European Psychiatry - Volume 33 - March 2016

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S132 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
Introduction Although early interventions in individuals with
bipolar disorder may reduce the associated personal and economic
burden, the neurobiologic markers of enhanced risk are unknown.
Objectives The objective of this paper is to analyze the existence
of neurobiological abnormalities in individuals with genetic risk for
developing bipolar disorder (HR)
Material and methods A literature search was performed in the
available scientific literature on the subject study object, by search-
ing MEDLINE.
Results There were 37 studies included in this systematic review.
The overall sample for the systematic review included 1258 con-
trols and 996 HR individuals. No significant differences were
detected between HR individuals and controls in the selected ROIs
(regions of interest): striatum, amygdala, hippocampus, pituitary
and frontal lobe. The HR group showed increased grey matter vol-
ume comparedwith patients with established bipolar disorder. The
HR individuals showed increased neural response in the left supe-
rior frontal gyrus, medial frontal gyrus and left insula compared
with controls. The overall results found no significant differences
between individuals at high genetic risk and controls since the
magnitude of the association as corresponds to an OR < 1.5 (low
association)
Conclusion There is accumulating evidence for the existence of
neurobiologic abnormalities in individuals at genetic risk for bipo-
lar disorder at various scales of investigation. The etiopathogenesis
of bipolar disorder will be better elucidated by future imaging
studies investigating larger and more homogeneous samples and
using longitudinal designs to dissect neurobiologic abnormalities
that are underlying traits of the illness from those related to psy-
chopathologic states, such as episodes of mood exacerbation or
pharmacologic treatment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW47
Evolution of bipolar disorder over
12 years in a psychiatric hospital
E. Ribera ∗ Grifell . Campillo zquiaga
L. Martínez , L. González , A. Palomo , V. Pérez , L. Galindo
1 Institut de Neuropsiquiatria i Addiccions, Parc de Salut Mar,
Psychiatry, Barcelona, Spain
2 Institut de neuropsiquiatria i addiccions Parc de Salut Mar, Institut
Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain
3 Institut de neuropsiquiatria i addiccions Parc de Salut Mar- Centro
de investigación Biomédica en Red de Salud Mental CIBERSAM G21,
Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain
∗ Corresponding author.
Introduction Bipolar disorder is a leading cause of hospitalization
in psychiatric hospitals. It is known that early detection of bipolar
disorder is associated with a better prognosis.
Objectives The aimof this study is to conduct a demographic anal-
ysis of patients hospitalized for bipolar disorder in a single center
between 2003 to 2014.
Methods Retrospective cohort study of 1230 patients admitted
with bipolar disorder diagnosis from 2003 to 2014 at Centre Assis-
tencial Emili Mira i López of Parc Salut Mar of Barcelona. We divided
the study in two periods: 2003–2008 and 2009–2014. We analyzed
the following variables: frequency of admissions, age, sex and days
of hospital stay, comparing both periods. Chi-square test for cate-
gorical variables and Student t test for quantitative variables were
applied.
Results The mean ages at the first and second period are 52 and
47, respectively (P < 0.001). There are no significant differences in
sex and days of hospitalization. The frequency of admissions on the
first and third trimesters is higher than in the second and fourth,
although the differences are not statistically significant.
Conclusions Despite the large number of patients in the study,
there are limitations, such as being a retrospective study and not
being adjusted for confounding factors. The average age of patients
in the second period is lower than in the first. This could suggest
an improvement in early detection of bipolar disorder in the last
years. Further research is needed to confirm this hypothesis.
Disclosure of interest LG is funded by the Instituto de Salud Carlos
III(CM14/00111).
EW48
Onset episode in a bipolar patient
sample: A preliminary study
F. Romosan ∗, R.S. Romosan , A. Draghici
1 “Victor Babes” University of Medicine and Pharmacy, Neuroscience,
Timisoara, Romania
2 Vasile Goldis West University of Arad, Psychiatry, Arad, Romania
∗ Corresponding author.
Introduction Bipolar disorder usually has an atypical onset, either
with a depressive or a psychotic (non-manic) episode. Potential
predictive factors for bipolarity should increase diagnostic accuracy
since onset.
Objectives Identifying the onset episode type in a Romanian bipo-
lar patient sample.
Methods Seventy-two patients diagnosed with bipolar disorder
according to ICD-10 diagnostic criteria, admitted in our hospital
between 2009 and 2015, were included in this study. For assessing
the type of the onset episode, we used the MADRS and YMRS (for
affective symptoms) and the PANSS (for psychotic symptoms).
Results Out of the 72 bipolar patients, at onset: 24 had a moder-
ate or severe depressive episode (without psychotic features), 19
had a severe depressive episode with psychotic features, 11 had
a manic episode with psychotic features, 8 had a manic episode
without psychotic features, 6 had the diagnosis of acute polymor-
phic psychotic disorder (5 without symptoms of schizophrenia and
1 with symptoms of schizophrenia), 3 had the diagnosis of other
acute predominantly delusional psychotic disorder and 1 had the
diagnosis of acute schizophrenia-like psychotic disorder.
Conclusions More than half of the patients included in this study
had moderate or severe depressive symptom severity at onset.
Identifying predictors for bipolarity in a depressive first episode
should aid in more adequate treatment since onset.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW49
Cognitive emotional regulation in
euthymic unipolar, bipolar and
schizoaffective patients
R.S. Romosan ∗, A. Draghici , F. Romosan , V.R. Enatescu ,
L. Dehelean , C. Bredicean , I. Papava , C. Giurgi-Oncu
1 “Victor Babes” University of Medicine and Pharmacy, Neuroscience,
Timisoara, Romania
2 Vasile Goldis West University of Arad, Psychiatry, Arad, Romania
∗ Corresponding author.
Introduction The way an individual responds to emotionally
arousing information best describes cognitive emotional regula-
tion. In affective disorders, emotional regulation strategies vary
widely depending on the phase of the disorder and the episode
type.
Objectives Identifying differences in cognitive emotion regula-
tion of remitted bipolar patients (after a depressive episode),
remitted schizoaffective patients (after a depressive episode),
remitted unipolar patients and a healthy control group.