European Psychiatry - Volume 33 - March 2016

400 / 812

S396 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
made on seventh day, after one, two and nine months. Daily PG
dose ranged from 150–300mg.
Within both groups there was highly significant difference in the
decline of scores on the VAS and CGI in all repeated measurements,
except for CGI in both groups between second and ninth month-
there was no statistical difference, Wilcoxon Signed Ranks Test:
CGIeg P = 0.102, CGIcg P= 0.317. Comparing results between CG and
EG on both scales, there were no statistically significant differences
in all measurements. At the end of the study, Mann-Whitney test
for CGI P = 0.560 and VAS P = 0.705 and no difference in the effects
of the drugs between EG and CG on both scales CGI P = 0.467, VAS
P = 0.860.
Efficacy of PG is equal as PG + AD combinations in SD treatments.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV144
Anxiety, depression and perceived
health status in patients with epilepsy
F. Smaoui ∗, E. Turki , N. Halouani ∗, M. Turki , I. Bouchhima ,
N. Bouzidi , M. Ben Amar , O. Amami , C. Mhiri
1 Habib Bourguiba Hospital, Neurology, Sfax, Tunisia
2 Hedi Chaker, Psychiatry, Sfax, Tunisia
∗ Corresponding author.
Introduction Epilepsy is a chronic disease often disabling, source
of stigma and poor quality of life.
Objectives Determine the prevalence of anxiety and depression
in patients with epilepsy and the associated factors.
Methods We conducted a prospective, descriptive and analytical
study among 20 patients followed for epilepsy in our department of
neurology. The study was conducted from February to April 2015.
We used a preestablished form to collect the socio-demographic
and clinic profile of the patients. The assessment of anxiety and
depression was made via the HADS “Hospital Anxiety and Depres-
sion Scale” and the perceived health status via GHQ scale “General
Health Questionnaire”.
Results The average age of our patients was 35.9 years. The
average GHQ score was 27.7. It was higher in women without a sta-
tistically significant difference. It was positively correlatedwith the
number of attacks during the last 12 months (P= 0.042), poor treat-
ment adherence (P = 0.007), the feeling of disability (P = 0.021) and
the feeling of stigma (P = 0.008). Anxiety was estimated in 35% of
cases and 45%were depressed. Depressionwas significantly associ-
ated to the celibacy (P= 0.012), the feeling of stigma (P = 0.038) and
the GHQ score (P = 0.016). Anxiety was correlated with the absence
of hobbies (P = 0.02) and the GHQ score (P = 0.008).
Conclusion It is important to detect these psychiatric disorders
and to manage generators factors to ensure a better quality of life
and social integration for these patients with epilepsy.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV145
The psychological impact of melasma.
A report of 30 Tunisian women
F. Fatma aati Mseddi allemi ∗ Turki
J. Masmoudi
1 Hedi Chaker University Hospital, Psychiaty A, Sfax, Tunisia
2 Hedi Chaker University Hospital, Dermatology, Sfax, Tunisia
∗ Corresponding author.
Introduction Melasma is a common disorder of acquired hyper-
pigmentation characterized by tan or brown macules and patches
localized to photo-exposed areas of the face.
Objective To study the psychological impact of melasma on
Tunisian women.
Methods We conducted a cross-sectional study on thirty patients
with melasma who attended the dermatology department of the
University Hospital in Sfax (Tunisia).
The questionnaire included socio-demographic and clinical data.
We used four measurement scales:
– MELASQOL questionnaire;
– Rosenberg Self-Esteem Scale;
– Hospital Anxiety and Depression Scale;
– Body Image Questionnaire.
Results The mean age was 34.6 years. The majority was living in
urban areas (90%), was married (56.7%) and had a profession (80%).
Sixty percent of patients were anxious and 16.7% were depressed.
Both self-esteemand body imagewere respectively altered in 43.3%
and 36.6%. The average score of MELASQOL was 31.77%. It was
higher in single woman (36.8 vs. 28.4), younger than 40 years old
(31.5 vs. 21.7), having a low socioeconomic status (45.2 vs. 29) and
working in private sector (40 vs. 24).
The quality of life was more damaged in patients with disease dura-
tion less than five years (P = 0.024).
Anxious patients had higher MELASQOL scores than non-anxious
(38.17 vs. 22.17; P = 0.008), as well as depressed patients (49 vs.
28.32; P = 0.009).
High MELASQOL scores were correlated with low self-esteem
(P = 0.05) and altered body image (P = 0.04).
Conclusion Although benign, melasma causes an important psy-
chological impact such as anxiety, depression, low self-esteem and
poor body image. These effects should be considered in the care
plan.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV146
Efficacy of antidepressants in
post-traumatic stress disorder
H. Snene
Military Hospital of Tunisia, Psychiatry, Tunis, Tunisia
Introduction The treatment of post-traumatic stress disorder
(PTSD) has several aims such as reducing the severity of symp-
toms, minimizing the functional impact and improving the quality
of life. Antidepressants are considered as the first line pharmaco-
logical treatment for PTSD. However, recent reports concluded that
current evidence to determine their efficacy is at best suggestive.
Aims The purpose of this study was to evaluate the efficacy of
antidepressant treatment in PTSD.
Methods This was a prospective and descriptive study concern-
ing patients who consulted from August to October 2013 in the
psychiatry department of military hospital of Tunis and were
then diagnosed as having a PTSD according to the DSM-IV-TR cri-
teria (n = 28). All patients had an antidepressant treatment. An
evaluation by the Clinician-Administered PTSD Scale (CAPS) was
performed at diagnosis and after 12 weeks. The most common def-
inition of therapeutic response for patients with PTSD is a decrease
of 30% or more in the CAPS score.
Results
Conclusion Antidepressants have shown efficacy in the treat-
ment of over half of PTSD cases. However, these results confirm
that a large proportion of patients do not respond to this therapeu-
tic class. Other options are needed to overcome these shortcomings
in order to improve the prognosis of this particularly disabling dis-
ease.