European Psychiatry - Volume 33 - March 2016

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S458 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
underlying interpersonal emotional transmissions have been
mainly studied using static images in non-social setups. Here, we
investigated how the human brain responds to dynamic emotional
input, coming from another, co-present individual.
Using an innovative approach developed in our lab, we provided
participants with continuous emotional feedback from another
participant while they watched emotional movie in the fMRI
scanner. To disentangle between the socially-driven and stimulus-
driven effects, we introduced a control group, inwhich participants
received identical stimulus, but thought that the feedback is gen-
erated by a computer algorithm.
We mapped the brain regions, which exhibited reliable activity
in the experimental and control groups. In addition, we assessed
neural response synchronizationwith the time-course of the social-
emotional feedback and compared it across groups.
Comparing the experimental and the control groups, we found that
response time-courses in the bilateral insula, amygdala, thalamus
and dorsal MPFC exhibited moment-by-moment alignment with
the feedback time-line. In addition, right lateral prefrontal regions
were reliably recruited in the experimental (social) but not in the
control (non-social) groups. Finally, synchronization with the feed-
back in the right amygdala and in theMPFCwas strongly associated
with the emotional effects of the feedback, reported after the exper-
iment.
Taken together, our results suggested that continuous processing of
emotional input fromothers shape one’s own responses by evoking
response synchronization in the core emotion brain regions and
recruitment of prefrontal emotion regulation mechanisms.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV344
The effects of alexithymia in the
recognition of dynamic emotional
faces
M. Rocha oares ilva Madeira ∗ ilva
1 Center for Health Technology and Services Research CINTESIS-UA,
Department of Education, University of Aveiro, Aveiro, Portugal
2 Karolinska Institute, Department of Clinical Neuroscience, Division
of Psychology, Solna, Sweden
3 University of Aveiro, Department of Education, Aveiro, Portugal
4 Coimbra Hospital and University Centre, Psychiatry, Coimbra,
Portugal
5 Faculty of Medicine, University of Coimbra, Psychological Medicine
Department, Coimbra, Portugal
∗ Corresponding author.
Introduction Alexithymia is a multifactorial personality trait
observed in several mental disorders, especially those with poor
social functioning. Although it has been proposed that difficulties
in interpersonal interactions in highly alexithymic individuals may
stem from their reduced ability to express and recognize facial
expressions, this still remains controversial.
Aim In everyday life, faces displaying emotions are dynamic,
although most studies have relied on static stimuli. The aim of
this study was to investigate whether individuals with high levels
of alexithymia differed from a control group in the categorization
of emotional faces presented in a dynamic way. Given the highly
dynamic nature of facial displays in real life, we used morphed
videos depicting faces varying 1% from neutral to angry, disgust
or happy faces, with a video presentation of 35 seconds.
Method Sixty participants (27 males and 33 females) were
divided into high (HA) and low levels of alexithymia (LA) by
using the Toronto Alexithymia Scale (TAS-20). Participants were
instructed to watch the face change from neutral to an emotion
and to press a keyboard as soon as they could categorize an emotion
expressed in the face.
Results The results revealed an interaction between alexithymia
and emotion showing that HA, compared to LA, were more inaccu-
rate at categorizing angry faces.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV345
Neuro-Behc¸ et’s psychiatric symptoms
F. Maduro ∗ eiva issarra uarte
L. Marques
1 Centro Hospitalar Universitário de Coimbra, Servic¸ o de Psiquiatria,
Coimbra, Portugal
2 Centro Hospitalar Universitário de Coimbra, Servic¸ o de
Pedopsiquiatria, Coimbra, Portugal
∗ Corresponding author.
Neuro-Behc¸ et (NB) results from inflammatory peri-vasculitis
affecting the central nervous system. Non-specific neurological and
psychiatric symptoms are rarely the first presentation and may
difficult or delay diagnosis and treatment.
We review, based on a case study and published literature, the
psychiatric symptoms of NB when no clear evidence of neurologic
disease activity is present.
We present the case of a female patient, who was diagnosed NB at
age 23 for recurrent meningo-encephalitis, that showed progres-
sive behavioral changes, with increased impulsivity, disinhibition,
hostility and self-neglect.
Raised in a dysfunctional family, she ran away from home at 16,
abandoned her studies, started abusing cannabinoids and showed
an erratic life course.
In 2015, because of increasing psychiatric symptoms, she was
admitted to hospital and a complete neuropsychological evaluation
showed that she had a significant decline from an above aver-
age premorbid cognitive function, specifically related to memory
deficits. CT and MRI didn’t show typical signs of active disease.
However, a SPECT scan showed hypo-perfusion of the frontal cortex
compatible with the patient’s symptoms.
It is difficult to assess NB’s activity as brain inflammation is only
observed after structural changes are present. In this case the
SPECT correlated well with psychiatric symptoms. The differential
diagnosis includes organic pathology with psychiatric symptoms,
psychiatric disease, personality disorders and substance abuse.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV346
Transcatheter laser treatment of
Binswanger’s disease
I. Maksimovich
Clinic of Cardiovascular Diseases named after Most Holy John
Tobolsky, iterventional neuroangiology, Moscow, Russia
Introduction Due to increasing lifespan, the number of patients
withBinswanger’s disease is growing. The study of the effectiveness
of brain transluminal laser revascularization in the treatment of
Binswanger’s disease.
Methods Fourteen patients, 9 male (64.29%) and 5 female
(35.71%), aged 58–81 (average age 77) with Binswanger’s disease
were examined. Each patient underwent CDR, CT, MRI, SG, REG,
cerebral multi-gated angiography (MUGA).
Single postischemic microcysts (3–4mm) of brain’s white mat-
ter were detected in 1 case; multiple microcysts including the
merged ones – in 13 cases. All the patients had leucoariosis,
inovolutive changes of the cerebral cortex, unocclusive hydro-
cephalus. Intracranial atherosclerotic lesion typewas detected in all
cases. Multiple arteriovenous shunts of brain’s white matter were
detected in all cases. All the patients underwent transcatheter laser