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S444

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

were assessed using the K-SADS and very few of them meet the

criteria for at least one psychiatric disorder. Biomedical variables

were associated in the expected direction to children’s SDQ scores

such as birth weight, head circumference and Apgar scores.

Conclusion

To conclude, being born with very low birth weight

seems to be related to the emotional and behavioral functioning

that these children appear to show between 10 and 15 years later.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1284

EV300

School refusal: Idiom of distress

and/or Babel tower?

J. Sibeoni

, A. Moscoso , A. Revah-Levy

Hospital de D. Estefânia Department of Child and Adolescent

Psychiatry, Rua Jacinta Marto, Lisbon, Portugal

Corresponding author.

Across Europe, school absenteeism is an increasing problem on the

crossroad between educational and public-health political matters.

This issue underlies socio-economical, sociological and school-

related factors as much as it questions individual psychopathology

and family functioning. Indeed, school refusal behavior among ado-

lescents has become a very frequent reason to seek for psychiatric

consultations. A recent review about this topic has shown that

around 90% of these adolescents met the criteria for a psychi-

atric diagnosis, mostly anxiety disorders

[1] .

It appears to be a

very complex and heterogeneous phenomenon which raises many

questions, to date still unsolved: terminology confusions (tru-

ancy, school phobia, school refusal), lack of a concise definition,

contradictory hypothesis regarding etiology, psychopathology and

treatment plan depending on the paradigm the authors would refer

to. In this presentation, we will elicit why school refusal can be

considered as a new idiom of distress for adolescents in west-

ern societies, and we will show how, in clinical practice, these

situations can become a genuine Babel tower in which no one,

among health-care professionals, teachers, parents and patients,

are speaking the same language.

Keywords

School refusal; School phobia; Truancy; Adolescents;

Idiom of distress

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

Reference

[1] Ek, Eriksson. Psychological factors behind truancy, school pho-

bia, and school refusal: a literature study. Child Family Behav

Ther 2013;35(3):228–48.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1285

EV301

Psychological responses to traumas of

children younger than 6 years old

diagnosed with posttraumatic stress

disorder

M. Stankovic

1 ,

, G .

Grbesa

2 , M.

Simonovic

2 , J. K

ostic

1 , N.

Ilic

1

1

Clinic for Mental Health Protection, Child Psychiatry, Nis, Serbia

2

Medical Faculty- University of Nis-Serbia, Psychiatry, Nis, Serbia

Corresponding author.

Introduction

Criterion A2 causes many controversies in the diag-

nostic process of posttraumatic stress disorder (PTSD) among

young children. Depending on the manner in which the trauma is

indirectly experienced, clinical picture of disorder could be formed

by different groups of symptoms. Profiles of symptoms groups are

dependent of children ability to speak, describe or of play observa-

tion by expert.

Methods

The study included 8 children younger than 6with PTSD

diagnosis. Children were observed in a routine clinical practice.

Results

Examinees under the age of six, whose can describe trau-

matic event, produce symptoms that represent compaction of a

traumatic event, associated with fantasies and meanings related to

previous traumatic experiences. Reexperiencing symptoms asso-

ciated with A2 criterion (intrusive thoughts, images, scenes of the

traumatic event, recurring nightmares with oneiric sequences of

the accident) were rare. Avoidance and inhibited reactions were

attributable.

Discussion

Manners in which children younger than 6 experi-

enced the trauma shows a large range from florid symptoms stated

by the existing accepted classification. The results point out possi-

ble multifactorial cause of PTSD etiology.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1286

EV302

Side effects of a psychiatry drug:

Effect of phenytoin and aging on

regulation of 3 enzymes of gingival

fibroblasts in pediatrics and adults

V. Surena

Tehran, Iran

Introduction

Epidemiologic data has shown that gingival over-

growth as a side effect of phenytoin, one of the major drugs against

Epilepsy is more common in pediatrics than in adults. The alter-

ation of cytokine balance is suggested to exert greater influence on

gingival overgrowth compared to the direct effect of drug on the

regulation of extracellular matrix metabolism or proliferation of

gingival over growth.

Purpose

Current study was performed to evaluate the phenytoin

effect on the regulation of collagen, lysyl oxidase and elastin in the

gingival fibroblasts in pediatrics and adults.

Methods andmaterials

Normal human gingival fibroblasts (HGFs)

were obtained from 4 healthy children and 4 adults. Samples were

cultured with phenytoin. MTT test was used to evaluate the pro-

liferation and ELISA was performed to determine the level of IL1

and PGE2 production by HGFs. Total RNA of gingival fibroblasts was

extracted and RT-PCR was performed on samples. The analysis of

proliferation was assessed by independent ANOVA; Kruskal-Wallis

was used to assess the production of mediators with an alpha error

level less than 0.05.

Results

There was significant difference in the expression of

elastin between the controls and treated samples in both adult and

pediatric groups and also in the lysyl-oxidase expression of adult

controls and treated adult. No significant difference was found

between the collagen expressions in adults.

Conclusion

The only significant difference was in the elastin and

lysyl oxidase expression between adult and pediatric samples indi-

cating the significant effect of age in their production of both control

and experimental groups.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1287

EV303

Advantages of telepsychiatry in child

and adolescent mental health

R. Szeftel

1 , 2 ,

, L. Piacentini

3

, C. Pataki

1 , 4

1

David Geffen School of Medicine at UCLA, Psychiatry &

Biobehavioral Science, Los Angeles-California, USA

2

Department of Mental Health, Psychiatry, Los Angeles-California,

USA