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S118

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

the 6% WH-250 (

n

= 3). Origin of the sample was Catalunya 23%

(

n

= 11), other provinces of Spain 46% (

n

= 22); other EU countries

23% (

n

= 11) and internet-unknown country 8% (

n

= 8). From the

(

n

= 47) samples, were delivered (

n

= 16) in 2012, (

n

= 12) in 2013,

(

n

= 11) in 2011, (

n

= 3) in 2010 and (

n

= 3) in 2014.

Conclusion

JWH’S represent a low percentage of new psy-

choactive substances analyzed. Its presence in the market seems

decreasing.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

Acknowledgements

Supported by grants of ISCIII-FEDER-

(RTA RD12/0028/0009), FIS-PI14/00715 and the European

Commission-Drug Prevention and Information Programme

2014-16, JUST/2013/DPIP/AG/4823-EU-MADNESS project). L.

Galindo is a Rio-Hortega-fellowship-(ISC-III; CM14/00111).

http://dx.doi.org/10.1016/j.eurpsy.2016.01.123

EW06

Is lithium implicated in tobacco

addiction?

I. Houas

1 ,

, D. Haj Mouhamed

2

, G. Gallelo

3

, W. Douki

2

, L. Gaha

1

,

M.L. Cervera

3

, M. De la Guardia

3

1

Faculty of Medicine, University of Monastir, Research Laboratory

“Vulnerability to psychosis, RS 05ES10”, Monastir, Tunisia

2

University Hospital Fattouma Bourguiba of Monastir, Biochemistry

and Toxicology, Monastir, Tunisia

3

University of Valencia, Campus of Burjassot, Analytical Chemistry

Department, Valencia, Spain

Corresponding author.

Introduction

Tobacco is a source of mineral elements that can

affect human health in various ways, such as lithium, which

is used as a psychiatric medication. Lithium salts are used as

mood-stabilizing drugs and indicated in the treatment of manic-

depressive psychosis.

Objective

Studying the lithiumcontent in tobacco over the smok-

ers’plasma content and evaluate the potential role of lithium in

tobacco addiction.

Methods

A total of 18 different tobacco products (cigarettes,

smokeless and water pipe tobacco) and 125 plasma samples (45

from smokers, 10 from ex-smokers and 70 from non-smokers)

were collected to determinate the lithium content. Tobacco sam-

ples were digested with nitric acid and lithium concentration was

measured by inductively coupled plasma-optical emission. The col-

lected plasma samples were diluted 1/10 with a nitric acid solution

and the lithium level wasmeasured by inductively coupled plasma-

mass spectrometry.

Results

The average concentration of lithium in the cigarettes

(16.59

±

0.59 g/g) was higher compared to those in the smoke-

less tobacco (8.39

±

4.44 g/g) and in the water pipe tobacco

(6.13

±

6.32 g/g) but with no significant difference (

P

= 0.182).

For plasma lithium levels, there was no significant difference

(

P

= 0.186) between smokers and non-smokers (6.20

±

6.24 vs.

4.98

±

6.20 g/g). However, a significant negative correlation was

noted between plasma and the lithium content in tobacco prod-

ucts (

r

= –0.435;

P

= 0.04). The lithiumplasma level was significantly

and negatively correlated with the dependence score (

r

= –0.316;

P

= 0.031).

Conclusion

The correlation between plasmatic lithium and

dependence score in smokers suggests that lithium would be

involved in tobacco addiction probably through his regulating

action of mood.

Disclosure of interest

The authors have not supplied their

declaration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.124

EW07

Sleep quality and sexual function in

patients under methadone

maintenance treatment

A. Kheradmand

1 ,

, N. Nakhaee

2

, A.R. Sabahy

2

, Z. Amini Rnjbar

3

,

Z. Zeynali

3

1

Shahid Beheshti University of Medical Sciences, Taleghani Hospital

Research Development Committee, Tehran, Iran

2

Kerman University of Medical University, Kerman neuroscience

research center, Kerman, Iran

3

Kerman University of Medical University, Institute of Futur Studies

in Health, Kerman, Iran

Corresponding author.

Background

Methadone maintenance has remained the main

modality of treatment for opioid dependent subjects. Side effects

of methadone treatment may be potential obstacles to its contin-

uation. Sleep quality and sexual function are two culture-based

concerns, directly related to patients’ compliance with methadone

maintenance treatment (MMT) program. This research was con-

ducted to examine the frequency of sleep disparity and sexual

dysfunction in patients under MMT referring to MMT clinics of

Kerman, Iran.

Methods

In this cross-sectional study, 198 adult subjects under

MMT for more than 6months were enrolled. Measurement tool

consisted of Pittsburgh Sleep Quality Index (PSQI), Arizona Sexual

Experience Scale (ASEX), the 12-itemGeneral Health Questionnaire

(GHQ-12), and a demographic questionnaire. The questionnaires

were self-completed, except where individuals were illiterate.

Results

Mean

±

SD age of the subjects was 41.2

±

7.9 years and

93.4% of them were male. More than half of them used heroin.

Prevalence of poor sleeping and sexual dysfunction in patients

under MMT were 67.7% and 18.2%, respectively. There was no

association between sleep quality and sexual dysfunction and

demographics or methadone dose. However, a significant corre-

lation was observed between mental health and sleep quality

(

r

= 0.16,

P

= 0.033), and sexual function (

r

= 0.18,

P

= 0.011).

Conclusions

Sleep quality showed a poorer profile than sexual

function. Therefore, more emphasis should be laid on treatment of

sleep disparity during followup ofMMT patients comparing to their

sexual function. Patients should be reassured that probable sexual

dysfunctions should not be regarded as a consequence of MMT.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.125

EW08

Optimization of therapy

clinic-immunological disorders with

heroin addiction

N. Khodjaeva

, S. Sultanov

Tashkent medical academy, Psychiatry and Narcology, Tashkent,

Uzbekistan

Corresponding author.

The immune defect can be found in all forms of addiction (Frank,

2004). These data determine the use of funds in immunotropic

heroin addiction.

Objective

To study the effectiveness of antidepressant sevpram

(citalopram) and its combination with galavit (imunomodulyator)

on a background of standard pharmacotherapy in heroin addiction.

To evaluate the immune status of the following methods:

– evaluation of lymphocytes (CD4), (CD8) with monoclonal anti-

bodies in cytotoxicity assay;

– determination of serum immunoglobulin classes A, M, G per-

formed by turbidimetric analysis;