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S124

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

of grandiosity and minimum for depression. Age, illness duration,

substance use, family history 2nd or later episodes were negatively

correlatedwith treatment response. Pretreatment T4 level was pos-

itively correlated while pre-treatment TSH level was negatively

correlated with the treatment response.

Conclusion

Pre-treatment T4 and TSH level were predictors of

treatment response with lithium.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.140

EW23

Determining the cut-off for recurrent

depressive episode to predict

diagnostic conversion from unipolar

depression to bipolar disorder: 5-year

retrospective study in one university

hospital

W.M. Bahk

1 ,

, Y.S. Woo

1

, H.R. Wang

1

, B.H. Yoon

2

, D.I. Jon

3

,

Y.J. Kwon

4

, K.H. Lee

5

, K.J. Min

6

, S.Y. Lee

7

, M.D. Kim

8

1

Yeouido St. Mary’s Hospital, Psychiatry, Seoul, Republic of Korea

2

Naju National Hospital, Psychiatry, Naju, Republic of Korea

3

Sacred Heart Hospital, Hallym University, Psychiatry, Anyang,

Republic of Korea

4

Soonchunhyang Cheonan Hospital, Psychiatry, Cheona, Republic of

Korea

5

College of Medicine, Dongguk University, Psychiatry, Gyeongju,

Republic of Korea

6

College of Medicine, Chung-Ang University, Psychiatry, Seoul,

Republic of Korea

7

Wonkwang University School of Medicine, Psychiatry, Iksan,

Republic of Korea

8

College of Medicine, Jeju National University, Psychiatry, Jeju,

Republic of Korea

Corresponding author.

Objectives

The aim of this study was to determining the cut-off

for recurrent depressive episode to predict diagnostic conversion

from unipolar depression to bipolar disorder by means of retro-

spective reviews of medical records.

Methods

The medical records of 250 patients with a diagnosis

of major depressive disorder for at least 5 years were retrospec-

tively reviewed for this study. We reviewed DSM-IV diagnosis and

detailed clinical information at the index admission with assess-

ments made every year after discharge to determining the cut-off

for recurrent depressive episode to predict diagnostic conversion

from unipolar depression to bipolar disorder.

Results

Receiver operating characteristic curve analysis indi-

cated cut-off scores for recurrent depressive episode of more than

three times (area under curve = 0.647, sensitivity = 0.435, speci-

ficity = 0.819, positive predictive value = 0.351, negative predictive

value = 0.865).

Conclusions

These findings suggest that it could predict the best

diagnostic conversion from unipolar depression to bipolar disor-

der when depressive episodes are recurrent more than three times.

Based on these findings, it will be able to promote the accuracy of

diagnosis and the efficiency of treatment.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.141

EW24

Cognitive training for bipolar

disorder. Functional wellness

L. Bernabei

1 ,

, E. Pompili

2

, S. Quinto

1

, L. Basco

1

, L. Di Gennaro

1

,

G. D’Antoni

1

, C. Murtinu

1

, M. Biondi

1

, R. Delle Chiaie

1

1

Policlinico Umberto I, Sapienza University of Rome, Neurology and

Psychiatry, Roma, Italy

2

ASL Roma G, Mental Health Centre, Colleferro, Italy

Corresponding author.

Patients with bipolar disorder (BD) show a typical neuropsychol-

ogical profile, characterized by an alteration of attentive, amnesic

and executive ability. The aim of the study is evaluate the effective-

ness of cognitive training in integrated treatment (CTiIT) for bipolar

disorder.

Methods

A total of 30 BD euthymic patients were enrolled. All

participants completed a comprehensive neuropsychological and

psychosocial (SF-36 and PSQ) assessment. Patients were random

assigned to CTiIT group or control group. CTiIT is designed to be

a short therapy (20 individual sessions of about 1 hour for three

days at week) for the neurocognition, and for psychosocial aspects.

Cognitive training consisted of computerized tasks selected from

CogPACK. Attention, memory and executive tasks available within

the CogPACK program were selected for use in this study, based

on the cognitive domains typically affected in BD patients. Training

with this program is hierarchically organized. All individuals in the

present study had the potential to complete all of the tasks, regard-

less of degree of impairment. Statistical analyses were conducted

using Statistical Package for the Social Sciences Version 20.0 (SPSS

20.0) for windows (SPSS Inc., Chicago, Ill).

Results

Results showed that CTiIT for BD is effective in improv-

ing verbal learning andmemory, executive functions and attention.

Moreover CTiIT increases social wellness measured by SF-36 and

reduces stress perception’s (PSQ).

Conclusions

Cognitive training in integrated treatment – CTiIT

is an important tool for achievement of personal recovery and

becomes necessary to use it, in the daily treatment of BD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.142

EW25

First rank symptoms in mania: An

indistinct diagnostic strand

A. Channa

1 ,

, S. Aleem

2

, H. Mohsin

1

1

Liaquat National Hospital, Psychiatry, Karachi, Pakistan

2

Agha Khan University, Psychiatry, Karachi, Pakistan

Corresponding author.

First rank symptoms (FRS) are considered to be pathognomic

for schizophrenia. However, FRS is not distinctive feature of

schizophrenia. It has also been noticed in affective disorder, albeit

not inclusive in diagnostic criteria. Its existence in the first episode

of bipolar disorder may be predictor of poor short-term outcome

and decompensating course of illness.

Objective

To determine the frequency of first rank symptoms in

manic patients.

Method

The cross sectional study was done at psychiatric ser-

vices of Aga Khan University Hospital, Karachi, Pakistan. One

hundred and twentymanic patientswere recruited fromNovember

2014 to May 2015.FRS was assessed by administration of validated

Urdu version of Present State Examination (PSE) tool.

Result

The mean age of the patients was 37.62 + 12.51. The mean

number of previous manic episode was 2.17 + 2.23. In total, 11.2%

males and 30.6% females had FRS. This association of first rank