European Psychiatry - Volume 33 - March 2016

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S122 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
Results High novelty seeking was associated with increased
consumption, binging and heavy drinking among both sexes at
both time points ( P < 0.01). Lower persistence was associated with
increased consumption at both time points among men and among
women at age 46. Baseline novelty seeking predicted both increas-
ing (OR 1.1; 95% CI: 1.0–1.1) and reducing (1.1; 1.0–1.1) for men
and for women also increasing (1.1; 1.0–1.1) and reducing (1.1;
1.0–1.1), but when adjustedwith baseline alcohol use novelty seek-
ing only predicted increasing for men (1.0; 1.0–1.1).
Conclusions High novelty seeking and low persistence are asso-
ciated with problematic alcohol use among middle-aged Northern
Finns. Gender differences in predictors existed: novelty seeking
predicted increase only for men in the adjusted model. Temper-
ament scores do not seem to affect strongly changes in alcohol
use.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Anxiety disorders and somatoform disorders
EW17
Depressive symptoms and bone
mineral density in menopause and
postmenopausal women: A still
increasing and neglected problem
A. Bener
Istanbul Unıversity, Biostatistics & Public Health, Istanbul, Turkey
Objective The objective of current study was to investigate
whether associaction exist between depression and low BMD dur-
ing menopausal and post-menopausal period.
Methods A cross-sectional descriptive study and 1650 women
aged 45–65 years were included during 1182 women agreed to
participate (71.6%). Data on body mass index (BMI), clinical bio-
chemistry variables including serum 25-hydroxyvitamin D were
collected. The Beck Depression Inventory (BDI) was administered
for depression purposes.
Results A total of 1182 women agreed to participate and
responded to the study. The mean age and SD of the menopausal
age were 48.71 ±2.96 with depressed and 50.20 ± 3.22 without
depressed (P < 0.001). Also, the mean and SD of postmenopausal
age were 58.55 ± 3.27 depressed and 57.78 ± 3.20 without
depressed (P < 0.001). There were statistically significance dif-
ferences between menopausal stages with regards to number
of parity, and place of living. There were statistically signifi-
cance differences between menopausal stages with regards to
BMI, systolic and diastolic blood pressure, vitamin D deficiency,
calcium deficiency and sheesha smoking habits. Overall, osteope-
nia and osteoporosis and bone loss were significantly lower in
post-menopausal women than in menopausal women (P < 0.001).
Similarly, T-score and z-score were lower with depressed
menopause and postmenopausal women (P < 0.001).
Conclusion Themultivariate logistic regression analyses revealed
that the depression, the mean serum vitamin D deficiency, cal-
cium level deficiency, less physical activity, co-morbidity, number
of parity, systolic and diastolic blood pressure and sheesha smok-
ing habits were considered as the main risk factors associated with
bone mineral loss after adjusting for age, BMI and other variables.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EW18
Depression, anxiety and stress
[DASS21] symptoms in menopausal
Arab women: Shedding more light on
a complex relationship
A. Bener
Istanbul Unıversity, Biostatistics & Public Health, Istanbul, Turkey
Objective To determine correlation between depression, anxiety
and stress in menopausal and post-menopausal women and shed-
ding more light on a complex relationship.
Methods A cross-sectional descriptive study was used and 1468
women aged 45–65 years were included and 1101 women agreed
to participate (75.0%). Depression, anxiety and stress were mea-
sured using the Depression Anxiety Stress Scales (DASS-21). Data
on body mass index (BMI), clinical and other parameters was used.
Results A total of 1101 women agreed to participate after
informed consent was obtained. The mean age and SD of
the menopausal age was 49.55 ±3.12, the mean and SD of
postmenopausal age was 58.08 ± 3.26 (P < 0.001). There were sta-
tistically significant differences between menopausal stages with
regards to age, ethnicity, educational status, occupation sta-
tus, and place of living. Also, there were statistically significant
differences between menopausal stages with regards to BMI,
systolic and diastolic blood pressure, vitamin D deficiency, and
diseases. Depression and anxiety were more common among post-
menopause women. Also, there were no differences between the
groups regarding the frequency of certain levels of stress among
menopause and post-menopause. Multivariate regression analy-
ses revealed that age in years, diastolic BP, consanguinity, regular
exercise were predictor for depression. Meanwhile, diastolic BP,
occupation and physical activity considered the main risk factors
for anxiety. Furthermore, age in years, occupation and sheesha
smoking habits were considered as the main risk factors associated
with stress.
Conclusion A large number of factors were associated with
experiencing menopausal and psychosocial problems which had
negative effects on the quality of life among Arabian women.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EW19
Neurocognitive deficit in first-episode,
drug-naive obsessive-compulsive
disorder
S.N. Kim ∗, T.Y. Lee , Y.B. Yoon , J.S. Kwon
1 Seoul National University Hospital, Psychiatry, Seoul, Republic of
Korea
2 Seoul National University, Neuropsychiatry, Seoul, Republic of Korea
∗ Corresponding author.
Objective Obsessive compulsive disorder (OCD) is one of the
most common psychiatric chronic disorders (prevalence 2–3%)
and has been associated with various neurocognitive impairment,
including visual memory function. Although the relapse rate of
OCD is highly considerable, little is known regarding the relation-
ship between neurocognitive dysfunction and the chronicity of
the illness, mainly because there are confounding factors as the
medication effect. Therefore, we compared the difference of neu-
rocognitive functions of the first-episode, medication-naive OCD
patents to chronic, medication-naïve OCD patients.
Method We defined the first-episode (FEOCD) if the illness dura-
tion was less than 3-year by DSM-IV criteria. Twenty-one FEOCD
and 28 chronic OCD patients performed Korean version of the
Wechsler Adult Intelligence Scale (K-WAIS), the Trail Making Test
(TMT). All the participants were medication-naïve.