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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S285

were likely to have memory and executive dysfunctions. It has

been shown that psychosocial risk factors had played an impor-

tant role in developing psychosis. However, these factors also may

negatively affect cognitive functions that may make the patient

predispose to develop psychosis in FEP patients.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.604

EW487

Pharmacokinetics, safety, and

tolerability of four 28-day cycle

intramuscular injections for

risperidone-ISM 75 mg in patients

with schizophrenia: A phase-2

randomized study (PRISMA-2)

L. Anta

, J. Llaudó , I. Ayani , B. Gorostidi , M. Monreal ,

J. Martínez-González , L. Ochoa , I. Gutierro

Rovi S.A., Medical Dpt, Madrid, Spain

Corresponding author.

Introduction

Risperidone-ISM is a new long acting intramuscu-

lar formulation of risperidone, for monthly administration without

oral supplementation.

Objective

To characterize the pharmacokinetic of risperidone

overmultiple intramuscular injections in patients with schizophre-

nia.

Method

A multicenter, open label, two-arm, parallel design clin-

ical trial was performed. Each patient received 4 intramuscular

injections of 75 mg of risperidone-ISM in either, gluteal or deltoid

muscle at 28-day intervals.

Results

A total of 70 patients were randomized, 67 received at

least one dose of study medication. Preliminary data show that

mean C

max

of the active moiety was achieved 24-48 hours (T

max

)

after each administration and ranged over four consecutive doses

from 39.6-53.2 ng/mL and 54.1-61 ng/mL, when given in gluteal

or deltoid, respectively. All subjects achieved therapeutic levels

(> 7.5 ng/mL for the active moiety) between 2-8 hours after drug

administration. The mean concentrations were maintained above

therapeutic levels throughout the 4-week dosing period. No signif-

icance changes across the study were observed, either on Positive

and Negative Syndrome Scale or Extrapyramidal Symptoms Scale.

Overall, 63 subjects (94%) experienced at least 1 Treatment Emer-

gent Adverse Event (TEAE) during the study. One serious TEAE

(dystonia) was related to study treatment. One death not related

to study medication was informed. The most frequently reported

TEAEs were hyperprolactinaemia (57.7%) and injection site pain

(32.8%).

Conclusions

Risperidone-ISM achieved therapeutic levels from

the first hours after drug administration and provided a sus-

tained release throughout the 4-weeks dosing period over multiple

intramuscular injections independently of the injection site.

Risperidone-ISM was found to be safe and well tolerated.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.605

EW488

The association between childhood

trauma and empathy in patients with

stable schizophrenia

A. Arous

, R. Trabelsi , J. Mrizak , A. Aissa , H. Ben Ammar ,

Z. El Hechmi

Razi hospital, department psychiatry F, Tunis, Tunisia

Corresponding author.

Introduction

Empathy, which refers to the ability to understand

and share the thoughts and feelings of others, has emerged as an

important topic in the field of social neuroscience. It is one of the

most understudied dimensions of social cognition in schizophrenia

(SCZ).

Objectives

To investigate the relationship between cognitive and

affective empathy and CT in SCZ.

Methods

Fifty-eight outpatients with stable SCZ completed the

Childhood Trauma Questionnaire retrospectively assessing five

types of childhood trauma (emotional, physical and sexual abuse,

and emotional andphysical neglect). They also completed theQues-

tionnaire of Cognitive and Affective Empathy (QCAE) comprising

five subscales intended to assess cognitive and affective compo-

nents of empathy.

Results

Patients with a history of sexual abuse better emotion

contagion scores (

P

= 0.048) which means that develop more easily

self-oriented emotional state matching the affective states of oth-

ers. Patients with a history of emotional neglect or/and in denial

of CT had higher scores in perspective taking score (

P

= 0.017). Per-

spective taking assesses the extent to which respondents can take

another’s perspective or see things from another’s point-of-view.

Conclusions

Investigating psychosocial mechanisms, specifically

the role of CT, underlying the development of empathic capacities

is important since empathy can represent a treatment-target.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.606

EW489

How do social cognition dimensions

relate to DSM-5 dimensions of

psychosis?

A. Arous

, J. Mrizak , R. Trabelsi , A. Aissa , H. Ben Ammar ,

Z. El Hechmi

Razi hospital, department psychiatry F, Tunis, Tunisia

Corresponding author.

Introduction

Existing research shows that individuals with

schizophrenia (SCZ) show substantial deficits in social cognitive

domains, including facial emotion recognition (FER), empathy, and

Theory of Mind (ToM). Their exact relationship with the differ-

ent dimensions included in the “Clinician- Rated Dimensions of

Psychosis Symptom Severity” of the 5th edition of the Diagnos-

tic and Statistical Manual of Mental Disorders (DSM-5) remains

unexplored.

Objectives

To investigate the relationship between different

social cognition dimensions and the dimensions of psychosis

included in the DSM-5.

Methods

Fifty-eight outpatients with stable SCZ completed the

Intention-Inferencing Task (IIT), a non-verbal ToM task and the

Questionnaire of Cognitive and Affective Empathy (QCAE). They

also completed a newly developed and validated FER task con-

structed from photographs of the face of a famous Tunisian actress

and evaluating the ability to correctly identify Ekman’s six basic

facial emotions. The clinician-rated dimensions of psychosis symp-

tom severity was used to evaluate 8 dimensions of psychosis.

Results

The patients presenting higher cognitive empathy capac-

ities had less present abnormal psychomotor behaviour scores

(

P

= 0.05). Higher levels of affective empathy were correlated to

lower present delusions score (

P

= 0.037). Better scores in the IIT

were correlated to less present negative scores (

P

= 0.013) and less

impaired cognition scores (

P

= 0.009). FER task score didn’t corre-

lated with any clinical dimension.

Conclusions

Our results suggest the existence of specific rela-

tionships between social cognition dimensions and psychosis

dimensions. Further studies are needed to confirm these relation-

ships.