European Psychiatry - Volume 33 - March 2016

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S402 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
EV163
Cognitive impairment in manic
schizoaffective and bipolar patients: A
Romanian sample
A. Draghici ∗, L. Dehelean , F. Romosan , R.S. Romosan ,
V.R. Enatescu , I. Papava
1 Vasile Goldis West University of Arad, Psychiatry, Arad, Romania
2 Victor Babes University of Medicine and Pharmacy Timisoara,
Neuroscience, Timisoara, Romania
∗ Corresponding author.
Introduction Cognitive functions are known to be impaired both
in schizoaffective and bipolar patients during the acute manic
episode, but also in euthymia.
Objectives The purpose of the study was to identify differences in
neurocognitive functioning of schizoaffective and bipolar patients.
Methods The study was conducted between 2012 and 2015. It
included inpatients from the Timisoara Psychiatric Clinic, diag-
nosed with either bipolar disorder ( n = 45) or schizoaffective
disorder (n = 43), according to ICD-10 criteria, and a healthy con-
trol group (n = 85). The Rey verbal memory test and the d2 Test of
Attention were used to assess cognitive functions.
Results Statistically significant differences (P < 0.0001) were
found between the control group and the patients group in regard
to “total number of items processes” (TN), “percentage of errors”
(E%) and in “concentration of performance” (CP). No significant dif-
ferences were found concerning neurocognitive functions between
the two patient groups during the acute manic episode. However,
cognitive functions were significantly more impaired in schizoaf-
fective than inbipolar patients during euthymia (lowermean scores
in bipolar patients regarding all the aforementioned parameters).
Conclusions The severity of cognitive deficits is similar in both
bipolar and schizoaffective disorder during the acute manic
episode. During euthymic periods, schizoaffective patients have a
poorer neurocognitive functioning than bipolar patients.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV164
Empathic response in manic bipolar
and schizoaffective patients: A
Romanian sample
A. Draghici ∗, F. Romosan , D. Podea , L. Dehelean ,
R.S. Romosan , V.R. Enatescu , I. Papava
1 Vasile Goldis West University of Arad, Psychiatry, Arad, Romania
2 Victor Babes University of Medicine and Pharmacy, Neuroscience,
Timisoara, Romania
∗ Corresponding author.
Introduction Empathy is described as the ability to infer or share
the feeling state of another person. Despite knowledge of impair-
ments in cognitive and social functioning, to date, little work
has been conducted concerning empathic response in bipolar and
schizoaffective patients.
Objectives Finding potential differences regarding the empathic
response of manic bipolar and schizoaffective patients.
Methods Inpatients from the Timisoara Psychiatric Clinic, diag-
nosed with either bipolar disorder ( n = 50) or schizoaffective
disorder (n = 45), according to ICD-10 criteria, and a healthy control
group (n = 80) were included in the study. The study was conducted
between 2011 and 2015. To assess the empathic response we used
Empathy Quotient (EQ).
Results We found statistically significant differences (P < 0.0001)
between the patient groups and the control group (lower mean for
empathy scores than the control group in both bipolar and schizoaf-
fective patients). During the acute manic episode, no significant
differences were found concerning the empathic response between
the two patient groups. In euthymia, however, patients with
schizoaffective disorder had significantly lower EQ mean scores
than bipolar patients ( P = 0.03).
Conclusions Bipolar and schizoaffective patients seem to have
similar lower levels of empathy during the acute manic episode,
but schizoaffective patients have a poorer empathic response than
bipolar patients during euthymic periods.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV165
Mixed states – hallmark
characteristics and controversial
nosologic evolution
D. Durães ∗, J. Martins , R. Borralho
Centro Hospitalar Barreiro-Montijo, Mental Health and Psychiatry
Department, Barreiro, Portugal
∗ Corresponding author.
Introduction Classically described as the contemporary presence
of affective symptoms of opposite polarity during amaniac ormajor
depressive episode, mixed states (MS) still remain a controversial
topic and a diagnostic challenge, remaining many times undiag-
nosed and mistreated.
Objectives/aims This work aims to review the conceptualization
and definition of MS over the years, their main characteristics and
the controversy around the latest diagnostic criteria.
Methods A review of relevant literature was conducted along-
side online database research (PubMed and Medscape) using the
keywords “mixed state”, “bipolar” and “depression”.
Results Since their first description, by Johann Heinroth, the con-
ceptualization and diagnostic features of MS have been largely
contested. Subsequently, Emil Kraepelin systematized several sub-
types of MS, being the first to introduce the term, and Wilhelm
Weygandt published the first book on the subject (1899). Since
then, largely due to Kurt Schneider disbelief, their study was
neglected for several years.
MS definition suffered numerous changes through the different
DSM editions, which clearly reflects the difficulty in their correct
understanding. Recently DSM-5 introduced a broader definition
that seems to better depict their nature and will certainly impact
the known epidemiology, diagnosis and treatment.
Conclusions Accurate identification and prompt diagnosis of MS
are crucial for clinical practice since these patients appear to show
a more severe form of disease and a worse prognosis, with longer,
more frequent relapses, substance use comorbidities and higher
suicide risk with poorer response to treatment. Further investiga-
tion seems necessary to clarify the validity of the DSM-5 diagnostic
criteria.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV166
Subthreshold symptoms in bipolar
disorder
R. Feki ∗ rigui , I. Feki , I. Baati , J. Masmoudi
CHU Hédi Chaker, Psychiatrie A, Sfax, Tunisia
∗ Corresponding author.
Introduction Bipolar disorder is a severe mental illness charac-
terized by intermittent episodes of mania, depression and mixed
states. The presence of residual symptoms, seems to be the common
factor in many studies assessing functioning in BD patients.