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S412

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

Methods

The study group consisted of 83 patients diagnosedwith

BD, compared to the healthy control group (

n

= 73) and matched

according to age, gender, and body mass index (BMI). Lifetime psy-

chopathology has been assessed according to predominant polarity

as well as previous history of suicide attempts and psychotic

episodes.

Results

Age at menarche in BD patients was similar to that in

controls. After covarying for confounders, we observed that age

at menarche is negatively related to number of previous depres-

sive episodes in euthymic BD patients, but not other indicators of

lifetime psychopathology.

Conclusions

BD patients with earlier age at menarche are more

likely to present with more depressive episodes in the course of

illness. Systemic, longitudinal monitoring of the course of illness,

and potential hormonal fluctuations within particular groups of

patients are warranted.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1180

EV196

Socio-biographical and evolutive

aspects in bipolar disorder and

unipolar depression – comparative

study

I. Papava

1 ,

, C. Bredicean

1

, V. Enatescu

1

, L. Dehelean

1

,

R. Romosan

1

, S. Papava

2

, A. Draghici (Ph.D Candidate)

3

,

A. Popescu (Ph.D Candidate)

4

1

“Victor Babes” University of Medicine and Pharmacy, Neuroscience,

Discipline of Psychiatry, Timisoara, Romania

2

Medical Office “Dr. Novac”, Psychiatry, Timisora, Romania

3

“Vasile Goldis” West University, Faculty of Medicine and Pharmacy,

Arad, Psychiatry, Timisora, Romania

4

University of Medicine and Pharmacy, Targu Mures, Psychiatry,

Timisora, Romania

Corresponding author.

Introduction

In present, bipolar disorder and unipolar depression

are accepted as distinct nosological entities, still there are authors

who describe bipolar disorders as a comorbidity between depres-

sion and mania.

Objectives

The comparative assessments of socio-biographical

and evolutive aspects in two samples, some of them diagnosed

with bipolar affective disorder (BAD) and the others with recurrent

depressive disorder (RDD), according to ICD 10.

Aims

To highlight significant differences between these two

types of pathologies regarding socio-demographic and evolutive

aspects.

Methods

We have selected two samples which comprise 30 sub-

jects, one with subjects with BAD and the other subjects with RDD.

We have assessed the following features of these subjects: the age,

educational level, professional and marital status, the existence of

triggers at the onset, the period of time until the first readmis-

sion into hospital, the period of hospitalization for the depressive

episodes, the total number of hospital admissions during the first

5 years of evolution.

Results

We have found significant differences regarding the age

of onset, the existence of triggers before the onset of the disease,

the period of time until the first readmission into hospital, the

period of hospitalization of depressive episodes, the marital sta-

tus at the onset, the marital and professional status after 5 years of

evolution.

Conclusions

Although these studied disorders are periodic affec-

tive disorders which have in common depression, the existence of

the manic pole changes the bipolar disorder into a disorder which

is different from a unipolar disorder.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1181

EV197

The importance of establishing a good

differential diagnosis in bipolar

disorder

I. Pe˜nuelas Calvo

1 ,

, J. S

evilla Llewellyn-Jones

2 , C. C

ervesi

3 ,

A. Sareen

4

, A. González Moreno

1

1

Hospital Universitario Virgen de la Victoria, Psychiatry, Málaga,

Spain

2

Hospital Universitario Virgen de la Victoria, Psychologist, Málaga,

Spain

3

Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”,

Psychiatry, Trieste, Italy

4

The Zucker Hillside Hospital, North Shore, Long Island Jewish Health

System, Psychiatry Research, New York, USA

Corresponding author.

Diagnosis plays a key role in identification of a disease, learn about

its course, management and predicting prognosis. Inmental health,

diseases are often complex and coalesce of different symptoms.

Diagnosing a mental health condition requires careful evaluation

of the symptoms and excluding other differential disorders that

may share common symptoms. Diagnose hastily can lead to misdi-

agnosis. A premature diagnosis or misdiagnosis has clear negative

consequences. This is one of the problems related to mental health

and one needs to optimize the diagnostic process to achieve a bal-

ance between sensitivity and specificity. Currently, the diagnosis of

bipolar disorder (BD) is one of the major mental health conditions

that is often misdiagnosed.

To differentiate BD from unipolar depression with recurrent

episodes or with personality disorder (PD), especially type Clus-

ter B – with features shared with mania/hypomania like mental

instability or impulsivity, it is important to differentiate between

a diagnosis and its comorbidity. BD is often misdiagnosed as per-

sonality disorder and vice versa specially when both are coexisting

(almost 20% of patients with bipolar disorder type II are misdiag-

nosed as personality disorders). This is common especially with

borderline PD, although in some cases the histrionic PD may also

be misdiagnosed as mania.

Due to the inconsistency in patient care involving different psy-

chiatrists combined with difficulty in obtaining a precise patient

history and family history leads to loss of key information which in

turn leads to misdiagnosis of the condition. The time delay in mak-

ing the correct diagnosis cause by such inconsistencies may worsen

the prognosis of the disease in the patient.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1182

EV198

Bipolar mood disorder (BMD) is the

result of ambiguity between master

and slave circadian oscillator

K. Pirkalani

1 ,

, Z. Talaeerad

2

1

Mehr Medical Group, Internal Medicine, Tehran, Iran

2

Mehr Medical Group, Gynecology, Tehran, Iran

Corresponding author.

Introduction

Derangement of the circadian system is a generally

accepted theory for the pathogenesis of BMD but its mechanism is

unclear.