

S134
24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
Introduction
Deficient prepulse inhibition (PPI) of the startle
response, indicating sensorimotor gating deficits, has been
reported in schizophrenia and other neuropsychiatric disorders.
Objectives and aims
The present study aimed to assess sensorim-
otor gating deficits in euthymic bipolar patients. Furthermore, we
analysed the relationships between PPI and clinical and cognitive
measures.
Method
PPI was measured in 64 euthymic bipolar patients and
in 64 control subjects matched for age, gender, education level
and smoking status. Clinical characteristics and level of function-
ing were assessed in all participants using the Hamilton Depression
Rating Scale (HDRS), Young Mania Rating Scale (YMRS) and Func-
tioning Assessment Short Test (FAST). Cognition was evaluated
using the MATRICS Consensus Cognitive Battery (MCCB) and the
Stroop Test as an additional measure of executive function.
Results
Compared with controls, patients with bipolar disorder
exhibited PPI deficits at 60- and 120-milliseconds prepulse-pulse
intervals. Among patients with bipolar disorder, PPI was correlated
with the social cognition domain of the MCCB. PPI was not signifi-
cantly correlated with other clinical or neurocognitive variables in
either group.
Conclusions
Our data suggest that PPI deficit is a neurobiologi-
cal marker in euthymic bipolar disorder, which is associated with
social cognition but not with other clinical, functional or cognitive
measures.
Disclosure of interest
The authors have not supplied their decla-
ration of competing interest.
http://dx.doi.org/10.1016/j.eurpsy.2016.01.170EW53
Lurasidone treatment of major
depression with mixed features:
Effect on sexual function
A. Clayton
1 ,∗
, J. Tsai
2 , Y. Mao
3 , A.Pikalov
4 , A.Loebel
41
University of Virginia, Psychiatry and Neuorbehavioral Sciences,
Charlottesville, USA
2
Sunovion Pharmaceuticals Inc, Medical Affairs, Marlborough, USA
3
Sunovion Pharmaceuticals Inc., Biostatistics, Fort Lee, USA
4
Sunovion Pharmaceuticals Inc., Medical Affairs, Fort Lee, USA
∗
Corresponding author.
Introduction
Sexual dysfunction is common in major depressive
disorder (MDD), and frequently is worsened by antidepressant
treatment.
Objectives/aims
To evaluate the effect of lurasidone on sexual
functioning as measured by the Changes in Sexual Functioning
Questionnaire (CSFQ) in patients with MDD with mixed features.
Methods
Patients meeting DSM-IV-TR criteria for MDD, who
presented with 2 or 3 protocol-specified manic symptoms, were
randomized to 6weeks of double-blind treatment with either
lurasidone monotherapy 20–60mg/d (
n
= 109) or placebo (
n
= 100).
Change from baseline in the Montgomery-Asberg Depression Rat-
ing Scale (MADRS) total at week 6 was the primary efficacy
endpoint, analyzed by MMRM. The CSFQ was assessed at baseline
and week 6, analyzed by ANCOVA (LOCF).
Results
Themean CSFQ total scores at baselinewere 36.5 and 34.1
in the lurasidone and placebo groups, respectively. Sexual func-
tion was rated as abnormal at baseline on the CSFQ by 77.8% of
patients on lurasidone and 89.8% of patients on placebo. Treatment
with lurasidone was associated with significant improvement in
CSFQ total scores at week 6 (LOCF) compared with placebo (+5.1 vs.
+3.1;
P
< 0.05; effect size, 0.28). Significant improvement was also
noted on the CSFQ-pleasure sub-scale, and numerical improvement
on the CSFQ-desire/frequency, desire/interest, arousal, and orgasm
subscales. Sexual function was rated as abnormal at week 6 (LOCF)
on the CSFQ by 59.0% of patients on lurasidone and 70.1% of patients
on placebo (odds ratio, 0.75).
Conclusion
Lurasidone treatment of MDD with mixed features
was associated with significant improvement in sexual function.
Disclosure of interest
Sponsored by Sunovion Pharmaceuticals
Inc.
http://dx.doi.org/10.1016/j.eurpsy.2016.01.171EW54
Sensory processing patterns, coping
strategies, and quality of life among
patients with major affective
disorders
B. Engel-Yeger
1, G. Serafini
2 ,∗
, X. Gonda
3, M. Pompili
4,
M. Amore
51
Faculty of Social Welfare and Health Sciences, University of Haifa,
Occupational Therapy, Haifa, Israel
2
Section of Psychiatry, San Martino Hospital, University of Genoa,
Neuroscience DINOGMI, Genoa, Italy
3
Kutvolgyi Clinical Center, Semmelweis University, Clinical and
Theoretical Mental Health, Budapest, Hungary
4
Sant’Andrea Hospital, University of Rome, Neurosciences, Rome,
Italy
5
Section of Psychiatry, San Martino Hospital, University of Genoa,
Neuroscience, Genoa, Italy
∗
Corresponding author.
Introduction
Several studies suggested the involvement of sen-
sory perception in emotional processes and major affective
disorders. Similarly, cognitive capacities and coping strategies are
reported to influence quality of life of patients with unipolar and
bipolar disorders.
Objectives
The main objective of this study was to investigate
the nature of the association between sensory processing patterns,
coping strategies, and quality of life among patients with major
affective disorders.
Aims
The study aimed to compare unipolar/bipolar patients con-
cerning sensory processing, coping strategies and quality of life
(QOL); examine correlations between sensory processing and QOL;
investigate the relative contribution of socio-demographic charac-
teristics, sensory processing, and coping strategies to the prediction
of QOL.
Methods
Two hundred and sixty-seven participants, aged
16–85 years (mean = 53.6
±
15.7), 157 diagnosed with unipolar
major depressive disorder and 110 with bipolar disorder type I
and type II completed the Adolescent/Adult Sensory Profile, Coping
Orientations to Problems Experienced, and Short Form 12 Health
Survey 2.
Results
The unipolar and bipolar groups did not differ concerning
sensory processing, coping strategies, and QOL. Sensory processing
patterns correlated with QOL independently of the mediation by
coping strategies. Correlations between low registration, sensory
sensitivity, sensation avoidance, and reduced QOL were found
more frequently in unipolar patients than bipolar patients. Elevated
physical QOL was mainly predicted by lower age and lower sensory
sensitivity whereas elevated mental QOL was mainly predicted by
coping strategies.
Conclusions
Future studies should further investigate the impact
of sensory processing and coping strategies on patients’ QOL to
enhance adaptive and functional behaviors related to affective dis-
turbances.
Disclosure of interest
The authors have not supplied their decla-
ration of competing interest.
http://dx.doi.org/10.1016/j.eurpsy.2016.01.172