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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S415

In order to exclude organic causes a brain CT scan was performed

that revealed a possible frontal lesion. A brain MRI confirmed the

presence of a frontal meningioma with an approximate diameter

of 1.4 cm.

Conclusions

The majority of the cases described in the literature

refer to large tumors presenting with major depressive symptoms.

Given the absence of similar cases in the literature, it seems unlikely

that such a small benign lesionmay cause amanic episodewith psy-

chotic features. Nevertheless, we cannot exclude that possibility.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1189

EV205

C-reactive protein levels and cognitive

functions in patients with bipolar I

disorder

N. Raafat

1 ,

, A. Mohamed

2

, A. Youssif

3

, N. El Masry

3

, N. Raafat

4

1

Zagazig, Egypt

2

Faculty of Medicine, Zagazig University, Psychiatry Department,

Zagazig, Egypt

3

Faculty of Medicine, Zagazig University, Psychiatry, Zagazig, Egypt

4

Faculty of Medicine, Zagazig University, Medical Biochemistry,

Zagazig, Egypt

Corresponding author.

Background

In the previous studies, the relevance of inflamma-

tory processes to disorders of the brain and body may serve as an

important touchstone for increasing integration of psychiatry and

medicine. Until recently, few studies had examined the potential

role of inflammation in bipolar I disorder. We aimed at compar-

ing C-reactive protein (CRP) serum levels as a marker of systemic

inflammation between bipolar disorder (BD) patients in different

affective phases and matched healthy controls and investigating

the possible effects of CRP elevations on the cognitive impairment

in BD remitted patients group.

Methods

Forty-two patients with bipolar I disorder subdivided

into (manic, depressive, full remitted) groups were examined.

We measured the circulating levels of high-sensitivity C-reactive

protein (hs-CRP), The results were compared with 42 age- and sex-

matched healthy control, Then the neuropsychological function for

the full remitted group only was assessed using the Repeatable

Battery for the Assessment of Neuropsychological Status (RBANS)

test and examine the correlation between the neuropsychological

function and hs-CRP levels in this group.

Results

It showed that hs-CRP levels were significantly higher

in BD patients than healthy controls. By comparing each group

(manic, depressed and remitted) separately with healthy controls,

the difference was still statistically highly significant (

P

< 0.001).

There was statistically significant positive correlation between hs-

CRP levels and poorer performance on the RBANS total and four of

its five subscales (

P

< 0.05) except for visuospatial/constructional

subtest (

P

> 0.05).

Conclusion

Our finding adds to the growing evidence that inflam-

mation has a role in mood disorders psychopathology.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1190

EV206

Differences in plasma concentration

of acylethanolanydes and

acylglycerols in paired samples of

bipolar patients and first- and

second-degree relatives

P. Romero-Sanchiz

1 ,

, J. Guzman-Parra

1

, F. Mayoral-Cleríes

1

,

F. Rivas-Guerrero

1

, P. Araos-Gómez

2

, M. Pedraz-Fernández

2

,

A. Serrano-Criado

2

, F.J. Pavón-Morón

2

, R. De la Torre-Fornell

3

,

A. Pastor-Bosch

3

, F. Rodríguez de Fonseca

2

1

IBIMA, Hospital Regional Universitary Málaga, Mental Health,

Málaga, Spain

2

IBIMA, Neuropsychopharmacology, Málaga, Spain

3

IMIM, Integrated Pharmacology and Systems Neurosciences,

Barcelona, Spain

Corresponding author.

Introduction

Endocannabinoid System (ECS) has been high-

lighted as one of the most relevant research topics by neurobiol-

ogists, pharmacists, basic scientists and clinicians (Skaper and Di

Marzo, 2012). Recent work has associated major depressive dis-

order with the ECS (Ashton and Moore, 2011). Despite the close

relationship between depression and bipolar disorders, as far as

we know, there is no characterization of ECS and congeners in a

sample of patients with bipolar disorders.

Aims and objectives

The objective of this work is to characterize

the plasma levels of endocannabinoids and congeners in a sample

of patients with bipolar disorders.

Method

The clinical group was composed by 19 patients with a

diagnosis of bipolar disorders using SCID-IV (First et al., 1999). The

control group was formed by 18 relatives of first- or second-degree

of the patients.

The following endocannabinoids and congeners were

quantified:

N-palmitoleoylethanolamide (POEA),

N-

palmitolylethanolamide (PEA), N-oleoylethanolamide (OEA),

N-stearoylethanolamide (SEA),

N-arachidonoylethanolamide

(AEA),

N-dihomo- -linolenoylethanolamide (DGLEA),

N-

docosatetraenoylethanolamide (DEA), N-linoleoylethanolamide

(LEA),

N-docosahexaenoylethanolamide (DHEA),

2-

arachidonoylglycerol (2-AG), 2-linoleoylglycerol (2-LG), and

2-oleoylglycerol (2-OG).

Results

The result showed statistically significant lower levels of

AEA, DEA and DHEA in clinical sample. Previous research also iden-

tified lower levels of AEA in depressed women (Hill et al., 2008,

2009). Until date, it is unknown if DEA and DHEA have some effect

on EC receptors, and whether they have some direct effects on

endocannabinoids.

Conclusions

It would be necessary to carry our other research

with a larger sample, which could allow the control of potential

confounding variables.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1191

EV207

Quality of life in bipolar and

schizoaffective euthymic patients: A

Romanian sample

F. Romosan

1 ,

, M. Ienciu

1

, R.S. Romosan

1

, A. Draghici

2

,

I. Papava

1

1

“Victor Babes” University of Medicine and Pharmacy, Neuroscience,

Timisoara, Romania

2

Vasile Goldis West University of Arad, Psychiatry, Arad, Romania

Corresponding author.