European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S289
ToM abilities and the symptoms or the neuropsychological evalu-
ation.
Conclusions Thus, the interactive task we used appears to be an
original option for studying ToM ability in schizophrenia since it is
close to what happens in real-life interactions.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW499
A multicentric study on cognitive
functions in a large sample of patients
with schizophrenia and their
unaffected first-degree relatives
M. Chieffi ∗, A. Mucci , A. Rossi , P. Rocca , A. Bertolino ,
S. Galderisi , M. Maj
1 University of Naples SUN, psychiatry, Naples, Italy
2 University of L’Aquila, department of biotechnological and applied
clinical sciences - section of psychiatry, L’Aquila, Italy
3 University of Turin, department of neuroscience - section of
psychiatry, Turin, Italy
4 University of Bari, department of neurological and psychiatric
sciences, Bari, Italy
∗ Corresponding author.
Introduction Neurocognition may represent an indicator of
genetic risk and poor outcome in schizophrenia patients (SCZ) pre-
dicting real life functioning.
Objectives As cognitive performance of unaffected first-degree
relatives (UR) is intermediate between SCZ and healthy controls
(HC), neurocognitive impairment may represent a marker of vul-
nerability to schizophrenia.
Aims To investigate social and neurocognition in all subjects and
their impact on functional capacity of patients as markers of vul-
nerability.
Methods Sample: 922 SCZ, 379 UR and 780 HC. Assessment:
MATRICS Consensus Cognitive Battery (neurocognition), Facial
Emotion Identification Test and Awareness of Social Inference Test
(social cognition) and Specific Level of Functioning Scale (social
functioning). Analyses: Structural Equation Model (SEM) analyses
to model the impact of all variables on functional outcome.
Results SCZ scored worse in all domains than UR and HC. UR had
significant impairments in all cognitive domainswith respect toHC.
Cognitive functioning had direct and indirect impacts on functional
outcome mainly through social cognition and functional capacity.
Social cognition had a direct impact on outcome, independent of
neurocognition.
Conclusion SCZ and UR display similar patterns of social and
neurocognition deficits. Our results confirma strong impact of neu-
rocogniton on functional outcome. Social cognition has become an
interesting object of study and its conceptualization as trait vari-
able and the existence of a continuum between SCZ and UR are
hypotheses for further research.
Acknowledgements The study was carried out within the project
“Multicenter study on factors influencing real-life social function-
ing of people with a diagnosis of schizophrenia” of the Italian
Network for Research on Psychoses.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW500
Validation of the remission criteria in
a Chinese population with chronic
schizophrenia
Y.H. Chou
Taipei Veterans general hospital, psychiatry, Taipei, Taiwan
Background A consensus definition of symptomatic remission in
schizophrenia was recently established based on a fixed thresh-
old for symptom severity and a time component. The objective of
this study was to determine the clinical relevance of this definition
in a Chinese population and find the predictors of symptomatic
remission, functional outcome and cognition.
Methods Seventy-five schizophrenic patients were recruited
within a period of 2 years. All patients need to prospectively be fol-
lowed up in an outpatient clinic for at least 6 months. During this
period, it was not allowed to adjust their medications. Three differ-
ent definitions of symptomatic remission included the Remission
in Schizophrenia Working Group (RSWG), clinical global impres-
sion (CGI) and brief psychiatric rating scale (BPRS) was evaluated.
In addition, the function and cognition was assessed as the mea-
sured outcomes. The prediction model of outcomes measurement
was used for statistic analysis.
Results The cumulative percentage of achieving remission crite-
ria among three different definitions of symptomatic remissionwas
52% in RSWG criteria, 63% in CGI and 65% in BPRS, respectively.
In comparison of remitted and non-remitted groups, there were
significant differences in sex, education, function and cognition in
terms of RSWG definition but not in CGI and BPRS. Female gender
and education were two factors for predicting symptomatic remis-
sion and function, whereas body mass index and education were
two factors for prediction of better cognition.
Conclusions Our study indicates that the definition of RSWG was
more clinical relevant compared with CGI and BPRS in Chinese
schizophrenia.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW501
Association between implicit motor
learning and neurological soft signs in
schizophrenia
A. Chrobak ∗ iuda-Krzywicka Siwek Tereszko
M. Siwek Dudek
1 Jagiellonian university medical college, faculty of medicine, Cracow,
Poland
2 École des neurosciences à Paris, Paris, France
3 Jagiellonian university medical college, department of affective
disorders, Cracow, Poland
∗ Corresponding author.
Introduction Schizophrenia (SZ) patients present subtle motor
deficits known as Neurological Soft Signs (NSS). Those deficits
encompass impairments of motor coordination, sequencing of
complex motor acts and sensory integration. It has been shown
that SZ patients present also deficits of higher motor functions
as implicit motor learning. Growing number of studies indicate
that both NSS and implicit motor learning deficits are associated
with impairments of common cortico-cerebellar pathways, how-
ever relationship between these two deficits has not been evaluated
yet.
Objectives To assess NSS and implicit motor learning in SZ
patients.
Aims To evaluate associations between NSS and implicit motor
learning scores in SZ patients.
Methods Twenty schizophrenia patients and 20 healthy controls
were examined. Patients were under olanzapine, clozapine or que-
tiapine treatment. NSS were assessed with Neurological Evaluation
Scale (NES). Implicit motor learning were assessed with a use of
Serial Reaction Time Task.
Results SZ patients presented statistically higher NSS scores than
healthy controls (P < 0.001) and presented no signs of implicit
motor learning. There was statistically significant negative corre-
lation between implicit motor learning score and total score of