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S128

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

Methods

Two hundred and twenty patients diagnosedwith bipo-

lar disorder (according DSM-5 criteria) that were in the euthymic

phase (defined as less than 7 points in YMRS and 10 points in HDRS)

and attended the community care centers of three provinces of

Andalusia (Spain). Patients who consumed in the last month qual-

ified for the level of motivation for change (measured by URICA

scale); before and after conducting a brief intervention of no more

than 30minutes in total, divided in three contacts during a month,

two face to face and one phone contact. We evaluated the results

in the smokers at baseline after 12months of the intervention.

Results

After 12months of follow-up, a 7.1% was abstinent, a

35.7% tried to abandon the consume at least once during the follow-

up an average 8 days (2–30). A 14.3% discontinued the study.

Conclusions

This is the first paper that evaluate the 3 A’s inter-

vention in bipolar disorderwith 12months of follow-up. The results

of abstinence after were similar to those obtained in patients with

schozophrenia using the same intervention (5%) (Dixon et al., 2009).

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.152

EW35

Subthreshold symptoms in bipolar

disorder: Impact on quality of life

R. Khemakhem

, W. Homri , D. Karoui , H. Belhadj , L. Mouelhi ,

N. Bram , I. Ben Romdhane , R. Labbene

Razi Hospital, Psychiatry C, Mannouba, Tunisia

Corresponding author.

Introduction

Several studies have analyzed the influence of bipo-

lar disorder (BD) related to many kinds of functioning. Even if it is

obvious that patients in relapse have poor quality of live (QoL),

what’s about it in interictal phases with subthreshold symptoms?

Aims

To study the potential relationship between QoL and sub-

threshold symptoms in bipolar I patients in remission.

Objective

To evaluate the above relationship, we hypothesized

that subsyndromic BD phases can be related to worse subjectively

QoL.

Methods

This was a cross-sectional study. Forty-four BD patients

were enrolled. The subthreshold symptoms were evaluated by

Hamilton Depression Rating Scale (HDRS) and Young Mania Rating

Scale (YMRS). Patients with HDRS lower than 7 and YMSR lower

than 6 were the successful applicants. Then, we run the Tunisian

version of SF-36 to measure the QoL.

Results

Twenty-seven men and seventeen women with an aver-

age age of 39.3 years were selected. Age of beginning of BD was

31.5 years and patients were in relapse since 1.56 years. The HDRS’s

average score was 2.73. Twenty patients (45.5%) have an HDRS

upper than 4. The YMRS’s average score was 2.25 and twenty-nine

BD’s patients have a score between 1 and 6. The overall average

score at SF-36 scale were 64.2 and 25% of BD patient with sub-

threshold symptoms had a poor QoL.

Conclusions

Subsyndromic interictal phases affect the QoL of BD

patients and it’s necessary to introduce therapy adapted accord-

ing to troubles in order to improve patient’s quality of life and

functioning.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.153

EW36

First bipolar episode and

functionality: Relation with

depressive symptoms and

inflammation levels

M. Martinez-cengotitabengoa

1 ,

, C. Bermudez-ampudia

2

,

M.P. Lopez

2

, A. Garcia-alocen

2

, I. Gonzalez-ortega

3

, I. Zorrilla

2

,

A. Gonzalez-pinto

4

1

CIBERSAM, University Hospital of Alava, National Distance

Education University UNED, Psychiatry, Vitoria, Spain

2

CIBERSAM, University Hospital of Alava, Psychiatry, Vitoria, Spain

3

CIBERSAM, University Hospital of Alava, University of the Basque

Country EHU-UPV, Psychiatry, Vitoria, Spain

4

CIBERSAM- University Hospital of Alava, University of the Basque

Country EHU-UPV, Psychiatry-Neurosciences, Vitoria, Spain

Corresponding author.

Introduction

It is important to make an early and effective inter-

vention from the first bipolar episode. The presence of depressive

symptoms in the course of a manic episode could influence nega-

tively the evolution and the prognosis of the patient. Inflammation

and oxidative stress are also related with functionality.

Objectives

To explore the relationship between depressive symp-

toms during a first episode of mania, inflammatory parameters and

patient functionality during the follow-up.

Method

We included in the study 92 are patients with a first

manic episode and 92 matched healthy controls. We compared

13 inflammatory/oxidative stress parameters measured at base-

line (TFN , IL6, PGE2, MCP1, TBARS, NO2, SOD, CAT, GSHTOT, GSSG,

GSHfree, GPx, TAS) between both groups. Between patients, 46 pre-

sented pure mania (PM) (no depressive symptoms) and 46 mixed

mania (MM) (with depressive symptoms). We explored the influ-

ence of inflammatory factors in functionality, exploring differences

between PMandMM. Tomeasure patients’ general functioning one

year after illness onset, we used the Functional Assessment Short

Test (FAST).

Results

We found significant differences in TFN , MCP1 and

TBARS (higher in patients) and in SOD, GSHtot, GSSG, GSHfree, GPx

and TAS levels (lower in patients). Only In MM group, there was a

significant influence of SOD and GSHfree in FAST scores suggesting

that a higher antioxidant levels at baseline the patient functionality

improves one year after.

Conclusions

Some parameters of oxidative stress at baseline are

related with patient’s functionality one year after the first episode

of mania, but only when mania debuts with depressive symptons

simultaneously.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.154

EW37

Aspects of sexuality in bipolar women

L. Damian

1 ,

, I. Miclutia

2

1

Psychiatric hospital Ergoterapie, Cluj Municipal Hospital,

Cluj-Napoca, Romania

2

University of Medicine & Pharmacy Cluj-Napoca, Neuroscience-

discipline of Psychiatry, Cluj-Napoca, Romania

Corresponding author.

Introduction

In spite of more studies dedicated to the topic of

sexual disorders among schizophrenic patients or to the sexual

effects of antipsychotics and antidepressants, few studies entan-

gle broadly the issue of sexual attitudes and behaviors of bipolar

patients, due partly to the heterogeneity of the disorder and the

variety of episodes, and treatments.

Objectives

To establish if special sexual patterns are specific to

depressive or manic episodes and if the sexual disorders are related

to the severity of the mood episodes.