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S402

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

EV163

Cognitive impairment in manic

schizoaffective and bipolar patients: A

Romanian sample

A. Draghici

1 ,

, L. Dehelean

2

, F. Romosan

2

, R.S. Romosan

2

,

V.R. Enatescu

2

, I. Papava

2

1

Vasile Goldis West University of Arad, Psychiatry, Arad, Romania

2

Victor Babes University of Medicine and Pharmacy Timisoara,

Neuroscience, Timisoara, Romania

Corresponding author.

Introduction

Cognitive functions are known to be impaired both

in schizoaffective and bipolar patients during the acute manic

episode, but also in euthymia.

Objectives

The purpose of the study was to identify differences in

neurocognitive functioning of schizoaffective and bipolar patients.

Methods

The study was conducted between 2012 and 2015. It

included inpatients from the Timisoara Psychiatric Clinic, diag-

nosed with either bipolar disorder (

n

= 45) or schizoaffective

disorder (

n

= 43), according to ICD-10 criteria, and a healthy con-

trol group (

n

= 85). The Rey verbal memory test and the d2 Test of

Attention were used to assess cognitive functions.

Results

Statistically significant differences (

P

< 0.0001) were

found between the control group and the patients group in regard

to “total number of items processes” (TN), “percentage of errors”

(E%) and in “concentration of performance” (CP). No significant dif-

ferences were found concerning neurocognitive functions between

the two patient groups during the acute manic episode. However,

cognitive functions were significantly more impaired in schizoaf-

fective than inbipolar patients during euthymia (lowermean scores

in bipolar patients regarding all the aforementioned parameters).

Conclusions

The severity of cognitive deficits is similar in both

bipolar and schizoaffective disorder during the acute manic

episode. During euthymic periods, schizoaffective patients have a

poorer neurocognitive functioning than bipolar patients.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1148

EV164

Empathic response in manic bipolar

and schizoaffective patients: A

Romanian sample

A. Draghici

1 ,

, F. Romosan

2

, D. Podea

1

, L. Dehelean

2

,

R.S. Romosan

2

, V.R. Enatescu

2

, I. Papava

2

1

Vasile Goldis West University of Arad, Psychiatry, Arad, Romania

2

Victor Babes University of Medicine and Pharmacy, Neuroscience,

Timisoara, Romania

Corresponding author.

Introduction

Empathy is described as the ability to infer or share

the feeling state of another person. Despite knowledge of impair-

ments in cognitive and social functioning, to date, little work

has been conducted concerning empathic response in bipolar and

schizoaffective patients.

Objectives

Finding potential differences regarding the empathic

response of manic bipolar and schizoaffective patients.

Methods

Inpatients from the Timisoara Psychiatric Clinic, diag-

nosed with either bipolar disorder (

n

= 50) or schizoaffective

disorder (

n

= 45), according to ICD-10 criteria, and a healthy control

group (

n

= 80) were included in the study. The study was conducted

between 2011 and 2015. To assess the empathic response we used

Empathy Quotient (EQ).

Results

We found statistically significant differences (

P

< 0.0001)

between the patient groups and the control group (lower mean for

empathy scores than the control group in both bipolar and schizoaf-

fective patients). During the acute manic episode, no significant

differences were found concerning the empathic response between

the two patient groups. In euthymia, however, patients with

schizoaffective disorder had significantly lower EQ mean scores

than bipolar patients (

P

= 0.03).

Conclusions

Bipolar and schizoaffective patients seem to have

similar lower levels of empathy during the acute manic episode,

but schizoaffective patients have a poorer empathic response than

bipolar patients during euthymic periods.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1149

EV165

Mixed states – hallmark

characteristics and controversial

nosologic evolution

D. Durães

, J. Martins , R. Borralho

Centro Hospitalar Barreiro-Montijo, Mental Health and Psychiatry

Department, Barreiro, Portugal

Corresponding author.

Introduction

Classically described as the contemporary presence

of affective symptoms of opposite polarity during amaniac ormajor

depressive episode, mixed states (MS) still remain a controversial

topic and a diagnostic challenge, remaining many times undiag-

nosed and mistreated.

Objectives/aims

This work aims to review the conceptualization

and definition of MS over the years, their main characteristics and

the controversy around the latest diagnostic criteria.

Methods

A review of relevant literature was conducted along-

side online database research (PubMed and Medscape) using the

keywords “mixed state”, “bipolar” and “depression”.

Results

Since their first description, by Johann Heinroth, the con-

ceptualization and diagnostic features of MS have been largely

contested. Subsequently, Emil Kraepelin systematized several sub-

types of MS, being the first to introduce the term, and Wilhelm

Weygandt published the first book on the subject (1899). Since

then, largely due to Kurt Schneider disbelief, their study was

neglected for several years.

MS definition suffered numerous changes through the different

DSM editions, which clearly reflects the difficulty in their correct

understanding. Recently DSM-5 introduced a broader definition

that seems to better depict their nature and will certainly impact

the known epidemiology, diagnosis and treatment.

Conclusions

Accurate identification and prompt diagnosis of MS

are crucial for clinical practice since these patients appear to show

a more severe form of disease and a worse prognosis, with longer,

more frequent relapses, substance use comorbidities and higher

suicide risk with poorer response to treatment. Further investiga-

tion seems necessary to clarify the validity of the DSM-5 diagnostic

criteria.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1150

EV166

Subthreshold symptoms in bipolar

disorder

R. Feki

, D. T

rigui , I. Feki , I. Baati , J. Masmoudi

CHU Hédi Chaker, Psychiatrie A, Sfax, Tunisia

Corresponding author.

Introduction

Bipolar disorder is a severe mental illness charac-

terized by intermittent episodes of mania, depression and mixed

states. The presence of residual symptoms, seems to be the common

factor in many studies assessing functioning in BD patients.