Table of Contents Table of Contents
Previous Page  469 / 812 Next Page
Information
Show Menu
Previous Page 469 / 812 Next Page
Page Background

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S465

disappeared psychotic symptoms and paranoia, and after discharge

he has managed to remain abstinent to psychostimulants.

Conclusions

Adequate characterization of patients with psy-

chotic symptoms and substance abuse is essential to determine

whether the psychotic disorder is associated with primary or

induced TUS. Therefore, it is essential a thorough clinical evalua-

tion to make an accurate diagnosis and to draw an individualized

treatment plan.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1349

EV365

Psychiatric disorders among

asthmatic patients: Literature review

C.A. Moreira

, A.M. Marinho , L.C. Gil , M. Bairrão , L. Queiroz

Centro Hospitalar Psiquiátrico de Lisboa, Psychiatry, Lisbon, Portugal

Corresponding author.

Introduction

Asthma is a major public health problem and its

prevalence has increased in both developed and developing coun-

tries during the last few years. Once it is a chronic illness, it has

also revealed psychological consequences. Moreover, recent stud-

ies have suggested an association between asthma (especially of

severe grade) and mental disorders.

Objectives

The authors pretend tomake a brief reviewconcerning

psychiatric disorders among asthmatic patients.

Aims

To understand and to be able to deal with the psychiatric

disorders among chronic asthmatic patients.

Methods

The reviewwas based on scientific documentation pub-

lished in PubMed database, using the following terms as keywords:

“asthma”, “depression”, “anxiety” and “panic disorder”.

Results

Compared to the general population, both anxiety and

mood disorders rates are at least two times those observed in

asthmatic patients. Moreover, certain psychiatric disorders rates,

including panic disorder (PD) and major depressive disorder, are

as much as six times more prevalent among asthmatics when

compared to the general population. The association between psy-

chiatric disorders and poor asthma control and asthma-related

quality of life could occur through several pathways, such as

behavioural pathways; cognitive or perceptual pathways; or

through the direct physiological effects of depression and anxi-

ety on the autonomic nervous system (ANS) and immune systems

which increase asthma symptomatology.

Discussions/Conclusions

There is a close correlation between anx-

iety, PD and depression, and a poor controlled asthma. A better

understanding of this association may have major clinical implica-

tions, mainly in patients with poor controlled asthma in whom the

presence of anxiety and depression should be investigated.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1350

EV366

Opioids consumption and delusional

symptomatology

A. Duque Domínguez

1 ,

, R . D

uque Domínguez

2 , L. M

artín Díaz

1 ,

C. García Montero

1 , M.

Palomo Monge

3 ,

M.D.M. Lázaro Redondo

1 , F. d

e la Torre Brasas

1 ,

N. Echeverría Hernández

1

1

Complejo Asistencial de Ávila, Servicio de Psiquiatría, Ávila, Spain

2

Hospital Universitario de Fuenlabrada, Servicio de Psiquiatría,

Madrid, Spain

3

Complejo Asistencial de Talavera de la Reina, Servicio de Psiquiatría,

Talavera de la Reina Toledo, Spain

Corresponding author.

Introduction

Opioids are the most powerful drugs commer-

cialised for acute and chronic pain relief. The main emerging

problem in ourmidst is the abuse and addiction to synthetic opioids

iatrogenically established in general population.

Objectives

We report the case of a female patient aged 48 admit-

ted to the Acute Psychiatric Unit after a suicide attempt. She refers

she finds herself more irritable and depressed since she began a

treatment with oxycodone after shewas diagnosedwith fibromyal-

gia. She has lost a lot of weight, is not able to get to sleep and has

become socially isolated.

Methodology

During the first few days, the patient is unco-

operative and shows a marked self-referentiality and verbalises

delusional ideation related to her immediate surroundings. Once

the treatment with opioids was withdrawn and we had prescribed

paliperidone ER, she seemed more cooperative and calmed. She

was discharged from the Psychiatric Day Hospital showing a good

evolution.

Results

Paranoid personality disorder (F60); mental and

behavioural disorders due to use of opioids (F11); recur-

rent depressive disorder, current episode moderate (F33.1);

fibromyalgia (M79.7).

Conclusions

The use of synthetic opioids (tramadol, fentanyl,

oxycodone) in easy-to-use formats (patches, pills, dispersible

tablets, lollipops) and their dissemination inpain treatment, is lead-

ing to an increase of problems related to it, both their side effects

(psychotic symptoms) and the generation of misuse and addiction.

We should pay greater attention to the prescription of opioids to

patients with dysfunctional personality traits.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1351

EV367

The effect of alcohol administration

on social behavior of rats with

experimental schizophrenia

A. Egorov

, E. K

utcher , N. Chernikova , M. Dorofeikova

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry,

Behavior Neurophysiology and Pathology, St-Petersburg, Russia

Corresponding author.

Experimental animal modeling of schizophrenia and alcoholism

allows understanding the mechanisms of comorbid pathology

formation. The aimwas to investigate the effect of ethanol adminis-

tration on social relations in rats with experimental schizophrenia.

The study was carried out on 30 Wistar adult male rats aged.

After 2 weeks isolation rat social ranks were determined. Alco-

hol preference was evaluated in the two-bottle test. Schizophrenia

was modeled by administering to rats (

n

= 15) dopamine precur-

sor levodopa-carbidopa (LC) during 5 days each month in four

months experiment. The control animals (

n

= 15) received water.

All animals were subjected to intermittent alcoholization through-

out the experiment after the introduction of the LC. The behavioral

parameters evaluated in the “open field” and “despair” tests.

It was found out that the experimental rats who received alco-

hol did not differ in the number of interactions compared to

the rats who received only alcohol. In the rats with experimen-

tal schizophrenia a significantly higher social interactions were

observed compared to the control group. This is consistent with

the results of the clinical studies, which have shown that patients

often drink alcohol to relieve anxiety and tension. The two-bottle

test has shown the difference between the experimental and con-

trol groups only in the first week of the experiment. Apparently,

this can be explained by the prolonged isolation. In the despair test,

before the alcoholization, the rats with experimental schizophre-

nia were completely immobilized, compared to the controls. After

alcoholization the differences in the despair test were not observed.