European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S407
Objectives/aims Aim of our study was to investigate the associa-
tion between clinical variables and poor psychosocial functioning
in euthymic BD-II patients. Hypothesis of this study was that
euthymic BD-II patients would have low level of psychosocial func-
tioning compared with healthy individuals.
Methods BD-II (n = 37) and healthy subjects (n = 35) were com-
pared in terms of their psychosocial functioning which were
assessed by Functional Assessment Short Test (FAST). The euthymic
state was confirmed by low scores both on the Hamilton Depres-
sion Rating Scale (HDRS) and the YoungMania Rating Scale (YMRS).
Anxiety symptoms were also assessed by Hamilton Anxiety Rat-
ing Scale (HARS) in both groups. Clinical variables were taken as
independent variables and FAST scores were taken as dependent
variable in order to run correlation analysis in BD-II group.
Results No socio-demographic differences were found between
two groups. Euthymic BD-II patients had significantly higher FAST,
HARS, HDRS YMRS scores compared with healthy individuals. Only
HDRS scores correlated with FAST scores of BD-II patients.
Conclusions This study indicated that euthymic BD-II patients
had poorer psychosocial functioning. And subclinical depressive
symptoms were associated with poor psychosocial functioning.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV180
Insight in bipolar disorder through
the course of manic episode and its
clinical correlates
E. Ince ∗, C. Aksoy-Poyraz , M.K. Arikan , B.C. Poyraz ,
S. Turan , A. Sakalli-Kani , E. Aydin
1 Istanbul University, Istanbul Faculty of Medicine, Department of
Psychiatry, Istanbul, Turkey
2 Istanbul University, Cerrahpasa Faculty of Medicine, Department of
Psychiatry, Istanbul, Turkey
∗ Corresponding author.
Introduction Insight is a well-documented phenomenon for psy-
chotic disorders. It has been studied extensively in schizophrenia
and its association with clinical outcomes has drawn increased
attention. Although less is known for affective disorders, recent
studies point out that impaired insight in bipolar disorder may take
part in patients’ overall well-being.
Aims Exploring the main components of insight in psychiatry,
particularly in bipolar disorder.
Objectives With this study, we wanted to examine how clini-
cal and cognitive insights change in patients with bipolar disorder
through their hospitalization period and how they correlate with
symptom severity and neuropsychological functioning.
Methods In this prospective study, inpatientswith bipolar I disor-
der who were presented by manic episode with psychotic features
were included. The patients were assessed with Young Mania Rat-
ing Scale, Beck Cognitive Insight Scale, Schedule for the Assessment
of Insight-Expanded Version (SAI-E) and a neuropsychological test
battery both at the time of admission and discharge.
Results As of October 2015, a total number of 20 patients with
bipolar I disorder participated in the study. Preliminary results
revealed a significant improvement in the total score of clinical
insight, which was measured with SAI-E by the time of dis-
charge (P = 0.001). This transition was strongly correlated with the
decrease in symptom severity (P = 0.006, r = −0.61). Improved clin-
ical insight exhibited significant correlation with the increase in
patients’ memory span (P = 0.007, r= −0.596).
Conclusion The preliminary results suggest that changes in
symptom severity and working memory might be the determi-
nants of improvement in clinical insight of inpatients with bipolar
disorder through manic episode.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV181
Decrease in prolactine levels after
treatment with aripiprazole during a
maniac episode: A case report
J.M. Coll ∗ artínez-Alés Salgado
1 Hospital Universitario La Paz, Psychiatry, Madrid, Spain
2 Hospital Dr. Rodriguez Lafora, Psychiatry, Madrid, Spain
∗ Corresponding author.
Introduction Hyperprolactinemia can produce clinical symptoms
affecting the patient’s quality of life and therefore limiting thera-
peutic approaches to bipolar disorder.
Case report We report a case of a 46-year-old woman, with a
10 year history of type I bipolar disorder and a microprolacti-
noma, who was admitted to a psychiatry inpatient unit due to
a maniac episode. Current symptoms at the moment of admis-
sion included hyperthymia, verbiage, flight of ideas and insomnia.
Menstrual changes and galactorrea had been present previously.
Aripiprazole was introduced, reaching a dose of 30mg/day, in
addition to her usual treatment with lithium and gabapentin.
Response to treatment was good and euthymia was reached within
10 days. Moreover, gabapentin was substituted by Valproic acid,
and the patient was discharged once therapeutic levels were
attained. Prolactin levels were measured at the moment of admis-
sion (128.75 ng/mL) and after 11 days of treatment (92.93 ng/mL).
Discussion Choosing an adequate antipsychotic agent can reduce
the risk of iatrogenesis and thus enhance adherence to treatment
and quality of life. Aripiprazole had previously shown a high poten-
tial at decreasing levels of prolactine. In this case, clinical practice
supports scientific evidence.
Conclusions Aripiprazole is an effective treatment for type I bipo-
lar disorder. Especially, it can be a treatment of choice in patients
suffering from symptoms related to high levels of prolactine, even
using a high dosage.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV182
Clinical and socio-demographic
profile of bipolar I disorder patients
R. Khemakhem ∗, W. Homri , D. Karoui , H. Belhadj , L. Mouelhi ,
N. Bram , I. Ben Romdhane , R. Labbene
Razi Hospital, Psychiatry C, Mannouba, Tunisia
∗ Corresponding author.
Introduction The bipolar disorder (BD) is a chronic and severe
disease which diagnosis and treatment are still raising the issues.
Aims To show a potential clinical and socio-demographic profile
in BD patients.
Objective We hypothesized that BD patients have a particular
clinical and socio-demographic characteristics.
Methods This was a descriptive and retrospective study which
assesses 49 BD’s outpatients. The diagnosis was accorded to DSM-
IV criteria. The enrollment was conducted from January 2010 to
August 2015. The socio-demographic and clinical data were col-
lected by a preestablished railing.
Results The mean age was 39.7 years with a sex ratio of 1.33.
Six patients (12.2%) lived in urban zones and 61% (n = 30) patients
have a lowly socioeconomic conditions. Celibacywas the prevailing
civil status in 57.1% (n = 28) among which 17 lived in family home.
Thirty-four (69.4%) patients were unemployed.