European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S465
disappeared psychotic symptoms and paranoia, and after discharge
he has managed to remain abstinent to psychostimulants.
Conclusions Adequate characterization of patients with psy-
chotic symptoms and substance abuse is essential to determine
whether the psychotic disorder is associated with primary or
induced TUS. Therefore, it is essential a thorough clinical evalua-
tion to make an accurate diagnosis and to draw an individualized
treatment plan.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV365
Psychiatric disorders among
asthmatic patients: Literature review
C.A. Moreira ∗, A.M. Marinho , L.C. Gil , M. Bairrão , L. Queiroz
Centro Hospitalar Psiquiátrico de Lisboa, Psychiatry, Lisbon, Portugal
∗ Corresponding author.
Introduction Asthma is a major public health problem and its
prevalence has increased in both developed and developing coun-
tries during the last few years. Once it is a chronic illness, it has
also revealed psychological consequences. Moreover, recent stud-
ies have suggested an association between asthma (especially of
severe grade) and mental disorders.
Objectives The authors pretend tomake a brief reviewconcerning
psychiatric disorders among asthmatic patients.
Aims To understand and to be able to deal with the psychiatric
disorders among chronic asthmatic patients.
Methods The reviewwas based on scientific documentation pub-
lished in PubMed database, using the following terms as keywords:
“asthma”, “depression”, “anxiety” and “panic disorder”.
Results Compared to the general population, both anxiety and
mood disorders rates are at least two times those observed in
asthmatic patients. Moreover, certain psychiatric disorders rates,
including panic disorder (PD) and major depressive disorder, are
as much as six times more prevalent among asthmatics when
compared to the general population. The association between psy-
chiatric disorders and poor asthma control and asthma-related
quality of life could occur through several pathways, such as
behavioural pathways; cognitive or perceptual pathways; or
through the direct physiological effects of depression and anxi-
ety on the autonomic nervous system (ANS) and immune systems
which increase asthma symptomatology.
Discussions/Conclusions There is a close correlation between anx-
iety, PD and depression, and a poor controlled asthma. A better
understanding of this association may have major clinical implica-
tions, mainly in patients with poor controlled asthma in whom the
presence of anxiety and depression should be investigated.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV366
Opioids consumption and delusional
symptomatology
A. Duque Domínguez ∗ uque Domínguez artín Díaz
C. García Montero Palomo Monge
M.D.M. Lázaro Redondo e la Torre Brasas
N. Echeverría Hernández
1 Complejo Asistencial de Ávila, Servicio de Psiquiatría, Ávila, Spain
2 Hospital Universitario de Fuenlabrada, Servicio de Psiquiatría,
Madrid, Spain
3 Complejo Asistencial de Talavera de la Reina, Servicio de Psiquiatría,
Talavera de la Reina Toledo, Spain
∗ Corresponding author.
Introduction Opioids are the most powerful drugs commer-
cialised for acute and chronic pain relief. The main emerging
problem in ourmidst is the abuse and addiction to synthetic opioids
iatrogenically established in general population.
Objectives We report the case of a female patient aged 48 admit-
ted to the Acute Psychiatric Unit after a suicide attempt. She refers
she finds herself more irritable and depressed since she began a
treatment with oxycodone after shewas diagnosedwith fibromyal-
gia. She has lost a lot of weight, is not able to get to sleep and has
become socially isolated.
Methodology During the first few days, the patient is unco-
operative and shows a marked self-referentiality and verbalises
delusional ideation related to her immediate surroundings. Once
the treatment with opioids was withdrawn and we had prescribed
paliperidone ER, she seemed more cooperative and calmed. She
was discharged from the Psychiatric Day Hospital showing a good
evolution.
Results Paranoid personality disorder (F60); mental and
behavioural disorders due to use of opioids (F11); recur-
rent depressive disorder, current episode moderate (F33.1);
fibromyalgia (M79.7).
Conclusions The use of synthetic opioids (tramadol, fentanyl,
oxycodone) in easy-to-use formats (patches, pills, dispersible
tablets, lollipops) and their dissemination inpain treatment, is lead-
ing to an increase of problems related to it, both their side effects
(psychotic symptoms) and the generation of misuse and addiction.
We should pay greater attention to the prescription of opioids to
patients with dysfunctional personality traits.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV367
The effect of alcohol administration
on social behavior of rats with
experimental schizophrenia
A. Egorov ∗ utcher , N. Chernikova , M. Dorofeikova
I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry,
Behavior Neurophysiology and Pathology, St-Petersburg, Russia
∗ Corresponding author.
Experimental animal modeling of schizophrenia and alcoholism
allows understanding the mechanisms of comorbid pathology
formation. The aimwas to investigate the effect of ethanol adminis-
tration on social relations in rats with experimental schizophrenia.
The study was carried out on 30 Wistar adult male rats aged.
After 2 weeks isolation rat social ranks were determined. Alco-
hol preference was evaluated in the two-bottle test. Schizophrenia
was modeled by administering to rats (n = 15) dopamine precur-
sor levodopa-carbidopa (LC) during 5 days each month in four
months experiment. The control animals (n = 15) received water.
All animals were subjected to intermittent alcoholization through-
out the experiment after the introduction of the LC. The behavioral
parameters evaluated in the “open field” and “despair” tests.
It was found out that the experimental rats who received alco-
hol did not differ in the number of interactions compared to
the rats who received only alcohol. In the rats with experimen-
tal schizophrenia a significantly higher social interactions were
observed compared to the control group. This is consistent with
the results of the clinical studies, which have shown that patients
often drink alcohol to relieve anxiety and tension. The two-bottle
test has shown the difference between the experimental and con-
trol groups only in the first week of the experiment. Apparently,
this can be explained by the prolonged isolation. In the despair test,
before the alcoholization, the rats with experimental schizophre-
nia were completely immobilized, compared to the controls. After
alcoholization the differences in the despair test were not observed.