Table of Contents Table of Contents
Previous Page  465 / 812 Next Page
Information
Show Menu
Previous Page 465 / 812 Next Page
Page Background

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S461

Importantly, they contribute to elucidate the functions and mech-

anisms of the fear system and may have important implications for

understanding emotional disorders, since many of these involve

the fear system.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1337

EV353

Alterations in retinal processing in

regular cannabis users

R. Schwan

1 ,

, T . S

chwitzer

1 , 2 , A .

Giersc

h 2 , V.

Laprevote

1

1

CPN Laxou, Psychiatry, Nancy, France

2

Inserm U1114, Psychiatry, Strasbourg, France

Corresponding author.

Introduction

Cannabis is one of the most prevalent drugs used

worldwide. However, the neural consequences of cannabis remain

poorly understood. There is a need for a rapid improvement of the

scientific knowledge on the cerebral impact of cannabis use. Since

the retina is an easy-to-access part of the central nervous system,

it can reflect the neurochemistry of the brain.

Objectives

Considering the anatomical and functional distribu-

tion of the cannabinoid system in the retinal ganglion cells, the

objective of this study was to assess whether the regular use of

cannabis could affect the ganglion cells functioning.

Aims

Assessment of the ganglion cells function in regular

cannabis users compared to healthy controls.

Methods

Recordings of pattern electroretinogram (PERG) were

performed in regular cannabis users and healthy controls using

standard of the International Society for Clinical Electrophysiology

of Vision (ISCEV). The amplitude and implicit time of the PERG N95

were assessed.

Results

The N95 implicit time of PERG was significantly

decreased in regular cannabis users compared to healthy controls.

Conclusions

We found alterations in the ganglion cells function

in regular cannabis users, as showed by the increase in N95 implicit

time. The ganglion cells represent the ultimate retinal relay before

the visual information is relayed to the brain and, according to these

results, we suppose that the signal elicited by these cells and trans-

ferred through the visual pathways is altered in cannabis users. A

direct action of exogenous cannabinoids in the retinal glutamater-

gic transmission is discussed.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1338

EV354

Characteristics of selected cognitive

functions in patients with systemic

lupus erythematosus using Cambridge

neuropsychological test automated

battery

A. Bogaczewicz

1

, J. Kowalski

2

, J. Z˛abek

3

, A. Wo ˙zniacka

4

,

J. Bogaczewic

z 4 , T. S

obow

1 ,

1

Medical University of Lodz, Medical Psychology, Lodz, Poland

2

Medical University of Lodz, Internal Diseases and Cardiological

Rehabilitation, Lodz, Poland

3

Institute of Rheumatology, Microbiology and Serology, Warsaw,

Poland

4

Medical University of Lodz, Dermatology and Venerology, Lodz,

Poland

Corresponding author.

Introduction

Cognitive dysfunction in patients with systemic

lupus erythematosus affects 10–36% of them.

Objective

To determine a profile of selected cognitive functions

in systemic lupus erythematosus.

The aim

To investigate and characterize selected cognitive

parameters in patients with systemic lupus erythematosus (SLE)

using a standardized, comparable and reproducible computer-

based method.

Material and methods

The study included 25 patients with SLE.

For neuropsychological assessment, the Cambridge Neuropsycho-

logical Test Automated Battery was used. Following parameters

were investigated: mean latency and mean error in motor screen-

ing (MOTML, MOTME), big little circle (BLC), paired associated

learning (PAL), problems solved in minimum moves in stock-

ings of Cambridge (SOC PSMM) and graded naming test (GNT).

Results were referred automatically to determined ranges of norms

matched according to age and gender.

Results

In patients with SLE results displayed by median and

upper and lower quartiles were as follows: MOTML = 1.1 (0.9–1.34),

MOTME = 0.41 (0.31–0.52), BLC = 0.16 (0.16–0.18), PAL =

0.43

(

1.28;

0.18), SOCPSMM=

0.62 (

1.19–0.04), and GNT =

0.8

(

1.6;

0.32).

MOTML correlated negatively with MOTME (

r

=

0.51), MOTME

correlated with SOCPSMM (

r

= 0.41), and PAL correlated with GNT

(

r

= 0.48) (

P

< 0.05).

Conclusions

In our study, predominant abnormalities were those

related to lexical and semantic memory, revealed by the GNT, spa-

tial planning and spatial working memory, assessed by the SOC,

together with visual memory and new learning, assessed with the

PAL.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1339

EV355

Laser test for identification of latent

tremor at alcohol and drug addiction

I. Sosin

, Y. C

huev , O. Goncharova

Kharkov Medical Academy of Postgraduate Education, Narcology,

Kharkov, Ukraine

Corresponding author.

Introduction

Distinctness of tremor in abstinent disorders at

alcohol and drug addiction are polymorphous in expressiveness

degree, localization, typical dynamics of growing from latent, sub-

clinical to big swing tremor of fingers.

Aims and objectives

To elaborate the differentiated diagnosis

method for tremor in drug addicts to solve examination and med-

ical problems in clinical narcology.

Method

The new method of expert diagnosis of latent tremor in

narcology with complex examination of the respondent’s capacity

to complete test tasks for the precisement of purposeful sen-

sorimotor movements and operations coordination with laser

test was introduced. Laser beam pointer visual manual guid-

ance at 2–3meter distance standard target and the beam fixation

at the centre (“top ten”) reveals the patient’s capacity within

5–10 seconds. Laser light spot trembling appearance out of “top

ten” circle while twice-thrice completing the test is considered the

positive result and tremor severity is evaluated depending on the

beam vibration amplitude.

Results

Twenty-five alcohol and 25 drug addicts were exam-

ined. Visually, tremor presence and severity coincided with testing

results entirely. Ability to keep beam in “top ten” area demon-

strated tremor absence; laser spot vibration over “top ten”–the

latent tremor; laser spot trembling within circles 9–10 – the mod-

erate tremor; within the 6th–4th circles – medium severity; from

3rd–1st and 0th circle – the severe tremor is identified.

Conclusions

The method allows to increase the diagnosis effi-

ciency and tremor identification at narcological diseases that gives