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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S133

Methods

This study was conducted between 2009 and 2015 and

consists of outpatients from the Timisoara Hospital and Men-

tal Health Center, diagnosed with either bipolar disorder (

n

= 35),

schizoaffective disorder (

n

= 29) and recurrent depressive disorder

(

n

= 39), according to ICD-10 criteria and a healthy control group

(

n

= 84). For assessing cognitive emotional regulation, we used the

CERQ.

Results

Statistically significant differences between the patient

groups and the control groupwere found in the following subscales:

“selfblame”, “rumination”, “catastrophizing”, “blaming others”

(negative emotional response strategies – highermean scores than

the control group), “positive refocusing” and “putting into per-

spective” (positive emotional response strategies – lower mean

scores than the control group). When comparing the three patient

groups, we found statistically significant differences in the follow-

ing subscales: “self-blame” and “rumination” (higher mean scores

for unipolar subject), “blaming others” (higher mean scores for

bipolar and schizoaffective subjects), “positive refocusing” (higher

mean scores for unipolar subjects) and “catastrophizing” (higher

scores for schizoaffective patients).

Conclusions

Cognitive emotional regulation strategies used by

unipolar, bipolar and schizoaffective patients seem to differ and

might be an insight to the medium and long-term outcome, thus

potentially guiding future therapeutic strategies.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.167

EW50

Euthymia is not always euthymia:

Clinical status of bipolar patients after

6 months of clinical remission

L. Samalin

1 , 2 ,

, I. De chazeron

1

, M. Reinares

3

, C. Torrent

3

,

C.D.M. Bonnin

3 , D.

Hidalgo

3 , A. M

urru

3 , I. P

acchiarotti

3 ,

F. Bellivier

4 , P.M

. Llorca

1 , E. V

ieta

3

1

EA7280, CHU Clermont-Ferrand, Psychiatry B, Clermont-Ferrand,

France

2

Institute of Neurosciences, Hospital Clinic, University of Barcelona,

Barcelona, Spain

3

Institute of Neurosciences, Hospital Clinic, University of Barcelona,

IDIBAPS, CIBERSAM, Barcelona, Spain

4

Inserm, U1144, AP–HP, groupe Saint-Louis-Lariboisière-F.-Widal,

Paris, France

Corresponding author.

Introduction

Most studies selected euthymic patients with bipo-

lar disorder in inter-episodic phase according to clinical remission

criteria at least between 1 and 6months. However, possible differ-

ences can exist in the course of clinical symptoms inbipolar patients

related to the duration of clinical remission.

Objectives

The main aim of this study was to evaluate the clinical

status of bipolar patients after 6months of clinical remission.

Methods

We performed a cross-sectional study of bipolar outpa-

tients in clinical remission for at least 6months. Bipolar Depression

Rating Scale (BDRS), Young Mania Rating scale, Pittsburgh Sleep

Quality Index (PSQI) scale, Visual Analogic Scales (VAS) evaluated

cognitive impairment were used to assess residual symptomato-

logy of patients. Multivariate analysis (MANCOVA) was conducted

for analysing possible differences between 3 groups of patients

according to their duration of clinical remission (< 6months–1 year,

< 1 year–3 years, < 3 years–5 years).

Results

A total of 525 patients were included into the study. The

multivariate analysis indicated a significant effect of the duration

of clinical remission on the different residual symptoms (Pillai’s

trace:

F

4.48,

P

< 0.001). The duration of clinical remission was asso-

ciated with the significant improvement of the BDRS total score

(

P

= 0.013), the PSQI total score (

P

< 0.001) and the cognitive VAS

total score (

P

< 0.001)

Conclusion

These results support a possible improvement of

residual symptoms according to the duration of clinical remission

in bipolar patients. Any definition of euthymia should specify the

duration criteria.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.168

EW51

Emotion processing and social

functioning in euthymic bipolar

disorder

A. Aparicio

1 ,

, E.M. Sánchez-Morla

2

, J.L. Santos

3

, J. Mateo

4

1

University of Castilla La Mancha, School of Nursery, Cuenca, Spain

2

University of Alcalá, Shool of Medicine, Psychiatry, Alcalá de

Henares, Spain

3

Hospital Virgen de La Luz, Psychiatry, Cuenca, Spain

4

University of Castilla La Mancha, Innovation in Bioengineering,

Cuenca, Spain

Corresponding author.

Introduction

A large number of studies have found that patients

with bipolar disorders have a poor performance in tasks assessing

social cognition.

Objectives and aims

The present study aimed to investigate

whether euthymic bipolar patients (EBP) have a dysfunction in

emotion processing when compared to controls. An additional

objective was to determine whether there is association between

emotion processing and psychosocial functioning.

Methods

A sample of 53 EBP and 53 healthy controls matched

for age, gender, education level and premorbid intelligence were

studied. All subjects were assessed using the MATRICS Consensus

Cognitive Battery (MCCB) and two additional executive function

measures: the Trail Making Test–Part B and the Stroop Test. Emo-

tion processing was examined using the Mayer-Salovey-Caruso

Emotional Intelligence Test (MSCEIT). Psychosocial functioningwas

assessed using the Global Assessment of Functioning (GAF) scale

and the Functional Assessment Short Test (FAST).

Results

For the MSCEIT, EBP obtained lower total scores

(

P

= 0.001), experiential area scores (

P

= 0.012), strategic area

scores (

P

= 0.000), perceiving emotions branch scores (

P

= 0.008),

understanding emotions branch scores (

P

= 0.014) and managing

emotions branch scores (

P

= 0.000) than controls. There were no

significant differences between groups for the using emotions

branch (

P

= 0.113). In addition, partial correlations controlling for

sub-clinical psychopathology in EBP showed the existence of a sig-

nificant correlation of MSCEIT total score andMSCEIT strategic area

score with FAST total score.

Conclusions

EBP exhibit deficits in several areas of emotion

processing. Performance in emotion processing tasks is associated

with social functioning in these patients.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.169

EW52

Prepulse inhibition in euthymic

bipolar disorder patients in

comparison with control subjects

J.L. Santos

1 ,

, J. Mateo

2

, A. Aparicio

3

, E.M. Sánchez-Morla

4

1

Hospital Virgen de La Luz, Psychiatry, Cuenca, Spain

2

University of Castilla La Mancha, Innovation in Bioengineering,

Cuenca, Spain

3

University of Castilla La Mancha, School of Nursery, Cuenca, Spain

4

School of Medicine, Psychiatry, Alcalá de Henares, Spain

Corresponding author.