European Psychiatry - Volume 33 - March 2016

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S286 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW490
Evaluation of reproductive hormones
relations with response to treatment
in male patients with first episode
psychosis
A. Ates ∗, I. Oner , C. Basoglu , A. Algul , R. Tutuncu ,
H. Balibey , O. Ipcioglu
1 GATA Haydarpasa training hospital, Istanbul, Turkey
2 Istanbul, Turkey
3 Biochemistry service, Istanbul, Turkey
∗ Corresponding author.
Objectives Data regarding schizophrenia treatment has been
increasing whereas the information about predictors of treatment
response is limited. In this study, our aim is to investigate the serum
levels of reproductive hormones as a biological predictor in terms.
Methods Thirty-three hospitalized male patients in GATA Hay-
darpasa Training Hospital with the diagnosis of first episode
psychosis were included into the study. The study was prospec-
tive and naturalistic in design. The clinical course was recorded by
means of Positive andNegative SymptomScale (PANSS) in pretreat-
ment period, 2nd and 6th weeks of the study. Prolactin, FSH, LH,
estrogen, testesterone and oxytocin serum levels were also mea-
sured at the same dates.
Results Treatment response was assessed as unresponsive when
PANSSttl scores were lower than 25%, partial response when
PANSSttl scores were between 25%-40% changes, and response
when PANSSttl scores were higher than 40%. Patients were grouped
according to those cut-off points. There was a significant posi-
tive correlation between oxytocin, FSH serum levels and positive
symptoms ( = 0.437, P= 0.011; r = 0.385, P = 0.027). There was also
significant negative correlation between testesterone serum lev-
els and negative and total psychopathology scores (r = −0.352,
P = 0.044; r= −0.429, P = 0.013). It was seen that pretreatment tes-
terone levels had a significant biological marker on predicting
remission when the serum levels were lower than 460,91 ng/dL.
Conclusions This study shows that hypothalamo-hypophysial-
gonadal axis hormones and reproductive hormones, especially
testesterone, may be an important biological marker of treatment
response prediction in first episode psychosis.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW491
The validity of observer-based scales
in the measure of drug-induced motor
symptoms in a spanish sample of
patients with severe mental disorders
J. Aznarte ∗ respo glesias-Parro F. Soriano-Pe˜na
A. Ibá˜nez Molina
1 Servicio Andaluz de Salud, Psiquiatria, Linares, Spain
2 Universidad de Jaén, PhD Biology, Jaén, Spain
3 Universidad de Jaén, Psychology, Jaén, Spain
4 Servicio Andaluz de Salud, Mental Health, Linares, Spain
∗ Corresponding author.
Background Antipsychotic drugs are effective in schizophrenic
disorders, but they are also used to treat other psychiatric con-
ditions. Typical antipsychotics cause important extrapyramidal
symptoms (EPS), which frequently result in non-compliance with
antipsychotic medication. It has been stated that the second-
generation antipsychotics (atypical) provoke EPS side effects less
frequently than typical antipsychotics. However, there is some
controversy around this statement, especially because of ineffi-
cient measures of EPS. Clinical assess of EPS normally relies upon
observer-based ratings, but their reliability and validity has not
been consistently established.
Objective In the present work, we have explored the convergent
and discriminant validity of the Abnormal Involuntary Movement
Scale (AIMS) and the Simpson-Angus Scale (SEE), in a Spanish sam-
ple of patients with severe mental disorders. Patients could be
under typical or atypical antipsychotics, antidepressants, benzo-
diacepines, or a combination of these.
Method Sixty-one patients with severe mental disorders from
the Mental Health Day Hospital of St. Agustín (Linares, Spain) par-
ticipated in the study. Inclusion criteria were DSM-V diagnosis of
schizophrenia or schizophrenic disorder, bipolar, or borderline per-
sonality disorders, and age between 18-61. In order to explore
the discrimination capacity of each rating scale, Receiver Operator
Characteristic (ROC) analyses were conducted.
Results ROC curves indicated a suitable construct validity of the
scales in themeasurement of drug-inducedmotor symptoms. How-
ever, the scales were not sensitive to the number of years under
treatment.
Conclusions In line with previous research, our results question
the use of rating scales as the only measure in the evaluation of EPS
symptoms.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW492
Metacognitive training vs
psycho-educational group, results
from a clinical trial in patients with
psychosis of recent onset
M.L. Barrigon ∗ .S.G
1 Fundación Jiménez Díaz, Psychiatry Department, Madrid, Spain
2 Spain
∗ Corresponding author.
Aim To assess the efficacy of Metacognitive Training (MCT) in
symptoms and metacognitive variables in people with a recent
onset of psychosis.
Method A multicenter, randomized and controlled clinical trial
was performed. One hundred and twenty-six patients were ran-
domized to MCT or a psycho-educational intervention. Patients
with a recent onset of psychosis were recruited from 9 centers of
Spain. The treatment consisted in 8 weekly sessions in both groups.
Patients were assessed at baseline, post-treatment, and 6 months
of follow-up. Symptoms were assessed by the PANSS. Metacogni-
tion was assessed by a battery of questionnaires of cognitive biases
and social cognition: BCIS, IPSAQ, TCI, Hinting task and Emotional
Recognition Test.
Results PANSS positive symptoms significant declined between
baseline and post-treatment in psycho-educational (P = 0.04) and
MCT group (P = 0.01), while general PANSS and total PANSS were
significant between baseline and post-treatment in the MCT group
only (P = 0.008; P= 0.005). Across time, the MCT group was superior
to psycho-educational on the BCIS total and self-certainty sub-
scale (P= 0.042). Regarding irrational beliefs, the intolerance to
frustration subscale declined more strongly in the MCT in rela-
tion to psycho-educational group (P = 0.016). ToM, Personalizing
Bias and JTC improved more strongly in the MCT group com-
pared to psycho-educational group (P < 0.001–0.032). Most results
remained significant at the follow-up.
Conclusions MCT could be an effective psychological interven-
tion for people with a recent onset of psychosis in order to improve
symptoms, insight, tolerance to frustration and personalizing
bias.