European Psychiatry - Volume 33 - March 2016

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S124 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
of grandiosity and minimum for depression. Age, illness duration,
substance use, family history 2nd or later episodes were negatively
correlatedwith treatment response. Pretreatment T4 level was pos-
itively correlated while pre-treatment TSH level was negatively
correlated with the treatment response.
Conclusion Pre-treatment T4 and TSH level were predictors of
treatment response with lithium.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW23
Determining the cut-off for recurrent
depressive episode to predict
diagnostic conversion from unipolar
depression to bipolar disorder: 5-year
retrospective study in one university
hospital
W.M. Bahk ∗, Y.S. Woo , H.R. Wang , B.H. Yoon , D.I. Jon ,
Y.J. Kwon , K.H. Lee , K.J. Min , S.Y. Lee , M.D. Kim
1 Yeouido St. Mary’s Hospital, Psychiatry, Seoul, Republic of Korea
2 Naju National Hospital, Psychiatry, Naju, Republic of Korea
3 Sacred Heart Hospital, Hallym University, Psychiatry, Anyang,
Republic of Korea
4 Soonchunhyang Cheonan Hospital, Psychiatry, Cheona, Republic of
Korea
5 College of Medicine, Dongguk University, Psychiatry, Gyeongju,
Republic of Korea
6 College of Medicine, Chung-Ang University, Psychiatry, Seoul,
Republic of Korea
7 Wonkwang University School of Medicine, Psychiatry, Iksan,
Republic of Korea
8 College of Medicine, Jeju National University, Psychiatry, Jeju,
Republic of Korea
∗ Corresponding author.
Objectives The aim of this study was to determining the cut-off
for recurrent depressive episode to predict diagnostic conversion
from unipolar depression to bipolar disorder by means of retro-
spective reviews of medical records.
Methods The medical records of 250 patients with a diagnosis
of major depressive disorder for at least 5 years were retrospec-
tively reviewed for this study. We reviewed DSM-IV diagnosis and
detailed clinical information at the index admission with assess-
ments made every year after discharge to determining the cut-off
for recurrent depressive episode to predict diagnostic conversion
from unipolar depression to bipolar disorder.
Results Receiver operating characteristic curve analysis indi-
cated cut-off scores for recurrent depressive episode of more than
three times (area under curve = 0.647, sensitivity = 0.435, speci-
ficity = 0.819, positive predictive value = 0.351, negative predictive
value = 0.865).
Conclusions These findings suggest that it could predict the best
diagnostic conversion from unipolar depression to bipolar disor-
der when depressive episodes are recurrent more than three times.
Based on these findings, it will be able to promote the accuracy of
diagnosis and the efficiency of treatment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW24
Cognitive training for bipolar
disorder. Functional wellness
L. Bernabei ∗, E. Pompili , S. Quinto , L. Basco , L. Di Gennaro ,
G. D’Antoni , C. Murtinu , M. Biondi , R. Delle Chiaie
1 Policlinico Umberto I, Sapienza University of Rome, Neurology and
Psychiatry, Roma, Italy
2 ASL Roma G, Mental Health Centre, Colleferro, Italy
∗ Corresponding author.
Patients with bipolar disorder (BD) show a typical neuropsychol-
ogical profile, characterized by an alteration of attentive, amnesic
and executive ability. The aim of the study is evaluate the effective-
ness of cognitive training in integrated treatment (CTiIT) for bipolar
disorder.
Methods A total of 30 BD euthymic patients were enrolled. All
participants completed a comprehensive neuropsychological and
psychosocial (SF-36 and PSQ) assessment. Patients were random
assigned to CTiIT group or control group. CTiIT is designed to be
a short therapy (20 individual sessions of about 1 hour for three
days at week) for the neurocognition, and for psychosocial aspects.
Cognitive training consisted of computerized tasks selected from
CogPACK. Attention, memory and executive tasks available within
the CogPACK program were selected for use in this study, based
on the cognitive domains typically affected in BD patients. Training
with this program is hierarchically organized. All individuals in the
present study had the potential to complete all of the tasks, regard-
less of degree of impairment. Statistical analyses were conducted
using Statistical Package for the Social Sciences Version 20.0 (SPSS
20.0) for windows (SPSS Inc., Chicago, Ill).
Results Results showed that CTiIT for BD is effective in improv-
ing verbal learning andmemory, executive functions and attention.
Moreover CTiIT increases social wellness measured by SF-36 and
reduces stress perception’s (PSQ).
Conclusions Cognitive training in integrated treatment – CTiIT
is an important tool for achievement of personal recovery and
becomes necessary to use it, in the daily treatment of BD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW25
First rank symptoms in mania: An
indistinct diagnostic strand
A. Channa ∗, S. Aleem , H. Mohsin
1 Liaquat National Hospital, Psychiatry, Karachi, Pakistan
2 Agha Khan University, Psychiatry, Karachi, Pakistan
∗ Corresponding author.
First rank symptoms (FRS) are considered to be pathognomic
for schizophrenia. However, FRS is not distinctive feature of
schizophrenia. It has also been noticed in affective disorder, albeit
not inclusive in diagnostic criteria. Its existence in the first episode
of bipolar disorder may be predictor of poor short-term outcome
and decompensating course of illness.
Objective To determine the frequency of first rank symptoms in
manic patients.
Method The cross sectional study was done at psychiatric ser-
vices of Aga Khan University Hospital, Karachi, Pakistan. One
hundred and twentymanic patientswere recruited fromNovember
2014 to May 2015.FRS was assessed by administration of validated
Urdu version of Present State Examination (PSE) tool.
Result The mean age of the patients was 37.62 + 12.51. The mean
number of previous manic episode was 2.17 + 2.23. In total, 11.2%
males and 30.6% females had FRS. This association of first rank