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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S291

had 2 treatments. Treatment “A” consisted in 1 psychoeducation

session. Treatment “B” was 1 visit (real or virtual) to the Thyssen-

Bornemisza museum. Persons exercising as museum guides had

been diagnosedwithmental illness. They alreadywere participants

in the PCEA program of the CRPS Latina. The instrument to assess

stigma was the AQ-27, validated in Spanish.

Results

We found significant reductions of stigma in all dimen-

sions explored: Anger (A vs BC;

P

< 0.001), Threat (A vs BC;

P

< 0.001), Fear (A vs BC;

P

< 0.001), Coercion (A vs BC;

P

< 0.001)

Segregation (A vs BC;

P

< 0.001) and Avoidance (A vs BC;

P

< 0.001).

Conclusions

The combination of treatments for intervention on

stigma in samples of school students seems to be a very effective

option to reduce stigma.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.622

EW505

Avolition in schizophrenia:

associations with trait and state

anhedonia

S. De Simone

, A. Mucci , P. Bucci , E. Merlotti , M. Chieffi ,

G. Piegari , T. Campana , S. Patriarca , M. Rocco , D. Palumbo ,

S. Galderisi

University of Naples SUN, department of psychiatry, Naples, Italy

Corresponding author.

Introduction

Current research suggested that avolition in

patients with schizophrenia (SCZ) is not due to a deficit of hedonic

experience, but to a poor ability to translate pleasurable experi-

ences into motivational states. In line with this hypothesis, several

evidences showed a preserved hedonic experience, even in the

presence of severe trait anhedonia and avolition in SCZ.

Objectives

To test the hypothesis that memory dysfunction, gen-

erally found in SCZ, could lead to inaccurate representations of

emotional experiences and interferewith translation of pleasurable

experience in motivation.

Aims

The present study was aimed to investigate the relation-

ships between state and trait anhedonia, avolition and cognitive

functioning in 35 SCZ.

Methods

In SCZ and matched healthy controls (HC) the Tempo-

ral experience of Pleasure (TEPS) and Chapman’s scales were used

to assess trait anhedonia. The MID task was used to assess in-

the-moment hedonic experience. Avolition was measured by the

Schedule for the Deficit Syndrome. MATRICS Consensus Cognitive

Battery was used to assess cognition.

Results

SCZ did not differ fromHC on TEPS or on MID task perfor-

mance but reported higher scores for trait social anhedonia. Trait

social anhedonia was associated with memory dysfunction and

showed a correlation with avolition.

Conclusions

Our results confirm the disjunction between state

and trait anhedonia and demonstrate a relationship of the latter

with memory impairment and avolition, suggesting that inaccu-

rate representations of emotional experiences might impede their

translation in motivation to act.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.623

EW506

Relation between EEG source

functional connectivity and the

negative symptom severity in

schizophrenia: a preliminary report

from a multicentre study

G. Di Lorenzo

1 ,

, A .

Mucci

2 , A. D

averio

1 , F. F

errentino

1 ,

A. Vignapian

o 2 , D.

Marasco

3 , C. N

iolu

1 , M.

Altamura

3 ,

S. Galderisi

2

1

University of Rome “Tor Vergata”, department of systems medicine,

Rome, Italy

2

University of Naples SUN, department of psychiatry, Naples, Italy

3

University of Foggia, department of clinical and experimental

medicine, Foggia, Italy

Corresponding author.

Introduction

Neural dysconnectivity is hypothesized to be a

key element in pathophysiology of schizophrenia. However, the

relation of disordered connectivity with the different clinical char-

acteristics of the syndrome is not fully elucidated.

Objectives

The current research investigated the relations

between resting-state EEG Source Functional Connectivity (EEG-

SFC) and the two main clusters of negative symptoms derived from

the Brief Negative Symptom Scale, the Expressive Deficit (ED) and

the Avolition (AV), in subjects with schizophrenia (SCZ) enrolled

to the multicentre study of the Italian Network for Research on

Psychoses.

Methods

Out of 97 chronic, stabilized SCZ included, we selected

subjects according the lower and the upper quartile of the ED and

AV value distribution: 25were in upper and 24 in the lower quartile

of ED (respectively, HIGH-ED and LOW-ED); 27 were in upper and

24 in the lower quartile of AV (respectively, HIGH-AV and LOW-AV).

Fifty-five healthy controls (HC) were included, comparable to SCZ

for gender, age and educational level. EEG-SFC analysis was based

on the lagged phase synchronization (LPS) computed by eLORETA

from 5 minutes resting-state EEG recordings in eyes closed con-

dition. LPS indices were determined for each spectrum band and

between all 28 regions of interest (ROI) pairs. Group differences

were significant for corrected

P

-value < 0.05.

Results

SCZ had higher theta band LPS than HC. Respect to

LOW-ED, HIGH-ED showed significant increased alpha LPS in

fronto-cingulate, para-hippocampal and insular inter-hemispheric

ROI pairs. No significant difference emerged between HIGH-AV and

LOW-AV.

Conclusions

Subgrouping SCZ according to negative symptom

severity reveals heterogeneous patterns of resting-state LPS con-

nectivity.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.624

EW507

Low erythrocyte glutathione

peroxidase activity in schizophrenic

patients is mediated by gender, the

number of episodes, disease duration

and drug treatment

V. Djordjevic

1 ,

, M. Knezevic

2

1

Clinical center Nis, Daily hospital, Nis, Serbia

2

Faculty of medical sciences, institute for psychiatry, Kragujevac,

Serbia

Corresponding author.

Introduction

Inconsistent data showed that erythrocyte glu-

tathione peroxidase (GPx) activity in schizophrenics is altered.

Aim

The aim of this study was to evaluate whether some of the

demographic, clinical and therapeutic factors had any significant

impact on erythrocyte GPx activity in patients with schizophrenia.

Methods

This study included 68 schizophrenic patients and 59

healthy individuals. GPx activity was tested related to patient age,

gender, heredity, the onset of the disease, the duration of the dis-

ease, the number of episodes, PANSS scores and drug treatment.

GPx activity was determined in erythrocyte hemolysates by Ransel

commercially available test.