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S476

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

Methods

The sample covers a cross-sectional study including

15 female patients and 59 male patients under treatment in the

Emergency Department at the Psychiatric Hospitality “Sveti Ivan”

in September 2015. The patients were divided into three groups,

according to their BMI. All patients fulfilled the DASS 21 (Depres-

sion, Anxiety and Stress Scale by Fernando Gomez) and Suicide

Severity Rating Scale (Columbia–Suicide Severity Rating Scale [Cen-

ter for Suicide Risk Assesment] questionnaires).

Results

Inmale patients, 30.91%were found to be obese and36.4%

overweight. In total, seven patients had from comorbidity, of which

fivewere obese. In female patients, 33.3%were overweightwhereas

only six patientswere obese. Of those six obesewomen, all had from

comorbidity.

Conclusions

The results identify that a significant part of individ-

uals with psychological disorders are either obese or overweight,

resulting in repercussions in the course of disease and treatment.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1384

EV400

Casting wider diagnostic nets for

anxiety and depression:

Disability-driven cross-diagnostic

subtypes in a large population study

R. Wanders

1 ,

, H.M. van Loo

1

, K.J. Wardenaar

1

, J.K. Vermunt

2

,

R.R. Meijer

3

, P. De Jonge

1

1

University Medical Center Groningen, Department of Psychiatry,

Groningen, Netherlands

2

Tilburg University, Department of Methodology and Statistics,

Tilburg, Netherlands

3

University of Groningen, Department of Psychometrics and

Statistics, Groningen, Netherlands

Corresponding author.

Introduction

Data-driven techniques are frequently applied to

identify subtypes of depression and anxiety. Although they are

highly comorbid and often grouped under a single internalizing

banner, most subtyping studies have focused on either depression

or anxiety. Furthermore, most previous subtyping studies have not

taken into account experienced disability.

Objectives

To incorporate disability into a data-driven cross-

diagnostic subtyping model.

Aims

To capture heterogeneity of depression and anxiety symp-

tomatology and investigate the importance of domain-specific

disability-levels to distinguish between homogeneous subtypes.

Methods

Sixteen symptoms were assessed without skips using

the MINI-interview in a population sample (LifeLines;

n

= 73403).

Disability was measured with the RAND-36. To identify the best-

fitting subtyping model, different nested latent variable models

(latent class analysis, factor analysis andmixed-measurement item

response theory [MM-IRT]) with and without disability covariates

were compared. External variables were compared between the

best model’s classes.

Results

A five-class MM-IRT model incorporating disability

showed the best fit (Fig. 1). Accounting for disability improved

the differentiation between classes reporting isolated non-

specific symptoms (“Somatic” [13.0%], and “Worried” [14.0%]) and

those reporting more psychopathological symptoms (“Subclinical”

[8.8%], and “Clinical” [3.3%]). A “Subclinical” class reported symp-

tomatology at subthreshold levels. No pure depression or anxiety,

but only mixed classes were observed.

Conclusions

An overarching subtyping model incorporating

both symptoms and disability identified distinct cross-diagnostic

subtypes. Diagnostic nets should be cast wider than current

phenomenology-based categorical systems.

Figure not available.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1385

EV401

Pediatric asthma biomarkers in

relation to mental disorders of

asthmatic children and their

caregivers

E. Zaky

1 ,

, E. Fouda

1

, E. Samir

2

, F. Ahmed

3

1

Ain Shams university- faculty of medicine, pediatrics, Cairo, Egypt

2

Ain Shams university- faculty of medicine, biochemistry, Cairo,

Egypt

3

Ain Shams university, pediatrics, Cairo, Egypt

Corresponding author.

Background

Pediatric bronchial asthma as a chronic airway

inflammatory disorder has a significant impact on asthmatic chil-

dren both biologically and psychologically. On the other hand,

parental stress and depression has been linked to pediatric asthma

and claimed to play an important role in its morbidity.

Objectives

Assessment of pediatric asthma biomarkers as param-

eters of disease severity in relation to mental disorders of an

Egyptian sample of asthmatic children and their caregivers.

Methodology

The current cross-sectional study comprised 60

Egyptian asthmatic children as Group I and 35 clinically healthy

children of comparable age and sex as Group II. Thorough clini-

cal evaluation and psychometric assessment were carried out for

all enrolled children and their caregivers. In addition, pulmonary

function testing and measurement of esinophilic count, IL-5, and

total IgE were carried out for children of both studied groups.

Results

Enrolled asthmatics had significant elevation of all stud-

ied asthma biomarkers with significant reduction of measured

pulmonary functions compared to controls. Furthermore, asth-

matics had significantly more encountered poor self-esteem,

clinically manifest anxiety, and psychosocial impairment com-

pared to controls. Meanwhile, parents of studied asthmatics had

higher frequency of severer grades of clinically manifest isolation,

anxiety, depression, and stress. Strikingly, the severer the asthma,

the more the elevation of studied asthma biomarkers, the severer

the asthmatic child’s and caregivers’ anxiety and depression, and

the more the caregivers’ isolation and stress.

Conclusion

Pediatric asthma biomarkers as parameters of disease

severity has been proven to be linked to mental health impairment

of asthmatic children and their caregivers.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1386

EV402

Paliperidone palmitate could reduce

the consumption of drugs of abuse in

psychotic patients?

A. Zangrando

1 ,

, F . B

abici

2 , E. P

ascolo-Fabrici

1 , A.

Riolo

3

1

UCO Clinica Psichiatrica, department of mental health, Trieste, Italy

2

CSM Domio Trieste, department of mental health, Trieste, Italy

3

CSM Domio, department of mental health, Trieste, Italy

Corresponding author.

Introduction

It’s not easy to choose between different antipsy-

chotics in the treatment of patients with schizophrenia that use

drugs of abuse both legal (alcohol, benzodiazepine, anticholiner-

gics) and illicit (heroin, cannabis, cocaine). The use of substances

is a powerful risk factor for poor outcome. From CATIE study, we

know that the discontinuity is lower with Olanzapine but psy-

chotic patients continue to take drugs of abuse despite medication.