European Psychiatry - Volume 33 - March 2016

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S292 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
Results Erythrocyte GPx activity was significantly lower in
patients with schizophrenia than in controls. Male patients had
significantly lower GPx activity in comparison with those in
female ones. Heredity negative patients showed significantly lower
enzyme activity compared to control values. Significantly lower
GPx activitywas obtained independently of the onset of the disease.
The patient group having more than one psychotic episode also
showed significantly lower GPx activity compared to the control
group. The disease duration of more than 1 year caused a signifi-
cant decrease in enzyme activity. There was a significant difference
in GPx activity between patients with different PANSS scores. In
patients treatedwith second generation antipsychotics and in those
treated with both first and second generation antipsychotics, GPx
activity was significantly lower than in controls.
Conclusion This study shows that the low erythrocyte GPx activ-
ity in schizophrenics depends on patient gender, the number of
episodes, disease duration and drug treatment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW508
Exploration of the link between
clinical judgments and subjective
perceptions of clinical change in
patients treated for schizophrenia
S. Egger ∗, S. Vetter , S. Prinz , G. Weniger , M. Müller
University hospital for psychiatry, ZIP- Rheinau, Zurich, Switzerland
∗ Corresponding author.
Introduction Subjective perceptions of clinical change in patients
with schizophrenia are often not congruent to the objective evi-
dence of the same, especially since a lack of insight is part of
the symptomatology. However, the exploration of the relationship
between clinical judgments from mental health experts and the
patients’ perception of symptom change is fairly understudied.
Aims and objectives This study aimed to investigate the perfor-
mance of the Positive and Negative Syndrome Scale (PANSS) as a
tool for clinical outcome monitoring in schizophrenia in concord-
ance with the change of self-reported psychopathology assessed
with the Frankfurt Complaint Questionnaire (FCQ) in patients with
a schizophrenia.
Methods A consecutive sample of patients admitted to a Swiss
psychiatric hospital for schizophrenia was assessed with the FCQ
at admission and discharge. The PANSSwas rated by the responsible
clinicians at admission and discharge. Complete data of admission
and discharge were available from approximately 60 cases. Reli-
able change index (RCI) was calculated to determine a clinically
meaningful change based on the PANSS scores. Logistic regression
models were conducted to explore the link between RCI levels and
the change of self-reported perceptions of psychopathology.
Results and xonclusions Our study found no relationship between
the change of PANSS and FCQ from admission to discharge in a
sample of patients treated for schizophrenia. Therefore, our find-
ings provide evidence for a large discrepancy between the observed
clinical severity and the subjective perception of symptoms in indi-
viduals with schizophrenia.
Keywords Positive and Negative Syndrome Scale; Frankfurt
Complain Questionnaire; Schizophrenia; Outcome monitoring;
Subjective perception
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW509
Ethnic difference in medication
adherence and compounding factors
in treatment of early stages of
psychotic disorders
T. Elanjithara ∗, T. Winton-Brown
1 Durham, United Kingdom
2 Kings College London, Psychosis Studies, London, United Kingdom
∗ Corresponding author.
Introduction Studies shown ethnic difference in illness-
awareness, medication acceptance, difference in types and doses
of medication prescribed in certain ethnic groups in treatment of
psychosis.
Objectives To study antipsychotic adherence patterns in ethnic
groups and to study factors influencing.
Aims To analyse any difference in the adherence patterns
between ethnic groups and identify factors mediating any effects.
Methods One hundred and twenty-seven consecutive patients
presenting to early-intervention service in South-London included
in naturalistic study. Sample binarised into Caucasian (white
British, other white background, n = 36, 28%) and combined Black
and Minority Ethnic (BME, n = 91, 72%) groups. Medication adher-
ence studied using self and carer reports, looking for percentage of
times taking medications, any gaps in treatment (atleast 1 month).
Range of demographic and clinical parameters collected including
use of substances and medications side-effects.
Results Patients with treatment gap (atleast 1 month) had simi-
lar demographic and clinical characteristics with the rest, except
the former were more likely to have reported extra-pyramidal
(EPSE) (Pearson 2 = 5.6, df = 1, P = 0.02), and to be BME rather
than Caucasian (BME n = 57, 64%, Caucasian n = 16. 44%, Pearson
2 = 4.5, df = 1, P = 0.05). These variables were further entered in
stepped multivariate regression, only the effect of EPSE remained
significant, with odds ratio 8, P = 0.05. There was no difference in
Chlorpromazine equivalent dose between ethnic groups (Caucasian
mean-dose 156 mg, BME 138 mg, t = 1.2, P = 0.2). Also there was no
significant difference in types of antipsychotics prescribed ( 2 = 4,
P = 0.1, df = 2) between the ethnic groups.
Conclusions Ethnic difference in antipsychotic adherence may
also be influenced by sensitivity to certain side effects.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW510
Anti-DNA antibodies in the blood of
patients with schizophrenia possess
DNA-hydrolyzing activity
E. Ermakov ∗, L. Smirnova , L. Sinyanskii , D. Dobrygina ,
A. Semke , G. Nevinsky , V. Buneva , S. Ivanova
1 Mental health research institute, laboratory of molecular genetics
and biochemistry, Tomsk, Russia
2 Siberian state medical universitu, department of neurology and
neurosurgery, Tomsk, Russia
3 Mental health research institute, department endogenous disorders,
Tomsk, Russia
4 Institute of chemical biology and fundamental medicine, laboratory
repair enzymes, Novosibirsk, Russia
∗ Corresponding author.
Introduction Autoantibodies (Abs) to different neuronal recep-
tors and DNA were detected in the blood of patients with