European Psychiatry - Volume 33 - March 2016

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S444 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
were assessed using the K-SADS and very few of them meet the
criteria for at least one psychiatric disorder. Biomedical variables
were associated in the expected direction to children’s SDQ scores
such as birth weight, head circumference and Apgar scores.
Conclusion To conclude, being born with very low birth weight
seems to be related to the emotional and behavioral functioning
that these children appear to show between 10 and 15 years later.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV300
School refusal: Idiom of distress
and/or Babel tower?
J. Sibeoni ∗, A. Moscoso , A. Revah-Levy
Hospital de D. Estefânia Department of Child and Adolescent
Psychiatry, Rua Jacinta Marto, Lisbon, Portugal
∗ Corresponding author.
Across Europe, school absenteeism is an increasing problem on the
crossroad between educational and public-health political matters.
This issue underlies socio-economical, sociological and school-
related factors as much as it questions individual psychopathology
and family functioning. Indeed, school refusal behavior among ado-
lescents has become a very frequent reason to seek for psychiatric
consultations. A recent review about this topic has shown that
around 90% of these adolescents met the criteria for a psychi-
atric diagnosis, mostly anxiety disorders It appears to be a
very complex and heterogeneous phenomenon which raises many
questions, to date still unsolved: terminology confusions (tru-
ancy, school phobia, school refusal), lack of a concise definition,
contradictory hypothesis regarding etiology, psychopathology and
treatment plan depending on the paradigm the authors would refer
to. In this presentation, we will elicit why school refusal can be
considered as a new idiom of distress for adolescents in west-
ern societies, and we will show how, in clinical practice, these
situations can become a genuine Babel tower in which no one,
among health-care professionals, teachers, parents and patients,
are speaking the same language.
Keywords School refusal; School phobia; Truancy; Adolescents;
Idiom of distress
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Reference
[1] Ek, Eriksson. Psychological factors behind truancy, school pho-
bia, and school refusal: a literature study. Child Family Behav
Ther 2013;35(3):228–48.
EV301
Psychological responses to traumas of
children younger than 6 years old
diagnosed with posttraumatic stress
disorder
M. Stankovic ∗ Grbesa Simonovic ostic Ilic
1 Clinic for Mental Health Protection, Child Psychiatry, Nis, Serbia
2 Medical Faculty- University of Nis-Serbia, Psychiatry, Nis, Serbia
∗ Corresponding author.
Introduction Criterion A2 causes many controversies in the diag-
nostic process of posttraumatic stress disorder (PTSD) among
young children. Depending on the manner in which the trauma is
indirectly experienced, clinical picture of disorder could be formed
by different groups of symptoms. Profiles of symptoms groups are
dependent of children ability to speak, describe or of play observa-
tion by expert.
Methods The study included 8 children younger than 6with PTSD
diagnosis. Children were observed in a routine clinical practice.
Results Examinees under the age of six, whose can describe trau-
matic event, produce symptoms that represent compaction of a
traumatic event, associated with fantasies and meanings related to
previous traumatic experiences. Reexperiencing symptoms asso-
ciated with A2 criterion (intrusive thoughts, images, scenes of the
traumatic event, recurring nightmares with oneiric sequences of
the accident) were rare. Avoidance and inhibited reactions were
attributable.
Discussion Manners in which children younger than 6 experi-
enced the trauma shows a large range from florid symptoms stated
by the existing accepted classification. The results point out possi-
ble multifactorial cause of PTSD etiology.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV302
Side effects of a psychiatry drug:
Effect of phenytoin and aging on
regulation of 3 enzymes of gingival
fibroblasts in pediatrics and adults
V. Surena
Tehran, Iran
Introduction Epidemiologic data has shown that gingival over-
growth as a side effect of phenytoin, one of the major drugs against
Epilepsy is more common in pediatrics than in adults. The alter-
ation of cytokine balance is suggested to exert greater influence on
gingival overgrowth compared to the direct effect of drug on the
regulation of extracellular matrix metabolism or proliferation of
gingival over growth.
Purpose Current study was performed to evaluate the phenytoin
effect on the regulation of collagen, lysyl oxidase and elastin in the
gingival fibroblasts in pediatrics and adults.
Methods andmaterials Normal human gingival fibroblasts (HGFs)
were obtained from 4 healthy children and 4 adults. Samples were
cultured with phenytoin. MTT test was used to evaluate the pro-
liferation and ELISA was performed to determine the level of IL1
and PGE2 production by HGFs. Total RNA of gingival fibroblasts was
extracted and RT-PCR was performed on samples. The analysis of
proliferation was assessed by independent ANOVA; Kruskal-Wallis
was used to assess the production of mediators with an alpha error
level less than 0.05.
Results There was significant difference in the expression of
elastin between the controls and treated samples in both adult and
pediatric groups and also in the lysyl-oxidase expression of adult
controls and treated adult. No significant difference was found
between the collagen expressions in adults.
Conclusion The only significant difference was in the elastin and
lysyl oxidase expression between adult and pediatric samples indi-
cating the significant effect of age in their production of both control
and experimental groups.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV303
Advantages of telepsychiatry in child
and adolescent mental health
R. Szeftel ∗, L. Piacentini , C. Pataki
1 David Geffen School of Medicine at UCLA, Psychiatry &
Biobehavioral Science, Los Angeles-California, USA
2 Department of Mental Health, Psychiatry, Los Angeles-California,
USA