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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S459

revascularization. Low-energy laser systems were used for revas-

cularization of distal intra cerebral branches. Postoperatively, the

patients underwent desagrigatory, anticoagulatory and vasodila-

tor therapy following advanced interventional radiology schemes.

Clinical evaluation of postoperative results was carried out using

the CDR.

Results

Good immediate angiographic outcome manifested in

the restoration of lumen and patency of the affected vessels as well

as in collateral revascularization was obtained in all cases:

– good clinical outcome (no dementia) was obtained in 6 (42.86%)

cases;

– satisfactory clinical outcome (dementia reduction) – in 8

(57.14%) cases;

– no negative effect was observed after the interventions.

Conclusions

The method of brain transcatheter laser revascular-

ization is an effective one in the treatment of atherosclerotic lesions

of brain’s white matter accompanied by the development of Bin-

swanger disease.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1331

EV347

Inconsistent decline of executive

functions in patients with early and

late Huntington’s disease

S. Mörkl

, C. Blesl , A. Tmava , W. Wurm , A. Holl , A. Painold

Medical University of Graz, Psychiatry, Graz, Austria

Corresponding author.

Background

Huntington’s disease (HD) is characterized by execu-

tive dysfunctions like problems with planning, accuracy, inhibition

and impulsivity. During the course of the disease executive function

worsens with ongoing pathological changes in the basal ganglia.

However, it is not clear whether cognitive dysfunction develops

gradually or not during the course of the disease.

Methods

We assessed the development of executive dysfunction

in 23 patients with early HD and 29 patients with late HD on the

Tower of London (ToL) for the number of solved problems, planning

time and number of breaks.

Results

HD patients showed a linear decrease of accuracy (as

assessed by number of solved problems) during the course of the

disease. Controls scored significantly higher than early stage HD

patients and early stage HD patients scored significantly higher

than late stage HD patients. In planning time and number of breaks

a non-linear decrease was found.

Conclusion

Executive dysfunctions inHD are not alone connected

to degenerative changes in the striatum as they do not develop

gradually and linear during the course of the disease. Obviously,

executive function could not be seen as a single component, but as

a combination of different abilities, which show a non-linear and

non-parallel decline.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1332

EV348

Neuropsychiatric manifestations of

vitamin B12 and folate deficiencies:

Data from an inpatient psychiatric

department

A. Mota

1 ,

, M. Lázaro

1

, R. Alves

1

, A. Moreira

2

, M. Nobre

1

1

Centro Hospitalar Psiquiátrico de Lisboa, Psychiatry, Lisbon,

Portugal

2

Hospital de Dona Estefânia, Pedopsychiatry, Lisboa, Portugal

Corresponding author.

Introduction

The prevalence of vitamin B12 and folate deficiency

is significant in the psychiatric population. These deficiencies may

be associated with varied neuropsychiatric signs and symptoms,

caused by different pathophysiological mechanisms.

Objectives

Characterize the main neuropsychiatric signs and

symptoms associated with vitamin B12 and folate deficiencies.

Evaluate the prevalence of these vitamins deficiencies in an acute

inpatient psychiatric department, dedicated to Affective Disorders.

Aims

To review the clinical significance of vitamin B12 and folate

deficiencies in psychiatric disorders and reflect on the importance

of routine screening in mental health care.

Material and methods

Observational, retrospective and descrip-

tive study, with analysis of clinical and blood tests data concerning

the total number of inpatient episodes in 2015. Non-systematic

review of the scientific literature.

Results

A small case series of the patients that had folate or B12

deficiency detected is presented. The prevalence of vitamin B12 and

folate deficiencies found in our study is in accordance with the data

found in the literature.

Conclusions

Vitamin B12 and folate deficiencies should be

considered in the approach to the psychiatric patient as its neu-

ropsychiatric manifestations are varied, can be severe, and may

constitute a potentially treatable cause of mental disorder. Our data

shows that folate and B12 deficiencies are significant in inpatients

and we believe it justifies routine screening at admission.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1333

EV349

The association between childhood

trauma and facial emotion

recognition in patients with stable

schizophrenia

J. Mrizak

, A. A

rous , R. Trabelsi , A. Aissa , H. Ben Ammar ,

Z. El Hechmi

Razi Hospital, Psychiatry F, Mannouba, Tunisia

Corresponding author.

Introduction

The impairment of facial emotion recognition (FER)

among patients with schizophrenia (SCZ) is a significant feature of

the illness. Childhood trauma (CT) is reported with a high preva-

lence in SCZ and is considered one of its risk factors.

Objectives

To investigate the relationship between FER and CT in

SCZ.

Methods

Fifty-eight outpatients with stable SCZ completed the

Childhood Trauma Questionnaire retrospectively assessing five

types of childhood trauma (emotional, physical and sexual abuse,

and emotional and physical neglect). They also completed a newly

developed and validated FER task constructed from photographs

of the face of a famous Tunisian actress and evaluating the ability

to correctly identify Ekman’s six basic facial emotions (happiness,

sadness, anger, disgust, fear and surprise).

Results

Patients with higher scores of CT performed significantly

worse in FER task. Our results suggest that the presence of sex-

ual abuse is specifically correlated to a poor identification of anger

(

P

= 0.02) and disgust (

P

= 0.03) while the presence of emotional

abuse and physical neglect are correlated to a poor identification

of happiness and sadness.

Conclusions

CTmay represent one of the causes of the FER deficits

in schizophrenia. Further studies are necessary to confirm the link

between specific kinds of childhood trauma and deficits in the

recognition of discrete emotions.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1334