European Psychiatry - Volume 33 - March 2016

132 / 812

S128 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
Methods Two hundred and twenty patients diagnosedwith bipo-
lar disorder (according DSM-5 criteria) that were in the euthymic
phase (defined as less than 7 points in YMRS and 10 points in HDRS)
and attended the community care centers of three provinces of
Andalusia (Spain). Patients who consumed in the last month qual-
ified for the level of motivation for change (measured by URICA
scale); before and after conducting a brief intervention of no more
than 30minutes in total, divided in three contacts during a month,
two face to face and one phone contact. We evaluated the results
in the smokers at baseline after 12months of the intervention.
Results After 12months of follow-up, a 7.1% was abstinent, a
35.7% tried to abandon the consume at least once during the follow-
up an average 8 days (2–30). A 14.3% discontinued the study.
Conclusions This is the first paper that evaluate the 3 A’s inter-
vention in bipolar disorderwith 12months of follow-up. The results
of abstinence after were similar to those obtained in patients with
schozophrenia using the same intervention (5%) (Dixon et al., 2009).
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW35
Subthreshold symptoms in bipolar
disorder: Impact on quality of life
R. Khemakhem ∗, W. Homri , D. Karoui , H. Belhadj , L. Mouelhi ,
N. Bram , I. Ben Romdhane , R. Labbene
Razi Hospital, Psychiatry C, Mannouba, Tunisia
∗ Corresponding author.
Introduction Several studies have analyzed the influence of bipo-
lar disorder (BD) related to many kinds of functioning. Even if it is
obvious that patients in relapse have poor quality of live (QoL),
what’s about it in interictal phases with subthreshold symptoms?
Aims To study the potential relationship between QoL and sub-
threshold symptoms in bipolar I patients in remission.
Objective To evaluate the above relationship, we hypothesized
that subsyndromic BD phases can be related to worse subjectively
QoL.
Methods This was a cross-sectional study. Forty-four BD patients
were enrolled. The subthreshold symptoms were evaluated by
Hamilton Depression Rating Scale (HDRS) and Young Mania Rating
Scale (YMRS). Patients with HDRS lower than 7 and YMSR lower
than 6 were the successful applicants. Then, we run the Tunisian
version of SF-36 to measure the QoL.
Results Twenty-seven men and seventeen women with an aver-
age age of 39.3 years were selected. Age of beginning of BD was
31.5 years and patients were in relapse since 1.56 years. The HDRS’s
average score was 2.73. Twenty patients (45.5%) have an HDRS
upper than 4. The YMRS’s average score was 2.25 and twenty-nine
BD’s patients have a score between 1 and 6. The overall average
score at SF-36 scale were 64.2 and 25% of BD patient with sub-
threshold symptoms had a poor QoL.
Conclusions Subsyndromic interictal phases affect the QoL of BD
patients and it’s necessary to introduce therapy adapted accord-
ing to troubles in order to improve patient’s quality of life and
functioning.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW36
First bipolar episode and
functionality: Relation with
depressive symptoms and
inflammation levels
M. Martinez-cengotitabengoa ∗, C. Bermudez-ampudia ,
M.P. Lopez , A. Garcia-alocen , I. Gonzalez-ortega , I. Zorrilla ,
A. Gonzalez-pinto
1 CIBERSAM, University Hospital of Alava, National Distance
Education University UNED, Psychiatry, Vitoria, Spain
2 CIBERSAM, University Hospital of Alava, Psychiatry, Vitoria, Spain
3 CIBERSAM, University Hospital of Alava, University of the Basque
Country EHU-UPV, Psychiatry, Vitoria, Spain
4 CIBERSAM- University Hospital of Alava, University of the Basque
Country EHU-UPV, Psychiatry-Neurosciences, Vitoria, Spain
∗ Corresponding author.
Introduction It is important to make an early and effective inter-
vention from the first bipolar episode. The presence of depressive
symptoms in the course of a manic episode could influence nega-
tively the evolution and the prognosis of the patient. Inflammation
and oxidative stress are also related with functionality.
Objectives To explore the relationship between depressive symp-
toms during a first episode of mania, inflammatory parameters and
patient functionality during the follow-up.
Method We included in the study 92 are patients with a first
manic episode and 92 matched healthy controls. We compared
13 inflammatory/oxidative stress parameters measured at base-
line (TFN , IL6, PGE2, MCP1, TBARS, NO2, SOD, CAT, GSHTOT, GSSG,
GSHfree, GPx, TAS) between both groups. Between patients, 46 pre-
sented pure mania (PM) (no depressive symptoms) and 46 mixed
mania (MM) (with depressive symptoms). We explored the influ-
ence of inflammatory factors in functionality, exploring differences
between PMandMM. Tomeasure patients’ general functioning one
year after illness onset, we used the Functional Assessment Short
Test (FAST).
Results We found significant differences in TFN , MCP1 and
TBARS (higher in patients) and in SOD, GSHtot, GSSG, GSHfree, GPx
and TAS levels (lower in patients). Only In MM group, there was a
significant influence of SOD and GSHfree in FAST scores suggesting
that a higher antioxidant levels at baseline the patient functionality
improves one year after.
Conclusions Some parameters of oxidative stress at baseline are
related with patient’s functionality one year after the first episode
of mania, but only when mania debuts with depressive symptons
simultaneously.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW37
Aspects of sexuality in bipolar women
L. Damian ∗, I. Miclutia
1 Psychiatric hospital Ergoterapie, Cluj Municipal Hospital,
Cluj-Napoca, Romania
2 University of Medicine & Pharmacy Cluj-Napoca, Neuroscience-
discipline of Psychiatry, Cluj-Napoca, Romania
∗ Corresponding author.
Introduction In spite of more studies dedicated to the topic of
sexual disorders among schizophrenic patients or to the sexual
effects of antipsychotics and antidepressants, few studies entan-
gle broadly the issue of sexual attitudes and behaviors of bipolar
patients, due partly to the heterogeneity of the disorder and the
variety of episodes, and treatments.
Objectives To establish if special sexual patterns are specific to
depressive or manic episodes and if the sexual disorders are related
to the severity of the mood episodes.