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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S125
symptoms with gender in patients of mania was found to be sig-
nificant with a P value of 0.008. All-inclusive, 19.2% exhibited FRS
in their course of illness, 43.5% had thought broadcasting, made
feeling, impulses, action and somatic passivity, 39.1% had thought
insertion, 30.4% had auditory perceptual distortion, and 17.4% had
thought withdrawal. However, none displayed delusional percep-
tion.
Conclusion The study confirms the presence of FRS in mania in
both male and female, irrespective of the duration of current manic
illness or previous number of manic episodes. A substantial differ-
ence was established between both the genders.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW26
Emotional reactivity, functioning and
chronic inflammation in remitted
bipolar patients: Clinical relevance of
a dimensional approach
A. Ayub Dargél ∗, V. Hirakata , C. Henry
1 Institut Pasteur and Molecular Psychiatry Laboratory, Perception
and Memory Laboratory, Paris, France
2 Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
3 Hospital de Clínicas de Porto Alegre, GPPG-Statistics, Porto Alegre,
Brazil
4 Institut Pasteur, Université Paris XII, Inserm U955, Paris, France
∗ Corresponding author.
Aims To examine emotional reactivity (ER) as a dimension that
may contribute to the better characterization of subsyndromal
mood symptoms in bipolar disorder (BD) patients during remission,
and to explore the association between ER, psychosocial function-
ing and levels of C-reactive protein (CRP, a biomarker of low-grade
inflammation) including as to whether CRP is a biosignature of ER
in BD.
Method Six hundred and thirteen adult BD outpatients. Assess-
ments: psychosocial functioning by Functional Assessment Short
Test (FAST),mood by Multidimensional Assessment of Thymic
States(MAThyS). The MAThyS ER sub-score (0–40) characterized
3 patients:
– <16: emotional hyporeactivity (HypoER);
– 16–24: normal emotional reactivity (NormalER);
– > 24: emotional hyperreactivity (HyperER).
CRP was measured by using standard enzyme immunoassay. Sta-
tistical analyses were performed using SPSS v21.
Results HypoER (n = 144; m= 12.4 ±3.4), NormalER (n = 198;
m = 19.9± 2.6); HyperER (n = 271; m = 28.9 ±3.7). BD patients with
HypoER or HyperER had significantly greater levels of residual
mood symptoms than patients with NormalER (P < .0001). Patients
with HypoER (FAST m = 21 ±14.1) or HyperER (FAST m= 20 ±11.2
presented lower functioning (P < .0001). CRP levels were sig-
nificantly increased in BD patients with HypoER (m= 2.8 ±2.0;
P < .0001) and mostly with HyperER (m = 4.3 ±2.8; P < .0001) com-
pared with NormalER patients (m= 1.4 ± 1.4).
Conclusions ER appear to impact psychosocial functioning aswell
as to be a pertinent dimension to discriminate subsyndromal mood
states in remitted BD patients. CRP could be a biological validator
of emotional reactivity in BD. Association between ER-CRP may be
useful proxy to examine the relationship between specific symp-
tom profiles and chronic inflammation, a potential biological state
associated with BD. These novel findings could be clinically rele-
vant, if tested and confirmed by future studies.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW27
Impact of sleep disturbance in
functioning and quality of life in
euthymic patients with bipolar
disorder
L. de la Fuente-Tomás ∗, M. García-Portilla , G. Safont ,
B. Arranz , M. Sánchez , P. Sierra
1 Universidad de Oviedo, Área de Psiquiatría, CIBERSAM, Oviedo,
Spain
2 Hospital Universitario Mutua de Terrasa, Psiquiatría, Barcelona,
Spain
3 Fundación San Juan de Dios, Universidad de Barcelona,
Psiquiatría-Cibersam, Barcelona, Spain
4 Hospital Mutua de Terrassa, Psiquiatría, Barcelona, Spain
5 Hospital La Fe, Psiquiatría, Valencia, Spain
∗ Corresponding author.
Introduction Sleep impairment has been described as a core
mechanism of bipolar disorder (BD) frequently associated low
global function and quality of life (QoL)
Aim To investigate the impact of sleep disturbance in daily func-
tioning and QoL in a sample of euthymic BD patients with presence
and absence of sleep complaints, assessed with a valid sleep quality
questionnaire
Methods Naturalistic, multicenter, cross-sectional study. Sam-
ple: 119 euthymic outpatients with BD [34.5%males; mean age
(SD) = 46.28 (12.22)]: (1) without sleep complaints (60.5%); (2) with
sleep complaints (31.9%) and insomnia diagnosis (7.6%). Instru-
ments: Cuestionario de Oviedo de Calidad de Sue˜no (COS), FAST,
SF-36, HDRS, CGI and SCIP.
Results No significant differences were found between groups in
age, sex, global severity illness, and cognitive impairment (P > 0.05).
Likewise, there was not statistical difference neither in daily func-
tion (P > 0.05) nor in QoL (P > 0.05), with the exception of emotional
role (t = 2.26; P < 0.05), sleep complaints group showing higher
interference.
Conclusions Despite 39.5% euthymic patients with BD experi-
enced sleep complaints, this study showed that sleep disturbance
not affected patients’ daily functioning and QoL. Both groups report
similar outcomes.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
References
[1] Giglio MF, Andreazza C, Andersen M, Ceresér M, Walz C, Sterz L,
et al. Sleep in bipolar patients. Sleep Breath 2009;13:169–73.
[2] García-Portilla MP, Sáiz PA, Díaz-Mesa EM, Fonseca E, Arrojo
M, Sierra P, et al. Rendimiento psicométrico del Cuestionario
Oviedo de Sue˜no en pacientes con trastorno mental grave.
Psiquiatr Salud Ment (Barc) 2009;2(4):169–77.
EW28
Haloperidol, risperidone and
quetiapine in the treatment of acute
severe manic episode in bipolar
disorder: The experience at the mood
disorder unit in Milan
D. Delmonte ∗, C. De Santis , S. Brioschi , B. Barbini ,
C. Colombo
1 San Raffaele-Turro Hospital, Clinical Neurosciences, Milan, Italy
2 University Vita-Salute San Raffaele, Clinical Neurosciences, Milan,
Italy
∗ Corresponding author.
Introduction Patients affected by severe manic episode, often
with delusional symptoms, are commonly treated with a