European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S471
Introduction The endogenous opiate system (EOS) has been
linked to social attachment in classical animal experiments, to
addictive disorders (AD) and, more recently, to specific traits of
personality through research in genetic polymorphisms and neu-
roimaging techniques.
Objectives To expose the relation between social bonding andAD,
via the latest neurobiological findings in the EOS. To propose a theo-
retical framework which may allow a clinical approach based upon
respect and no stigmatization.
Methods Literature review in MEDLINE database with the key-
words “opioid”, “polymorphism”, “object attachment”, “addictive
behavior”, “personality”.
Results Polymorphisms in the mu-opioid receptor gene lead to
different attachment behaviors in primates. The EOS in humans
has been related to pain and placebo effect and recently, to social
rejection and acceptance. Thus, some authors talk about “social
pain”. Interestingly, the EOS has a role in harm avoidance and in
the reward system. These traits of personality (harm avoidance
and reward dependence) predispose to AD, and likely, pathological
models of social bondingmay drive to a need of palliating excessive
discomfort originated by an altered opioid function through addic-
tive behaviors. The origin of AD must be focused on the individual
vulnerability rather than in the addictive substance/behavior.
Conclusions The latest findings in the EOS yield concrete evi-
dences that support the classical hypothesis of an opioid nexus
between social attachment and AD, and shift the spotlight from the
addictive object to the vulnerable subject. This theoretical frame-
work may ease a clinical approach based upon respect and no
stigmatization.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV385
Mental disturbances in patients with
acute medical condition
B. Fedak
Kharkov medical academy of postgraduate education - Kharkov,
psychotherapy, Kharkov, Ukraine
Contemporary remains understudied health issue - the psycholog-
ical aspect of the acute therapeutic diseases problem. Among the
most common diseases - coronary heart disease (CHD), myocardial
infarction (MI), crisis states in patients with arterial hypertension
(AH), transient ischemic attack (TIA) and acute stroke (AS), gas-
tric ulcer and duodenal ulcer (GU&DU). Clinical features of the
structure, dynamics, current and immediate link with the medi-
cal conditions is not fully understood. The basis of our research,
the purpose of which, was to identify mental disturbances in
patients with acute therapeutic diseases. One hundred and eighty-
seven patients were examined, 34 CHD patients, 37–MI, 38 - TIA,
39–AH, 39 - GU&DU, 65% male and 35% female aged 20 to 60
years. The main research method was clinical and psychopatholog-
ical. A high-level affective and neurotic disorders in these patients
was observed. Structured analysis allowed identifying four main
options disturbances: nosogenic neurotic reaction–68 patients;
somatogenic asthenic syndrome–46 patients; reaction psycho-
logical maladjustment–34 patients; acute stress reactions–39
patients. Stratification of structure psychopathological syndroms
allowed systematizing them in 4 different groups: asthenic–24%;
anxiety - 46%; subdepressive - 11%; somatoform - 19%. That was
the basis for the determination early psychotherapeutic correction
program, formed by integrativemodel. The high efficacywas shown
in 74% patients, middle range–in 15%, low–in 11% patients.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV386
Prevalence and clinical correlates of
comorbid drug use and ADH
L. Reula , A. Portilla Fernández , E. Manrique Astiz ,
L.A. Nú˜nez Domínguez ∗, O. Arbeo Ruiz , M. Gracía Nicolás ,
O. Fernández de la Vega
1 Clínica de rehabilitación, Psychiatry, Pamplona, Spain
2 Hospital de Día Irubide, Psychiatry, Pamplona, Spain
3 Mental Health Center, Psychiatry, Tafalla, Spain
4 Centro Médico, Psychiatry, Pamplona, Spain
5 Centro de Día Zuría, Psychiatry, Pamplona, Spain
6 Menatl Health Center, Psychiatry, Tudela, Spain
7 Menatl Health Center, Psychiatry, Pamplona, Spain
∗ Corresponding author.
The prevalence of drug use in patients suffering ADH is very high.
The main purpose of this paper is to make a review of the recnet
literatura in this field.
We make a review in PUB Med using “ADH” and “drug abuse”,
selecting papers not older than 5 years.
The conclusions are that adult patients suffering ADH presents
higher prevalence of drug use and/or dependence, showing that
ADH is a risk factor for this comorbidity.
This conclusion implies the neccesity of strat the treatment in
young people, treating to avoid drug use and/or dangerous behav-
iors in this group of patients.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV387
The influence of
psychopharmacological treatment in
the long-term outcome in patients
suffering ADH with comorbid drug use
L.A. Nú˜nez Domínguez ∗ ortilla Fernández eula
E. Manrique Asti Arbeo Ruiz García Nicolás
O. Fernández de la Vega
1 Centro Médico, Psychiatry, Pamplona, Spain
2 Hospital de Día, Psychiatry, Pamplona, Spain
3 Clínica de Rehabilitación, Psychiatry, Pamplona, Spain
4 Mental Health Center, Psychiatry, Tafalla, Spain
5 Centro de Día Zuría, Psychiatry, Pamplona, Spain
6 Menatl Health Center, Psychiatry, Tudela, Spain
7 Menatl Health Center, Psychiatry, Pamplona, Spain
∗ Corresponding author.
ADH is one of mental disease with a higher prevalence of alco-
hol and drug abuse. ADH is a risk factor for drug use, and that’s
true in the reverse sense. The mutual influence in both disorders
is clear and the presence of both disorders together could be a real
challenge for a clincial professional.
The main objective of the study is to evaluate the influence of the
psychopharmacological treatment in the longterm outcome of this
sample, using ameasurement drug use, adherence to the treatment
and impulsivity.
We make a study that includes a group of patients with both disor-
ders. We select a sample from the Centro de Día Zuría. The patients
complete a battery of scales (SCL-90, BArratt, SF-36) before and
after the beginning of psychopharmacological treatment.
Our results shows a better prognosis in the patients with a good
adherence to treatment, with a decrease in frequency and levels of
drug use and a decrease in impulsivity, with a low level of behav-
ioral disorders and violence.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.