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S416

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

Introduction

Decreased quality of life can be observed in both

bipolar and schizoaffective disorder, more so in the acute episode,

but also during remission.

Objectives

To assess the quality of life of bipolar and schizoaffec-

tive patients after at least 6 months of euthymia.

Methods

Eighty-nine outpatients diagnosed with bipolar disor-

der and 74 outpatients diagnosed with schizoaffective disorder,

according to ICD 10 diagnostic criteria and 90 healthy subjects

were selected for this study. The assessment of the subjects took

place during remission (present for at least 6 months), between

2009 and 2015. As work instruments we used the SF-36 Scale for

assessing quality of life and the HAMD Scale (Hamilton Depression

Rating Scale) andYMRS Scale (YoungMania Rating Scale) to confirm

remission.

Results

The schizoaffective group scored lower regarding quality

of life when compared to the bipolar group. Both affective disor-

der groups showed significantly lower quality of life scores when

compared to the healthy control group.

Conclusions

Both affective disorders have a significant negative

impact on quality of life even during remission. Schizoaffective

patients seem to have a lower quality of life than bipolar patients.

Interventions regarding education, care planning, social interven-

tions and interventions towards improving physical health should

aid in the improvement of the quality of life.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1192

EV208

Religious delusions in bipolar and

schizoaffective patients: A Romanian

sample

R.S. Romosan

1 ,

, F. Romosan

1

, V.R. Enatescu

1

, A. Draghici

2

,

L. Dehelean

1 , D.

Podea

2 , C. B

redicean

1 , I. P

apava

1 ,

C. Giurgi-Oncu

1

1

“Victor Babes” University of Medicine and Pharmacy, Neuroscience,

Timisoara, Romania

2

Vasile Goldis West University of Arad, Psychiatry, Arad, Romania

Corresponding author.

Introduction

Religious delusions have regularly been reported

throughout history in patients with schizophrenia, affective

psychoses, complex partial seizure disorders and drug-induced

psychoses.

Objectives

The purpose of the study was to identify potential dif-

ferences regarding demographic and clinical features of bipolar and

schizoaffective patients presenting religious delusions.

Method

Thirty-five inpatients diagnosed with bipolar disorder

and 32 inpatients diagnosed with schizoaffective disorder, accord-

ing to ICD 10 diagnostic criteria, were selected for this study. The

assessment of the subjects took place between 2012 and 2015.

We divided the subjects into two samples: with and without reli-

gious delusions. Socio-demographic (age, sex, education, marital

status) and clinical data were analysed. The Brief Psychiatric Rat-

ing Scale (BPRS) and the Global Assessment of Functioning Scale

(GAF) were used to assess current psychopathology and global

functioning.

Results

Among the schizoaffective patients, 17.8% and 16.9% of

bipolar patients presented religious delusions. Similarly, in both

samples, patients with religious delusion were older, more fre-

quently unmarried women, had graduated high school, had higher

BPRS total scores and higher BPRS psychotic cluster scores and had

lesser global functioning.

Conclusions

Religious delusions were not related to any of the

two diagnostic groups but were associated, in both bipolar and

schizoaffective patients, with an increased severity of psychotic

positive symptoms and had worse global functioning.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1193

EV209

Efficacy of electroconvulsive therapy

(ECT) in the first trimester of

pregnancy: A case of manic patient

M. Sahin

, O. S

ahmelikoglu Onur , N. Fıstıkcı , C. Karsıdag

Bakırkoy Research and Training Hospital for Psychiatry Neurology

and Neurosurgery, Psychiatry, Istanbul, Turkey

Corresponding author.

Women with bipolar disorder have a risk for symptom exacerba-

tion during pregnancy. ECT is an appropriate option for psychiatric

symptoms during pregnancy although it is often neglected. We

report a case of bipolar, week 6 of gestation woman who discon-

tinued medication in the second week of pregnancy but resumed

pharmacotherapy with ECT due to manic episode that recurred

during the first trimester.

Case

A 23-year-old female, with a history of one psychiatric

hospitalization (a manic episode three years ago) and lithium

900mg/day, olanzapine 5mg/day use for three years until week

2 of gestation admitted to clinic with complaints of decreased need

for sleep, increased speech, lability of emotions, religious delusions

and irritability for the last two weeks. Young Mani Score (YMS)

was 32. ECT, which was considered as the first-line treatment, was

not carried out due to low pseudocholinesterase (2401). There-

fore, olanzapine was reinstated with a dose of up to 20mg/day.

Although olanzapine, irritability still continued. Therefore, medica-

tion was switched from olanzapine to haloperidol 15mg/day and

quetiapine 25mg/day. Due to persistent symptoms, after neces-

sary consultations and family approval taken, shewas administered

6 sessions of ECT with oral haloperidole, although low pseudo-

cholinesterase. Since 7 YMS, she was discharged with haloperidol

15mg/day, biperiden 4mg/day and quetiapine 25mg/day.

Conclusion

This case highlights the effectiveness of ECT in mania

during the first trimester of pregnancy. We suggest that ECT might

be considered as a valid option formanic episode during pregnancy.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1194

EV210

Evolution of bipolar disorder in dual

pathology

C.F. Silvia

, M.D. Sánchez García , A. Gómez Peinado , P. Cano Ruiz

HNSPS, PSIQUIATRIA, Albacete, Spain

Corresponding author.

Introduction

The substance use is common among people with

a diagnosis of bipolar disorder. In addition, alcoholism and bipolar

disorder coexist with a high frequency. This association is higher in

men than in women, and this consumption is the factor that most

strongly influences the hospitalization.

Objectives

To analyze the clinical, epidemiological, diagnostic

approach and evolution of bipolar disorder and alcoholism.

Methods

Review of the subject on recent articles of alcoholism in

bipolar disorder.

Results

The stages of mania associatedwith alcohol consumption

up to 40% of cases and aremore common at this stage that in depres-

sive. This association is greater than that which occurs between

alcoholism and schizophrenia or depression. Patients with bipo-

lar disorder who have mixed and irritative states and those with

rapid cycling have a prevalence of alcohol consumption and sub-

stance use higher than those who do not use substances. It has also

been observed that the consumption of alcohol and substance use