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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S125

symptoms with gender in patients of mania was found to be sig-

nificant with a

P

value of 0.008. All-inclusive, 19.2% exhibited FRS

in their course of illness, 43.5% had thought broadcasting, made

feeling, impulses, action and somatic passivity, 39.1% had thought

insertion, 30.4% had auditory perceptual distortion, and 17.4% had

thought withdrawal. However, none displayed delusional percep-

tion.

Conclusion

The study confirms the presence of FRS in mania in

both male and female, irrespective of the duration of current manic

illness or previous number of manic episodes. A substantial differ-

ence was established between both the genders.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.143

EW26

Emotional reactivity, functioning and

chronic inflammation in remitted

bipolar patients: Clinical relevance of

a dimensional approach

A. Ayub Dargél

1 , 2 ,

, V. Hirakata

3

, C. Henry

4

1

Institut Pasteur and Molecular Psychiatry Laboratory, Perception

and Memory Laboratory, Paris, France

2

Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

3

Hospital de Clínicas de Porto Alegre, GPPG-Statistics, Porto Alegre,

Brazil

4

Institut Pasteur, Université Paris XII, Inserm U955, Paris, France

Corresponding author.

Aims

To examine emotional reactivity (ER) as a dimension that

may contribute to the better characterization of subsyndromal

mood symptoms in bipolar disorder (BD) patients during remission,

and to explore the association between ER, psychosocial function-

ing and levels of C-reactive protein (CRP, a biomarker of low-grade

inflammation) including as to whether CRP is a biosignature of ER

in BD.

Method

Six hundred and thirteen adult BD outpatients. Assess-

ments: psychosocial functioning by Functional Assessment Short

Test (FAST),mood by Multidimensional Assessment of Thymic

States(MAThyS). The MAThyS ER sub-score (0–40) characterized

3 patients:

– <16: emotional hyporeactivity (HypoER);

– 16–24: normal emotional reactivity (NormalER);

– > 24: emotional hyperreactivity (HyperER).

CRP was measured by using standard enzyme immunoassay. Sta-

tistical analyses were performed using SPSS v21.

Results

HypoER (

n

= 144;

m

= 12.4

±

3.4), NormalER (

n

= 198;

m

= 19.9

±

2.6); HyperER (

n

= 271;

m

= 28.9

±

3.7). BD patients with

HypoER or HyperER had significantly greater levels of residual

mood symptoms than patients with NormalER (

P

< .0001). Patients

with HypoER (FAST

m

= 21

±

14.1) or HyperER (FAST

m

= 20

±

11.2

presented lower functioning (

P

< .0001). CRP levels were sig-

nificantly increased in BD patients with HypoER (

m

= 2.8

±

2.0;

P

< .0001) and mostly with HyperER (

m

= 4.3

±

2.8;

P

< .0001) com-

pared with NormalER patients (

m

= 1.4

±

1.4).

Conclusions

ER appear to impact psychosocial functioning aswell

as to be a pertinent dimension to discriminate subsyndromal mood

states in remitted BD patients. CRP could be a biological validator

of emotional reactivity in BD. Association between ER-CRP may be

useful proxy to examine the relationship between specific symp-

tom profiles and chronic inflammation, a potential biological state

associated with BD. These novel findings could be clinically rele-

vant, if tested and confirmed by future studies.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.144

EW27

Impact of sleep disturbance in

functioning and quality of life in

euthymic patients with bipolar

disorder

L. de la Fuente-Tomás

1 ,

, M. García-Portilla

1

, G. Safont

2

,

B. Arranz

3

, M. Sánchez

4

, P. Sierra

5

1

Universidad de Oviedo, Área de Psiquiatría, CIBERSAM, Oviedo,

Spain

2

Hospital Universitario Mutua de Terrasa, Psiquiatría, Barcelona,

Spain

3

Fundación San Juan de Dios, Universidad de Barcelona,

Psiquiatría-Cibersam, Barcelona, Spain

4

Hospital Mutua de Terrassa, Psiquiatría, Barcelona, Spain

5

Hospital La Fe, Psiquiatría, Valencia, Spain

Corresponding author.

Introduction

Sleep impairment has been described as a core

mechanism of bipolar disorder (BD) frequently associated low

global function and quality of life (QoL)

[1] .

Aim

To investigate the impact of sleep disturbance in daily func-

tioning and QoL in a sample of euthymic BD patients with presence

and absence of sleep complaints, assessed with a valid sleep quality

questionnaire

[2] .

Methods

Naturalistic, multicenter, cross-sectional study. Sam-

ple: 119 euthymic outpatients with BD [34.5%males; mean age

(SD) = 46.28 (12.22)]: (1) without sleep complaints (60.5%); (2) with

sleep complaints (31.9%) and insomnia diagnosis (7.6%). Instru-

ments: Cuestionario de Oviedo de Calidad de Sue˜no (COS), FAST,

SF-36, HDRS, CGI and SCIP.

Results

No significant differences were found between groups in

age, sex, global severity illness, and cognitive impairment (

P

> 0.05).

Likewise, there was not statistical difference neither in daily func-

tion (

P

> 0.05) nor in QoL (

P

> 0.05), with the exception of emotional

role (

t

= 2.26;

P

< 0.05), sleep complaints group showing higher

interference.

Conclusions

Despite 39.5% euthymic patients with BD experi-

enced sleep complaints, this study showed that sleep disturbance

not affected patients’ daily functioning and QoL. Both groups report

similar outcomes.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

References

[1] Giglio MF, Andreazza C, Andersen M, Ceresér M, Walz C, Sterz L,

et al. Sleep in bipolar patients. Sleep Breath 2009;13:169–73.

[2] García-Portilla MP, Sáiz PA, Díaz-Mesa EM, Fonseca E, Arrojo

M, Sierra P, et al. Rendimiento psicométrico del Cuestionario

Oviedo de Sue˜no en pacientes con trastorno mental grave.

Psiquiatr Salud Ment (Barc) 2009;2(4):169–77.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.145

EW28

Haloperidol, risperidone and

quetiapine in the treatment of acute

severe manic episode in bipolar

disorder: The experience at the mood

disorder unit in Milan

D. Delmonte

1 ,

, C. De Santis

2

, S. Brioschi

2

, B. Barbini

1

,

C. Colombo

2

1

San Raffaele-Turro Hospital, Clinical Neurosciences, Milan, Italy

2

University Vita-Salute San Raffaele, Clinical Neurosciences, Milan,

Italy

Corresponding author.

Introduction

Patients affected by severe manic episode, often

with delusional symptoms, are commonly treated with a