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S132

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

Introduction

Although early interventions in individuals with

bipolar disorder may reduce the associated personal and economic

burden, the neurobiologic markers of enhanced risk are unknown.

Objectives

The objective of this paper is to analyze the existence

of neurobiological abnormalities in individuals with genetic risk for

developing bipolar disorder (HR)

Material and methods

A literature search was performed in the

available scientific literature on the subject study object, by search-

ing MEDLINE.

Results

There were 37 studies included in this systematic review.

The overall sample for the systematic review included 1258 con-

trols and 996 HR individuals. No significant differences were

detected between HR individuals and controls in the selected ROIs

(regions of interest): striatum, amygdala, hippocampus, pituitary

and frontal lobe. The HR group showed increased grey matter vol-

ume comparedwith patients with established bipolar disorder. The

HR individuals showed increased neural response in the left supe-

rior frontal gyrus, medial frontal gyrus and left insula compared

with controls. The overall results found no significant differences

between individuals at high genetic risk and controls since the

magnitude of the association as corresponds to an OR < 1.5 (low

association)

Conclusion

There is accumulating evidence for the existence of

neurobiologic abnormalities in individuals at genetic risk for bipo-

lar disorder at various scales of investigation. The etiopathogenesis

of bipolar disorder will be better elucidated by future imaging

studies investigating larger and more homogeneous samples and

using longitudinal designs to dissect neurobiologic abnormalities

that are underlying traits of the illness from those related to psy-

chopathologic states, such as episodes of mood exacerbation or

pharmacologic treatment.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.164

EW47

Evolution of bipolar disorder over

12 years in a psychiatric hospital

E. Ribera

1 ,

, M .

Grifell

2 , M.T

. Campillo

1 , I. E

zquiaga

1 ,

L. Martínez

1

, L. González

1

, A. Palomo

1

, V. Pérez

3

, L. Galindo

2

1

Institut de Neuropsiquiatria i Addiccions, Parc de Salut Mar,

Psychiatry, Barcelona, Spain

2

Institut de neuropsiquiatria i addiccions Parc de Salut Mar, Institut

Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain

3

Institut de neuropsiquiatria i addiccions Parc de Salut Mar- Centro

de investigación Biomédica en Red de Salud Mental CIBERSAM G21,

Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain

Corresponding author.

Introduction

Bipolar disorder is a leading cause of hospitalization

in psychiatric hospitals. It is known that early detection of bipolar

disorder is associated with a better prognosis.

Objectives

The aimof this study is to conduct a demographic anal-

ysis of patients hospitalized for bipolar disorder in a single center

between 2003 to 2014.

Methods

Retrospective cohort study of 1230 patients admitted

with bipolar disorder diagnosis from 2003 to 2014 at Centre Assis-

tencial Emili Mira i López of Parc Salut Mar of Barcelona. We divided

the study in two periods: 2003–2008 and 2009–2014. We analyzed

the following variables: frequency of admissions, age, sex and days

of hospital stay, comparing both periods. Chi-square test for cate-

gorical variables and Student t test for quantitative variables were

applied.

Results

The mean ages at the first and second period are 52 and

47, respectively (

P

< 0.001). There are no significant differences in

sex and days of hospitalization. The frequency of admissions on the

first and third trimesters is higher than in the second and fourth,

although the differences are not statistically significant.

Conclusions

Despite the large number of patients in the study,

there are limitations, such as being a retrospective study and not

being adjusted for confounding factors. The average age of patients

in the second period is lower than in the first. This could suggest

an improvement in early detection of bipolar disorder in the last

years. Further research is needed to confirm this hypothesis.

Disclosure of interest

LG is funded by the Instituto de Salud Carlos

III(CM14/00111).

http://dx.doi.org/10.1016/j.eurpsy.2016.01.165

EW48

Onset episode in a bipolar patient

sample: A preliminary study

F. Romosan

1 ,

, R.S. Romosan

1

, A. Draghici

2

1

“Victor Babes” University of Medicine and Pharmacy, Neuroscience,

Timisoara, Romania

2

Vasile Goldis West University of Arad, Psychiatry, Arad, Romania

Corresponding author.

Introduction

Bipolar disorder usually has an atypical onset, either

with a depressive or a psychotic (non-manic) episode. Potential

predictive factors for bipolarity should increase diagnostic accuracy

since onset.

Objectives

Identifying the onset episode type in a Romanian bipo-

lar patient sample.

Methods

Seventy-two patients diagnosed with bipolar disorder

according to ICD-10 diagnostic criteria, admitted in our hospital

between 2009 and 2015, were included in this study. For assessing

the type of the onset episode, we used the MADRS and YMRS (for

affective symptoms) and the PANSS (for psychotic symptoms).

Results

Out of the 72 bipolar patients, at onset: 24 had a moder-

ate or severe depressive episode (without psychotic features), 19

had a severe depressive episode with psychotic features, 11 had

a manic episode with psychotic features, 8 had a manic episode

without psychotic features, 6 had the diagnosis of acute polymor-

phic psychotic disorder (5 without symptoms of schizophrenia and

1 with symptoms of schizophrenia), 3 had the diagnosis of other

acute predominantly delusional psychotic disorder and 1 had the

diagnosis of acute schizophrenia-like psychotic disorder.

Conclusions

More than half of the patients included in this study

had moderate or severe depressive symptom severity at onset.

Identifying predictors for bipolarity in a depressive first episode

should aid in more adequate treatment since onset.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.166

EW49

Cognitive emotional regulation in

euthymic unipolar, bipolar and

schizoaffective patients

R.S. Romosan

1 ,

, A. Draghici

2

, F. Romosan

1

, V.R. Enatescu

1

,

L. Dehelean

1

, C. Bredicean

1

, I. Papava

1

, C. Giurgi-Oncu

1

1

“Victor Babes” University of Medicine and Pharmacy, Neuroscience,

Timisoara, Romania

2

Vasile Goldis West University of Arad, Psychiatry, Arad, Romania

Corresponding author.

Introduction

The way an individual responds to emotionally

arousing information best describes cognitive emotional regula-

tion. In affective disorders, emotional regulation strategies vary

widely depending on the phase of the disorder and the episode

type.

Objectives

Identifying differences in cognitive emotion regula-

tion of remitted bipolar patients (after a depressive episode),

remitted schizoaffective patients (after a depressive episode),

remitted unipolar patients and a healthy control group.