European Psychiatry - Volume 33 - March 2016

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S118 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
the 6% WH-250 (n = 3). Origin of the sample was Catalunya 23%
(n = 11), other provinces of Spain 46% (n = 22); other EU countries
23% (n = 11) and internet-unknown country 8% (n = 8). From the
(n = 47) samples, were delivered ( n = 16) in 2012, (n = 12) in 2013,
(n = 11) in 2011, (n = 3) in 2010 and (n = 3) in 2014.
Conclusion JWH’S represent a low percentage of new psy-
choactive substances analyzed. Its presence in the market seems
decreasing.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Acknowledgements Supported by grants of ISCIII-FEDER-
(RTA RD12/0028/0009), FIS-PI14/00715 and the European
Commission-Drug Prevention and Information Programme
2014-16, JUST/2013/DPIP/AG/4823-EU-MADNESS project). L.
Galindo is a Rio-Hortega-fellowship-(ISC-III; CM14/00111).
EW06
Is lithium implicated in tobacco
addiction?
I. Houas ∗, D. Haj Mouhamed , G. Gallelo , W. Douki , L. Gaha ,
M.L. Cervera , M. De la Guardia
1 Faculty of Medicine, University of Monastir, Research Laboratory
“Vulnerability to psychosis, RS 05ES10”, Monastir, Tunisia
2 University Hospital Fattouma Bourguiba of Monastir, Biochemistry
and Toxicology, Monastir, Tunisia
3 University of Valencia, Campus of Burjassot, Analytical Chemistry
Department, Valencia, Spain
∗ Corresponding author.
Introduction Tobacco is a source of mineral elements that can
affect human health in various ways, such as lithium, which
is used as a psychiatric medication. Lithium salts are used as
mood-stabilizing drugs and indicated in the treatment of manic-
depressive psychosis.
Objective Studying the lithiumcontent in tobacco over the smok-
ers’plasma content and evaluate the potential role of lithium in
tobacco addiction.
Methods A total of 18 different tobacco products (cigarettes,
smokeless and water pipe tobacco) and 125 plasma samples (45
from smokers, 10 from ex-smokers and 70 from non-smokers)
were collected to determinate the lithium content. Tobacco sam-
ples were digested with nitric acid and lithium concentration was
measured by inductively coupled plasma-optical emission. The col-
lected plasma samples were diluted 1/10 with a nitric acid solution
and the lithium level wasmeasured by inductively coupled plasma-
mass spectrometry.
Results The average concentration of lithium in the cigarettes
(16.59 ± 0.59 g/g) was higher compared to those in the smoke-
less tobacco (8.39 ± 4.44 g/g) and in the water pipe tobacco
(6.13 ± 6.32 g/g) but with no significant difference (P = 0.182).
For plasma lithium levels, there was no significant difference
(P= 0.186) between smokers and non-smokers (6.20 ± 6.24 vs.
4.98 ± 6.20 g/g). However, a significant negative correlation was
noted between plasma and the lithium content in tobacco prod-
ucts (r= –0.435; P = 0.04). The lithiumplasma level was significantly
and negatively correlated with the dependence score (r= –0.316;
P = 0.031).
Conclusion The correlation between plasmatic lithium and
dependence score in smokers suggests that lithium would be
involved in tobacco addiction probably through his regulating
action of mood.
Disclosure of interest The authors have not supplied their
declaration of competing interest.
EW07
Sleep quality and sexual function in
patients under methadone
maintenance treatment
A. Kheradmand ∗, N. Nakhaee , A.R. Sabahy , Z. Amini Rnjbar ,
Z. Zeynali
1 Shahid Beheshti University of Medical Sciences, Taleghani Hospital
Research Development Committee, Tehran, Iran
2 Kerman University of Medical University, Kerman neuroscience
research center, Kerman, Iran
3 Kerman University of Medical University, Institute of Futur Studies
in Health, Kerman, Iran
∗ Corresponding author.
Background Methadone maintenance has remained the main
modality of treatment for opioid dependent subjects. Side effects
of methadone treatment may be potential obstacles to its contin-
uation. Sleep quality and sexual function are two culture-based
concerns, directly related to patients’ compliance with methadone
maintenance treatment (MMT) program. This research was con-
ducted to examine the frequency of sleep disparity and sexual
dysfunction in patients under MMT referring to MMT clinics of
Kerman, Iran.
Methods In this cross-sectional study, 198 adult subjects under
MMT for more than 6months were enrolled. Measurement tool
consisted of Pittsburgh Sleep Quality Index (PSQI), Arizona Sexual
Experience Scale (ASEX), the 12-itemGeneral Health Questionnaire
(GHQ-12), and a demographic questionnaire. The questionnaires
were self-completed, except where individuals were illiterate.
Results Mean ± SD age of the subjects was 41.2± 7.9 years and
93.4% of them were male. More than half of them used heroin.
Prevalence of poor sleeping and sexual dysfunction in patients
under MMT were 67.7% and 18.2%, respectively. There was no
association between sleep quality and sexual dysfunction and
demographics or methadone dose. However, a significant corre-
lation was observed between mental health and sleep quality
(r = 0.16, P = 0.033), and sexual function ( r= 0.18, P = 0.011).
Conclusions Sleep quality showed a poorer profile than sexual
function. Therefore, more emphasis should be laid on treatment of
sleep disparity during followup ofMMT patients comparing to their
sexual function. Patients should be reassured that probable sexual
dysfunctions should not be regarded as a consequence of MMT.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW08
Optimization of therapy
clinic-immunological disorders with
heroin addiction
N. Khodjaeva∗, S. Sultanov
Tashkent medical academy, Psychiatry and Narcology, Tashkent,
Uzbekistan
∗ Corresponding author.
The immune defect can be found in all forms of addiction (Frank,
2004). These data determine the use of funds in immunotropic
heroin addiction.
Objective To study the effectiveness of antidepressant sevpram
(citalopram) and its combination with galavit (imunomodulyator)
on a background of standard pharmacotherapy in heroin addiction.
To evaluate the immune status of the following methods:
– evaluation of lymphocytes (CD4), (CD8) with monoclonal anti-
bodies in cytotoxicity assay;
– determination of serum immunoglobulin classes A, M, G per-
formed by turbidimetric analysis;