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S286

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.607

EW490

Evaluation of reproductive hormones

relations with response to treatment

in male patients with first episode

psychosis

A. Ates

1 ,

, I. Oner

1

, C. Basoglu

1

, A. Algul

2

, R. Tutuncu

2

,

H. Balibey

2

, O. Ipcioglu

3

1

GATA Haydarpasa training hospital, Istanbul, Turkey

2

Istanbul, Turkey

3

Biochemistry service, Istanbul, Turkey

Corresponding author.

Objectives

Data regarding schizophrenia treatment has been

increasing whereas the information about predictors of treatment

response is limited. In this study, our aim is to investigate the serum

levels of reproductive hormones as a biological predictor in terms.

Methods

Thirty-three hospitalized male patients in GATA Hay-

darpasa Training Hospital with the diagnosis of first episode

psychosis were included into the study. The study was prospec-

tive and naturalistic in design. The clinical course was recorded by

means of Positive andNegative SymptomScale (PANSS) in pretreat-

ment period, 2nd and 6th weeks of the study. Prolactin, FSH, LH,

estrogen, testesterone and oxytocin serum levels were also mea-

sured at the same dates.

Results

Treatment response was assessed as unresponsive when

PANSSttl scores were lower than 25%, partial response when

PANSSttl scores were between 25%-40% changes, and response

when PANSSttl scores were higher than 40%. Patients were grouped

according to those cut-off points. There was a significant posi-

tive correlation between oxytocin, FSH serum levels and positive

symptoms ( = 0.437,

P

= 0.011;

r

= 0.385,

P

= 0.027). There was also

significant negative correlation between testesterone serum lev-

els and negative and total psychopathology scores (

r

=

0.352,

P

= 0.044;

r

=

0.429,

P

= 0.013). It was seen that pretreatment tes-

terone levels had a significant biological marker on predicting

remission when the serum levels were lower than 460,91 ng/dL.

Conclusions

This study shows that hypothalamo-hypophysial-

gonadal axis hormones and reproductive hormones, especially

testesterone, may be an important biological marker of treatment

response prediction in first episode psychosis.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.608

EW491

The validity of observer-based scales

in the measure of drug-induced motor

symptoms in a spanish sample of

patients with severe mental disorders

J. Aznarte

1 ,

, Y . C

respo

2 , S. I

glesias-Parro

3 , M.

F. Soriano-Pe˜na

4 ,

A. Ibá˜nez Molina

3

1

Servicio Andaluz de Salud, Psiquiatria, Linares, Spain

2

Universidad de Jaén, PhD Biology, Jaén, Spain

3

Universidad de Jaén, Psychology, Jaén, Spain

4

Servicio Andaluz de Salud, Mental Health, Linares, Spain

Corresponding author.

Background

Antipsychotic drugs are effective in schizophrenic

disorders, but they are also used to treat other psychiatric con-

ditions. Typical antipsychotics cause important extrapyramidal

symptoms (EPS), which frequently result in non-compliance with

antipsychotic medication. It has been stated that the second-

generation antipsychotics (atypical) provoke EPS side effects less

frequently than typical antipsychotics. However, there is some

controversy around this statement, especially because of ineffi-

cient measures of EPS. Clinical assess of EPS normally relies upon

observer-based ratings, but their reliability and validity has not

been consistently established.

Objective

In the present work, we have explored the convergent

and discriminant validity of the Abnormal Involuntary Movement

Scale (AIMS) and the Simpson-Angus Scale (SEE), in a Spanish sam-

ple of patients with severe mental disorders. Patients could be

under typical or atypical antipsychotics, antidepressants, benzo-

diacepines, or a combination of these.

Method

Sixty-one patients with severe mental disorders from

the Mental Health Day Hospital of St. Agustín (Linares, Spain) par-

ticipated in the study. Inclusion criteria were DSM-V diagnosis of

schizophrenia or schizophrenic disorder, bipolar, or borderline per-

sonality disorders, and age between 18-61. In order to explore

the discrimination capacity of each rating scale, Receiver Operator

Characteristic (ROC) analyses were conducted.

Results

ROC curves indicated a suitable construct validity of the

scales in themeasurement of drug-inducedmotor symptoms. How-

ever, the scales were not sensitive to the number of years under

treatment.

Conclusions

In line with previous research, our results question

the use of rating scales as the only measure in the evaluation of EPS

symptoms.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.609

EW492

Metacognitive training vs

psycho-educational group, results

from a clinical trial in patients with

psychosis of recent onset

M.L. Barrigon

1 ,

, S. M

.S.G

. 2

1

Fundación Jiménez Díaz, Psychiatry Department, Madrid, Spain

2

Spain

Corresponding author.

Aim

To assess the efficacy of Metacognitive Training (MCT) in

symptoms and metacognitive variables in people with a recent

onset of psychosis.

Method

A multicenter, randomized and controlled clinical trial

was performed. One hundred and twenty-six patients were ran-

domized to MCT or a psycho-educational intervention. Patients

with a recent onset of psychosis were recruited from 9 centers of

Spain. The treatment consisted in 8 weekly sessions in both groups.

Patients were assessed at baseline, post-treatment, and 6 months

of follow-up. Symptoms were assessed by the PANSS. Metacogni-

tion was assessed by a battery of questionnaires of cognitive biases

and social cognition: BCIS, IPSAQ, TCI, Hinting task and Emotional

Recognition Test.

Results

PANSS positive symptoms significant declined between

baseline and post-treatment in psycho-educational (

P

= 0.04) and

MCT group (

P

= 0.01), while general PANSS and total PANSS were

significant between baseline and post-treatment in the MCT group

only (

P

= 0.008;

P

= 0.005). Across time, the MCT group was superior

to psycho-educational on the BCIS total and self-certainty sub-

scale (

P

= 0.042). Regarding irrational beliefs, the intolerance to

frustration subscale declined more strongly in the MCT in rela-

tion to psycho-educational group (

P

= 0.016). ToM, Personalizing

Bias and JTC improved more strongly in the MCT group com-

pared to psycho-educational group (

P

< 0.001–0.032). Most results

remained significant at the follow-up.

Conclusions

MCT could be an effective psychological interven-

tion for people with a recent onset of psychosis in order to improve

symptoms, insight, tolerance to frustration and personalizing

bias.