Table of Contents Table of Contents
Previous Page  442 / 812 Next Page
Information
Show Menu
Previous Page 442 / 812 Next Page
Page Background

S438

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

involving them, their family or close friends (

2

(2,

n

= 100) = 19.8,

P

< 0.05).

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1264

EV280

Cognitive and functional outcomes

after a trial of an mTOR inhibitor in an

adolescent with neuropsychiatric

sequelae of TSC

A. Lachman

1 ,

, C. van de Merwe

2

, P. De Vries

3

1

Tygerberg, Psychiatry, Cape Town, South Africa

2

Stellenbosch University, Psychology, Cape Town, South Africa

3

University of Cape Town, Psychiatry, Cape Town, South Africa

Corresponding author.

Tuberous sclerosis complex (TSC) is a genetic autosomal dominant

condition with multi-organ involvement and highly variable clin-

ical manifestations. Neurological manifestations (subependymal

nodules, cortical tubers, and subependymal giant cell astrocytomas

[SEGAs]) are a leading cause of morbidity and mortality leading

to cognitive impairment, behavioural disturbances and refractory

seizure disorders. Experimental and human evidence suggest that

the use of mTOR inhibitors may induce regression of TSC tumor

types and provide an alternative to surgical resection of SEGA’s. In

the EXIST-1 trial everolimus (mTORi) was associated with clinically

meaningful increases in the time to progression of subependymal

giant cell astrocytomas and skin lesion response rate compared

with placebo. We present a case of a 16-year-old girl (MM) referred

withneuropsychiatric sequelae including disruptive anddangerous

behaviours not responding to outpatient management. Multiple

trials of anti-convulsants and antipsychotic treatments achieved

poor responses. During admission to a state facility, MMhad several

seizures followed by aggressive outbursts, inappropriate behaviour

and confusion. Her intrusiveness, sexual disinhibition and lack of

response inhibition suggested frontal lobe dysfunction impacting

on executive functioning. Despite seizure control being optimized

to an acceptable rate with anticonvulsants, improvement in social

or cognitive functioning was limited. She required individual con-

stant supervision for personal safety and independent functioning.

A trial of mTor inhibitor was initiated, and achieved an improve-

ment in cognitive, social and psychiatric functioning. This report

will discuss the challenges in this complex case, and report on

baseline as well as 6month post medication outcomes measured

by radiological, functional and cognitive testing.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1265

EV281

Clinical features of patients with

anorexia nervosa and necessity of

inpatient treatment

E. Lopes

1 ,

, R.G. Faria

1

, M. Araújo

2

, J. Guerra

2

, J. Saraiva

2

,

L. Confraria

2

1

Unidade Local de Saúde do Alto Minho, Departamento de

Psiquiatria e Saúde Mental, Viana do Castelo, Portugal

2

Centro Hospitalar do Porto, Departamento da Pedopsiquiatria e

Saúde Mental da Infância e Adolescência, Porto, Portugal

Corresponding author.

Introduction

Anorexia nervosa is a serious illness associatedwith

a chronic course and high mortality. Follow-up studies in this pop-

ulation showgreat variability in prognosis, and inpatient treatment

is frequently needed.

Objectives

This study aimed to examine association between dif-

ferent clinical variables of patients with anorexia nervosa and the

need of inpatient treatment, as a way to investigate possible pre-

dictors of severity of illness.

Methods

Descriptive, longitudinal, retrospective study of all

patients with a diagnosis of anorexia nervosa, with a first psychi-

atric appointment in a Child and Adolescent Psychiatry Department

at a major university hospital, between 2009 and 2013. Clinical

variables were compared based on the need of inpatient treatment

in the first year after initial psychiatric appointment. Clinical data

were collected from individual medical records. Statistic analysis

was performed using Statistical Package for the Social Sciences,

version 21.

Results

Eight-five patients with anorexia nervosa were evalu-

ated. In the first year after the initial psychiatric appointment,

47.1% of the sample received inpatient treatment. There were no

statistical significant differences between groups for any of the clin-

ical variables assessed: gender, age at onset of disease, body mass

index at first psychiatric appointment, duration of illness at first

psychiatric appointment, personal history of obesity, psychiatric

comorbid conditions and family history of an eating disorder.

Conclusions

No associations were found between the clinical

variables assessed and the treatment setting. Further investigation

is needed in order to identify other variables that may play a role

in the course of anorexia nervosa in adolescent patients.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1266

EV282

Study of behavioral disorders in

children born with infertility

treatments compared with children

born with natural methods, Kerman,

Iran, 2015

A. Mehdizadeh Zare Anari

1 ,

, F . I

ranmanesh

2 , V.

Habibzadeh

3

1

Kerman university of medical sciences, psychiatry, Kerman, Iran

2

Kerman university, psychology, Kerman, Iran

3

Kerman university of medical sciences, obstetrics and gynecology,

Kerman, Iran

Corresponding author.

Background

There are many causes of behavioral disorders in

children investigating the causes and efforts to reduce them are

useful for children.

Methods

This causal-comparative research is cross-sectional

study among of the children born with assisted reproductive tech-

nology and natural fertility methods in the Afzalipour hospital in

Kerman city. A sample of 30 children were born with assisted

reproductive technology and 30 children were born with natural

methods of fertility chooses randomly and two groups matched on

the basis age, sex, education, father’s occupation, and family mem-

bers. For two groups completed Czech list revision Quay-Peterson

and Data were analyzed by SPSS software version 16.

Findings

The results showed that differentiation between behav-

ioral disorders (0.002) and its components, including attention-

immaturity (0.008) and anxiety-recluse (0.000) in two groups were

significant (increased in children born with infertility treatments),

but between the elements of aggression (0.911) and conduct dis-

order (0.066) were not a significant difference.

Conclusion

This study showed that the kind of fertilization effec-

tive on behavioral disorders in children.

Keywords

Behavioral disorders; Fertility; Infertility; Assisted

reproductive techniques

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1267