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S396

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

made on seventh day, after one, two and nine months. Daily PG

dose ranged from 150–300mg.

Within both groups there was highly significant difference in the

decline of scores on the VAS and CGI in all repeated measurements,

except for CGI in both groups between second and ninth month-

there was no statistical difference, Wilcoxon Signed Ranks Test:

CGI

eg

P

= 0.102, CGI

cg

P

= 0.317. Comparing results between CG and

EG on both scales, there were no statistically significant differences

in all measurements. At the end of the study, Mann-Whitney test

for CGI

P

= 0.560 and VAS

P

= 0.705 and no difference in the effects

of the drugs between EG and CG on both scales CGI

P

= 0.467, VAS

P

= 0.860.

Efficacy of PG is equal as PG + AD combinations in SD treatments.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1128

EV144

Anxiety, depression and perceived

health status in patients with epilepsy

F. Smaoui

1 ,

, E. Turki

1

, N. Halouani

2 ,

, M. Turki

1

, I. Bouchhima

1

,

N. Bouzidi

1

, M. Ben Amar

1

, O. Amami

2

, C. Mhiri

1

1

Habib Bourguiba Hospital, Neurology, Sfax, Tunisia

2

Hedi Chaker, Psychiatry, Sfax, Tunisia

Corresponding author.

Introduction

Epilepsy is a chronic disease often disabling, source

of stigma and poor quality of life.

Objectives

Determine the prevalence of anxiety and depression

in patients with epilepsy and the associated factors.

Methods

We conducted a prospective, descriptive and analytical

study among 20 patients followed for epilepsy in our department of

neurology. The study was conducted from February to April 2015.

We used a preestablished form to collect the socio-demographic

and clinic profile of the patients. The assessment of anxiety and

depression was made via the HADS “Hospital Anxiety and Depres-

sion Scale” and the perceived health status via GHQ scale “General

Health Questionnaire”.

Results

The average age of our patients was 35.9 years. The

average GHQ score was 27.7. It was higher in women without a sta-

tistically significant difference. It was positively correlatedwith the

number of attacks during the last 12 months (

P

= 0.042), poor treat-

ment adherence (

P

= 0.007), the feeling of disability (

P

= 0.021) and

the feeling of stigma (

P

= 0.008). Anxiety was estimated in 35% of

cases and 45%were depressed. Depressionwas significantly associ-

ated to the celibacy (

P

= 0.012), the feeling of stigma (

P

= 0.038) and

the GHQ score (

P

= 0.016). Anxiety was correlated with the absence

of hobbies (

P

= 0.02) and the GHQ score (

P

= 0.008).

Conclusion

It is important to detect these psychiatric disorders

and to manage generators factors to ensure a better quality of life

and social integration for these patients with epilepsy.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1129

EV145

The psychological impact of melasma.

A report of 30 Tunisian women

F. Fatma

1 , I. B

aati

1 , M.

Mseddi

2 , R. S

allemi

1 ,

, H .

Turki

2 ,

J. Masmoudi

1

1

Hedi Chaker University Hospital, Psychiaty A, Sfax, Tunisia

2

Hedi Chaker University Hospital, Dermatology, Sfax, Tunisia

Corresponding author.

Introduction

Melasma is a common disorder of acquired hyper-

pigmentation characterized by tan or brown macules and patches

localized to photo-exposed areas of the face.

Objective

To study the psychological impact of melasma on

Tunisian women.

Methods

We conducted a cross-sectional study on thirty patients

with melasma who attended the dermatology department of the

University Hospital in Sfax (Tunisia).

The questionnaire included socio-demographic and clinical data.

We used four measurement scales:

– MELASQOL questionnaire;

– Rosenberg Self-Esteem Scale;

– Hospital Anxiety and Depression Scale;

– Body Image Questionnaire.

Results

The mean age was 34.6 years. The majority was living in

urban areas (90%), was married (56.7%) and had a profession (80%).

Sixty percent of patients were anxious and 16.7% were depressed.

Both self-esteemand body imagewere respectively altered in 43.3%

and 36.6%. The average score of MELASQOL was 31.77%. It was

higher in single woman (36.8 vs. 28.4), younger than 40 years old

(31.5 vs. 21.7), having a low socioeconomic status (45.2 vs. 29) and

working in private sector (40 vs. 24).

The quality of life was more damaged in patients with disease dura-

tion less than five years (

P

= 0.024).

Anxious patients had higher MELASQOL scores than non-anxious

(38.17 vs. 22.17;

P

= 0.008), as well as depressed patients (49 vs.

28.32;

P

= 0.009).

High MELASQOL scores were correlated with low self-esteem

(

P

= 0.05) and altered body image (

P

= 0.04).

Conclusion

Although benign, melasma causes an important psy-

chological impact such as anxiety, depression, low self-esteem and

poor body image. These effects should be considered in the care

plan.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1130

EV146

Efficacy of antidepressants in

post-traumatic stress disorder

H. Snene

Military Hospital of Tunisia, Psychiatry, Tunis, Tunisia

Introduction

The treatment of post-traumatic stress disorder

(PTSD) has several aims such as reducing the severity of symp-

toms, minimizing the functional impact and improving the quality

of life. Antidepressants are considered as the first line pharmaco-

logical treatment for PTSD. However, recent reports concluded that

current evidence to determine their efficacy is at best suggestive.

Aims

The purpose of this study was to evaluate the efficacy of

antidepressant treatment in PTSD.

Methods

This was a prospective and descriptive study concern-

ing patients who consulted from August to October 2013 in the

psychiatry department of military hospital of Tunis and were

then diagnosed as having a PTSD according to the DSM-IV-TR cri-

teria (

n

= 28). All patients had an antidepressant treatment. An

evaluation by the Clinician-Administered PTSD Scale (CAPS) was

performed at diagnosis and after 12 weeks. The most common def-

inition of therapeutic response for patients with PTSD is a decrease

of 30% or more in the CAPS score.

Results

Tables 1 and 2 .

Conclusion

Antidepressants have shown efficacy in the treat-

ment of over half of PTSD cases. However, these results confirm

that a large proportion of patients do not respond to this therapeu-

tic class. Other options are needed to overcome these shortcomings

in order to improve the prognosis of this particularly disabling dis-

ease.