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S120

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

5

Hospital Universitari Germans Trías i Pujol, IGTP, Universitat

Autònoma de Barcelona, Pharmacology, Barcelona, Spain

Corresponding author.

Introduction

In recent years, the increasing use tendency of NPS

has motivated both awareness and concern about their identifica-

tion and potential harmfulness. Synthetic cathinones represent a

significant proportion of the NPS available and methylone is one of

the most frequently found in Europe.

Objectives

The aim of the present study is to determine methy-

lone presence and characteristics from the samples analyzed by

Energy Control between the years 2009 and 2015 in Spain.

Methods

From all 21,198 samples analyzed from august 2009 to

august 2015, only those in which methylone was found are stud-

ied (

n

= 140). The samples have been analyzed by Energy Control, a

spanish harm-reduction NGO that offers to users the possibility of

analyzing the substances they intend to consume. The analysis is

done by gas chromatography–mass spectrometry.

Results

From the 140 samples containing methylone, 87 were

handled asmethylone, 20 asMDMA, 8 as other synthetic cathinones

and 25 as other substances. The peak of consume was registered in

2011 with 41 samples then the number decreased until 10 samples

in 2015.

Conclusions

Results suggest that methylone is most frequently

handled as methylone or as MDMA and that its consumption could

be decreasing. Further pharmacokinetic, pharmacodynamic, clini-

cal and epidemiological studies should be conducted to enhance the

knowledge not only about methylone consumption, but also about

synthetic cathinones in general in order to assess their potential

risk and study the complications and its management.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

Acknowledgements

Supported by grants of ISCIII-FEDER-(RTA

RD12/0028/0009),

and The European Commission-

(Drug Prevention and Information Programme 2014-16,

JUST/2013/DPIP/AG/4823, EU-MADNESS project). L. Galindo is

a Rio-Hortega-fellowship-(ISC-III;-CM14/00111).

http://dx.doi.org/10.1016/j.eurpsy.2016.01.129

EW12

Leptin and ghrelin levels in alcohol

dependent patients and their

relationship with withdrawal and

craving

S. Mehta

1 ,

, A. Baruah

2

, S. Khattri

1

, S. Das

2

, P. Avinash

2

1

SMI, Psychiatry, Dehradun, India

2

LGB Regional Institute of Mental Kealth, Psychiatry, Tezpur, India

Corresponding author.

Introduction

Association between leptin and ghrelin plasma lev-

els and alcohol craving have been found in few studies.

Objectives

To search this correlation in a different population

while comparing levels of these hormones with healthy individuals

and also to study this correlation with respect to hyper-excitable

state of alcohol withdrawal.

Aim

To assess leptin and ghrelin levels after 3weeks of absti-

nence in alcohol-dependent patients.

Methods

Twenty-five indoor patients fulfilling the alcohol

dependence criteria were assessed for withdrawal symptoms and

craving for alcohol. Leptin and ghrelin levels were measured on 1st

day, at the end of 1st week, at the end of 3rd week of stopping

alcohol. Withdrawal was assessed using CIWA-A at day 1 and day

7, craving was assessed using PENN’s scale of craving at the end

of week 1 and week 3. Control group consisted of 15 first-degree

relatives.

Results

It was found that leptin [

t

(38) = 2.95,

P

= 0.005] and

ghrelin [

t

(38) = 2.56,

P

= 0.015] were significantly higher in

alcohol-dependent patients. Levels of hormones had no signifi-

cant correlation with alcohol withdrawal scores but had positive

correlation with craving scores after abstinence.

Conclusions

Study shows that leptin and ghrelin, known for bal-

ancing the energy homeostasis of body, also seem to play role in

pathways of drug dependence and craving. This relation is inde-

pendent of stress hormone axis as leptin and ghrelin levels are not

correlated with withdrawal scores, which is an indicator of stress

hormone axis activation during alcohol withdrawal.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.130

EW13

Presence and evolution of a new

psychoactive tryptamines branch

Á. Palma Conesa

1 , 2 ,

, L. Galindo Guarin

1

, M. Grifell Guardia

1 , 2

,

P. Quintana Mathe

3

, C. Gil Lladanosa

3

, I. Fornís Espinosa

3

,

M. Ventura Vilamala

3

, M. Torrens Melich

1 , 2 , 4

,

M. Farré Albaladejo

4 , 5

, M.F. Fonseca Casals

1 , 2

1

Institut de Neuropsiquiatria i Addiccions, Parc de Salut Mar,

Psychiatry, Barcelona, Spain

2

Institut Hospital del Mar d’Investigacions Mèdiques, IMIM, Parc de

Salut Mar, Psychiatry, Barcelona, Spain

3

Energy Control, Asociación Bienestar y Desarrollo, Energy Control,

Barcelona, Spain

4

Universitat Autònoma de Barcelona, Psychiatry, Barcelona, Spain

5

Servei de Farmacología Clínica, Hospital Germans Trías i Pujol,

Clinical Farmacology, Barcelona, Spain

Corresponding author.

Introduction

New psychoactive substances (NPS) are substances

that have recently appeared on the market and are not under

international control. NPS use is experiencing an unprecedented

increase. DiPT, 4-HO-DiPT and 4-AcO-DiPT are new psychoactive

tryptamines and their effects may differ from those of other psy-

choactive tryptamines.

Objective

To explore the presence of DiPT, 4-HO-DiPT and 4-AcO-

DiPT from samples delivered to and analyzed by Spanish harm

reduction service Energy Control.

Materials and methods

All samples analyzed from 2009 to 2014

delivered as DiPT, 4-HO-DiPT and 4-AcO-DPT or containing these

substances. Analysis was performed by gas chromatography–mass

spectrometry.

Results

From 17,432 samples, 4-HO-DiPT was found in 16, deliv-

ered as 4-HO-DiPT (6); 4-AcO-DiPT (7); DiPT (1); 4-AcO-DMT (1)

and cocaine (1). 4-AcO-DiPT was found in 16, delivered as 4-AcO-

DiPT (12); 5-MeO-DMT (1); 5-MeO-DiPT (1); 4-AcO-DMT (1) and

cocaine (1). Only 4 samples contained DiPT, all presented as DiPT.

Nine samples contained both 4-AcO-DiPT and 4-HO-DiPT. Dur-

ing the years of study, 4-HO-DiPT deliverance was increasing (4

samples in 2014) while deliverance of 4-AcO-DiPT and DiPT was

decreasing (1 sample in 2014).

Conclusions

Increasing 4-HO-DiPT presence could translate a

progressive replacement of 4-AcO-DiPT and DiPT recreational use.

Clinical relevance comes from its growing use and the absence of

scientific evidence on humans, therefore relying on users subjective

experience to predict the effects.

Disclosure of interest

The authors declare that they have no com-

peting interest.

Acknowledgement

Supported in part by grants of Instituto de

Salud Carlos III-FEDER (RTA RD12/0028/0009), and The European

Commission (Drug Prevention and Information Programme 2014-

16, contract no.: JUST/2013/DPIP/AG/4823, EU-MADNESS project).

Liliana Galindo is a Rio Hortega fellowship (ISC-III; CM14/00111).

http://dx.doi.org/10.1016/j.eurpsy.2016.01.131