European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S133
Methods This study was conducted between 2009 and 2015 and
consists of outpatients from the Timisoara Hospital and Men-
tal Health Center, diagnosed with either bipolar disorder (n = 35),
schizoaffective disorder (n = 29) and recurrent depressive disorder
(n = 39), according to ICD-10 criteria and a healthy control group
(n = 84). For assessing cognitive emotional regulation, we used the
CERQ.
Results Statistically significant differences between the patient
groups and the control groupwere found in the following subscales:
“selfblame”, “rumination”, “catastrophizing”, “blaming others”
(negative emotional response strategies – highermean scores than
the control group), “positive refocusing” and “putting into per-
spective” (positive emotional response strategies – lower mean
scores than the control group). When comparing the three patient
groups, we found statistically significant differences in the follow-
ing subscales: “self-blame” and “rumination” (higher mean scores
for unipolar subject), “blaming others” (higher mean scores for
bipolar and schizoaffective subjects), “positive refocusing” (higher
mean scores for unipolar subjects) and “catastrophizing” (higher
scores for schizoaffective patients).
Conclusions Cognitive emotional regulation strategies used by
unipolar, bipolar and schizoaffective patients seem to differ and
might be an insight to the medium and long-term outcome, thus
potentially guiding future therapeutic strategies.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW50
Euthymia is not always euthymia:
Clinical status of bipolar patients after
6 months of clinical remission
L. Samalin ∗, I. De chazeron , M. Reinares , C. Torrent ,
C.D.M. Bonnin Hidalgo urru acchiarotti
F. Bellivier . Llorca ieta
1 EA7280, CHU Clermont-Ferrand, Psychiatry B, Clermont-Ferrand,
France
2 Institute of Neurosciences, Hospital Clinic, University of Barcelona,
Barcelona, Spain
3 Institute of Neurosciences, Hospital Clinic, University of Barcelona,
IDIBAPS, CIBERSAM, Barcelona, Spain
4 Inserm, U1144, AP–HP, groupe Saint-Louis-Lariboisière-F.-Widal,
Paris, France
∗ Corresponding author.
Introduction Most studies selected euthymic patients with bipo-
lar disorder in inter-episodic phase according to clinical remission
criteria at least between 1 and 6months. However, possible differ-
ences can exist in the course of clinical symptoms inbipolar patients
related to the duration of clinical remission.
Objectives The main aim of this study was to evaluate the clinical
status of bipolar patients after 6months of clinical remission.
Methods We performed a cross-sectional study of bipolar outpa-
tients in clinical remission for at least 6months. Bipolar Depression
Rating Scale (BDRS), Young Mania Rating scale, Pittsburgh Sleep
Quality Index (PSQI) scale, Visual Analogic Scales (VAS) evaluated
cognitive impairment were used to assess residual symptomato-
logy of patients. Multivariate analysis (MANCOVA) was conducted
for analysing possible differences between 3 groups of patients
according to their duration of clinical remission (< 6months–1 year,
< 1 year–3 years, < 3 years–5 years).
Results A total of 525 patients were included into the study. The
multivariate analysis indicated a significant effect of the duration
of clinical remission on the different residual symptoms (Pillai’s
trace: F 4.48, P < 0.001). The duration of clinical remission was asso-
ciated with the significant improvement of the BDRS total score
(P = 0.013), the PSQI total score (P < 0.001) and the cognitive VAS
total score (P < 0.001)
Conclusion These results support a possible improvement of
residual symptoms according to the duration of clinical remission
in bipolar patients. Any definition of euthymia should specify the
duration criteria.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW51
Emotion processing and social
functioning in euthymic bipolar
disorder
A. Aparicio ∗, E.M. Sánchez-Morla , J.L. Santos , J. Mateo
1 University of Castilla La Mancha, School of Nursery, Cuenca, Spain
2 University of Alcalá, Shool of Medicine, Psychiatry, Alcalá de
Henares, Spain
3 Hospital Virgen de La Luz, Psychiatry, Cuenca, Spain
4 University of Castilla La Mancha, Innovation in Bioengineering,
Cuenca, Spain
∗ Corresponding author.
Introduction A large number of studies have found that patients
with bipolar disorders have a poor performance in tasks assessing
social cognition.
Objectives and aims The present study aimed to investigate
whether euthymic bipolar patients (EBP) have a dysfunction in
emotion processing when compared to controls. An additional
objective was to determine whether there is association between
emotion processing and psychosocial functioning.
Methods A sample of 53 EBP and 53 healthy controls matched
for age, gender, education level and premorbid intelligence were
studied. All subjects were assessed using the MATRICS Consensus
Cognitive Battery (MCCB) and two additional executive function
measures: the Trail Making Test–Part B and the Stroop Test. Emo-
tion processing was examined using the Mayer-Salovey-Caruso
Emotional Intelligence Test (MSCEIT). Psychosocial functioningwas
assessed using the Global Assessment of Functioning (GAF) scale
and the Functional Assessment Short Test (FAST).
Results For the MSCEIT, EBP obtained lower total scores
(P = 0.001), experiential area scores (P = 0.012), strategic area
scores (P = 0.000), perceiving emotions branch scores (P = 0.008),
understanding emotions branch scores (P = 0.014) and managing
emotions branch scores (P = 0.000) than controls. There were no
significant differences between groups for the using emotions
branch (P = 0.113). In addition, partial correlations controlling for
sub-clinical psychopathology in EBP showed the existence of a sig-
nificant correlation of MSCEIT total score andMSCEIT strategic area
score with FAST total score.
Conclusions EBP exhibit deficits in several areas of emotion
processing. Performance in emotion processing tasks is associated
with social functioning in these patients.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW52
Prepulse inhibition in euthymic
bipolar disorder patients in
comparison with control subjects
J.L. Santos ∗, J. Mateo , A. Aparicio , E.M. Sánchez-Morla
1 Hospital Virgen de La Luz, Psychiatry, Cuenca, Spain
2 University of Castilla La Mancha, Innovation in Bioengineering,
Cuenca, Spain
3 University of Castilla La Mancha, School of Nursery, Cuenca, Spain
4 School of Medicine, Psychiatry, Alcalá de Henares, Spain
∗ Corresponding author.