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S408

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

A primary school level was found in 34.7% of the cases (

n

= 17).

Nineteen patients (38.8%) were schooled until the secondary level

and 9 patients (18.4%) followed a university program.

Addiction to smoking was found at 26 patients (53%) whose half

of them had moreover an alcoholic poisoning. The mean age at the

diagnosis was 35.6 years with an inaugural manic episode in 63.4%

(

n

= 31) of the cases. The average number of relapse was 1.23 and

the mean duration of follow-up was 3.2 years.

Conclusion

The knowledge of the profile of the consultants,

their socio-demographic and clinical characteristics would allow

to adapt the offer of care to the request.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1167

EV183

Association between the 5-HTTLPR

genotype and childhood impulsivity

in subjects with bipolar II disorder

E.J. Kim

Eulji General Hospital, Department of Psychiatry, Seoul, Republic of

Korea

Objective

It has been suggested that the features of childhood

ADHD are significantly associatedwith adult mood disorders. Some

genetic factors may be common to both ADHD and mood disor-

ders underlie the association between these two phenotypes. The

present study aimed to determine whether a genetic role may be

played by the serotonin transporter-linked polymorphic region (5-

HTTLPR) in the childhood ADHD features of adult patients with

mood disorders.

Methods

The present study included 232 patients withMDD, 154

patients with BPD, and 1288 normal controls. Childhood ADHD

features were assessed with the Korean version of the Wender

Utah Rating Scale. The total score and the scores of three factors

(impulsivity, inattention, mood instability) from the WURS-K were

analyzed to determine whether they were associated with the 5-

HTTLPR genotype.

Results

In the BPD II group, the 5-HTTLPR genotype was signifi-

cantly associatedwith the total score (

P

= 0.029) and the impulsivity

factor (

P

= 0.004) on the WURS-K. However, the inattention and

mood instability factors were not associated with the 5-HTTLPR

genotype, and the MDD and normal control groups did not exhibit

any significant associations between the WURS-K scores and the

5-HTTLPR genotype.

Conclusion

The present findings suggest that the 5-HTTLPR geno-

type may play a role in the impulsivity component of childhood

ADHD in patients with BPD II. Because of a small sample size and a

single candidate gene, further studies investigating other candidate

genes using a larger sample are warranted to more conclusively

determine any common genetic links.

Keywords

5-HTTLPR; ADHD; Biopolar II disorder; Childhood;

Impulsivity; WURS-K

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1168

EV184

Thyroid dysfunction in inpatients

with affective disorders

A.M. Leitão Moreira

1 ,

, R. Pacheco Alves

2

, M. Lazaro

2

,

A.M. Mota

2

, M.A. Nobre

2

1

Hospital de Dona Estefânia, Centro Hospitalar de Lisboa

Central-EPE, Área de Psiquiatria da Infância e Adolescência, Lisboa,

Portugal

2

Centro Hospitalar Psiquiátrico de Lisboa, Clinica 5 - Perturbac¸ ões

Afectivas e Obcessivo-Compulsivas, Lisboa, Portugal

Corresponding author.

Introduction

Thyroid dysfunction has been linked to psychiatric

disorders, particularly to affective disorders. Moreover, aging of

the population receiving mental health care leads to an increased

epidemiological risk of thyroid disease.

Objectives

Assess the prevalence of abnormal thyroid function,

and its correlations to clinical factors, in an acute psychiatric inpa-

tients ward dedicated to affective disorders.

Aims

Reflect on the clinical relevance of thyroid function screen-

ing on admission in mental health care.

Methods

Retrospective, descriptive study, concerning inpatient

episodes from a 12 month period (January to December 2015) in

a ward dedicated to affective disorders, in a tertiary psychiatric

hospital.

Results

The prevalence of thyroid dysfunction across all psychi-

atric diagnostic groups was 11%. Preliminary data has shown higher

prevalence in non-elderly women with personality disorder as a

main diagnosis (30%,

P

= 0.017). Only women were under thyroid

replacement therapy, which was significantly more prevalent in

those diagnosed with bipolar disorder.

Conclusion

The relatively high prevalence of thyroid dysfunction

underlines the relevance of its screening in mental health inpa-

tients. Our results were consistent with the known epidemiology of

thyroid disease. Correlations with bipolar and personality disorder

were noted, which can contribute to improve the understanding

of clinical-epidemiological relationships between thyroid disease

and specific psychiatric disorders.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1169

EV185

Recognition and treatment of bipolar

mixed states

F. Leite

1 ,

, H. Salgado

2

, C. Olga

2

, P. Carvalho

2

1

Matosinhos, Portugal

2

Hospital de Magalhães Lemos, Servic¸ o de Psiquiatria, Porto, Portugal

Corresponding author.

Introduction

Mixed features refers to the presence of high

and low symptoms occurring at the same time, or as part

of a single episode, in people experiencing an episode of

mania or depression. In most forms of bipolar disorder, moods

alternate between elevated and depressed over time. A per-

son with mixed features experiences symptoms of both mood

“poles” – mania and depression – simultaneously or in rapid

sequence.

Aims and objectives

To review the nosological status of bipolar

mixed states and its treatment.

Methods

Online search/review of the literature has been carried

out, using Medline/Pubmed, concerning “mixed states”, “affective

disorder”, “bipolar disorder”.

Results

The presence of depressive symptomatology during

acute mania has been termed mixed mania, dysphoric mania,

depressive mania or mixed bipolar disorder. Highly prevalent,

mixed mania occurs in at least 30% of bipolar patients. Correct

diagnosis is a major challenge. The presence of mixed features is

associated with a worse clinical course and higher rates of comor-

bidities. There is ongoing debate about the role of antidepressants

in the evolution of such states.

Conclusions

Clinical vigilance and careful evaluation are required

to ensure mixed states are not missed in the clinical context. Atypi-

cal antipsychotics are emerging as the medications of choice in the

pharmacological management of mixed states.