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S458

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

underlying interpersonal emotional transmissions have been

mainly studied using static images in non-social setups. Here, we

investigated how the human brain responds to dynamic emotional

input, coming from another, co-present individual.

Using an innovative approach developed in our lab, we provided

participants with continuous emotional feedback from another

participant while they watched emotional movie in the fMRI

scanner. To disentangle between the socially-driven and stimulus-

driven effects, we introduced a control group, inwhich participants

received identical stimulus, but thought that the feedback is gen-

erated by a computer algorithm.

We mapped the brain regions, which exhibited reliable activity

in the experimental and control groups. In addition, we assessed

neural response synchronizationwith the time-course of the social-

emotional feedback and compared it across groups.

Comparing the experimental and the control groups, we found that

response time-courses in the bilateral insula, amygdala, thalamus

and dorsal MPFC exhibited moment-by-moment alignment with

the feedback time-line. In addition, right lateral prefrontal regions

were reliably recruited in the experimental (social) but not in the

control (non-social) groups. Finally, synchronization with the feed-

back in the right amygdala and in theMPFCwas strongly associated

with the emotional effects of the feedback, reported after the exper-

iment.

Taken together, our results suggested that continuous processing of

emotional input fromothers shape one’s own responses by evoking

response synchronization in the core emotion brain regions and

recruitment of prefrontal emotion regulation mechanisms.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1328

EV344

The effects of alexithymia in the

recognition of dynamic emotional

faces

M. Rocha

1 , S. S

oares

1 , 2 , S . S

ilva

3 , N.

Madeira

4 , 5 ,

, C . S

ilva

1

1

Center for Health Technology and Services Research CINTESIS-UA,

Department of Education, University of Aveiro, Aveiro, Portugal

2

Karolinska Institute, Department of Clinical Neuroscience, Division

of Psychology, Solna, Sweden

3

University of Aveiro, Department of Education, Aveiro, Portugal

4

Coimbra Hospital and University Centre, Psychiatry, Coimbra,

Portugal

5

Faculty of Medicine, University of Coimbra, Psychological Medicine

Department, Coimbra, Portugal

Corresponding author.

Introduction

Alexithymia is a multifactorial personality trait

observed in several mental disorders, especially those with poor

social functioning. Although it has been proposed that difficulties

in interpersonal interactions in highly alexithymic individuals may

stem from their reduced ability to express and recognize facial

expressions, this still remains controversial.

Aim

In everyday life, faces displaying emotions are dynamic,

although most studies have relied on static stimuli. The aim of

this study was to investigate whether individuals with high levels

of alexithymia differed from a control group in the categorization

of emotional faces presented in a dynamic way. Given the highly

dynamic nature of facial displays in real life, we used morphed

videos depicting faces varying 1% from neutral to angry, disgust

or happy faces, with a video presentation of 35 seconds.

Method

Sixty participants (27 males and 33 females) were

divided into high (HA) and low levels of alexithymia (LA) by

using the Toronto Alexithymia Scale (TAS-20). Participants were

instructed to watch the face change from neutral to an emotion

and to press a keyboard as soon as they could categorize an emotion

expressed in the face.

Results

The results revealed an interaction between alexithymia

and emotion showing that HA, compared to LA, were more inaccu-

rate at categorizing angry faces.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1329

EV345

Neuro-Behc¸ et’s psychiatric symptoms

F. Maduro

1 ,

, S . N

eiva

2 , C. P

issarra

1 , F. D

uarte

1 ,

L. Marques

1

1

Centro Hospitalar Universitário de Coimbra, Servic¸ o de Psiquiatria,

Coimbra, Portugal

2

Centro Hospitalar Universitário de Coimbra, Servic¸ o de

Pedopsiquiatria, Coimbra, Portugal

Corresponding author.

Neuro-Behc¸ et (NB) results from inflammatory peri-vasculitis

affecting the central nervous system. Non-specific neurological and

psychiatric symptoms are rarely the first presentation and may

difficult or delay diagnosis and treatment.

We review, based on a case study and published literature, the

psychiatric symptoms of NB when no clear evidence of neurologic

disease activity is present.

We present the case of a female patient, who was diagnosed NB at

age 23 for recurrent meningo-encephalitis, that showed progres-

sive behavioral changes, with increased impulsivity, disinhibition,

hostility and self-neglect.

Raised in a dysfunctional family, she ran away from home at 16,

abandoned her studies, started abusing cannabinoids and showed

an erratic life course.

In 2015, because of increasing psychiatric symptoms, she was

admitted to hospital and a complete neuropsychological evaluation

showed that she had a significant decline from an above aver-

age premorbid cognitive function, specifically related to memory

deficits. CT and MRI didn’t show typical signs of active disease.

However, a SPECT scan showed hypo-perfusion of the frontal cortex

compatible with the patient’s symptoms.

It is difficult to assess NB’s activity as brain inflammation is only

observed after structural changes are present. In this case the

SPECT correlated well with psychiatric symptoms. The differential

diagnosis includes organic pathology with psychiatric symptoms,

psychiatric disease, personality disorders and substance abuse.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1330

EV346

Transcatheter laser treatment of

Binswanger’s disease

I. Maksimovich

Clinic of Cardiovascular Diseases named after Most Holy John

Tobolsky, iterventional neuroangiology, Moscow, Russia

Introduction

Due to increasing lifespan, the number of patients

withBinswanger’s disease is growing. The study of the effectiveness

of brain transluminal laser revascularization in the treatment of

Binswanger’s disease.

Methods

Fourteen patients, 9 male (64.29%) and 5 female

(35.71%), aged 58–81 (average age 77) with Binswanger’s disease

were examined. Each patient underwent CDR, CT, MRI, SG, REG,

cerebral multi-gated angiography (MUGA).

Single postischemic microcysts (3–4mm) of brain’s white mat-

ter were detected in 1 case; multiple microcysts including the

merged ones – in 13 cases. All the patients had leucoariosis,

inovolutive changes of the cerebral cortex, unocclusive hydro-

cephalus. Intracranial atherosclerotic lesion typewas detected in all

cases. Multiple arteriovenous shunts of brain’s white matter were

detected in all cases. All the patients underwent transcatheter laser