European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S415
In order to exclude organic causes a brain CT scan was performed
that revealed a possible frontal lesion. A brain MRI confirmed the
presence of a frontal meningioma with an approximate diameter
of 1.4 cm.
Conclusions The majority of the cases described in the literature
refer to large tumors presenting with major depressive symptoms.
Given the absence of similar cases in the literature, it seems unlikely
that such a small benign lesionmay cause amanic episodewith psy-
chotic features. Nevertheless, we cannot exclude that possibility.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV205
C-reactive protein levels and cognitive
functions in patients with bipolar I
disorder
N. Raafat ∗, A. Mohamed , A. Youssif , N. El Masry , N. Raafat
1 Zagazig, Egypt
2 Faculty of Medicine, Zagazig University, Psychiatry Department,
Zagazig, Egypt
3 Faculty of Medicine, Zagazig University, Psychiatry, Zagazig, Egypt
4 Faculty of Medicine, Zagazig University, Medical Biochemistry,
Zagazig, Egypt
∗ Corresponding author.
Background In the previous studies, the relevance of inflamma-
tory processes to disorders of the brain and body may serve as an
important touchstone for increasing integration of psychiatry and
medicine. Until recently, few studies had examined the potential
role of inflammation in bipolar I disorder. We aimed at compar-
ing C-reactive protein (CRP) serum levels as a marker of systemic
inflammation between bipolar disorder (BD) patients in different
affective phases and matched healthy controls and investigating
the possible effects of CRP elevations on the cognitive impairment
in BD remitted patients group.
Methods Forty-two patients with bipolar I disorder subdivided
into (manic, depressive, full remitted) groups were examined.
We measured the circulating levels of high-sensitivity C-reactive
protein (hs-CRP), The results were compared with 42 age- and sex-
matched healthy control, Then the neuropsychological function for
the full remitted group only was assessed using the Repeatable
Battery for the Assessment of Neuropsychological Status (RBANS)
test and examine the correlation between the neuropsychological
function and hs-CRP levels in this group.
Results It showed that hs-CRP levels were significantly higher
in BD patients than healthy controls. By comparing each group
(manic, depressed and remitted) separately with healthy controls,
the difference was still statistically highly significant (P < 0.001).
There was statistically significant positive correlation between hs-
CRP levels and poorer performance on the RBANS total and four of
its five subscales (P < 0.05) except for visuospatial/constructional
subtest (P > 0.05).
Conclusion Our finding adds to the growing evidence that inflam-
mation has a role in mood disorders psychopathology.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV206
Differences in plasma concentration
of acylethanolanydes and
acylglycerols in paired samples of
bipolar patients and first- and
second-degree relatives
P. Romero-Sanchiz ∗, J. Guzman-Parra , F. Mayoral-Cleríes ,
F. Rivas-Guerrero , P. Araos-Gómez , M. Pedraz-Fernández ,
A. Serrano-Criado , F.J. Pavón-Morón , R. De la Torre-Fornell ,
A. Pastor-Bosch , F. Rodríguez de Fonseca
1 IBIMA, Hospital Regional Universitary Málaga, Mental Health,
Málaga, Spain
2 IBIMA, Neuropsychopharmacology, Málaga, Spain
3 IMIM, Integrated Pharmacology and Systems Neurosciences,
Barcelona, Spain
∗ Corresponding author.
Introduction Endocannabinoid System (ECS) has been high-
lighted as one of the most relevant research topics by neurobiol-
ogists, pharmacists, basic scientists and clinicians (Skaper and Di
Marzo, 2012). Recent work has associated major depressive dis-
order with the ECS (Ashton and Moore, 2011). Despite the close
relationship between depression and bipolar disorders, as far as
we know, there is no characterization of ECS and congeners in a
sample of patients with bipolar disorders.
Aims and objectives The objective of this work is to characterize
the plasma levels of endocannabinoids and congeners in a sample
of patients with bipolar disorders.
Method The clinical group was composed by 19 patients with a
diagnosis of bipolar disorders using SCID-IV (First et al., 1999). The
control group was formed by 18 relatives of first- or second-degree
of the patients.
The following endocannabinoids and congeners were
quantified: N-palmitoleoylethanolamide (POEA), N-
palmitolylethanolamide (PEA), N-oleoylethanolamide (OEA),
N-stearoylethanolamide (SEA), N-arachidonoylethanolamide
(AEA), N-dihomo- -linolenoylethanolamide (DGLEA), N-
docosatetraenoylethanolamide (DEA), N-linoleoylethanolamide
(LEA), N-docosahexaenoylethanolamide (DHEA), 2-
arachidonoylglycerol (2-AG), 2-linoleoylglycerol (2-LG), and
2-oleoylglycerol (2-OG).
Results The result showed statistically significant lower levels of
AEA, DEA and DHEA in clinical sample. Previous research also iden-
tified lower levels of AEA in depressed women (Hill et al., 2008,
2009). Until date, it is unknown if DEA and DHEA have some effect
on EC receptors, and whether they have some direct effects on
endocannabinoids.
Conclusions It would be necessary to carry our other research
with a larger sample, which could allow the control of potential
confounding variables.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV207
Quality of life in bipolar and
schizoaffective euthymic patients: A
Romanian sample
F. Romosan ∗, M. Ienciu , R.S. Romosan , A. Draghici ,
I. Papava
1 “Victor Babes” University of Medicine and Pharmacy, Neuroscience,
Timisoara, Romania
2 Vasile Goldis West University of Arad, Psychiatry, Arad, Romania
∗ Corresponding author.