European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S459
revascularization. Low-energy laser systems were used for revas-
cularization of distal intra cerebral branches. Postoperatively, the
patients underwent desagrigatory, anticoagulatory and vasodila-
tor therapy following advanced interventional radiology schemes.
Clinical evaluation of postoperative results was carried out using
the CDR.
Results Good immediate angiographic outcome manifested in
the restoration of lumen and patency of the affected vessels as well
as in collateral revascularization was obtained in all cases:
– good clinical outcome (no dementia) was obtained in 6 (42.86%)
cases;
– satisfactory clinical outcome (dementia reduction) – in 8
(57.14%) cases;
– no negative effect was observed after the interventions.
Conclusions The method of brain transcatheter laser revascular-
ization is an effective one in the treatment of atherosclerotic lesions
of brain’s white matter accompanied by the development of Bin-
swanger disease.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV347
Inconsistent decline of executive
functions in patients with early and
late Huntington’s disease
S. Mörkl ∗, C. Blesl , A. Tmava , W. Wurm , A. Holl , A. Painold
Medical University of Graz, Psychiatry, Graz, Austria
∗ Corresponding author.
Background Huntington’s disease (HD) is characterized by execu-
tive dysfunctions like problems with planning, accuracy, inhibition
and impulsivity. During the course of the disease executive function
worsens with ongoing pathological changes in the basal ganglia.
However, it is not clear whether cognitive dysfunction develops
gradually or not during the course of the disease.
Methods We assessed the development of executive dysfunction
in 23 patients with early HD and 29 patients with late HD on the
Tower of London (ToL) for the number of solved problems, planning
time and number of breaks.
Results HD patients showed a linear decrease of accuracy (as
assessed by number of solved problems) during the course of the
disease. Controls scored significantly higher than early stage HD
patients and early stage HD patients scored significantly higher
than late stage HD patients. In planning time and number of breaks
a non-linear decrease was found.
Conclusion Executive dysfunctions inHD are not alone connected
to degenerative changes in the striatum as they do not develop
gradually and linear during the course of the disease. Obviously,
executive function could not be seen as a single component, but as
a combination of different abilities, which show a non-linear and
non-parallel decline.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV348
Neuropsychiatric manifestations of
vitamin B12 and folate deficiencies:
Data from an inpatient psychiatric
department
A. Mota ∗, M. Lázaro , R. Alves , A. Moreira , M. Nobre
1 Centro Hospitalar Psiquiátrico de Lisboa, Psychiatry, Lisbon,
Portugal
2 Hospital de Dona Estefânia, Pedopsychiatry, Lisboa, Portugal
∗ Corresponding author.
Introduction The prevalence of vitamin B12 and folate deficiency
is significant in the psychiatric population. These deficiencies may
be associated with varied neuropsychiatric signs and symptoms,
caused by different pathophysiological mechanisms.
Objectives Characterize the main neuropsychiatric signs and
symptoms associated with vitamin B12 and folate deficiencies.
Evaluate the prevalence of these vitamins deficiencies in an acute
inpatient psychiatric department, dedicated to Affective Disorders.
Aims To review the clinical significance of vitamin B12 and folate
deficiencies in psychiatric disorders and reflect on the importance
of routine screening in mental health care.
Material and methods Observational, retrospective and descrip-
tive study, with analysis of clinical and blood tests data concerning
the total number of inpatient episodes in 2015. Non-systematic
review of the scientific literature.
Results A small case series of the patients that had folate or B12
deficiency detected is presented. The prevalence of vitamin B12 and
folate deficiencies found in our study is in accordance with the data
found in the literature.
Conclusions Vitamin B12 and folate deficiencies should be
considered in the approach to the psychiatric patient as its neu-
ropsychiatric manifestations are varied, can be severe, and may
constitute a potentially treatable cause of mental disorder. Our data
shows that folate and B12 deficiencies are significant in inpatients
and we believe it justifies routine screening at admission.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV349
The association between childhood
trauma and facial emotion
recognition in patients with stable
schizophrenia
J. Mrizak∗ rous , R. Trabelsi , A. Aissa , H. Ben Ammar ,
Z. El Hechmi
Razi Hospital, Psychiatry F, Mannouba, Tunisia
∗ Corresponding author.
Introduction The impairment of facial emotion recognition (FER)
among patients with schizophrenia (SCZ) is a significant feature of
the illness. Childhood trauma (CT) is reported with a high preva-
lence in SCZ and is considered one of its risk factors.
Objectives To investigate the relationship between FER and CT in
SCZ.
Methods Fifty-eight outpatients with stable SCZ completed the
Childhood Trauma Questionnaire retrospectively assessing five
types of childhood trauma (emotional, physical and sexual abuse,
and emotional and physical neglect). They also completed a newly
developed and validated FER task constructed from photographs
of the face of a famous Tunisian actress and evaluating the ability
to correctly identify Ekman’s six basic facial emotions (happiness,
sadness, anger, disgust, fear and surprise).
Results Patients with higher scores of CT performed significantly
worse in FER task. Our results suggest that the presence of sex-
ual abuse is specifically correlated to a poor identification of anger
(P = 0.02) and disgust (P = 0.03) while the presence of emotional
abuse and physical neglect are correlated to a poor identification
of happiness and sadness.
Conclusions CTmay represent one of the causes of the FER deficits
in schizophrenia. Further studies are necessary to confirm the link
between specific kinds of childhood trauma and deficits in the
recognition of discrete emotions.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.