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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S455

suggesting a multimodal integration deficit for the constitution of

self-representation in this population.

Our results show the existence of a self-face recognition deficit in

individuals with ASD, which may be linked to a lack of multimodal

integration in the development of the self-face representation.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1318

EV334

Sex differences in the neural basis of

theory of mind during development

C. Frank

Fielding Graduate University, School of Psychology, Santa Barbara,

USA

Introduction

Theory of mind (ToM) is the ability to predict behav-

iors of others in terms of their underlying mental states. It is carried

out in order to make sense of and predict behavior. Impairments in

ToM have been found in many psychiatric/neurological disorders

including schizophrenia and autism spectrum disorders. Previous

research has indicated sex difference in ToM development. Previ-

ous research has also found some differences in the neural basis of

ToM.

Objectives/aims

An objective/aim of the present study was to

examine possible sex differences in the neural mechanism asso-

ciated with ToM development. Another objective was to examine

the neural basis of ToM that is shared by both sexes throughout

development.

Methods

Thirty-two adults (16women) and 24 children (12 girls)

were assessed with fMRI while performing a false belief (FB) task.

Results

During the ToMrelative to non-ToMcondition, adults and

children of both sexes showed increased activity in the medial pre-

frontal cortex (mPFC) and the temporo-parietal junction (TPJ). Both

boys and girls recruited more brain regions than adults. Moreover,

children employed structures involved in the humanmirror neuron

system (hMNS) more than adults. More specifically, boys recruited

the inferior frontal gyrus (IFG) more thanmen, while girls recruited

the precentral gyrus more than women.

Conclusions

These results suggest that boys/men and

girls/women employ different brain regions for ToM during

development.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1319

EV335

Instructional influence on learning

and decision making with respect to

cognitive functioning

D. Frydecka

1 ,

, J. Drapała

2

, B. Misiak

3

1

Wroclaw, Poland

2

Wroclaw University of Technology, Faculty of Computer Science and

Management, Wroclaw, Poland

3

Wroclaw Medical University, Department of Genetics, Wrocław,

Poland

Corresponding author.

Introduction

Humans learn how to behave both through rules

and instructions (explicit learning) as well as through environ-

mental experiences (implicit learning). It has been shown that

instructions can powerfully control people’s choices, often leading

to a confirmation bias.

Aim

To explore confirmation bias with respect to cognitive func-

tioning in healthy adult participants.

Methods

We recruited 25 healthy adult control subjects (9males,

16 females, age 31.40

±

6.08 years). Participants completed Repeat-

able Battery of Neuropsychological Status (RBANSS) as well as

Instructed Version of Probabilistic Selection Task (IPST) (Doll et al.,

2009).

Results

Based on the performance on IPST into two groups: a

groupwith higher and lower susceptibility to confirmation

bias.We

found no difference between these groupswith respect to any of the

cognitive domains measured with RBANSS (immediate memory,

visuospatial abilities, language, attention and delayed memory) (

U

Mann-Whitney test,

P

> 0.05).

Conclusion

In healthy adults, susceptibility to confirmation bias

is independent of cognitive functioning (immediate and delayed

memory, visuospatial abilities, language and attention).

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1320

EV336

Relationship between executive

functions and adherence to

antiretroviral therapy in HIV-infected

patients

D. Hernández Huerta

1 ,

, C. Parro Torres

2

, A. Madoz Gúrpide

3

,

E. Ochoa Mangado

3

, M.J. Pérez Elias

4

1

Hospital Provincial de Toledo, Psiquiatría, Toledo, Spain

2

Hospital Gregorio Mara˜nón, Psiquiatria, Madrid, Spain

3

Hospital Ramón y Cajal, Psiquiatría, Madrid, Spain

4

Hospital Ramón y Cajal, Enfermedades Infecciosas, Madrid, Spain

Corresponding author.

Introduction

HIV-related damage of the central nervous system

is manifested in varying severity of neurocognitive disturbances.

Research on measures of executive functioning has confirmed that

HIV infection is associated with progressive difficulties in these

abilities. Moreover, several studies in recent years have shown that

an impaired cognitive function confers a higher risk of poor adher-

ence to antiretroviral therapy.

Objectives/Aims

The aim of this study is to analyze the relation-

ship between executive functions and ART compliance.

Methods

We designed a cross-sectional case-control survey.

Cases were defined as HIV-infected patients who missing at least

10% intakes in the last year (reported by hospital pharmacy)

and self-reported non-adherence by Simplified Medication Adher-

ence Questionnaire (SMAQ). Controls were defined as HIV-infected

patients who accomplishing at least last 95% intakes in the last

year (reported by hospital pharmacy), and self-reported adher-

ence by SMAQ. Patients with adherences between 90–95% were

not included. Executive functions were evaluated with Wisconsin

Sorting Card Test. Linear regression was employed as statistical

analysis. Results were adjusted for follow-up years. Wisconsin

score was already adjusted for gender, age and education level

when data were corrected.

Results

Our sample was compound by 63 patients: 37 controls

and 26 cases. A statistical signification (

P

< 0.05) was found for total

correct, total errors, perseverative responses, perseverative errors,

conceptual level responses and trials to complete first category

score between adherence and non-adherence treatment patients.

Conclusions

In our sample worse executive function score, mea-

sured byWisconsin Card Sorting Test, was linked to poor adherence

to antiretroviral treatment in HIV patients.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1321