European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S291
had 2 treatments. Treatment “A” consisted in 1 psychoeducation
session. Treatment “B” was 1 visit (real or virtual) to the Thyssen-
Bornemisza museum. Persons exercising as museum guides had
been diagnosedwithmental illness. They alreadywere participants
in the PCEA program of the CRPS Latina. The instrument to assess
stigma was the AQ-27, validated in Spanish.
Results We found significant reductions of stigma in all dimen-
sions explored: Anger (A vs BC; P < 0.001), Threat (A vs BC;
P < 0.001), Fear (A vs BC; P < 0.001), Coercion (A vs BC; P < 0.001)
Segregation (A vs BC; P < 0.001) and Avoidance (A vs BC; P < 0.001).
Conclusions The combination of treatments for intervention on
stigma in samples of school students seems to be a very effective
option to reduce stigma.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW505
Avolition in schizophrenia:
associations with trait and state
anhedonia
S. De Simone ∗, A. Mucci , P. Bucci , E. Merlotti , M. Chieffi ,
G. Piegari , T. Campana , S. Patriarca , M. Rocco , D. Palumbo ,
S. Galderisi
University of Naples SUN, department of psychiatry, Naples, Italy
∗ Corresponding author.
Introduction Current research suggested that avolition in
patients with schizophrenia (SCZ) is not due to a deficit of hedonic
experience, but to a poor ability to translate pleasurable experi-
ences into motivational states. In line with this hypothesis, several
evidences showed a preserved hedonic experience, even in the
presence of severe trait anhedonia and avolition in SCZ.
Objectives To test the hypothesis that memory dysfunction, gen-
erally found in SCZ, could lead to inaccurate representations of
emotional experiences and interferewith translation of pleasurable
experience in motivation.
Aims The present study was aimed to investigate the relation-
ships between state and trait anhedonia, avolition and cognitive
functioning in 35 SCZ.
Methods In SCZ and matched healthy controls (HC) the Tempo-
ral experience of Pleasure (TEPS) and Chapman’s scales were used
to assess trait anhedonia. The MID task was used to assess in-
the-moment hedonic experience. Avolition was measured by the
Schedule for the Deficit Syndrome. MATRICS Consensus Cognitive
Battery was used to assess cognition.
Results SCZ did not differ fromHC on TEPS or on MID task perfor-
mance but reported higher scores for trait social anhedonia. Trait
social anhedonia was associated with memory dysfunction and
showed a correlation with avolition.
Conclusions Our results confirm the disjunction between state
and trait anhedonia and demonstrate a relationship of the latter
with memory impairment and avolition, suggesting that inaccu-
rate representations of emotional experiences might impede their
translation in motivation to act.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW506
Relation between EEG source
functional connectivity and the
negative symptom severity in
schizophrenia: a preliminary report
from a multicentre study
G. Di Lorenzo ∗ Mucci averio errentino
A. Vignapian Marasco iolu Altamura
S. Galderisi
1 University of Rome “Tor Vergata”, department of systems medicine,
Rome, Italy
2 University of Naples SUN, department of psychiatry, Naples, Italy
3 University of Foggia, department of clinical and experimental
medicine, Foggia, Italy
∗ Corresponding author.
Introduction Neural dysconnectivity is hypothesized to be a
key element in pathophysiology of schizophrenia. However, the
relation of disordered connectivity with the different clinical char-
acteristics of the syndrome is not fully elucidated.
Objectives The current research investigated the relations
between resting-state EEG Source Functional Connectivity (EEG-
SFC) and the two main clusters of negative symptoms derived from
the Brief Negative Symptom Scale, the Expressive Deficit (ED) and
the Avolition (AV), in subjects with schizophrenia (SCZ) enrolled
to the multicentre study of the Italian Network for Research on
Psychoses.
Methods Out of 97 chronic, stabilized SCZ included, we selected
subjects according the lower and the upper quartile of the ED and
AV value distribution: 25were in upper and 24 in the lower quartile
of ED (respectively, HIGH-ED and LOW-ED); 27 were in upper and
24 in the lower quartile of AV (respectively, HIGH-AV and LOW-AV).
Fifty-five healthy controls (HC) were included, comparable to SCZ
for gender, age and educational level. EEG-SFC analysis was based
on the lagged phase synchronization (LPS) computed by eLORETA
from 5 minutes resting-state EEG recordings in eyes closed con-
dition. LPS indices were determined for each spectrum band and
between all 28 regions of interest (ROI) pairs. Group differences
were significant for corrected P-value < 0.05.
Results SCZ had higher theta band LPS than HC. Respect to
LOW-ED, HIGH-ED showed significant increased alpha LPS in
fronto-cingulate, para-hippocampal and insular inter-hemispheric
ROI pairs. No significant difference emerged between HIGH-AV and
LOW-AV.
Conclusions Subgrouping SCZ according to negative symptom
severity reveals heterogeneous patterns of resting-state LPS con-
nectivity.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW507
Low erythrocyte glutathione
peroxidase activity in schizophrenic
patients is mediated by gender, the
number of episodes, disease duration
and drug treatment
V. Djordjevic ∗, M. Knezevic
1 Clinical center Nis, Daily hospital, Nis, Serbia
2 Faculty of medical sciences, institute for psychiatry, Kragujevac,
Serbia
∗ Corresponding author.
Introduction Inconsistent data showed that erythrocyte glu-
tathione peroxidase (GPx) activity in schizophrenics is altered.
Aim The aim of this study was to evaluate whether some of the
demographic, clinical and therapeutic factors had any significant
impact on erythrocyte GPx activity in patients with schizophrenia.
Methods This study included 68 schizophrenic patients and 59
healthy individuals. GPx activity was tested related to patient age,
gender, heredity, the onset of the disease, the duration of the dis-
ease, the number of episodes, PANSS scores and drug treatment.
GPx activity was determined in erythrocyte hemolysates by Ransel
commercially available test.