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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S407

Objectives/aims

Aim of our study was to investigate the associa-

tion between clinical variables and poor psychosocial functioning

in euthymic BD-II patients. Hypothesis of this study was that

euthymic BD-II patients would have low level of psychosocial func-

tioning compared with healthy individuals.

Methods

BD-II (

n

= 37) and healthy subjects (

n

= 35) were com-

pared in terms of their psychosocial functioning which were

assessed by Functional Assessment Short Test (FAST). The euthymic

state was confirmed by low scores both on the Hamilton Depres-

sion Rating Scale (HDRS) and the YoungMania Rating Scale (YMRS).

Anxiety symptoms were also assessed by Hamilton Anxiety Rat-

ing Scale (HARS) in both groups. Clinical variables were taken as

independent variables and FAST scores were taken as dependent

variable in order to run correlation analysis in BD-II group.

Results

No socio-demographic differences were found between

two groups. Euthymic BD-II patients had significantly higher FAST,

HARS, HDRS YMRS scores compared with healthy individuals. Only

HDRS scores correlated with FAST scores of BD-II patients.

Conclusions

This study indicated that euthymic BD-II patients

had poorer psychosocial functioning. And subclinical depressive

symptoms were associated with poor psychosocial functioning.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1164

EV180

Insight in bipolar disorder through

the course of manic episode and its

clinical correlates

E. Ince

1 ,

, C. Aksoy-Poyraz

2

, M.K. Arikan

2

, B.C. Poyraz

2

,

S. Turan

2

, A. Sakalli-Kani

2

, E. Aydin

2

1

Istanbul University, Istanbul Faculty of Medicine, Department of

Psychiatry, Istanbul, Turkey

2

Istanbul University, Cerrahpasa Faculty of Medicine, Department of

Psychiatry, Istanbul, Turkey

Corresponding author.

Introduction

Insight is a well-documented phenomenon for psy-

chotic disorders. It has been studied extensively in schizophrenia

and its association with clinical outcomes has drawn increased

attention. Although less is known for affective disorders, recent

studies point out that impaired insight in bipolar disorder may take

part in patients’ overall well-being.

Aims

Exploring the main components of insight in psychiatry,

particularly in bipolar disorder.

Objectives

With this study, we wanted to examine how clini-

cal and cognitive insights change in patients with bipolar disorder

through their hospitalization period and how they correlate with

symptom severity and neuropsychological functioning.

Methods

In this prospective study, inpatientswith bipolar I disor-

der who were presented by manic episode with psychotic features

were included. The patients were assessed with Young Mania Rat-

ing Scale, Beck Cognitive Insight Scale, Schedule for the Assessment

of Insight-Expanded Version (SAI-E) and a neuropsychological test

battery both at the time of admission and discharge.

Results

As of October 2015, a total number of 20 patients with

bipolar I disorder participated in the study. Preliminary results

revealed a significant improvement in the total score of clinical

insight, which was measured with SAI-E by the time of dis-

charge (

P

= 0.001). This transition was strongly correlated with the

decrease in symptom severity (

P

= 0.006,

r

=

0.61). Improved clin-

ical insight exhibited significant correlation with the increase in

patients’ memory span (

P

= 0.007,

r

=

0.596).

Conclusion

The preliminary results suggest that changes in

symptom severity and working memory might be the determi-

nants of improvement in clinical insight of inpatients with bipolar

disorder through manic episode.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1165

EV181

Decrease in prolactine levels after

treatment with aripiprazole during a

maniac episode: A case report

J.M. Coll

1 ,

, G . M

artínez-Alés

1 , N.

Salgado

2

1

Hospital Universitario La Paz, Psychiatry, Madrid, Spain

2

Hospital Dr. Rodriguez Lafora, Psychiatry, Madrid, Spain

Corresponding author.

Introduction

Hyperprolactinemia can produce clinical symptoms

affecting the patient’s quality of life and therefore limiting thera-

peutic approaches to bipolar disorder.

Case report

We report a case of a 46-year-old woman, with a

10 year history of type I bipolar disorder and a microprolacti-

noma, who was admitted to a psychiatry inpatient unit due to

a maniac episode. Current symptoms at the moment of admis-

sion included hyperthymia, verbiage, flight of ideas and insomnia.

Menstrual changes and galactorrea had been present previously.

Aripiprazole was introduced, reaching a dose of 30mg/day, in

addition to her usual treatment with lithium and gabapentin.

Response to treatment was good and euthymia was reached within

10 days. Moreover, gabapentin was substituted by Valproic acid,

and the patient was discharged once therapeutic levels were

attained. Prolactin levels were measured at the moment of admis-

sion (128.75 ng/mL) and after 11 days of treatment (92.93 ng/mL).

Discussion

Choosing an adequate antipsychotic agent can reduce

the risk of iatrogenesis and thus enhance adherence to treatment

and quality of life. Aripiprazole had previously shown a high poten-

tial at decreasing levels of prolactine. In this case, clinical practice

supports scientific evidence.

Conclusions

Aripiprazole is an effective treatment for type I bipo-

lar disorder. Especially, it can be a treatment of choice in patients

suffering from symptoms related to high levels of prolactine, even

using a high dosage.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1166

EV182

Clinical and socio-demographic

profile of bipolar I disorder patients

R. Khemakhem

, W. Homri , D. Karoui , H. Belhadj , L. Mouelhi ,

N. Bram , I. Ben Romdhane , R. Labbene

Razi Hospital, Psychiatry C, Mannouba, Tunisia

Corresponding author.

Introduction

The bipolar disorder (BD) is a chronic and severe

disease which diagnosis and treatment are still raising the issues.

Aims

To show a potential clinical and socio-demographic profile

in BD patients.

Objective

We hypothesized that BD patients have a particular

clinical and socio-demographic characteristics.

Methods

This was a descriptive and retrospective study which

assesses 49 BD’s outpatients. The diagnosis was accorded to DSM-

IV criteria. The enrollment was conducted from January 2010 to

August 2015. The socio-demographic and clinical data were col-

lected by a preestablished railing.

Results

The mean age was 39.7 years with a sex ratio of 1.33.

Six patients (12.2%) lived in urban zones and 61% (

n

= 30) patients

have a lowly socioeconomic conditions. Celibacywas the prevailing

civil status in 57.1% (

n

= 28) among which 17 lived in family home.

Thirty-four (69.4%) patients were unemployed.