European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S123
Results There was no differences in the severity of illness
(YBOCS), depressive symptoms (Hamilton depression rating scale),
general anxiety symptoms (Hamilton anxiety rating scale). FEOCD
group showed significant impairment on the block design subtest
of the K-WAIS (P = 0.04, t = 1.294).
Conclusions These results suggest that visual spatial cognitive
dysfunction in patients with OCD may deteriorate as the untreated
duration of illness get longer.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW20
Behavioral inhibition/behavioral
activation systems are relevant with
the interpersonal problem?
H. Na
Seoul St. Mary’s hospital, psychiatry, Seoul, Republic of Korea
Introduction and objectives It is well known that interpersonal
dysfunction has influence on the onset, treatment response, and
prognosis of depression. Exploring factors influencing interper-
sonal problems is important and anxiety-related characteristics
could be considered as one of the significant points. Based on
this background, we aimed to investigate the influence of anxiety-
related characteristics such as state anxiety, trait anxiety and
anxiety sensitivity on interpersonal problems in patients with
depressive disorders.
Aim and methods A total of 152 outpatients diagnosed with
depressive disorders completed questionnaire measuring socio-
demographic, clinical symptom severity, such as depression and
anxiety, and interpersonal problems. Beck Depression Inventory
(BDI) was used to measure depression severity and State and Trait
Anxiety Inventory (STAI) andAnxiety Sensitivity Index (ASI-R)were
used to evaluate various anxiety related symptoms. Interpersonal
relationship problems were measured by the short form of the
Korean version of the Inventory of Interpersonal Problems Circum-
plex Scales (KIIP-SC).
Result General interpersonal problem was affected by trait
anxiety and anxiety sensitivity. General and any other specific
interpersonal problems were not significantly different according
to state anxiety. Patients with higher trait anxiety and anxiety
sensitivity score tend to more distant, socially inhibited and non-
assertive interpersonal pattern. More domineering and intrusive
interpersonal pattern was observed in patient with high anxiety
sensitivity.
Conclusion The present study provides preliminary evidence that
predisposing characteristics, such as trait anxiety and anxiety
sensitivity, might influence interpersonal dysfunction, especially
socially inhibiting behaviors.
Keywords Interpersonal relationship; Trait anxiety; Anxiety
sensitivity; Depression
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EW21
Dynamics of biochemical changes in
anxious-depressed patients under
treatment with antidepressants with
different mechanisms of action on
serotonin reuptake
M. Uzbekov ∗, N. Maximova
Moscow Research Institute of Psychiatry, Brain Pathology, Moscow,
Russia
∗ Corresponding author.
Objectives Pharmacodynamics of serotonergic antidepressants
differently influencing on serotonin reuptake receptors is poorly
investigated.
Aim To compare biochemical profiles at patients with anxious
depression under treatment with tianeptine–serotonin reuptake
enhancer and sertraline–selective serotonin reuptake inhibitor.
Methods Platelet monoamine oxidase (MAO) and serum amine
oxidase (AO) activities, level of middle mass endotoxic molecules
(MMEM) and serum albumin functional properties – effective
albumin concentration (EAC) and reserve of albumin binding (RAB)
were investigated at 43 patients with anxious depression (F 32.1
and F 33.1). Clinical severity of illness was assessed using Hamil-
ton Depression (21 items) and Hamilton Anxiety Scales. All patients
were divided in two groups: group I (21 person) received tianeptine
(37, 5mg/day), group II – sertraline (50mg/day).
Results It was established that patients with anxious depres-
sion were characterized by significant increase in MAO activity
(by 95%) and the level of MMEM (by 86%) and significant decrease
in AO activity (by 28%) and EAC and RAB parameters by 43 and
38%, respectively, in comparison with healthy volunteers. Under
tianeptine and sertraline treatment, there were revealed contrary
directed changes of all investigated parameters.
Conclusion Results of study show that both tianeptine and ser-
traline are equally effective in treatment of anxious depression.
Present biochemical investigation, however, suggest that under-
lying biochemical changes are more complete following tianeptine
treatment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Bipolar disorders
EW22
Thyroid profile and its relationship
with response to treatment with
lithium in bipolar mood disorder
patients
P. Avinash ∗, K. Pathak
1 Deva Institute of Health Care and Research, Psychiatry, Varanasi,
India
2 LGBRIMH-Tezpur, Psychiatry, Tezpur, India
∗ Corresponding author.
Introduction There is substantial evidence that even minor per-
turbation of thyroid function plays a significant role in clinical
course and treatment outcome in bipolar mood disorder.
Aims and objectives To understand the relationship between
thyroid profile and bipolar disorder subtypes and to study the rela-
tionship between pre-treatment thyroid profile and response to
treatment with lithium along with other predictors of response to
treatment with lithium in cases of bipolar mood disorder.
Methods This study was conducted in the indoor facilities of
LGBRIMH, Tezpur in the year of 2012, after clearance from scientific
and review committee and Ethics committee of the institute. Forty-
five consecutive indoor patients diagnosed with bipolar mood
disorder using DSM-IV TR criteria were selected. On day 1, blood
was collected for thyroid profile and BPRS 24 item scale version
4.0 was applied. They were all started on lithium monotherapy,
and only lorazepam was used on SOS basis. On day 30, the BPRS
was applied again to check the response to treatment. Appropriate
statistical analysis was done using SPSS version 16.
Results The response to treatment was good with the mean % fall
of the BPRS score being 40%, with the maximum fall in the subscale