of hemi-
spheric processing of idioms in SZ as compared to ASD.
Methods Nineteen adults diagnosedwith SZ, 24 adults diagnosed
with ASD, and 22 typically developing (TD) adults participated in
the study. The SZ and the ASD groups were matched by gender and
verbal abilities. Participants performed a lexical decision task to
either literally or idiomatically related target words presented to
either the left or the right visual field using the divided visual field
paradigm.
Results First, although both SZ and ASD groups performed worse
than TD, they demonstrated relatively unimpaired comprehension
of idiomatic expressions. No significant difference in idiom com-
prehension was found between the SZ and the ASD groups. Second,
adults with SZ demonstrated a similar pattern of hemispheric lat-
eralization (i.e. right lateralization) as TD participants during the
processing of the literal interpretations of idioms. In contrast to
SZ and TD participants, ASD participants demonstrated a bilateral
pattern of hemispheric processing.
Conclusions Our findings suggest that brain lateralization is
intact in adults with SZ but atypical in adults with ASD. The atyp-
ical hemispheric processing in addition to relatively unimpaired
understanding of figurative language can point to a compensation
mechanism in ASD. Thus, the current findings point to a different
brain mechanism in each clinical group.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW114
Do patients with better
neuro-cognition have better theory of
mind?
J. Mrizak∗ rous , R. Trabelsi , A. Aissa , H. Ben Ammar ,
Z. El Hechmi
Razi Hospital, Psychiatry F, Mannouba, Tunisia
∗ Corresponding author.
Introduction Theory of mind (ToM) has repeatedly been shown
to be compromised in many patients with schizophrenia (SCZ). By
contrast, the association between ToMdeficits and neuro-cognitive
functioning (NF) remains uncertain.
Objectives To investigate the association between ToM function-
ing and neuro-cognitive functioning in SCZ.