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S446

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

in Karachi and to enable the sample population, to become emo-

tionally competent.

Aim

The aim is to evaluate the effectiveness of STAMP on the

reduction of symptoms in the sample population.

Method

Ten children with high functioning autism spectrum

disorder will be selected from various institutes in Karachi, and

randomized to experimental and waitlist control group after pre-

intervention assessment. Upon completion of the interventionwith

the experimental group, the waitlist control group will be offered

the intervention. Both the groups will be assessed, immediately

after the intervention, followed by a one-month follow up assess-

ment.

Results

It is expected that STAMP will significantly reduce the

incidence of problem behaviours as measured by the standardized

assessment questionnaires fromthemanual; aswell as significantly

reduce the severity of scores on the internalizing and externalizing

components of the strength and difficulties questionnaire, in the

experimental group as compared to the control group.

Conclusion

It is expected that the results of the present study

could be utilized to train mental health professionals in Karachi for

systematized treatment of ASD and related problems.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1290

EV306

Temperament and resilience of

children of alcohol dependent

individuals

C. Thanikachalam

1 ,

, A. Dhandapani

2

, S. Choudhury

1

,

A. Sankaran

1

, E. Subramaniam

1

1

Mahatma Gandhi Medical College and Research Institute,

Psychiatry, Pondicherry, India

2

National Institute of Mental Health and Neurosciences, Psychiatry,

Bangalore, India

Corresponding author.

Introduction

Children of alcohol dependent individuals are

affected by disturbed parent-child relationship and exhibit

externalizing symptoms, arrhythmicity, negative mood and low

persistence.

Objectives

To assess the temperament and resilience of children

of alcohol dependent individuals and to study their relationship

with the father’s severity and problems of alcohol intake.

Aims

To assess the psychological profile of children of alcohol

dependent individuals.

Methods

Cross-sectional study conducted in a tertiary care cen-

tre from January to August 2015. Severity of alcohol dependence in

father and problems related to it was assessed using ‘short alco-

hol dependence data’ and ‘alcohol problems questionnaire’; the

temperament and resilience of their children (

n

= 31) was assessed

using ‘temperament measurement schedule’ and ‘strengths and

difficulties questionnaire’ respectively.

Results

The sample comprised of 48% boys and 52% girls with

mean age (SD) of 9.32 (3.02) years. Eighty-one percent belonged

to lower socioeconomic status. Their fathers’ mean age (SD) was

37.13(4.9) years and duration of alcohol dependence being 16.32

(5.7) years, average use/day being 19.19 (14.9) units with mod-

erate (45.2%) to high (41.9%) dependence. Significant association

was observed between severity of alcohol dependence and tem-

peramental domain-threshold of responsiveness (

2

= 17.272,

P

value = 0.002)

( Table 1 ).

The average units of alcohol consumed/day

were a significant predictor for the presence of emotional problems

in the child (OR = 30.12; 95%CI 1.33–677.86).

Conclusion

There’s a significant association between father’s

alcohol use and child’s psychopathology which indicates the need

for preventive and curative mental health measures.

Table 1

Significant correlation between alcohol problems in father

and child’s temperament and resilience (*

P

< 0.05).

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1291

EV307

Managing an effective treatment for

catatonia and Cotard syndrome in an

adolescent with comorbidities and

CYP2D6 polymorphism

S. Turan

, B. Ay , B. Güller , B. Serim , S. Miral , Ö. Gencer Kidak

Dokuz Eylül Medicine Faculty, Child and Adolescent Psychiatry, Izmir,

Turkey

Corresponding author.

We describe a patient with catatonia and symptoms of psy-

chosis who developed neuroleptic malignant syndrome after using

risperidone, olanzapin and clozapin, thus requiring life support

equipment and Dantrolene, Bromocriptin, later recovering after

five days. From a psychiatric and neurological point of view, how-

ever, the persistence of catatonic syndrome and Cotard syndrome

delusions was observed, based on assertions such as ‘I don’t have

an arm’ (ideas of defalcation), ‘They killed me’, ‘My body’s getting

melt’ and statements about the patient being responsible for the

‘death of the whole family’ (ideas of guilty). Brain MRI shows that

a venous angioma has been in right frontal lobe. Also echocardio-

graphic findings were associated with history of myocarditis. Both

venous angioma and myocarditis sequel seemed to be relative con-

traindication for electroconvulsive therapy according to literature.

In addition; genotyping revealed that he was heterozygosis for a

CYP2D6*4 wild type allele. The patient responded well to ECT after

13 sessions and with ketiapin 1200mg/day medication. The case

highlights the importance of therapeutic drug monitoring in iden-

tification and differentiation of drug induced effects in psychiatric

disorder to NMS recurrence and also managing an effective treat-

ment for catatonia and Cotard syndrome.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1292

EV308

Potential neurobiological ADHD

biomarkers

M. Uzbekov

, E. Misionzhnik

Moscow Research Institute of Psychiatry, Brain Pathology, Moscow,

Russia

Corresponding author.

Objectives

Pathogenetic mechanisms of hyperkinetic syndrome

(HKS) or attention deficit hyperactivity disorder (ADHD) are not

clear.

Aim

To elucidate some aspects of monoamine involvement in

pathogenesis of disorder and response of monoaminergic systems

to psychostimulant medication.