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S122

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

Results

High novelty seeking was associated with increased

consumption, binging and heavy drinking among both sexes at

both time points (

P

< 0.01). Lower persistence was associated with

increased consumption at both time points among men and among

women at age 46. Baseline novelty seeking predicted both increas-

ing (OR 1.1; 95% CI: 1.0–1.1) and reducing (1.1; 1.0–1.1) for men

and for women also increasing (1.1; 1.0–1.1) and reducing (1.1;

1.0–1.1), but when adjustedwith baseline alcohol use novelty seek-

ing only predicted increasing for men (1.0; 1.0–1.1).

Conclusions

High novelty seeking and low persistence are asso-

ciated with problematic alcohol use among middle-aged Northern

Finns. Gender differences in predictors existed: novelty seeking

predicted increase only for men in the adjusted model. Temper-

ament scores do not seem to affect strongly changes in alcohol

use.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.134

Anxiety disorders and somatoform disorders

EW17

Depressive symptoms and bone

mineral density in menopause and

postmenopausal women: A still

increasing and neglected problem

A. Bener

Istanbul Unıversity, Biostatistics & Public Health, Istanbul, Turkey

Objective

The objective of current study was to investigate

whether associaction exist between depression and low BMD dur-

ing menopausal and post-menopausal period.

Methods

A cross-sectional descriptive study and 1650 women

aged 45–65 years were included during 1182 women agreed to

participate (71.6%). Data on body mass index (BMI), clinical bio-

chemistry variables including serum 25-hydroxyvitamin D were

collected. The Beck Depression Inventory (BDI) was administered

for depression purposes.

Results

A total of 1182 women agreed to participate and

responded to the study. The mean age and SD of the menopausal

age were 48.71

±

2.96 with depressed and 50.20

±

3.22 without

depressed (

P

< 0.001). Also, the mean and SD of postmenopausal

age were 58.55

±

3.27 depressed and 57.78

±

3.20 without

depressed (

P

< 0.001). There were statistically significance dif-

ferences between menopausal stages with regards to number

of parity, and place of living. There were statistically signifi-

cance differences between menopausal stages with regards to

BMI, systolic and diastolic blood pressure, vitamin D deficiency,

calcium deficiency and sheesha smoking habits. Overall, osteope-

nia and osteoporosis and bone loss were significantly lower in

post-menopausal women than in menopausal women (

P

< 0.001).

Similarly, T-score and z-score were lower with depressed

menopause and postmenopausal women (

P

< 0.001).

Conclusion

Themultivariate logistic regression analyses revealed

that the depression, the mean serum vitamin D deficiency, cal-

cium level deficiency, less physical activity, co-morbidity, number

of parity, systolic and diastolic blood pressure and sheesha smok-

ing habits were considered as the main risk factors associated with

bone mineral loss after adjusting for age, BMI and other variables.

Disclosure of interest

The author has not supplied his/her decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.135

EW18

Depression, anxiety and stress

[DASS21] symptoms in menopausal

Arab women: Shedding more light on

a complex relationship

A. Bener

Istanbul Unıversity, Biostatistics & Public Health, Istanbul, Turkey

Objective

To determine correlation between depression, anxiety

and stress in menopausal and post-menopausal women and shed-

ding more light on a complex relationship.

Methods

A cross-sectional descriptive study was used and 1468

women aged 45–65 years were included and 1101 women agreed

to participate (75.0%). Depression, anxiety and stress were mea-

sured using the Depression Anxiety Stress Scales (DASS-21). Data

on body mass index (BMI), clinical and other parameters was used.

Results

A total of 1101 women agreed to participate after

informed consent was obtained. The mean age and SD of

the menopausal age was 49.55

±

3.12, the mean and SD of

postmenopausal age was 58.08

±

3.26 (

P

< 0.001). There were sta-

tistically significant differences between menopausal stages with

regards to age, ethnicity, educational status, occupation sta-

tus, and place of living. Also, there were statistically significant

differences between menopausal stages with regards to BMI,

systolic and diastolic blood pressure, vitamin D deficiency, and

diseases. Depression and anxiety were more common among post-

menopause women. Also, there were no differences between the

groups regarding the frequency of certain levels of stress among

menopause and post-menopause. Multivariate regression analy-

ses revealed that age in years, diastolic BP, consanguinity, regular

exercise were predictor for depression. Meanwhile, diastolic BP,

occupation and physical activity considered the main risk factors

for anxiety. Furthermore, age in years, occupation and sheesha

smoking habits were considered as the main risk factors associated

with stress.

Conclusion

A large number of factors were associated with

experiencing menopausal and psychosocial problems which had

negative effects on the quality of life among Arabian women.

Disclosure of interest

The author has not supplied his/her decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.136

EW19

Neurocognitive deficit in first-episode,

drug-naive obsessive-compulsive

disorder

S.N. Kim

1 ,

, T.Y. Lee

2

, Y.B. Yoon

1

, J.S. Kwon

1

1

Seoul National University Hospital, Psychiatry, Seoul, Republic of

Korea

2

Seoul National University, Neuropsychiatry, Seoul, Republic of Korea

Corresponding author.

Objective

Obsessive compulsive disorder (OCD) is one of the

most common psychiatric chronic disorders (prevalence 2–3%)

and has been associated with various neurocognitive impairment,

including visual memory function. Although the relapse rate of

OCD is highly considerable, little is known regarding the relation-

ship between neurocognitive dysfunction and the chronicity of

the illness, mainly because there are confounding factors as the

medication effect. Therefore, we compared the difference of neu-

rocognitive functions of the first-episode, medication-naive OCD

patents to chronic, medication-naïve OCD patients.

Method

We defined the first-episode (FEOCD) if the illness dura-

tion was less than 3-year by DSM-IV criteria. Twenty-one FEOCD

and 28 chronic OCD patients performed Korean version of the

Wechsler Adult Intelligence Scale (K-WAIS), the Trail Making Test

(TMT). All the participants were medication-naïve.