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S398

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

Further reading

FOBIAS ESPECÍFICAS, Bados, Arturo.

http://diposit.ub.edu/dspace/ bitstream/2445/360/1/113.pdf

.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1134

EV150

Nonlinear electroencephalogram

analyse cortical functional activity in

patients with generalized anxiety

disorder

Y. Wang

Guiyang Medical University, Department of Psychiatry, Guiyang,

China

Background

The neurological correlates of generalised anxiety

disorder (GAD) are not well known, however there is evidence of

cortical dysregulation in patients with GAD. The aim of the study

was to examine cortical functional activity in patients with GAD

using nonlinear electroencephalogram (EEG) analysis, and to eval-

uate the contribution of anxiety severity.

New method

The sample consisted of 64 outpatients diagnosed

with GAD, anxiety severity was assessed using the Hamilton Rat-

ing Scale for Anxiety (HAMA) severity score, with 7–17 scores

indicating mild anxiety as A group and 18 and above indicating

moderate-severe anxiety as B group. EEGs were conducted, and

between-group differences on non-linear parameter Correlation

Dimension (D

2

) were analyzed. The association between D

2

value

and HAMA scores was analysed.

Results

Compared with the control group, D

2

values were

increased in anxiety groups. For those with mild anxiety, this

difference occurred only in the left prefrontal regions. For those

withmoderate-severe anxiety, significantly greater D

2

values were

observed in all of the cerebral regions, especially in the left and right

temporal and other left cerebral regions. When compared with

those with mild anxiety, D

2

values were significantly greater for

those with moderate-severe anxiety in the left and right temporal

lobe and all other left cerebral regions.

Conclusions

GADwas significantly associated with dysfunctional

cortical activity in the majority of cerebral regions, GAD severity

was associated with involvement of a larger number of cerebral

regions. This analysis method is suggested as a complementary tool

to examine dysfunctional cortical activity in GAD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1135

Bipolar disorders

EV151

Do bipolar II and bipolar I disorder

have different genotypes and why do

we observe unipolar depression

converting to bipolar II and then

bipolar I?

M. Agius

1 ,

, M. Fawcett

2

, R. Zaman

1

1

University of Cambridge, Psychiatry, Cambridge, United Kingdom

2

University of Cambridge, School of Clinical Medicine, Cambridge,

United Kingdom

Corresponding author.

We review the recent literature in order to establish the impor-

tance of a spectrum for bipolar affective disorder, and that unipolar

depression, bipolar II and bipolar I are discrete entities that may

however evolve in sequence. We discuss clinical, genetic and neu-

robiological data which illustrate the differences between bipolar I

and bipolar II. To fit the data we suggest a series of multiple mood

disorder genotypes, some of which evolve into other conditions on

the bipolar spectrum. Thence, we discuss the nature of the bipolar

spectrum and demonstrate how this concept can be used as the

basis of a staging model for bipolar disorder.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1136

EV152

Use of lithium in acute mania in

adolescents

C. Aksoy Poyraz

1 ,

, A. Özdemir

2

, G. Günay

2

, B.C¸ . poyraz

1

,

S. Enginkaya

2

, G. Karac¸ etin

2

, N. Tomruk

2

1

Istanbul University Cerrahpas¸ a Faculty of Medicine, psychiatry,

Istanbul, Turkey

2

Bakırköy Mazhar Osman Mental Health and Neurological Diseases

Education and Research Hospital, psychiatry, Istanbul, Turkey

Corresponding author.

The aim of the present study was to investigate whether the use of

lithium followed recommended practice in acutely manic adoles-

cent inpatients. This study was a 12-month retrospective review of

patients with manic episode admitted to Bakırköy Mazhar Osman

Mental Health and Neurological Diseases Education and Research

Hospital. Length of stay, medication data, serum levels and adverse

effects were recorded for patients who started lithium treatment

within average of 7 days of admission (

n

= 52). Average length of

stay was 23.63 (SD = 17.6). The maximum dose prescribed within

24 h of starting treatment was 721.15mg (SD = 239.5). The maxi-

mum daily dose was reached in an average of 7 days to 1136.5mg

(SD = 336.4). The average time after starting treatment until the first

recorded serum level was 5 days. The average serum level reached

was 0.5mEq/L (SD = 0.22), which was raised to 0.6mEq/L (SD = 0.3)

at discharge with an average daily dose of 1038.46mg (SD = 460).

In 8 admissions (15.4%), one adverse effect was recorded that could

have been related to lithium treatment but adverse events did not

lead to discontinuation of drug. The literature supports that rapidly

attained high serum levels are associated with positive outcomes.

In this current study, clinicians used a relatively slow dose titra-

tion and lower serum levels were obtained suggesting that lithium

was not considered as a primary agent for treating mania. Taking

advantage of lithium especially for the maintenance treatment of

bipolar disorder and tolerability may have driven these findings.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1137

EV153

Mental health and drug

R. Alonso Díaz

1 ,

, E . C

ortázar Alonso

2 ,

H. Guillén Rodrigo

2

1

Hospital Juan Ramón Jiménez, Huelva, Spain

2

Hospital Juan Ramón Jiménez, Salud Mental, Huelva, Spain

Corresponding author.

Introduction

Bipolar disorder (BD) is often associated with var-

ious comorbidities. It is substance use disorders (SUD) one of the

most frequent comorbidities.

The ECA study (Epidemiologic Catchment Area) observed a preva-

lence over the life of the 56, 1% for any TUS in the total sample of

patients with bipolar disorder. In subjects with bipolar I disorder

prevalence was 60.7%, and those of type II 48.1.