European Psychiatry - Volume 33 - March 2016

416 / 812

S412 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
Methods The study group consisted of 83 patients diagnosedwith
BD, compared to the healthy control group ( n = 73) and matched
according to age, gender, and body mass index (BMI). Lifetime psy-
chopathology has been assessed according to predominant polarity
as well as previous history of suicide attempts and psychotic
episodes.
Results Age at menarche in BD patients was similar to that in
controls. After covarying for confounders, we observed that age
at menarche is negatively related to number of previous depres-
sive episodes in euthymic BD patients, but not other indicators of
lifetime psychopathology.
Conclusions BD patients with earlier age at menarche are more
likely to present with more depressive episodes in the course of
illness. Systemic, longitudinal monitoring of the course of illness,
and potential hormonal fluctuations within particular groups of
patients are warranted.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV196
Socio-biographical and evolutive
aspects in bipolar disorder and
unipolar depression – comparative
study
I. Papava ∗, C. Bredicean , V. Enatescu , L. Dehelean ,
R. Romosan , S. Papava , A. Draghici (Ph.D Candidate) ,
A. Popescu (Ph.D Candidate)
1 “Victor Babes” University of Medicine and Pharmacy, Neuroscience,
Discipline of Psychiatry, Timisoara, Romania
2 Medical Office “Dr. Novac”, Psychiatry, Timisora, Romania
3 “Vasile Goldis” West University, Faculty of Medicine and Pharmacy,
Arad, Psychiatry, Timisora, Romania
4 University of Medicine and Pharmacy, Targu Mures, Psychiatry,
Timisora, Romania
∗ Corresponding author.
Introduction In present, bipolar disorder and unipolar depression
are accepted as distinct nosological entities, still there are authors
who describe bipolar disorders as a comorbidity between depres-
sion and mania.
Objectives The comparative assessments of socio-biographical
and evolutive aspects in two samples, some of them diagnosed
with bipolar affective disorder (BAD) and the others with recurrent
depressive disorder (RDD), according to ICD 10.
Aims To highlight significant differences between these two
types of pathologies regarding socio-demographic and evolutive
aspects.
Methods We have selected two samples which comprise 30 sub-
jects, one with subjects with BAD and the other subjects with RDD.
We have assessed the following features of these subjects: the age,
educational level, professional and marital status, the existence of
triggers at the onset, the period of time until the first readmis-
sion into hospital, the period of hospitalization for the depressive
episodes, the total number of hospital admissions during the first
5 years of evolution.
Results We have found significant differences regarding the age
of onset, the existence of triggers before the onset of the disease,
the period of time until the first readmission into hospital, the
period of hospitalization of depressive episodes, the marital sta-
tus at the onset, the marital and professional status after 5 years of
evolution.
Conclusions Although these studied disorders are periodic affec-
tive disorders which have in common depression, the existence of
the manic pole changes the bipolar disorder into a disorder which
is different from a unipolar disorder.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV197
The importance of establishing a good
differential diagnosis in bipolar
disorder
I. Pe˜nuelas Calvo ∗ evilla Llewellyn-Jones ervesi
A. Sareen , A. González Moreno
1 Hospital Universitario Virgen de la Victoria, Psychiatry, Málaga,
Spain
2 Hospital Universitario Virgen de la Victoria, Psychologist, Málaga,
Spain
3 Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”,
Psychiatry, Trieste, Italy
4 The Zucker Hillside Hospital, North Shore, Long Island Jewish Health
System, Psychiatry Research, New York, USA
∗ Corresponding author.
Diagnosis plays a key role in identification of a disease, learn about
its course, management and predicting prognosis. Inmental health,
diseases are often complex and coalesce of different symptoms.
Diagnosing a mental health condition requires careful evaluation
of the symptoms and excluding other differential disorders that
may share common symptoms. Diagnose hastily can lead to misdi-
agnosis. A premature diagnosis or misdiagnosis has clear negative
consequences. This is one of the problems related to mental health
and one needs to optimize the diagnostic process to achieve a bal-
ance between sensitivity and specificity. Currently, the diagnosis of
bipolar disorder (BD) is one of the major mental health conditions
that is often misdiagnosed.
To differentiate BD from unipolar depression with recurrent
episodes or with personality disorder (PD), especially type Clus-
ter B – with features shared with mania/hypomania like mental
instability or impulsivity, it is important to differentiate between
a diagnosis and its comorbidity. BD is often misdiagnosed as per-
sonality disorder and vice versa specially when both are coexisting
(almost 20% of patients with bipolar disorder type II are misdiag-
nosed as personality disorders). This is common especially with
borderline PD, although in some cases the histrionic PD may also
be misdiagnosed as mania.
Due to the inconsistency in patient care involving different psy-
chiatrists combined with difficulty in obtaining a precise patient
history and family history leads to loss of key information which in
turn leads to misdiagnosis of the condition. The time delay in mak-
ing the correct diagnosis cause by such inconsistencies may worsen
the prognosis of the disease in the patient.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV198
Bipolar mood disorder (BMD) is the
result of ambiguity between master
and slave circadian oscillator
K. Pirkalani ∗, Z. Talaeerad
1 Mehr Medical Group, Internal Medicine, Tehran, Iran
2 Mehr Medical Group, Gynecology, Tehran, Iran
∗ Corresponding author.
Introduction Derangement of the circadian system is a generally
accepted theory for the pathogenesis of BMD but its mechanism is
unclear.