European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S461
Importantly, they contribute to elucidate the functions and mech-
anisms of the fear system and may have important implications for
understanding emotional disorders, since many of these involve
the fear system.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV353
Alterations in retinal processing in
regular cannabis users
R. Schwan ∗ chwitzer Giersc Laprevote
1 CPN Laxou, Psychiatry, Nancy, France
2 Inserm U1114, Psychiatry, Strasbourg, France
∗ Corresponding author.
Introduction Cannabis is one of the most prevalent drugs used
worldwide. However, the neural consequences of cannabis remain
poorly understood. There is a need for a rapid improvement of the
scientific knowledge on the cerebral impact of cannabis use. Since
the retina is an easy-to-access part of the central nervous system,
it can reflect the neurochemistry of the brain.
Objectives Considering the anatomical and functional distribu-
tion of the cannabinoid system in the retinal ganglion cells, the
objective of this study was to assess whether the regular use of
cannabis could affect the ganglion cells functioning.
Aims Assessment of the ganglion cells function in regular
cannabis users compared to healthy controls.
Methods Recordings of pattern electroretinogram (PERG) were
performed in regular cannabis users and healthy controls using
standard of the International Society for Clinical Electrophysiology
of Vision (ISCEV). The amplitude and implicit time of the PERG N95
were assessed.
Results The N95 implicit time of PERG was significantly
decreased in regular cannabis users compared to healthy controls.
Conclusions We found alterations in the ganglion cells function
in regular cannabis users, as showed by the increase in N95 implicit
time. The ganglion cells represent the ultimate retinal relay before
the visual information is relayed to the brain and, according to these
results, we suppose that the signal elicited by these cells and trans-
ferred through the visual pathways is altered in cannabis users. A
direct action of exogenous cannabinoids in the retinal glutamater-
gic transmission is discussed.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV354
Characteristics of selected cognitive
functions in patients with systemic
lupus erythematosus using Cambridge
neuropsychological test automated
battery
A. Bogaczewicz , J. Kowalski , J. Z˛abek , A. Wo ˙zniacka ,
J. Bogaczewic obow ∗
1 Medical University of Lodz, Medical Psychology, Lodz, Poland
2 Medical University of Lodz, Internal Diseases and Cardiological
Rehabilitation, Lodz, Poland
3 Institute of Rheumatology, Microbiology and Serology, Warsaw,
Poland
4 Medical University of Lodz, Dermatology and Venerology, Lodz,
Poland
∗ Corresponding author.
Introduction Cognitive dysfunction in patients with systemic
lupus erythematosus affects 10–36% of them.
Objective To determine a profile of selected cognitive functions
in systemic lupus erythematosus.
The aim To investigate and characterize selected cognitive
parameters in patients with systemic lupus erythematosus (SLE)
using a standardized, comparable and reproducible computer-
based method.
Material and methods The study included 25 patients with SLE.
For neuropsychological assessment, the Cambridge Neuropsycho-
logical Test Automated Battery was used. Following parameters
were investigated: mean latency and mean error in motor screen-
ing (MOTML, MOTME), big little circle (BLC), paired associated
learning (PAL), problems solved in minimum moves in stock-
ings of Cambridge (SOC PSMM) and graded naming test (GNT).
Results were referred automatically to determined ranges of norms
matched according to age and gender.
Results In patients with SLE results displayed by median and
upper and lower quartiles were as follows: MOTML = 1.1 (0.9–1.34),
MOTME = 0.41 (0.31–0.52), BLC = 0.16 (0.16–0.18), PAL = −0.43
(−1.28; −0.18), SOCPSMM= −0.62 (−1.19–0.04), and GNT = −0.8
(−1.6; −0.32).
MOTML correlated negatively with MOTME (r= −0.51), MOTME
correlated with SOCPSMM (r = 0.41), and PAL correlated with GNT
(r= 0.48) (P < 0.05).
Conclusions In our study, predominant abnormalities were those
related to lexical and semantic memory, revealed by the GNT, spa-
tial planning and spatial working memory, assessed by the SOC,
together with visual memory and new learning, assessed with the
PAL.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV355
Laser test for identification of latent
tremor at alcohol and drug addiction
I. Sosin ∗ huev , O. Goncharova
Kharkov Medical Academy of Postgraduate Education, Narcology,
Kharkov, Ukraine
∗ Corresponding author.
Introduction Distinctness of tremor in abstinent disorders at
alcohol and drug addiction are polymorphous in expressiveness
degree, localization, typical dynamics of growing from latent, sub-
clinical to big swing tremor of fingers.
Aims and objectives To elaborate the differentiated diagnosis
method for tremor in drug addicts to solve examination and med-
ical problems in clinical narcology.
Method The new method of expert diagnosis of latent tremor in
narcology with complex examination of the respondent’s capacity
to complete test tasks for the precisement of purposeful sen-
sorimotor movements and operations coordination with laser
test was introduced. Laser beam pointer visual manual guid-
ance at 2–3meter distance standard target and the beam fixation
at the centre (“top ten”) reveals the patient’s capacity within
5–10 seconds. Laser light spot trembling appearance out of “top
ten” circle while twice-thrice completing the test is considered the
positive result and tremor severity is evaluated depending on the
beam vibration amplitude.
Results Twenty-five alcohol and 25 drug addicts were exam-
ined. Visually, tremor presence and severity coincided with testing
results entirely. Ability to keep beam in “top ten” area demon-
strated tremor absence; laser spot vibration over “top ten”–the
latent tremor; laser spot trembling within circles 9–10 – the mod-
erate tremor; within the 6th–4th circles – medium severity; from
3rd–1st and 0th circle – the severe tremor is identified.
Conclusions The method allows to increase the diagnosis effi-
ciency and tremor identification at narcological diseases that gives