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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S417

can change the symptoms of mania and turn them into a mixed

state symptoms. It also states that rapid cycles can be precipitated

by increased alcohol consumption during rotation from mania to

depression.

Conclusions

The association of bipolar disorder with addictive

behaviors is a factor that worsens the prognosis and comorbid alco-

hol itself is associated with a poor prognosis. Close monitoring of

bipolar patients and especially in those who consume alcohol is

very important.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1195

EV211

Clinical vignette – aripiprazol long

acting injection monotherapy as

long-term treatment for bipolar

disease

M. Solana

1 ,

, J.M. Oliveira

1

, A. Sousa

2

1

Centro Hospitalar Psiquiátrico de Lisboa, Psychiatry, Lisbon,

Portugal

2

Centro Hospitalar Barreiro-Montijo, E.P.E, Pychiatry, Barreiro,

Portugal

Corresponding author.

Introduction

Over the last decade a number of effective mainte-

nance treatments for bipolar disorder (BPD) have been developed.

Lithium remains the best-established option, but valproic acid,

lamotrigine, olanzapine, and quetiapine are also effective main-

tenance drugs. However, oral administration contributes to lower

adherence rates with these drugs. In the United States and Europe,

aripiprazole is approved for the acute management of manic and

mixed episodes and maintenance in BPD. It presents the advantage

of a low risk of metabolic side effects, sexual dysfunction, and seda-

tion, which can facilitate treatment adherence and help improve

clinical outcomes.

Objectives/aims

The authors present an illustrative case onwhich

aripiprazol long acting injection monotherapy was effective as

maintenance treatment in a patient with long history of BPD with

several hospital inpatient admissions and very poor therapeutic

adherence.

Methods

Case report based on the patient’s file. Narrative review

of articles available in PubMed about the use of aripiprazol in BPD.

Results

For this patient, aripiprazol long acting injection has

proved to be an excellent choice for long-term treatment of

BPD. The once-a-month injection promotes therapeutic adherence,

which in this casewas combinedwith involuntary outpatient treat-

ment, ensuring therapeutic compliance.

Conclusions

Aripiprazol has been shown to be safe and effec-

tive in the maintenance treatment in BPD. It shows similar efficacy

and a superior tolerability profile when compared with other well-

established treatments. Further studies are needed, warranted by

its potential advantages, particularly on patients with poor insight

and adherence.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1196

EV212

Assessing risky sexual behavior

among patients with bipolar disorder

in euthymic period

N. Staali

Tunis, Tunisia

Introduction

Risky sexual behaviors are typically seen in patients

with bipolar disorder, especially during the manic phases.

Disinhibition, impulsivity and risk taking expose these patients to

unplanned pregnancies and sexually transmitted infections.

However, there is a lack of studies regarding these behaviors in

stabilized bipolar patients during euthymia.

Objectives

The objective of this study was to look for a risky sex-

ual behavior by evaluating sexual knowledge and sexual behavior

of patients with bipolar disorder in the euthymic phase.

Methods

We conducted a descriptive cross-sectional study

including 30 patients diagnosed with bipolar disorder I or II (DSM-

IV).

Data were obtained through a semi-structured interview evalu-

ating the following: sexually transmitted infections, condom use,

multiple sexual partners, sex under the influence of drugs or alco-

hol, and prostitution.

The Young Mania Scale and the Hamilton Depression Scale were

used for clinical assessment.

Results

The preliminary results suggest a lack of knowledge lead-

ing to a tendency to risky sexual behavior in both male and female,

married and unmarried patients.

Conclusions

Patients with bipolar disorder are exposed to risky

and unsafe sex because of the clinical features of their disease and

associated comorbidities.

Prevention and awareness of sexual risks are unavoidable in the

management of these patients.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1197

EV213

Prevalence of insulin resistance and

diabetes mellitus type II in bipolar

disorders

L. Steardo

1 ,

, A. Tortorella

1

, M. Fabrazzo

1

, G. Del Buono

2

,

S. Ambrosio

2 , P. M

onteleone

2

1

University of Naples Sun, Department of Psychiatry, Naples, Italy

2

University of Salerno, Neurosciences Section-Department of

Medicine and Surgery, Salerno, Italy

Corresponding author.

Introduction

Bipolar disorder (BD) is associated with high mor-

bidity and mortality. Patients are symptomatic almost half of their

lives and experience significant disability. One subtype of BD is

associated with a more chronic course, refractoriness to treatment

and poor outcome. Diabetesmellitus type 2 (T2D) and insulin resis-

tance (IR) have been identified as risk factors for this more severe

form of BD.

Objectives and aims

We investigated the rates of IR and T2D in

patients with BD and whether this comorbidity is associated with

specific clinical features of BD such as rapid cycling or treatment

resistance.

Methods

IR and T2D were screened in patients with BD types

I or II, who were on stable treatment with mood stabilizers. The

response to treatment was assessed by means of the Alda scale.

Results

In a preliminary sample, we made a new diagnosis of IR

in 40% of patients. The 1% of this sample had a diagnosis of T2D. The

treatment response was worse in BD patients with comorbid IR or

T2D as compared to those without metabolic abnormalities.

Conclusions

These findings show that IR and T2D have high

prevalence in BD patients and have negative impact on treatment

response.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1198