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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S281

EW475

A six-year longitudinal

population-based cohort for the

extended psychosis phenotype: An

epidemiological study of the

gene-environment interactions

(TürkSch)

K. Alptekin

1 ,

, T. Binbay

1

, U. Kırlı

2

, H. Elbi

2

, B. Kayahan

2

,

H. Onay

3

, F. Özkınay

3

, J. van Os

4

1

Dokuz Eylul university faculty of medicine, department of

psychiatry, Izmir, Turkey

2

Ege university faculty of medicine, department of psychiatry, Izmir,

Turkey

3

Ege university faculty of medicine, department of medical genetics,

Izmir, Turkey

4

Maastricht university medical centre- school of mental health and

neuroscience MHeNS, department of psychiatry and

neuropsychology, Maastricht, Netherlands

Corresponding author.

Introduction

Both genetic and environmental factors play a role

in the extended psychosis phenotype which covers psychotic expe-

riences, symptoms and disorders.

Objectives

The respective contributions of genetic and environ-

mental factors over time remain largely unknown.

Aims

To describe the objectives and design of a multistage study.

Methods

The TürkSch (Izmir mental health survey for

gene-environment interaction in psychoses) is a prospective-

longitudinal study consisted of several data collection stages to

screen extended psychosis phenotype in a general population sam-

ple, and to assess individual, familial, genetic and neighbourhood

level variables.

Results

The study aimed to assess the prevalence of psychotic

experiences and symptoms in Izmir-Turkey (stage I, cross-

sectional;

n

: 4011), the socioeconomic deprivation and the social

capital of neighbourhoods in a separate sample (stage II, cross-

sectional;

n

: 5124) in 2008. A nested case-control study (stage III)

recruited individualswith psychotic outcomes and healthy controls

from stage I, and included blood sampling for gene-environment

interaction and clinical reappraisal as well. After 6 years, follow-up

study (stage IV)was set to assess themental healthoutcomeswith a

focus on extended psychosis phenotype, environmental exposures

of the eligiable sample (

n

: 2192) from the stage I, and to collect

blood samples for further genetic analysis. On both stages, Compos-

ite International Diagnostic Interviewwas used by clinically trained

interviewers, and was able to provide broad assessment of psy-

chotic experiences, experience-related disabilities, help-seeking

and health care utilization.

Conclusions

The TürkSch has a unique study design and yields

data of high quality in the Turkish population, with a specific focus

on psychosis.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.593

EW476

Google trends-enabled digital

pharmacovigilance: Monitoring

interest towards antidepressants and

their usage patterns in Italy

N. Bragazzi

1 ,

, A . S

iri

2

1

University of Genoa, school of public health- department of health

sciences DISSAL, Genoa, Italy

2

University of Genoa, UNESCO CHAIR “Anthropology of

Health–Biosphere and Healing system”, Genoa, Italy

Corresponding author.

Introduction

The Internet is playing a major role in nowadays life

andmore often psychiatric patients are using it as a valuable source

of information. Furthermore, the new media can be exploited for

providing them with personalized psycho-educational interven-

tions and counseling. On the other hand, a misuse of the new

technologies can lead to cyber-addiction behaviors and to others

psychopathologies.

Objectives and aims

In this contribution, we want to explore

the Internet pattern of searching online for antidepressants in

the Italian population. The prescriptions and usage of these drugs

have been increasing in the last years, and therefore constitute

an important economic burden for the National Health System

(NHS).

Methods

We analyzed the hit-search volumes with Google

Trends, an online tracking system of Internet hit-search volumes,

and the wavelet power spectrum analysis (WPSA), a mathematical

technique that decomposes a time series into time versus frequency

space. The hist-search volume data were compared with the data

provided by the Italian National Drug Agency. Pearson correlation

was used and

P

-values less than 0.05 were considered to be statis-

tically significant.

Results

We found a seasonality and cyclical pattern in searching

online for antidepressants, as confirmed by the WPSA. Moreover,

the pattern was increasing throughout the years, reflecting the

usage pattern as recorded and monitored by the Italian Drug

Agency. Pearson correlation yielded a value of 0.98 with a

P

-value

of 1.42

10

5

.

Conclusion

Digital pharmacovigilance can be employed as a

complementary approach together with the classical traditional

methodology.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.594

EW477

Agreement between clinical

judgments and subjective perceptions

of clinical change

M. Müller

, V. Stefan , W. Godehard , S. Prinz , S. Egger

University hospital for psychiatry Zurich, ZIP- Rheinau, Zurich,

Switzerland

Corresponding author.

Introduction

Research into the relationship between the sub-

jective perception of clinical change and the objective evidence

of the same is very limited. Less is known about the relation-

ship between clinical judgments by mental health experts and the

patient’s perception of symptom change, in particular across dif-

ferent diagnostic groups.

Aims and objectives

This study aims to determine the level of

concordance between the HONOS as a tool for clinical outcome

monitoring and the self-reported change in psychopathology in a

total sample of psychiatric patients as well as stratified by their

primary diagnosis at admission.

Methods

A consecutive sample of patients admitted to a Swiss

psychiatric hospital for either alcohol use disorders, schizophrenic

psychoses, mood disorders, anxiety and somatoform disorders,

or personality disorders, was assessed using the Brief Symptom

Inventory (BSI) at admission and at discharge. The HoNOS were

rated by the responsible clinicians. Complete data of admission

and discharge were available from approximately 600 cases. Reli-

able change index (RCI) will be calculated to determine a clinically

meaningful change based on the HoNOS scores. Concordance of RCI

and change in BSI scores will be explored and compared between

different diagnostic groups.

Results and conclusions

According to our preliminary results from

this ongoing evaluationprogram, we hope toprovide a step towards

a deeper understanding of the interrelationship between clinical