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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S447

Methods

Levels of different monoamines, their metabolites and

N-methylnicotinamide (end product of kynurenine pathway) were

measured in daily samples of urine from children (7–11 years old)

with mild and severe HKS using fluorimetric and chromatographic

methods as well as platelet monoamine oxidase (MAO) activity.

Thirty childrenwithmildHKS received psychostimulant Sydnocarb

5–15mg daily for 1–1.5 months (for ethical reasons children with

severe HKS were not included in study).

Results

HKS was accompanied by activation of dopaminergic and

inhibition of noradrenergic systems. There were found metabolic

differences between two forms of HKS. Compared with mild HKS,

severe HKS was characterized by significant 2-fold increase of MAO

activity and L-dopa, dopamine and adrenaline excretion. After syd-

nocarb treatment children’s clinical status improved along with

decrease of excretion of homovanillic, vanillylmandelic and 5-

hydroxyindoleacetic acids and increase of N-methylnicotinamide.

Conclusions

Results indicate that dopaminergic and nora-

drenergic systems play important role in pathogenesis of

HKS. Clinical improvement of HKS children was accompa-

nied by significant increase of N-methylnicotinamide excretion.

It is proposed that increased urine excretion of kynurenine

metabolite–N-methylnicotinamide and N-methylnicotinamide/5-

hydroxyindoleacetic acid ratio can serve as potential biomarkers for

evaluation of efficacy of psychostimulant medication. We hypoth-

esize that kynurenine system plays significant role in pathogenesis

of HKS/ADHD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1293

EV309

Neuroanatomical basis of emotional

dysregulation in children and adults

with ADHD

R. Vela

Massachusetts General Hospital, Psychiatry, Chelsea MA, USA

Introduction

Since the advent of DSM III, emotional dysregula-

tion has been relegated to “associated features” of ADHD. However,

research has shown that 25% to 40% of children and 30% to 70% of

adults with ADHD have emotional dysregulation. Deficient emo-

tional dysregulation is an important cause of disability, and poor

clinical course.

Objectives

At the end of this presentation, the participants will

be able to:

– discuss the prevalence, disability and clinical/behavioral man-

ifestations of emotional dysregulation in ADHD as a dimensional

trait;

– discuss themajor brain functions of the hypothalamus, amygdala,

ventral striatum, cingulate gyrus, anterior insula and orbitofrontal

cortex, and how these may explain emotional dysregulation in

ADHD.

Aims

The aim of this presentation is to elucidate the rela-

tionship between clinical manifestations of deficient emotional

self-regulation in ADHD and the neuroanatomical structures and

neurocircuitry involved in emotional regulation.

Methods

This presentation will selectively review specific

research findings of functional imaging ADHD studies and ana-

lyze them in the context of emotional regulation exerted by the

interrelationships between the amygdala, ventral striatum, medial

prefrontal cortex, orbitofrontal cortex and anterior insula.

Results

Bottom-up neuroanatomical mechanisms involve the

detection of hypothalamic and amygdalar firing, signaling higher

cortical structures that control is needed. Top-down regulatory

processes in ADHD subjects fail in the allocation of attention to

emotional stimuli and reward valuation necessary to maintain

focus on a goal.

Conclusions

Further research is needed to continue elucidating

the anatomical structures and functional connectivity underlying

deficient emotional self-regulation in ADHD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1294

EV310

Understanding of self-harm

behaviour in adolescents

L. Santri

c 1 , A.

Razic Pavicic

2 , A.

Vuk

3 ,

, A . T

omac

1

1

Clinic for Psychological Medicine-University Hospital Center Zagreb,

Child and adolescent psychiatry, Zagreb, Croatia

2

Clinic for Psychological Medicine-University Hospital Center Zagreb,

Adult psychiatry, Zagreb, Croatia

3

Psychiatric Hospital ‘Sveti Ivan’, Adult psychiatry, Zagreb, Croatia

Corresponding author.

Introduction

The incidence and prevalence of self-harm

behaviour, with or without suicidal intent, is on the rise, both in

other countries as well as in Croatia. Understanding the nature

of patients who show self-harm behaviour can help us to better

understand the components that contribute to their morbidity and

mortality.

Objectives

To expand the understanding of self-harm behaviour

in adolescents as a contribution to the planning and implementa-

tion of preventive and curative programs.

Aims

To explore the psychopathological characteristics of

adolescents with and without self-harm behaviour who seek psy-

chiatric help for their mental health problems.

Methods

In this study participated 150 adolescents, aged 14–18

years, of which 52% showed some form of self-harm behaviour.

During the initial examination of child and adolescent psychiatrist,

participants completed self-reported questionnaires: functional

assessment of self-mutilation (FASM, 1997) and the youth self

report (YSR, 2001).

Results

Statistically significant difference between groups of

female adolescents with and without self-harm behaviour was

observed in all of eight problem scales, while in male adolescents

it was observed in five of them. This indicates considerably higher

level of psychopathological features in the group of patients with

self-harm behaviour.

Conclusions

It is necessary to intensify monitoring of adoles-

cents who show self-harm behaviour because of the overall level

of psychopathological symptoms and the comorbidity which sig-

nificantly complicates the therapeutic process. It is particularly

important to continuously assess the suicide risk.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1295

EV311

Resilience in children of depressed

parents – a systematic review of

protective factors

O. Wlodarczyk

, A. S

chramm , F. Metzner , S. Pawils

University Medical Center Hamburg-Eppendorf, Department of

Medical Psychology, Hamburg, Germany

Corresponding author.

Introduction

Children of depressed parents have an increased

risk of developing mental disorders. While there are various stud-

ies concerning a pathogenetic perspective, fewer studies examined

factors that protect mental health of these children. Knowl-

edge about protective factors is necessary to establish prevention

projects.