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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S289

ToM abilities and the symptoms or the neuropsychological evalu-

ation.

Conclusions

Thus, the interactive task we used appears to be an

original option for studying ToM ability in schizophrenia since it is

close to what happens in real-life interactions.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.616

EW499

A multicentric study on cognitive

functions in a large sample of patients

with schizophrenia and their

unaffected first-degree relatives

M. Chieffi

1 ,

, A. Mucci

1

, A. Rossi

2

, P. Rocca

3

, A. Bertolino

4

,

S. Galderisi

1

, M. Maj

1

1

University of Naples SUN, psychiatry, Naples, Italy

2

University of L’Aquila, department of biotechnological and applied

clinical sciences - section of psychiatry, L’Aquila, Italy

3

University of Turin, department of neuroscience - section of

psychiatry, Turin, Italy

4

University of Bari, department of neurological and psychiatric

sciences, Bari, Italy

Corresponding author.

Introduction

Neurocognition may represent an indicator of

genetic risk and poor outcome in schizophrenia patients (SCZ) pre-

dicting real life functioning.

Objectives

As cognitive performance of unaffected first-degree

relatives (UR) is intermediate between SCZ and healthy controls

(HC), neurocognitive impairment may represent a marker of vul-

nerability to schizophrenia.

Aims

To investigate social and neurocognition in all subjects and

their impact on functional capacity of patients as markers of vul-

nerability.

Methods

Sample: 922 SCZ, 379 UR and 780 HC. Assessment:

MATRICS Consensus Cognitive Battery (neurocognition), Facial

Emotion Identification Test and Awareness of Social Inference Test

(social cognition) and Specific Level of Functioning Scale (social

functioning). Analyses: Structural Equation Model (SEM) analyses

to model the impact of all variables on functional outcome.

Results

SCZ scored worse in all domains than UR and HC. UR had

significant impairments in all cognitive domainswith respect toHC.

Cognitive functioning had direct and indirect impacts on functional

outcome mainly through social cognition and functional capacity.

Social cognition had a direct impact on outcome, independent of

neurocognition.

Conclusion

SCZ and UR display similar patterns of social and

neurocognition deficits. Our results confirma strong impact of neu-

rocogniton on functional outcome. Social cognition has become an

interesting object of study and its conceptualization as trait vari-

able and the existence of a continuum between SCZ and UR are

hypotheses for further research.

Acknowledgements

The study was carried out within the project

“Multicenter study on factors influencing real-life social function-

ing of people with a diagnosis of schizophrenia” of the Italian

Network for Research on Psychoses.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.617

EW500

Validation of the remission criteria in

a Chinese population with chronic

schizophrenia

Y.H. Chou

Taipei Veterans general hospital, psychiatry, Taipei, Taiwan

Background

A consensus definition of symptomatic remission in

schizophrenia was recently established based on a fixed thresh-

old for symptom severity and a time component. The objective of

this study was to determine the clinical relevance of this definition

in a Chinese population and find the predictors of symptomatic

remission, functional outcome and cognition.

Methods

Seventy-five schizophrenic patients were recruited

within a period of 2 years. All patients need to prospectively be fol-

lowed up in an outpatient clinic for at least 6 months. During this

period, it was not allowed to adjust their medications. Three differ-

ent definitions of symptomatic remission included the Remission

in Schizophrenia Working Group (RSWG), clinical global impres-

sion (CGI) and brief psychiatric rating scale (BPRS) was evaluated.

In addition, the function and cognition was assessed as the mea-

sured outcomes. The prediction model of outcomes measurement

was used for statistic analysis.

Results

The cumulative percentage of achieving remission crite-

ria among three different definitions of symptomatic remissionwas

52% in RSWG criteria, 63% in CGI and 65% in BPRS, respectively.

In comparison of remitted and non-remitted groups, there were

significant differences in sex, education, function and cognition in

terms of RSWG definition but not in CGI and BPRS. Female gender

and education were two factors for predicting symptomatic remis-

sion and function, whereas body mass index and education were

two factors for prediction of better cognition.

Conclusions

Our study indicates that the definition of RSWG was

more clinical relevant compared with CGI and BPRS in Chinese

schizophrenia.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.618

EW501

Association between implicit motor

learning and neurological soft signs in

schizophrenia

A. Chrobak

1 ,

, K . S

iuda-Krzywicka

2 , G.

Siwek

1 , A.

Tereszko

1 ,

M. Siwek

3 , D.

Dudek

3

1

Jagiellonian university medical college, faculty of medicine, Cracow,

Poland

2

École des neurosciences à Paris, Paris, France

3

Jagiellonian university medical college, department of affective

disorders, Cracow, Poland

Corresponding author.

Introduction

Schizophrenia (SZ) patients present subtle motor

deficits known as Neurological Soft Signs (NSS). Those deficits

encompass impairments of motor coordination, sequencing of

complex motor acts and sensory integration. It has been shown

that SZ patients present also deficits of higher motor functions

as implicit motor learning. Growing number of studies indicate

that both NSS and implicit motor learning deficits are associated

with impairments of common cortico-cerebellar pathways, how-

ever relationship between these two deficits has not been evaluated

yet.

Objectives

To assess NSS and implicit motor learning in SZ

patients.

Aims

To evaluate associations between NSS and implicit motor

learning scores in SZ patients.

Methods

Twenty schizophrenia patients and 20 healthy controls

were examined. Patients were under olanzapine, clozapine or que-

tiapine treatment. NSS were assessed with Neurological Evaluation

Scale (NES). Implicit motor learning were assessed with a use of

Serial Reaction Time Task.

Results

SZ patients presented statistically higher NSS scores than

healthy controls (

P

< 0.001) and presented no signs of implicit

motor learning. There was statistically significant negative corre-

lation between implicit motor learning score and total score of